PERSPECTIVES
ON GLOBAL
PUBLIC HEALTH
AND OTHER
ISSUES
    Collected Blogs II
    October 2019—December 2020


    Patricio V Marquez
Perspectives Of Global Public Health And Other Issues October 2019—December 2020
CONTENTS
A Few Reflections to Close the Year of COVID-19 | December 23, 2020
   http://www.pvmarquez.com/reflectionsend2020


Some Reflections on World AIDS Day 2020 Amidst COVID-19 | November 30, 2020
   http://www.pvmarquez.com/hivaids2020


What We Know About the New COVID-19 Vaccines:
Are We There Yet? | November 24, 2020
   http://www.pvmarquez.com/covid19vaccine


How to Strengthen Health Care Systems to Support
COVID 19-Vaccination? | November 16, 2020
   http://www.pvmarquez.com/covid-19vaccination


Health Systems Fit for the Future: How to Promote Better Health,
Economic Growth, and Social Cohesion? | October 23, 2020
   http://www.pvmarquez.com/romehsystems


The World Bank’s health response to COVID-19 (Coronavirus) | October 19, 2020
   https://blogs.worldbank.org/health/lets-invest-mental-health-inclusive-and-resilient-
   recovery-covid-19


Let’s Invest in Mental Health for an Inclusive and Resilient Recovery
from COVID-19 | October 8, 2020
   https://blogs.worldbank.org/health/lets-invest-mental-health-inclusive-and-resilient-
   recovery-covid-19


Addressing Alcohol Use Disorders through Taxation: A Public Health
and Economic Win-Win in the time of COVID-19 | September 6, 2020
   http://www.pvmarquez.com/alcoholuse


Let’s Not Forget About Mental Health during COVID-19! | August 22, 2020
   http://www.pvmarquez.com/mentalhealandthcovid-19
Perspectives Of Global Public Health And Other Issues October 2019—December 2020




Taxes on tobacco, alcohol, and sugar-sweetened beverages reduce health risks
and expand fiscal space for Universal Health Coverage post-COVID 19 | August 11, 2020
     https://blogs.worldbank.org/health/taxes-tobacco-alcohol-and-sugar-sweetened-
     beverages-reduce-health-risks-and-expand-fiscal


While waiting for a COVID-19 vaccine, it’s time to focus on gaps in vaccine
distribution, cold chain, and uptake | July 26, 2020
     http://www.pvmarquez.com/vaccinationsystems


Improving Health Services: A Global Imperative Amidst COVID-19 | June 22, 2020
     http://www.pvmarquez.com/qualityimprovement


Sustaining Essential Health Services during the Covid-19 Pandemic:
A Social Imperative | June 15, 2020
     http://www.pvmarquez.com/essentialhealthservices


Have South and Central America become the new coronavirus
(COVID-19) epicenter?  | June 3, 2020
     https://blogs.worldbank.org/health/have-south-and-central-america-become-new-
     coronavirus-covid-19-epicenter


Tobacco use and coronavirus (COVID-19): A deadly but
preventable association | May 27, 2020
     https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-covid-19-deadly-
     preventable-association


Social distancing in the time of COVID-19 in Latin America and
the Caribbean: Costs and Benefits | May 14, 2020
     http://pvmarquez.com/socialdistancing


Do BCG Vaccinated People Have Some Immunity Advantage Over
Non-Vaccinated People? | April 21, 2020
     http://www.pvmarquez.com/bcg


Searching for Evidence in the COVID-19 Era: The BCG Case | April 17, 2020
     http://www.pvmarquez.com/bcgcovid19
How to Prevent Jails and Prisons from Becoming New Hotspots for the Spread of
COVID-19? | April 13, 2020
   http://www.pvmarquez.com/prisoncovid19


Does Tobacco Smoking Increases the Risk of Coronavirus Disease (COVID-19)
Severity? the Case of China | March 3, 2020
   http://www.pvmarquez.com/Covid-19


The Unpredictable Social and Economic Cost of the Coronavirus
(COVID-19) Outbreak | February 27, 2020
   http://www.pvmarquez.com/coronavirus


Public Health Investments and Economic Gains: Learning from Latin America and
Caribbean History in the Time of Coronavirus | February 10, 2020
   http://www.pvmarquez.com/disease_control


Galapagos’ Charles Darwin Foundation: An International Good Practice
that Needs to be Supported | February 7, 2020
   http://www.pvmarquez.com/Galapagos_CDF


Common Myths Against Tobacco Taxation: Not Borne Out by
Global Evidence | February 2, 2020
   www.pvmarquez.com/tobacco_taxes


High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending,
High-Debt Levels, and Impoverishment | January 28, 2020
   http://pvmarquez.com/drug_prices


Mental Health and Healthy Futures: A Priority Theme at WEF
Davos 2020 | January 22, 2020
   http://www.pvmarquez.com/mental_health_davos


How to Accelerate Universal Health Coverage in Latin America
and the Caribbean? | January 16, 2020
   http://www.pvmarquez.com/health_reform
Perspectives Of Global Public Health And Other Issues October 2019—December 2020




Is the Growing Attachment to Smartphones and Digital Media Bad for
Our Health? An initial exploration | December 12, 2019
     http://www.pvmarquez.com/digital%20media_impacts


Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | November 27, 2019
     http://www.pvmarquez.com/plastic_pollution_galapagos


Retracing Darwin’s Footsteps in the Galapagos | November 24, 2019
     http://www.pvmarquez.com/node/5


An Ode to Halloween, Birthdays and Aging | October 30, 2019
     http://www.pvmarquez.com/halloween_aging


Social Disparities Among Indigenous Peoples in the Americas:
A Legacy to Overcome | October 27, 2019
     http://www.pvmarquez.com/legacy_to_overcome
1/12/2021                                                  A Few Reflections to Close the Year of COVID-19 | Patricio V. Marquez




  A Few Re ections to Close the Year of COVID-19
  Submitted by Patricio V. Marquez on Wed, 12/23/2020 - 01 35 PM




  A Few Re ections to Close the Year of COVID-19
  Posted by Patricio V. Marquez on Wed, 12/23/2020 - 01 35 PM




   
  “It was undoubtedly the feeling of exile—that sensation of a void within which never left us, that irrational longing to hark back to the past or else to speed up the
  march of time, and those keen shafts of memory that stung like re.”
  Albert Camus (1957 Nobel Prize Laureate for Literature). The Plague. Vintage, 1991.


  As we approach the end of 2020, perhaps a few re ections are warranted on a period unlike any other in our global
  collective memory. While the ceaseless movement of time, manifested in the passing of days and months, is mostly
  an unconscious fact in our lives, only made visible by calendars, birthdays, and other celebrations, during this year it
  was different.  The sameness of the days, with their now well-established routines, fears, frustrations, rebellions,
  and hopes, superseded our recent past by rmly imposing a very tangible present that continues to entrap us.

  COVID-19 in the historical context of public health crises

  Since the beginning of March, when the “Great Lockdown” gradually extended its tentacles across the world, as an
  initial response to the exponential spread of a novel coronavirus, SARS-CoV-2, few may have thought that come
  December we were going to still be ensconced as if in a state of siege. Indeed, this overwhelming reality has
  separated us from our loved ones, friends, and coworkers, and has imposed rigid norms that have forced us to alter
  and adapt our behaviors and routines to strict social distancing.

  But paradoxical, our COVID-19 norms are not so different from the isolation and con nement measures followed in
  Europe to control infectious disease outbreaks in the Middle Ages. Or that beginning in 1519, were also used in parts
  of my native region, Latin America and the Caribbean, in accordance with the 1423 Venetian quarantine control
  system, to detain ships and isolate their crews and passengers outside harbors until suf cient time had elapsed
  without the outbreak of “pestilences.”



www.pvmarquez.com/reflectionsend2020                                                                                                                                        1/3
1/12/2021                                 A Few Reflections to Close the Year of COVID-19 | Patricio V. Marquez

  The onslaught of COVID-19 has been relentless worldwide, with a growing accumulated damage painfully measured
  as of today with close to 80 million infected people – and about 1.7 million premature deaths (not counting the
  excess mortality due to other conditions), and millions of people unemployed or underemployed that has resulted
  from the disintegration and slowdown of economic activity, trade, and the ow of people and capital across
  countries.

  Exposing inequalities – and an opportunity for renewal

  This catastrophe has exposed and brought to the fore with great clarity the manifestations and impact of glaring,
  pre-existing inequalities in our societies, where minorities and others at the bottom of the economic ladder, the frail
  and the sicker, have been hit hardest, while the well-off, although still at risk and working from home, have been
  able to resist better.

  In our daily lives, like in a shipwreck, we have continued to hold on to memories of times past, as a way to recharge
  and remind ourselves that this too shall pass, and we can look forward to future times when we can hug and laugh
  with family and friends, work in close proximity to others, and travel and discover other geographies and people,
  without the fear that COVID-19 is waiting for us “just around the corner”.  But, more importantly, I think, we are
  realizing and learning to accept that change is needed in our lives and in the existing social contracts of countries
  and between countries. 

  Rising to the challenge – and looking forward with solidarity

  We, as a global collective, have resisted, mounted a strong response, and have seen the potential wonders that
  cooperation and solidarity can bring to enrich our arsenal against COVID-19. In an unprecedented historical feat, we
  have new vaccines produced in less than a year (good to keep in mind that the eradication of smallpox through a
  vaccine took several centuries, while the development of vaccines to deal with measles, in uenza, and yellow fever,
  took several decades), as well as new diagnostics and treatment protocols that have reduced signi cantly the risk of
  severity and death among the infected. 

  These scienti c leaps should amaze us: they have resulted from a mixture of accumulated knowledge and
  technologies, and the human capacity and capability to learn (an initial milestone was the publication of the genome
  sequence of the new virus on January 29, only weeks after the rst case was noti ed), innovate, develop new
  knowledge, and translate that knowledge into applications to solve our needs.  Also, we have come to realize that the
  adoption of basic public health measures such as wearing masks, washing hands, and social distancing, are once
  again helping us to keep the novel coronavirus virus at bay by preventing its uncontrolled spread as they have done
  over the centuries in similar outbreaks of infectious diseases. 

  During the past 10 months, we have been able to come together not only as a duty imposed by present challenges,
  but more importantly, we are realizing that the pandemic is offering us the opportunity to take stock and rebuild
  better our collective lives.  As we enter the holiday season and gaze with hope into 2021, perhaps it will do us good
  to look back into history to learn that in the face of all types of past calamities – war, famine, and plagues – the
  resilient human spirit has triumphed when acting as a collective and not as isolated individuals and countries.

  Going forward, particularly in the face of the momentous task of having to vaccinate entire populations in the new
  year, without leaving the most vulnerable and poor behind as our moral obligation, we could start planting the seeds
  of a better world that is rooted in cooperation, solidarity, and respect for others, accepting our differences as a
  source of strength and not of con ict, and trying every day to be there as men and women for others, giving our
  best effort for the betterment of all.

www.pvmarquez.com/reflectionsend2020                                                                                       2/3
1/12/2021                                                  A Few Reflections to Close the Year of COVID-19 | Patricio V. Marquez

  Indeed, together, as the gospel song (https://www.bing.com/videos/search?
  q=bruce+springsteen+we+shall+overcome&docid=608005599646253213&mid=5C988E6B548AE2F887725C988E6B548AE
  goes, “We shall overcome, We shall overcome, We shall overcome, some day!”

   

  Photo: Long, socially-distanced lines to access services in Lima, Peru. © Victor Idrogo / World Bank
  The original version of this blog was posted at the World Bank Group Investing in Health site on December 23, 2020:


  A few re ections to close the year of COVID-19 (worldbank.org) (https://blogs.worldbank.org/health/few-
  re ections-close-year-covid-19)

   




                                                      
                                                             (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/reflectionsend2020                                                                                               3/3
1/12/2021                            Some Reflections on World AIDS Day 2020 Amidst COVID-19 | Patricio V. Marquez




  Some Re ections on World AIDS Day 2020 Amidst COVID-19
  Submitted by Patricio V. Marquez on Mon, 11/30/2020 - 10 07 PM




  Some Re ections on World AIDS Day 2020 Amidst COVID-
  19
  Posted by Patricio V. Marquez on Mon, 11/30/2020 - 10 07 PM




  A lot has been accomplished over the past 20 years in the ght against HIV and AIDS.  According to UNAIDS data
  (https://aids2020.unaids.org/report/), of the 38 million people living with HIV, 25.4 million people are now on
  treatment. New HIV infections have been reduced by 23% since 2010, largely due to a substantial decrease of 38% in
  Eastern and Southern Africa.

  Yet, challenges persist. HIV infections have increased by 72% in Eastern Europe and Central Asia, by 22% in the
  Middle East and North Africa, and by 21% in Latin America.  Across the world, there were 1.7 million new infections,
  and still 690,000 AIDS-related deaths in 2019. The 2020 targets of reducing AIDS-related deaths to fewer than
  500,000 and new HIV infections to fewer than 500,000 will not be met.  And the impact of the COVID-19 pandemic
  stands to further slow the required progress to end AIDS as a public health threat by 2030.

  The Basis for Optimism 

  Looking back on what has been achieved in the past two decades, however, should ll us with optimism that
  momentum will be regained.  As recounted by Dr. Peter Piot, the former Executive Director of UNAIDS, in his
  memoire, No Time to Lose (https://www.goodreads.com/book/show/13554374-no-time-to-lose), after overcoming
  many obstacles and naysayers, the United Nations (UN) system, with its many organizations and agencies, working

www.pvmarquez.com/hivaids2020                                                                                            1/3
1/12/2021                            Some Reflections on World AIDS Day 2020 Amidst COVID-19 | Patricio V. Marquez

  together with governments, civil society and religious leaders, groups representing people living with AIDS, and
  eventually the pharmaceutical industry, came together in the rst decade of the XXI Century to rede ne existing
  HIV and AIDS prevention and treatment paradigms.

  There were also some landmark political events in this period, such as the UN Security Council Session held in
  January 2000 (https:/ /www.un.org/press/en/2000/20000110.sc6781.doc.html) that for the rst time focused on
  AIDS as a global health challenge, and the UN Special Session on AIDS held in June 2001, which paved the way for
  establishment of the Global Fund to Fight AIDS, Tuberculosis and Malaria (https://www.theglobalfund.org/en/)and
  the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) (https://www.state.gov/pepfar/), a great legacy of
  former United States President George W. Bush (https:/  /www.bushcenter.org/explore-our-work/support-our-
  work.html).  Not only was the power of scienti c and technological developments leveraged to confront the global
  epidemic, but an unprecedented commitment of funds helped scale up the international response.

  In the early 2000s, I was blessed to be working in the Caribbean Region, at a time when it became a trailblazer in
  the ght against HIV and AIDS.  Beginning with a meeting at the World Bank Group (WBG) in Washington DC in June
  2000, Caribbean nance ministers and of cials from international organizations placed the disease and its threat in
  a sobering context.  This was followed by a gathering in Barbados later that year where the international community,
  heeding former Prime Minister Owen Arthur’s call— “We do not have a choice in the matter—we must act now”—
  pledged millions of dollars to support a regional response.  With the establishment of the Pan Caribbean Partnership
  Against HIV/AIDS (PANCAP) (https:/   /pancap.org/pc/pcc/media/pancap_document/UNAIDS-BEST-PRACTICE-
  COLLECTION_A-Study-of-PANCAP.pdf) in 2001, spearheaded by Sir George Alleyne
  (https://www.amazon.com/Grooming-Chancellor-George-Alleyne/dp/9766406510/ref=sr_1_3?
  dchild=1&keywords=sir+george+alleyne&qid=1606788737&sr=8-3), the Director Emeritus  of the Pan American Health
  Organization (https:/ /www.paho.org/en), and the Caribbean Community (CARICOM (https:/         /caricom.org/)), the
  regional political umbrella organization, an international best practice evolved as a unique example of collective
  action to strengthen a regional response to a health crisis.  The World Bank Group contribution to that effort was
  framed within the US$150 million multi-country program
  (http://documents1.worldbank.org/curated/en/971971468238478200/pdf/709730WP0HIV0i0Box370064B000PUBLIC
  that funded for the rst time globally, beginning in Barbados in 2001, antiretroviral treatment,
  (http://documents1.worldbank.org/curated/en/287781468770370735/pdf/307240en0breve0450Barbados0HIV.pdf)
  along with related health system strengthening investments and intersectoral prevention efforts.

  As more and more HIV-infected people began to bene t from access to treatment, some cof n-makers were put 
  out of business as told in a story about Lesotho published in 2012 by the New York Times
  (https://www.nytimes.com/2012/07/08/opinion/sunday/the-cof n-maker-benchmark.html), and HIV and AIDS
  de facto became a chronic condition that requires long-term care across the world.

  Some Lessons for the Future

  In the face of newly emerging infectious diseases of animal origin such as COVID-19, and the still high prevalence of
  old scourges such as HIV and AIDS, malaria, yellow fever, and tuberculosis, coupled with the rapid increase in the
  relative importance of non-communicable diseases as a growing global health challenge, a major rethinking is
  needed globally and sustained action is required to transform how health services are organized, funded, and
  delivered to meet the changing health needs of the population in an interconnected world.

  The social and economic devastation brought by the COVID-19 global crisis has shown that disease prevention and
  public health preparedness can no longer be an afterthought in the universal health coverage agenda.  Rather,
  they need to be an integral element of a care continuum to anticipate, detect, and prevent the spread at the

www.pvmarquez.com/hivaids2020                                                                                             2/3
1/12/2021                                                Some Reflections on World AIDS Day 2020 Amidst COVID-19 | Patricio V. Marquez

  national, regional and global levels of uncontrolled infectious disease outbreaks that do not respect national
  borders, and to facilitate timely access to quality health services when required by the population.   

  This also calls for integration and resource-sharing, leveraging resources, experience, and models of existing
  programs to place greater emphasis on primary health care and community-based interventions that serve any
  health condition and comorbidities.  We must also advocate for the adoption of inclusive and sustainable schemes
  to fund the effort at the country level, offering nancial protection to the population
  (https://openknowledge.worldbank.org/handle/10986/31930) from the impoverishing effect of ill health,
  premature mortality, and disability.

  And, as the response to the HIV and AIDS epidemic clearly demonstrated over the past twenty years, knowledge
  generation and sharing across the world and their adaptation to local conditions, are paramount to advance the
  global health agenda in the future.

  Indeed, the scienti c developments that helped understand, treat, and prevent HIV infection and AIDS, and the
  unprecedented scienti c collaboration unleashed in 2020 to develop a safe and effective COVID-19 vaccine in a
  record eight months (http://pvmarquez.com/covid19vaccine), bode well for the promise of a world free of the threat
  of HIV and AIDS, and the improvement of people’s health and healthy longevity globally.  

   

  Photo Credit: AnomaliStudio (https://www.istockphoto.com/portfolio/AnomaliStudio?mediatype=illustration)
  Stock illustration ID:1069507882




                                                          
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www.pvmarquez.com/hivaids2020                                                                                                           3/3
1/12/2021                          What We Know About the New COVID-19 Vaccines: Are We There Yet? | Patricio V. Marquez




  What We Know About the New COVID-19 Vaccines: Are We
  There Yet?
  Submitted by Patricio V. Marquez on Tue, 11/24/2020 - 02 09 PM




  What We Know About the New COVID-19 Vaccines: Are We
  There Yet?
  Posted by Patricio V. Marquez on Tue, 11/24/2020 - 02 09 PM




  Patricio V Marquez and Betty Hanan

   

  Typically, the development of new vaccines requires years of research and testing before being deployed.  In the
  case of the new COVID-19 vaccines, scientists have been racing to produce a safe and effective vaccine in record
  time (https://www.sciencemag.org/news/2020/11/covid-19-vaccine-trial-complete-p zer-and-biontech-update-
  their-promising-result).  In a historical feat, the trials of some of the vaccines have taken less than a year.   

  As of today, (https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html) researchers
  are testing 54 vaccines in clinical trials on humans, and at least 87 preclinical vaccines are under active
  investigation in animals.

  In contrast, history shows that in some cases it took decades of work to develop vaccines
  (https://www.businessinsider.com/how-long-it-took-to-develop-other-vaccines-in-history-2020-7).  For example,
  the eradication of smallpox through a vaccine--one of the biggest achievements in public health history —took

www.pvmarquez.com/covid19vaccine                                                                                           1/7
1/12/2021                          What We Know About the New COVID-19 Vaccines: Are We There Yet? | Patricio V. Marquez

  several centuries.  After a decade of work, Max Theiler, developed the rst safe and effective yellow fever vaccine in
  1937, for which he receive the Nobel Prize in Physiology or Medicine in 1951.  Similarly, it took years of research to
  understand the complexities of the in uenza virus, before the rst vaccine was approved for use in the United
  States in 1945. And then, two years later in 1947, researchers concluded that seasonal changes in the composition of
  the virus rendered existing vaccines ineffective--there are two main types of in uenza viruses that cause epidemic
  seasonal infections nearly every year, in uenza A and in uenza B, along with multiple new strains of the virus. 
  Because of this, scientists have had to adjust the in uenza vaccine every year.

  In this blog, we provide a snapshot of the development of some leading COVID-19 vaccines based on a quick review
  of available literature.

  The Frontrunner COVID-19 Vaccine Candidates

    1. Genetic Vaccines

  P zer/BioNTech and Moderna have developed new COVID-19 vaccines using a new technology that has never
  before been approved for human use.  Both use a synthetic version of coronavirus genetic material, called mRNA, to
  program a person’s cells to churn out many copies of a fragment of the virus. That fragment sets off alarms in the
  immune system and stimulates it to attack as if the person were exposed to the real virus.  The two companies are
  the rst to announce interim data from large studies.

  P zer/BioNTech Vaccine

  The companies announced on November 18, 2020 that the vaccine was safe.  Its 95% ef cacy was consistent across
  age, race, and ethnicity, and it worked well in older people to prevent severe COVID-19 disease, well above the
  50% ef cacy level that the U.S. Food and Drug Administration (FDA) had said it would accept in order to grant
  emergency approval for vaccines. The most common serious adverse event was fatigue, with 3.7% of volunteers
  reporting tiredness after they took the second dose. Two percent of volunteers reported a headache after the
  second dose.

  P zer submitted trial data and a request for emergency authorization for its COVID-19 vaccine to the FDA on
  November 20, 2020, with the expectation that a decision by the FDA for the vaccine’s use will be made by mid-
  December 2020.

  The application will be reviewed by teams of the FDA’s Center for Biologics Evaluation and Research.   Key moments
  in the process are: the rst comes two days before members of the FDA Advisory Committee meet, when the FDA
  typically releases its staff report on the clinical trial data, offering an insight into whether the agency is leaning
  toward authorizing the vaccine; and the second is at the end of the Committee process scheduled for December 10,
  2020, when the Committee will take a non-binding vote on whether the FDA should clear the vaccine for public use.

  P zer has also begun regulatory submissions in Australia, Canada, the European Union, Japan and the United
  Kingdom (UK). It has announced also that it plans to apply in other countries as well.

  Moderna Vaccine

  Positive interim results from a nal-stage trial have been released. The next step will be submission to the FDA of
  a request for emergency authorization. This would follow shortly after the review of P zer’s vaccine.  The Moderna
  vaccine uses similar technology to the one from P zer and BioNTech. It is reported to have a 94.5% ef cacy, and

www.pvmarquez.com/covid19vaccine                                                                                           2/7
1/12/2021                          What We Know About the New COVID-19 Vaccines: Are We There Yet? | Patricio V. Marquez

  appears to prevent the COVID-19 disease, including severe cases. A big unknown, however, is how long the
  immunity provided by the vaccine will last.

  Emergency Authorization Process

  Both of the companies’ vaccine candidates began large human trials on July 27, 2020. Emergency authorization
  (https://www.bloomberg.com/news/newsletters/2020-11-21/covid-vaccines-still-face-a-few-hurdles?
  utm_campaign=news&utm_medium=bd&utm_source=applenews)allows drugs and vaccines targeting COVID-19 to
  reach limited groups of people in the United States (US) much faster than through standard approval channels. The
  FDA review process normally takes about six to ten months, depending on the candidate’s priority status. 

  P zer (https://www.nytimes.com/2020/11/18/health/p zer-covid-vaccine.html?referringSource=articleShare) has
  indicated that if the FDA authorizes the two-dose vaccine, up to 50 million doses could be available by the end of the
  2020, and up to 1.3 billion by the end of 2021.  It  is estimated that once the P zer/ BioNTech and the Moderna
  vaccines are authorized for emergency use, there will be enough doses to immunize about 20 million people in the
  United States before the end of 2020, a group that would most likely include health care workers and nursing home
  residents (there are an estimated 17 million to 20 million health care workers in the United States, and about a
  million people living in nursing homes).  The 50 million doses would also allow older people with co-morbid
  conditions to be immunized.

  P zer/BioNTech and Moderna have arranged deals with the U.S. Government so that the vaccines will be free to
  the population (https://www.nytimes.com/2020/11/20/health/p zer-covid-vaccine.html?
  referringSource=articleShare) and distributed according to plans worked out between the federal government and
  the states.

  Cold Chain Requirements

  After the FDA authorizes the use of the P zer/BioNTech and Moderna vaccines, the critical next step is vaccine
  deployment. The P zer/BioNTech vaccine must be stored at minus 94 degrees Fahrenheit, colder than any other
  vaccine in development. P zer will ship the vaccine in special boxes of 1,000 to 5,000 doses that are stuffed with dry
  ice and equipped with GPS-enabled sensors.  The vaccine can be stored in conventional freezers for up to ve days,
  or in the special coolers for up to 15 days, as long as the dry ice is replenished and the boxes are not opened more
  than twice a day.  The Moderna vaccine must also be stored in a freezer long-term, but at minus 4 degrees
  Fahrenheit. The company has indicated that its vaccine could be stored at standard refrigerator temperatures of
  36 to 46 degrees Fahrenheit for up to 30 days, which could make it easier to store than the P zer vaccine.

   2. Viral Vector Vaccines

  These vaccines contain viruses engineered to carry coronavirus genes. Some viral vector vaccines enter cells and
  cause them to make viral proteins. Other viral vectors slowly replicate, carrying coronavirus proteins on their
  surface.  And the viral proteins stimulate the body's production of antibodies to confer immunity.

  AstraZeneca Vaccine

  The British-Swedish company AstraZeneca and the University of Oxford have developed a vaccine based on a
  chimpanzee adenovirus (these are common viruses that cause a range of illness, such as cold-like symptoms,
  fever, sore throat, bronchitis, pneumonia, diarrhea, and conjunctivitis). 



www.pvmarquez.com/covid19vaccine                                                                                           3/7
1/12/2021                          What We Know About the New COVID-19 Vaccines: Are We There Yet? | Patricio V. Marquez

  In a press release on November 23, 2020 (https:/  /www.astrazeneca.com/media-centre/press-
  releases/2020/azd1222hlr.html), the company reported interim ndings from two of their ongoing trials — one in
  the UK and one in Brazil. The trials used different approaches to inoculating the more than 11,000 people who
  participated, and found two levels of ef cacy, which they averaged to 70 percent. The researchers also found no
  severe cases or hospitalizations in the study participants who got the vaccine.

  According to the press reports (https:/  /ca.news.yahoo.com/astrazeneca-covid-19-vaccine-highly-073721980.html?
  guccounter=1&guce_referrer=aHR0cHM6Ly93d3cuYmluZy5jb20v&guce_referrer_sig=AQAAAHK_GSFSL_VNzYKlDK3
  CfAuM5Vixnq_c-5FO7d4VkoJJeFzU4eu-WS9a13JUMbZqQzWsR_SeZCsjeHbBEn_jIFwnNz-
  ICgQAcJo7YhZfYv2xTArKHBEoDnDUW4xOyDlE4WgUb68R), AstraZeneca, has pledged it will not make a pro t on
  the vaccine during the pandemic.  It has reached agreements with governments and international health
  organizations that its cost will be $3 to $4 a dose.  In contrast, P zer’s vaccine is likely to cost about $20, while
  Moderna’s is $15 to $25, based on agreements the companies have struck to supply their vaccines to the U.S.
  Government.

  The preliminary analysis (https://www.nytimes.com/2020/11/16/health/Covid-moderna-vaccine.html?
  referringSource=articleShare) also indicates that the vaccine did not just reduce cases of COVID-19 with symptoms,
  it also reduced the number of asymptomatic cases. This latter nding may mean that the vaccine will be good at
  reducing the transmission of the virus from person to person.  Another advantage of the vaccine is that it can be
  kept in a refrigerator for up to six months, unlike P zer and Moderna’s vaccines, which have to be frozen.

  AstraZeneca has secured a series of agreements to provide vaccines to governments should they prove effective,
  including 300 million doses to the United States and 400 million doses to the European Union.  The company has
  noted that its total annual manufacturing capacity for the vaccine stands at three billion doses.   

  However, since unveiling the preliminary results and after the original version of this blog was posted,
  AstraZeneca acknowledged on November 25, 2020, a key mistake in the vaccine dosage received by some study
  participants, adding to questions about whether the vaccine’s apparently spectacular ef cacy will hold up under
  additional testing (https://www.msn.com/en-us/money/companies/after-admitting-mistake-astrazeneca-faces-
  dif cult-questions-about-its-vaccine/ar-BB1bmqfQ?ocid=msedgdhp).  Scientists and industry experts said the error
  and a series of other irregularities and omissions (https:/ /www.nytimes.com/2020/11/24/world/what-we-know-
  about-astrazenecas-head-scratching-vaccine-results.html) in the way AstraZeneca initially disclosed the data have
  eroded their con dence in the reliability of the results.  Of cials in the United States have noted that the results were
  not clear. The head of the agship federal vaccine initiative suggested that the vaccine’s most promising results may
  not have re ected data from older people.

  China’s CanSino Biologics Vaccine

  The Chinese company CanSino Biologics has developed a vaccine based on an adenovirus called Ad5, in partnership
  with the Institute of Biology at the country’s Academy of Military Medical Sciences. After publishing promising
  results from a Phase 1 safety trial, and reports that Phase 2 trials that demonstrated the vaccine produced a strong
  immune response, the Chinese military approved the vaccine on June 25, 2020 for a year as a “specially needed
  drug”, but it is not clear whether vaccination would be mandatory or optional for soldiers.  Starting in August 2020,
  CanSino began running Phase 3 trials in a number of countries, including Saudi Arabia, Pakistan, and Russia.

  Russia’s Sputnik V Vaccine




www.pvmarquez.com/covid19vaccine                                                                                              4/7
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  The Gamaleya Research Institute, part of Russia’s Ministry of Health, launched clinical trials in June 2020 of a
  COVID-19 vaccine. It is a combination of two adenoviruses, Ad5 and Ad26, both engineered with a coronavirus gene.
   On August 11, 2020, President Vladimir V. Putin announced that a Russian health care regulator had approved the
  vaccine, named Sputnik V, before Phase 3 trials had even begun. However, it was later indicated that the approval
  was a “conditional registration certi cate,” which would depend on positive results from the Phase 3 trials. Those
  trials, initially planned for just 2,000 volunteers, were expanded to 40,000. In addition to Russia, volunteers were
  recruited in Belarus, the United Arab Emirates, and Venezuela. On October 17, 2020, a phase 2/3 trial was launched
  in India.  On September 4, 2020, Gamaleya researchers published the results of phase 1/2 trials.
  (https:/ /www.nytimes.com/live/2020/11/11/world/covid-19-coronavirus-live-updates?
  referringSource=articleShare#russias-vaccine-proves-effective-in-early-trial-data-company-says) In a small study,
  they found that Sputnik-V yielded antibodies to the coronavirus and mild side effects.  On November 11, 2020, the
  Russian Direct Investment Fund announced preliminary evidence from the Phase 3 trial indicating that the
  vaccine has a 92% ef cacy. 

  Russia has negotiated agreements to supply the vaccine to several countries including Argentina, Brazil, Mexico, and
  India.

  China’s Sinovac Biotech Vaccine

  Sinovac Biotech’s CoronaVac is in Phase 3 of clinical trials (https://www.bloomberg.com/features/2020-
  coronavirus-drug-vaccine-status/).  It uses inactivated virus, which can help the body develop antibodies to the
  pathogen without risking infection. The shot had already been approved in China for emergency use for doctors,
  customs of cials, and other frontline workers, while simultaneously in Phase 3 trials in multiple other countries. 

  How do Pharmaceutical Companies Determine the Ef cacy of a Vaccine?

  Clinical trials (https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effectiveness.html)provide data and
  information about how well a vaccine prevents an infectious disease and about how safe it is. The fundamental logic
  behind today’s vaccine trials was worked out by statisticians over a century ago.
  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2004181/)  Researchers vaccinate some people and give a
  placebo to others, and then wait for participants to get sick and look at how many illnesses occur in each group. 
  From these numbers, researchers calculate the proportion of volunteers in each group who get sick. They determine
  the relative difference between those two fractions and express that difference with a value they call ef cacy. If
  there is no difference between the vaccine and placebo groups, the ef cacy is zero. If none of the sick people had
  been vaccinated, the ef cacy is 100%.

  A 95 percent ef cacy is compelling evidence that a vaccine works well
  (https://www.nytimes.com/2020/11/20/health/covid-vaccine-95-effective.html?referringSource=articleShare),
  but it does not tell what the chances are of a person becoming sick after being vaccinated. Also, it does not say how
  well the vaccine will reduce COVID-19 across a country.

  Difference Between Ef cacy and Effectiveness

  Ef cacy and effectiveness are related to each other, but they are not the same thing
  (https://www.sciencenews.org/article/coronavirus-what-does-covid-19-vaccine-ef cacy-mean). Both terms refer
  to the ability to produce a desired or intended result, with a difference.  While ef cacy refers to a result acquired
  under ideal or controlled conditions (e.g., in a clinical trial where the patient population and other variable factors
  can be controlled), effectiveness refers to how well a drug or vaccine works out in real-world situations, where the

www.pvmarquez.com/covid19vaccine                                                                                            5/7
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  patient population and other variables cannot be controlled (e.g., differences in the underlying medical conditions of
  people vaccinated in the real-world compared to those in the clinical trials, how a vaccine is transported and stored,
  or even how patients are vaccinated). 

  It is therefore possible that the effectiveness of coronavirus vaccines will or will not match their impressive
  ef cacy in clinical trials. But if previous vaccines are any guide, effectiveness may prove somewhat lower.

  The Importance of Pharmacovigilance

  Post-vaccine surveillance needs serious attention given the risk of possible adverse vaccine effects.  Clinically
  important, adverse events following any vaccination must be reported by healthcare providers to the
  Pharmacovigilance System (PVS) as required of all vaccination providers. Adverse events can also be monitored
  through electronic health record and claims-based systems. 

  This is important because before a vaccine is marketed, its safety and ef cacy exposure are limited to its use in
  clinical trials.  Generally, clinical trials cover a limited number of patients with strict inclusion criteria, often
  excluding special patient groups like those with co-morbid conditions, children, elderly, and pregnant women. 
  Hence, they do not re ect the experience in larger populations and in different geographical regions.  People from
  different geographical regions differ from one another with respect to genetics, nutritional habits, lifestyle, and
  clinical practices.  This makes it obligatory to maintain a constant vigilance on the use of new vaccines during the
  post-marketing period.

  Strong testing systems are essential for vaccine surveillance. Testing is a critical tool to be used alongside vaccines,
  given that: (i) vaccine-induced immunity must be monitored with testing at a population level; (ii) the real-world
  effectiveness of COVID-19 vaccines will be largely uncertain and possibly variable across settings and populations;
  and (iii) vaccine coverage will be incomplete and focused on priority populations.

  It is also of paramount importance to get a baseline sero-surveillance study done - representative samples of target
  populations to receive the COVID-19 vaccine to be able to distinguish between infection and vaccine-acquired
  immunity.

  Moving Forward

  Vaccines not only protect the people who get them, but also, they can help drive down new infection rates and
  protect society as a whole by slowing the spread of the virus. However, as observed in an editorial at The Lancet
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32472-7/fulltext), it should be clear that
  whether the COVID-19 vaccines prevent transmission of the coronavirus or mainly just protect against illness is still
  largely unknown. If the latter, achieving herd immunity through immunization becomes a dif cult prospect.

  While the good news that a coronavirus vaccine could be available by late December 2020 should help boost our
  optimism about “returning to normal times” in a not-too-distant future, it is imperative that we continue to follow
  COVID-19 safety guidelines and remain vigilant about the risks posed by the pandemic.  Indeed, as noted by Dr.
  Tedros Adhanom Ghebreyesus, WHO Director-General, “while a vaccine will be essential for bringing the pandemic
  under control, it is important to emphasize that a vaccine will complement the other tools that we have, not replace
  them.”   (https://twitter.com/AFP/status/1328314929741504513?s=20)

  Until vaccines become widely available, therefore, it should be clear to all that basic public health measures, such as
  disease surveillance, testing, contact tracing, medical isolation and quarantines, wearing masks in public spaces,
  social distancing, and hand hygiene, will continue to be our best rewall against the spread of the coronavirus and
www.pvmarquez.com/covid19vaccine                                                                                             6/7
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  to save lives. 

  Another key point to highlight, as shown in a recent study in Health Affairs
  (https://www.healthaffairs.org/doi/10.1377/hlthaff.2020.02054), is that when it comes to cutting down on COVID-
  19 infections, hospitalizations, and deaths, a well-coordinated and timely deployment of vaccines matters just as
  much as their ef cacy. So, as we discussed in a previous post (http:/ /www.pvmarquez.com/covid-19vaccination),
  the urgent preparation for the massive deployment of the vaccine in the months to come is a public health, social,
  and economic imperative in countries across the world that cannot wait.




                                        
                                               (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/covid19vaccine                                                                                           7/7
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   HOW TO STRENGTHEN HEALTH CARE
   SYSTEMS TO SUPPORT COVID 19-
   VACCINATION?
   Submitted by Patricio V. Marquez on Mon, 11/16/2020 - 06 56 PM




   HOW TO STRENGTHEN HEALTH CARE
   SYSTEMS TO SUPPORT COVID 19-
   VACCINATION?
   Posted by Patricio V. Marquez on Mon, 11/16/2020 - 06 56 PM




   Patricio V. Marquez, Betty Hanan, Sheila Dutta, Mary Mulusa




www.pvmarquez.com/covid-19vaccination                                                                                        1/12
1/12/2021                     HOW TO STRENGTHEN HEALTH CARE SYSTEMS TO SUPPORT COVID 19-VACCINATION? | Patricio V. Marquez

   The announcement (https:/   /www.nature.com/articles/d41586-020-03248-
   7) last week by P zer and the German company BioNTech, and early this
   week by Moderna, that their COVID-19 vaccines are 90% and 94% effective,
   respectively, is making the world optimistic about the possibility that we
   may overcome the pandemic in a not too distant future. The optimism was
   further reinforced by news that Russia’s Sputnik V vaccine may be as
   effective as these two candidate vaccines. 

   While waiting for peer-reviewed data from the phase III clinical trials and
   the formal approval of the vaccines by regulatory bodies, the critical
   challenge facing all countries is how to ensure that “
   (https://www.theguardian.com/world/2020/nov/16/us-coronavirus-
   vaccine-distribution-challenges)the most logistically dif cult vaccination
   campaign in history
   (https://www.theguardian.com/world/2020/nov/16/us-coronavirus-
   vaccine-distribution-challenges)”
   (https://www.theguardian.com/world/2020/nov/16/us-coronavirus-
   vaccine-distribution-challenges) is conducted in the face of a “hesitant and
   weary public”, and at least one vaccine with “unprecedented cold chain
   requirements.” 

   So, what needs to be in place at the country level to move from vaccine
   promises to actual vaccination?  On the basis of an initial review of
   available literature, we prepared a summary that highlights some
   key structural and process building blocks.

   1. An integrated approach to healthcare delivery is key for a successful
   immunization campaign effort

   Accumulated experience with the delivery of vaccines under the essential
   program of immunizations (EPI) suggests that a strong public health and
   primary care partnership is vital to achieving national vaccination coverage
www.pvmarquez.com/covid-19vaccination                                                                                        2/12
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   targets and control the spread of disease.  While primary care bene ts from
   public health’s role in policy, population health, health equity, and education,
   public health bene ts from primary care’s ability to provide individual
   patient assessment, disease management, screening of patients, care
   coordination, and quality improvement. 

   To articulate this partnership for the delivery of a new COVID-19 vaccine,
   sustained effort is needed to support governments in strengthening some
   key Core Activity Areas, in accordance to country-speci c context and
   epidemic status.

   2. Core Activity Areas

   Four core activity areas are identi ed and discussed below.

   Core Activity Area 1   Planning and Management 

   Activities in this Area include: 

            Development of national deployment and vaccination plans.  Since at
            this time there are not as yet COVID-19 vaccines that have been
            approved for use, the focus of national plans may center on two major
            phases of vaccine availability and distribution: Phase 1 will be when there
            is limited vaccine availability and will focus on target/priority groups to
            receive vaccination.  Phase 2 will be wide scale distribution vaccine
            associated with broad availability to the general population.
            Identi cation of target populations and development of micro-plans. 
            This is an important activity as it would help identify and prioritize
            critical populations for the different phases of vaccine availability,
            consistent with the World Health Organization (WHO) Fair Allocation
            Framework (https:/  /www.who.int/publications/m/item/fair-allocation-
            mechanism-for-covid-19-vaccines-through-the-covax-facility).  More
            speci cally, it would help estimate numbers for priority groups, and
www.pvmarquez.com/covid-19vaccination                                                                                        3/12
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            establish a transparent allocation.  For example, in some countries
            vaccination could focus initially in the workforce that provides
            healthcare and maintains essential functions of society, staff and
            residents in long-term care facilities, elderly people and those with two
            or more co-morbidities that put them at high risk for complications from
            COVID-19.
            Use and deployment of real-time monitoring tools such as RapidPro
            (https://www.unicef.org/innovation/rapidpro), a free, open source
            software, used by UNICEF, governments, and civil society partners. 
             RapidPro collects data via short message service (SMS) and other
            communication channels (e.g. voice; social media channels, such as
            Facebook Messenger, Telegram, WhatsApp) to enable real-time data
            collection and mass-communication with target end-users, including
            bene ciaries and frontline workers.
            Strengthening national immunization budgeting and budget tracking
            capacity. This would need to include the identi cation of options to
            address the investment cost implications, including recurrent costs,
            associated with the introduction of the vaccine for country health
            spending, and how the vaccine can be sustainably deployed moving
            forward. We should be clear that additional health workers/staff will be
            required to carry out this unprecedented effort and their salaries should
            be budgeted and funded. The new vaccine and its administration,
            therefore, will require a substantial increase in public health nancing
            in many countries.

   Core Activity Area 2   Supply and Distribution

   Key activities under this Area include:   

            Procurement and distribution of COVID-19 vaccine and ancillary
            supplies  



www.pvmarquez.com/covid-19vaccination                                                                                        4/12
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   Some countries may choose to purchase vaccines through multilateral
   mechanisms such as the COVAX Facility (https:/     /www.gavi.org/covax-
   facility#what.), which is co-led by Gavi, the Coalition for Epidemic
   Preparedness Innovations (CEPI) and WHO.  Other countries may choose to
   purchase vaccines directly via bilateral deals or may choose to pursue
   multiple mechanisms for vaccine purchase.  

   In undertaking this activity, due consideration needs to be given to the
   threshold for eligibility for vaccine purchase either: (i) approval by
   Stringent Regulatory Authorities (SRAs)
   (https://www.who.int/medicines/regulation/sras/en/), or (ii) WHO
   prequali cation and approval by SRAs.

   The procurement of ancillary supply kits may also be necessary, including
   needles, syringes, alcohol prep pads, COVID-19 vaccination record cards for
   each vaccine recipient, and a minimal supply of PPE, including surgical
   masks and face shields, for vaccinators.

            COVID-19 Vaccine Allocation

   Support is needed to develop country-speci c mechanisms for the
   allocations of the COVID-19 vaccine to jurisdictions in accordance with
   multiple factors, including, but not limited to, priority populations, current
   local spread and prevalence of COVID-19, and COVID-19 vaccine production
   and availability.  This would include coordination with manufacturers and
   procurement agents on freight, logistics, insurance and storage to deliver
   COVID-19 vaccine doses.  

   Key activities include:




www.pvmarquez.com/covid-19vaccination                                                                                        5/12
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   Ensuring adequate logistics and transportation capacity, including
   conducting eet assessments; and procurement and deployment of trucks
   (e.g. cold trucks) and vehicles.

   Strengthening immunization supply chain system, including capacity
   building with respect to both supply chain systems and training of health
   sector human resources; and adoption of global tools and best practices.

   Leveraging innovations and technology to: test and pilot track & trace
   technology; strengthen remote temperature monitoring systems; and
   strengthen logistics information systems to accommodate COVID-19
   vaccines

            Ensure Quality of Vaccination Services

   Quality assurance is very important for vaccine delivery. Vaccines must be
   stored at correct temperatures and safely handled to ensure the best
   protection.  Training and technical assistance are needed to support health
   personnel effectively implement vaccination programs.  Also, support is
   needed to conduct monitoring and supervision activities to ensure
   appropriate vaccine storage and handling practices, and to identify
   opportunities to improve vaccination coverage of target populations. To this
   end, support would be required to further strengthen vaccine distribution
   and cold chain systems while awaiting vaccine availability.

   If current cold chain gaps and new requirements are addressed in a timely
   way, it will facilitate widespread administration, not only of a new COVID-19
   vaccine, but will also help revamp the delivery of routine vaccines,
   particularly those for children.  The latter task is of critical importance since
   the pandemic has disrupted national immunization programs.

   Core Activity Area 3 Program Delivery

www.pvmarquez.com/covid-19vaccination                                                                                        6/12
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   Key activities to be supported under this Area include:

            Community Engagement and Advocacy

   Vaccine hesitancy is expected to be high, so public communication efforts
   should focus on building a foundation of trust. Public communication
   about COVID-19 vaccinations should aim to in uence the population in a
   country to: trust the information that they receive from national and local
   public health institutions, increasing knowledge of vaccine and the process
   of COVID-19 vaccine development; understand the bene ts and risks,
   setting and managing expectations by clearly informing about limited
   availability of vaccines at the onset of the vaccine delivery and on the need
   to prioritize administration of available vaccines to high risk group; make
   informed decision; and know how and where to get a COVID-19 vaccination.

   To this end, support would be needed to strengthen risk communication
   and community engagement could be expanded, with a focus on increasing
   awareness for COVID-19 prevention and to strengthen strategic
   communication addressing demand-side challenges for vaccine uptake. 
   Such communications efforts need to address speci c national/subnational
   knowledge, attitudes, and beliefs about vaccination. 

   Ensure vaccines reach the target populations.  This will require: (i)
   adequate amount of vaccinators / health workers; (ii) support training of
   vaccinators and health workers; (iii) adopting global tools to local context;
   and (iv) funding of targeted outreach to ensure prioritized population know
   where and when to receive vaccinations.   

            De ne Access Points for Vaccine Administration




www.pvmarquez.com/covid-19vaccination                                                                                        7/12
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   This would include identi cation and enrollment of  providers into the
   COVID-19 vaccination program for early narrow and later broad
   vaccination plans, such as broad-based healthcare partners (primary and
   specialty care providers, skilled nursing facilities, other long-term care
   settings, local public health agencies, hospitals and health systems,
   pharmacies, mobile vaccination providers, occupational health for large
   employers, providers serving incarcerated populations, and payers);
   preparations for vaccinations through regular healthcare channels and new
   mobile or community-based mass vaccination sites;  community partners to
   increase accessibility, uptake, and reach by creating a transition plan from
   low supply/high demand to high supply/low demand. 

   Support would also be provided for:  creation of a registry to identify
   priority target populations and develop strategies for outreach, speci cally a
   list of front-line healthcare workers, the elderly, and those with pre-existing
   conditions.  

            Adequate Waste Management System in Health Facilities

   Good practices for safely managing health care waste and infection
   prevention and control should be followed, including assigning
   responsibility and suf cient human and material resources to dispose of
   such waste safely.  All health care waste produced during the care of
   COVID-19 patients should be collected safely in designated containers and
   bags, treated, and then safely disposed of or treated, or both, preferably on-
   site. This also would be an opportunity to ensure that health facilities
   possess at least a minimum level of WASH facilities.

   Core Activity Area 4 Supporting Systems and Infrastructure

   Key interventions under this Area include:


www.pvmarquez.com/covid-19vaccination                                                                                        8/12
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            COVID-19 Vaccine Safety Monitoring

   A comprehensive and effective vaccination program requires a robust data
   infrastructure at different levels of a health system.  This is needed to: (i)
   further strengthen vaccination practices in both the public and private
   sectors; (ii) assesses the impact of vaccination programs through disease
   surveillance; (iii) provide credible evidence-based information to healthcare
   consumers; (iv) support outbreak investigation and control; and (v) monitor
   vaccine coverage, effectiveness, and safety. 

   Post-vaccine surveillance needs serious attention given risk of adverse
   vaccine effects.  Clinically important, adverse events following any
   vaccination must be reported by healthcare providers to the
   Pharmacovigilance System (PVS) as required of all COVID-19 vaccination
   providers. Adverse events will also be monitored through electronic health
   record and claims-based systems.  

   This is of importance because before a medicinal product is marketed, its
   safety and ef cacy exposure are limited to its use in clinical trials. 
   Generally, clinical trials cover limited number of patients with strict
   inclusion criteria, often excluding special patient groups like those with co-
   morbid conditions, children, elderly and pregnant women.  Hence, they do
   not re ect the experience in larger population sand in different
   geographical regions.  People from different geographical regions differ
   from one another with respect to genetics, food habits, life style, or clinical
   practices.  This makes it obligatory to maintain a constant vigil on the use of
   medicinal products during the post-marketing period.

   Strong testing systems are essential for vaccine surveillance. Testing is a
   critical tool to be used alongside vaccines, given that: vaccine induced
   immunity must be monitored with testing on a population level; the real-
   world effectiveness of COVID-19 vaccines will be largely uncertain and

www.pvmarquez.com/covid-19vaccination                                                                                        9/12
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   possibly variable across settings and populations; and vaccine coverage will
   be incomplete and focused on priority populations. To this end, support may
   be required for:  developing/adapting the national diagnostic strategy and
   plans as new diagnostic technologies become available, selecting of
   diagnostic tests for appropriate use following international guidelines and
   national priorities, and, training on infection prevention and control (IPC)
   measures, provision of IPC supplies (e.g. hand hygiene products,
   disinfectants), biosafety measures (e.g., safe specimen collection and
   handling and appropriate disposal of diagnostic tests and supplies), and
   availability of protocols for proper testing at facility and community levels. 

   It would also be of paramount importance to get a baseline sero-
   surveillance study done - representative samples of target populations to
   receive the COVID-19 vaccine to be able to distinguish between infection
   and vaccine acquired immunity.

            WASH in health care settings

   Existing recommendations for water, sanitation and hygiene measures in
   health care settings are important for providing adequate care for patients
   and protecting patients, staff and caregivers from infection risks.  Hand
   hygiene is also extremely important.  Cleaning hands with soap and water
   or an alcohol-based hand rub should be performed according to
   instructions. Functional hand hygiene facilities should be present for all
   health care workers at all points of care and in areas where PPE is put on or
   taken off.

   3. How are governments going to address compensation issues related to
   the liability shield offered to pharmaceutical rms that will be supplying
   the COVID-19 vaccines?



www.pvmarquez.com/covid-19vaccination                                                                                        10/12
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   This question is of particular importance for middle-income countries that
   have to assume this obligation, including under COVAX arrangements. Low-
   and lower middle-income countries are expected to be covered under a
   proposed scheme co-led by WHO to set up a compensation fund for people
   in poor nations who might suffer any side-effects from COVID-19 vaccines,
   aiming to allay fears that could hamper a global rollout of shots.

   The public sector guarantors of the liability shield offered to
   pharmaceutical rms will have to look at how to manage this.   It is critical,
   therefore, to have clarity about this now, i.e. before vaccines start owing. 
   With the scale of distribution of the vaccines even rare side effects could
   end up affecting thousands.

   A recent review (https://journals.plos.org/plosone/article?
   id=10.1371/journal.pone.0233334) (https://journals.plos.org/plosone/article?
   id=10.1371/journal.pone.0233334)of existing compensation programs in the
   world shows that the bene ts most referred to in existing no-fault
   compensation programs were: fair compensation for individuals
   inadvertently injured by a vaccine meant for public good and increasing
   con dence in public vaccination programs. The most notable operational
   challenge of existing programs was identi ed to be lack of public
   awareness of programs existence, strict requirements for standard of proof
   that vaccine caused injury, and long timelines for ling claims and receiving
   compensation.

   Conclusion

   It should be clear to all that the approval of effective COVIX-19 vaccine is
   only the rst step in the process to reverse the global pandemic.  We also
   have to realize that multiple vaccines to meet demand would add complexity
   of the delivery effort.   Besides the supply of vaccines, a key challenge to


www.pvmarquez.com/covid-19vaccination                                                                                        11/12
1/12/2021                     HOW TO STRENGTHEN HEALTH CARE SYSTEMS TO SUPPORT COVID 19-VACCINATION? | Patricio V. Marquez

   deal with is gaining public trust, including among healthcare workers who
   will be asked to take the vaccine rst as part of the priority population
   groups.

   Hence, the activities outlined above will need to be undertaken sooner,
   rather than later, to address the logistical and cold chain challenges
   enabling the rapid distribution and administration of COVID-19 vaccines.  

    
   Photo credit:
   Luca Lorenzelli
   Stock photo ID:1212565443




                                  
                                          (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/covid-19vaccination                                                                                        12/12
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez




   Health Systems Fit for the Future: How
   to Promote Better Health, Economic
   Growth, and Social Cohesion?
   Submitted by Patricio V. Marquez on Fri, 10/23/2020 - 04 47 PM




   Health Systems Fit for the Future:
   How to Promote Better Health,
   Economic Growth, and Social
   Cohesion?
   Posted by Patricio V. Marquez on Fri, 10/23/2020 - 04 47 PM




   I recently had the honor of serving as a panelist in plenary session 5 “Health
   systems t for the future: promoting better health, economic growth, and
   social cohesion”, that was held virtually as part of the 16th World Congress
www.pvmarquez.com/romehsystems                                                                                                                           1/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   on Public Health: “Public health for the future of humanity: analysis,
   advocacy and action” (https://wcph2020.com/), on October 15th, 2020. 

   While all the participants in the Congress regretted not having been able to
   travel to Rome, the Eternal City, and participate in person due to the
   COVID-19 pandemic, the organization of the virtual event was awless.  So,
   our sincere congratulations are conveyed to the organizers for a job well
   done!

   My session was chaired by Prof. Walter Ricciardi and Prof. Sheila Dinotshe
   Tlou, Co-chairs of the  16th World Congress on Public Health, and included
   as my fellow panelists Natasha Azzopardi Muscat, Director for Country
   Health Policies and Systems at the WHO Regional Of ce for Europe and
   Immediate Past President of the European Public Health Association
   (EUPHA); Sara Cerdas, a Portuguese medical doctor and since July of 2019 a
   Member of the European Parliament; Katie Gallagher, Senior Policy Adviser,
   European Patients’ Forum; Rüdiger Krech, Director, Department of Health
   Promotion, World Health Organization; and Gita Sen, Director of the
   Ramalingaswami Centre on Equity and Social Determinants of Health at the
   Public Health Foundation of India and Adjunct Professor of Global Health
   and Population at the Harvard T. H. Chan School of Public Health.

   In my presentation, I conveyed three action points to address the
   overarching questions guiding the discussion in the session.  These were:

   Question 1   How can we improve health, wealth, and societal well-being
   by investing in health systems?

   Action 1   Prevent, detect, and respond to the threat posed by zoonotic
   diseases and strengthen national systems for public health preparedness



www.pvmarquez.com/romehsystems                                                                                                                           2/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   The worldwide spread of COVID-19 is demonstrating the impact that
   infectious diseases of animal origin can exert on global health and
   development.  More than 70% of new infectious diseases are zoonotic.  The
   COVID-19 pandemic is currently affecting 188 countries and territories
   across all regions.  As of mid-October 2020, (https://coronavirus.jhu.edu/)
   more than 37 million con rmed cases and more than 1 million con rmed
   deaths have been reported.

   Besides growing numbers of infected people and loss of life, the pandemic
   has caused an economic free-fall not experienced since World War II. 
   International Monetary Fund (IMF) estimates show that 170 countries will
   see income per capita go down.
   (https:/ /www.imf.org/en/Publications/WEO/Issues/2020/09/30/world-
   economic-outlook-october-
   2020#Full%20Report%20and%20Executive%20Summary)  And  World Bank
   Group projections (https:/ /www.worldbank.org/en/news/press-
   release/2020/10/07/covid-19-to-add-as-many-as-150-million-extreme-
   poor-by-2021) suggest that rising unemployment and loss of income,
   including in some countries a signi cant drop in remittances, could push
   between 88 million and 115 million people back into extreme poverty as a
   result of the pandemic, with an additional increase of between 23 million
   and 35 million in 2021, potentially bringing the total number of new people
   living in extreme poverty to between 110 million and 150 million. 

   The pandemic is also putting at risk the past decade's progress in building
   human capital, including gains in health, survival rates, school enrollment,
   and reduced stunting. The economic impact of the pandemic has been
   particularly deep for women and for the most disadvantaged families,
   leaving many vulnerable to food insecurity and poverty.




www.pvmarquez.com/romehsystems                                                                                                                           3/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   The COVID-19 pandemic, therefore, is a stark remainder of the ongoing
   challenge of emerging and reemerging infectious diseases and the need for
   (//blogs.worldbank.org/health/regional-disease-surveillance-globalized-
   world) (https://blogs.worldbank.org/health/regional-disease-surveillance-
   globalized-world)constant disease surveillance, prompt diagnosis, and
   robust research (//blogs.worldbank.org/health/regional-disease-
   surveillance-globalized-world) to understand the basic biology of new
   organisms and our susceptibilities to them, as well as to develop effective
   countermeasures to control them.

   A critical long-term aspect of the response
   (https://blogs.worldbank.org/health/world-banks-health-response-covid-
   19-coronavirus) is strengthening and building a resilient health system able
   to manage similar future health system shocks by supporting the realization
   of the universal health coverage (UHC) agenda, which includes timely access
   to health care when needed, nancial protection, and disease prevention
   and preparedness. To this end, the universal health coverage agenda needs
   to strengthen its focus on prevention to help guide investments, identify
   and prioritize the biggest risks, and promote pandemic preparedness for
   future outbreaks building upon the One Health Strategy.
   (https://blogs.worldbank.org/health/one-health-approach-critical-de-
   risk-human-animal-and-environmental-health)

   Question 2 Which investments inside and beyond the health system
   should be performed to increase quality and reduce inequities? 

   Action 2   Avoid the false dichotomy between physical health and mental
   health

   In this midst of a global pandemic, this year’s World Mental Health Day
   campaign (https:/  /www.who.int/campaigns/world-mental-health-
   day/world-mental-health-day-2020) called for greater investment in mental

www.pvmarquez.com/romehsystems                                                                                                                           4/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   health. This is timely and justi ed. Recent estimates suggest that most low-
   and middle-income countries spend less than $2 per person on the
   treatment and prevention of mental and substance use disorders – and this
   was prior to the global outbreak of the novel coronavirus.

   A fundamental rethinking is needed to overcome the false dichotomy
   between physical health and mental health in health services. Mental health
   parity must be placed at the core of human capital development.  The social
   cost of mental illness and substance use disorders – which compound the
   impact of poor physical health – are terribly high for individuals, families,
   communities, and the economy. Yet the cost of effective treatments is
   surprisingly low.

   We must be wary of siloed approaches to increased mental health funding.
   Rather, governments can mobilize new resources and leverage existing
   funding streams by integrating mental health interventions
   (https://blogs.worldbank.org/health/lets-invest-mental-health-inclusive-
   and-resilient-recovery-covid-19?
   CID=WBW_AL_BlogNoti cation_EN_EXT)into existing service delivery
   platforms across sectors.

   There are numerous potential cross-sectoral entry points that would align
   funding, service provision, and population needs:

   (i) Integrating mental and physical health services at primary health care
   and community levels

   (ii) School-based and youth interventions are critically important because 75
   percent of mental and substance use disorders begin before age 25, and
   suicide is a leading cause of death among youth



www.pvmarquez.com/romehsystems                                                                                                                           5/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   (iii) Integrating mental health into wellness programs in the workplace can
   mobilize private companies to invest in health promotion activities

    (iv) Programs in fragile and con ict-affected settings can be leveraged to
   mainstream integrated physical and mental health interventions alongside
   other social services to address the needs of displaced populations and
   refugees

   (v) Microcredit schemes to provide low-interest, small business loans,
   training, and mentorship to entrepreneurs with a history of mental health or
   addiction challenges (including former prisoners), facilitate reintegration
   into the community

   Question 3 How can we guarantee that health systems are sustainable,
   resilient, and accessible?

   Action 3 Pro-health taxes reduce health risks, expand scal space for
   universal health coverage, and enhance equity

   Taxes on tobacco, alcohol, and sugar-sweetened beverages
   (https://blogs.worldbank.org/health/taxes-tobacco-alcohol-and-sugar-
   sweetened-beverages-reduce-health-risks-and-expand- scal) are effective
   but underused policies of disease prevention and health promotion, that
   could also help mobilize additional government revenue to fund investments
   and programs that bene t the entire population and enhance equity.

   Raising taxes on tobacco, in particular, can do more to reduce premature
   mortality than any other single health policy. The evidence across a wide
   range of countries shows that a 50% increase in cigarette price typically
   leads to a 20% decline in cigarette consumption. Lowering consumption
   reduces tobacco-attributable sickness and death: about half of this effect
   comes from current smokers quitting and the other by reducing smoking

www.pvmarquez.com/romehsystems                                                                                                                           6/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   initiation among young people.  Taxing alcohol and sugar-sweetened
   beverages helps to reduce consumption and prevent the onset of related
   chronic diseases such as cardiovascular diseases, cirrhosis of the liver,
   obesity, and diabetes. Moreover, taxation to increase the price of alcohol
   products, along with strict enforcement of drunk-driving laws, can help
   reduce the high human and economic cost of road traf c injuries, fatalities,
   and domestic violence. 

   Emerging evidence shows positive health impacts from sugar-sweetened
   beverages taxes by reducing consumption and hence helping to control the
   growing obesity epidemic and its impact on NCDs.
   Tobacco, alcohol, and sugar-sweetened beverage taxes can substantially
   boost government revenues.  This is of critical importance during COVID-19,
   as policymakers must maintain their public health responses while also
   mobilizing domestic revenue for investment in future pandemic
   preparedness and other essential health services.

   These health tax increases would have the additional advantage of reducing
   future health care costs by curbing the growth of the non-communicable
   diseases that tobacco, alcohol, and sugar-sweetened beverages can cause.
    Elimination of fossil fuel subsidies, which impose large scal costs while
   adding to negative environmental and health impacts, could also help
   expand scal space for health. 

   Projections presented in a World Bank Group report for the G-20 meeting in
   Osaka, Japan in 2019
   (https://openknowledge.worldbank.org/handle/10986/31930) showed that
   the substantial UHC nancing gap in low- and lower-middle-income
   countries (now exacerbated by COVID-19), can be attenuated by excise tax
   increases on tobacco, alcohol, and sugar-sweetened beverages. These
   calculations showed that a 50% increase in prices for these products could


www.pvmarquez.com/romehsystems                                                                                                                           7/8
1/12/2021                 Health Systems Fit for the Future: How to Promote Better Health, Economic Growth, and Social Cohesion? | Patricio V. Marquez

   generate additional revenues of approximately $24.7 billion in 54 low- and
   middle-income countries by 2030.  Importantly, the revenue raised can
   additionally bene t poorer households when it is used progressively.

   Take Away Message

   As voiced by my fellow panelists during the session, it should be clear to all
   going forward that high-quality health systems include not only the right to
   quality health care but also equity. Evidence-based, cost-effective
   investments and rigorous assessment are key to guarantee high quality
   health systems for all.

    




                                 
                                            (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/romehsystems                                                                                                                           8/8
1/12/2021                                                     The World Bank’s health response to COVID-19 (Coronavirus)


            Learn how the World Bank Group is helping countries with COVID-19 (coronavirus).                               Find Out 




                           Publish d on Inv stin in H                                                   lth (/h             lth)


   Th World B nk’s h lth r spons to
   COVID-19 (Coron virus)
   PATRICIO V. MARQUEZ (/TEAM/PATRICIO-V-MARQUEZ), SHEILA DUTTA (/TEAM/SHEILA-DUTTA) & BETTY
   HANAN (/TEAM/BETTY-HANAN) | OCTOBER 19, 2020
   This page in: English


                                      




   Freetown City Council community engagement to prevent the spread of COVID-19 in Sierra Leone. © Valena McEwen,
   World Bank Health team in Sierra Leone




   In response to the rapid spread of the COVID-19 pandemic, and building on
   accumulated experience with health crises in the past 20 years, the World Bank
   Group sprang into action in late February 2020.   (https://twitter.com/intent/tweet?
   text=In+response+to+the+rapid+spread+of+the+COVID-
   19+pandemic%2C+and+building+on+accumulated+experience+with+health+crises+in+
   banks-health-response-covid-19-coronavirus/?

https://blogs.worldbank.org/health/world-banks-health-response-covid-19-coronavirus                                                     1/8
1/12/2021                                                     The World Bank’s health response to COVID-19 (Coronavirus)

   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)  Working closely with national
   teams, WHO, UNICEF and other international partners to support countries’
   responses, the World Bank prepared the $6 billion
   (https://www.worldbank.org/en/news/press-release/2020/03/17/world-bank-group-
   increases-covid-19-response-to-14-billion-to-help-sustain-economies-protect-
   jobs#:~:text=WASHINGTON%2C%20March%2017%2C%202020%20%E2%80%94,rapid%
   COVID-19 emergency health response in just a few weeks.

   The Bank currently provides emergency health and social support to 111 countries
   (https://www.worldbank.org/en/news/speech/2020/10/16/remarks-by-world-bank-
   group-president-david-malpass-to-the-annual-meetings-2020-development-
   committee), covering about 70% of the world’s population, including millions who
   live in places a ected by con ict and fragility.

   The progress has been fast and signi cant

   The Bank’s goal is to assist countries in their e orts to prevent, detect and respond
   to COVID-19, and to strengthen national public health preparedness systems.  
   (https://twitter.com/intent/tweet?
   text=The+Bank%E2%80%99s+goal+is+to+assist+countries+in+their+e orts+to+prevent
   19%2C+and+to+strengthen+national+public+health+preparedness+systems.+&url=http
   banks-health-response-covid-19-coronavirus/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)  A menu of options allowed
   World Bank country teams to tailor projects to the speci c circumstances of each
   country.   

   Country examples illustrate how funding allocated under the program is aligned to
   service provision and population needs.

   Case detection, con rmation, contact tracing, recording, reporting

   In Ghana, support has been provided to recruit and train 4,410 health professionals,
   1,385 contact tracers and 318 laboratory technicians. Drone delivery of samples
   from remote areas to test centers has also been initiated, along with the potentially
   time saving practice of “pool testing,” in which multiple blood samples are tested
   together and processed separately only if a positive result is found. This has led to
   the identi cation and testing of 361,542 persons as of July 2020.
                                                                                                                   x
     This site uses cookies to optimize functionality and give you the best possible experience. If you continue to
        navigate this website beyond this page, cookies will be placed on your browser. To learn more about
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1/12/2021                                                     The World Bank’s health response to COVID-19 (Coronavirus)

   In Georgia, support is being provided to strengthen public health laboratories and
   epidemiological capacity. As of the end of September 2020, an average of 9,000
   polymerase chain reaction (PCR) tests and 1,700 rapid tests were being performed
   daily.

   In Cambodia, the Bank supports decentralized laboratories and helps strengthen
   services in remote and underserved areas. 

   In Yemen, six central public-health laboratories have opened, and 930 health
   professionals have been trained in COVID-19 case management.

   In Ethiopia, in the rst 100 days after project approval, more than 11 million
   households nationwide were screened, lab professionals trained, and about 23
   laboratories throughout the country are now conducting COVID-19 tests. A parallel
   project is also supporting the Africa Center for Disease Control’s region-wide
   response.

   Health system strengthening

   In Afghanistan, initial support has included procurement of emergency supplies,
   including 555,000 personal protective equipment (PPE) kits. These supplies have
   enabled health care workers to improve clinical management of about 10,000
   hospitalized COVID-19 patients.

   In Papua New Guinea, 6,846 infection, prevention and control (IPC) supplies and
   31,200 PPEs arrived in June 2020 for nationwide use. 

   In India, the Bank’s operation helps cover salaries of more than 50,000 contractual
   frontline sta operating across the country’s 35 states and union territories. 

   In Argentina, Ecuador, Indonesia, Haiti, Iran, Senegal, Somalia, and Ukraine, the
   Bank has been supporting the acquisition of medical equipment to enhance service
   delivery capacity.

   In Mongolia, as well as in China, support is being provided to strengthen capacities
   for a multi-sectoral response, particularly the interface of environmental, veterinary,
   and public health services to contain the spread of new viruses of animal origin at
   their source. 

   Water, sanitation and hygiene (WASH)                                                                            x
     This site uses cookies to optimize functionality and give you the best possible experience. If you continue to
        navigate this website beyond this page, cookies will be placed on your browser. To learn more about
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1/12/2021                                                     The World Bank’s health response to COVID-19 (Coronavirus)

   Many projects include actions on water and/or sanitation in health facilities. 57
   projects include components of behavior change, hygiene and handwashing in
   health facilities, and 47 projects include support for medical waste management.

   In Senegal, for example, the project supports a mix of water supply, hand washing,
   and sanitation activities in urban, peri-urban, and rural areas, including the
   connection of unserved localities to existing water supply systems.

   Social and nancial support to households

   In Sri Lanka, additional nancing of $89 million supports temporary scaled-up cash
   transfers under existing programs for registered elderly and disabled people and
   those with chronic diseases.

   In Pakistan cash support covers 15 million vulnerable families. Additional support is
   being provided to 4 million female bene ciaries who were already receiving direct
   income support under this program.

   In Kosovo, under the government’s existing social assistance program, cash
   transfers are being provided to 24,000 poor families, and to an additional 29,000
   newly poor families.

   In Rwanda, emergency cash transfers support 19,000 vulnerable households in
   Kigali, 8,400 other vulnerable households, and 7,700 vulnerable agricultural
   households (to enable access to seeds and fertilizers). 

   In Argentina, COVID-19 services are free when are delivered by public hospitals and
   health centers.

   In Paraguay and Uruguay, testing and treatment services for COVID-19 are free of
   charge to the bene ciaries of the country’s public health and social health insurance
   programs.

   Mental health interventions

   In many countries, including Bosnia and Herzegovina, Cambodia, Ecuador,
   Guatemala, India, Lesotho, Liberia, Mali, Marshall Islands, Morocco, Mongolia,
   Niger, Nigeria, Republic of Congo, Senegal, Sri Lanka, Turkey, and Yemen, Bank
   projects  support psychosocial interventions to help people deal with the negative
   psychological e ects from stressors such as lockdowns, self-isolation and
   quarantines, infection fears, inadequate information, job and nancial losses, and
   stigma and discrimination.

https://blogs.worldbank.org/health/world-banks-health-response-covid-19-coronavirus                                        4/8
1/12/2021                                                     The World Bank’s health response to COVID-19 (Coronavirus)

   Community engagement

   In Egypt, when movement was restricted, virtual communication tools helped to
   prepare the project. These tools enabled consultations with a wide range of
   stakeholders including governmental o cials, frontline health workers and NGO
   partners. Virtual hospital visits guided by hospital sta equipped with PPE helped to
   gather information on how projects were being implemented and to get stakeholder
   feedback.

   In Sierra Leone, building on the Ebola experience, the project has supported the
   Freetown City Council and the mayor to implement risk communication campaigns
   by forming teams of volunteers in each of the city’s wards, teamed with local
   councilors, chiefs, tribal heads, Mammie Queens and youth leaders, to conduct
   outreach activities and house visits to foster community engagement and in uence
   behavior change. 

   In the Democratic Republic of Congo, a community-centered approach has been
   successful to counter misinformation, with feedback mechanisms to communicate
   critical risk and event information to all communities in the local languages.



   As the COVID-19 pandemic continues to evolve, with new diagnostics and
   therapeutics developed, and vaccines trials progressing, the exibility and agility of
   the World Bank’s health response will continue to be critical to support the next
   phase of country responses.

   It is important to ensure that programs are adjusted and aligned with the spread of
   COVID-19, the level of pandemic preparedness, the capacity of health and social
   support systems, and lessons learned from the early phase of the pandemic
   response.   (https://twitter.com/intent/tweet?
   text=It+is+important+to+ensure+that+programs+are+adjusted+and+aligned+with+the+
   19%2C+the+level+of+pandemic+preparedness%2C+the+capacity+of+health+and+socia
   banks-health-response-covid-19-coronavirus/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)



   For a full list of the World Bank Group’s COVID-19 projects, please refer here
   https://www.worldbank.org/en/about/what-we-do/brief/world-bank-group-
   operational-response-covid-19-coronavirus-projects-list
https://blogs.worldbank.org/health/world-banks-health-response-covid-19-coronavirus                                        5/8
1/12/2021                                      Let’s Invest in Mental Health for an Inclusive and Resilient Recovery from COVID-19


            Learn how the World Bank Group is helping countries with COVID-19 (coronavirus).                                   Find Out 




                       Publish d on Inv stin in H                                                         lth (/h               lth)


   L t’s Inv st in M nt l H lth for n
   Inclusiv nd R sili nt R cov r from
   COVID-19
   PATRICIO V. MARQUEZ (/TEAM/PATRICIO-V-MARQUEZ) | OCTOBER 08, 2020
   This page in: English


                                  




/ Mental health parity must be placed at the core of human capital development.

                      https://blogs.worldbank.org/health/lets-invest-mental-health-inclusive-and-resilient-recovery-covid-19


            “I believe more than ever that we have the power to help change the world for people
            who have mental illnesses and addictions, and for all of those whose lives are touched
            by these brain diseases—which is to say, all of us.”- Patrick J. Kennedy
                                                                                                                                            x




                                                                                                                                                1/7
1/12/2021                                            Let’s Invest in Mental Health for an Inclusive and Resilient Recovery from COVID-19

   In this midst of a global pandemic, this year’s World Mental Health Day
   (https://www.who.int/campaigns/world-mental-health-day/world-mental-health-day-
   2020) campaign is calling for greater investment in mental health. This focus is timely
   and                    justi ed.                  Recent                    estimates
   (https://documents.worldbank.org/en/publication/documents-
   reports/documentdetail/270131468187759113/out-of-the-shadows-making-mental-
   health-a-global-development-priority) suggest that most low- and middle-income
   countries spend less than $2 per person on the treatment and prevention of mental
   and substance use disorders – and this was prior to the global outbreak of the novel
   coronavirus.

   The pandemic has brought social isolation, bereavement, nancial hardship, and
   interrupted health care services – which are negatively impacting the mental well-
   being of people.   (https://twitter.com/intent/tweet?
   text=The+pandemic+has+brought+social+isolation%2C+bereavement%2C+ nancial+ha
   being+of+people.+&url=https://blogs.worldbank.org/health/lets-invest-mental-
   health-inclusive-and-resilient-recovery-covid-19/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) New research also shows that
   substance use disorders (https://www.nature.com/articles/s41380-020-00880-7),
   including opioids, alcohol, and smoking, are tied to an increased risk for COVID-19
   and serious adverse outcomes, including hospitalization and death.
   A fundamental rethinking is needed to overcome the false dichotomy between
   physical health and mental health in health services. Mental health parity must be
   placed at the core of human capital development. The social cost
   (https://www.goodreads.com/book/show/37651095-the-origins-of-happiness) of
   mental illness and substance use disorders – which compound the impact of poor
   physical health – are terribly high, for individuals, families, communities, and the
   economy. But the cost of e ective treatments
   (https://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(16)30024-4.pdf) is
   surprisingly low.

   Integrating mental and physical health services
   Faced with the global economic fall-out as the COVID-19 pandemic rages, budgetary
   capacity of governments and international assistance co ers are stretched. What
   can be done to deliver on this year’s World Mental Health Day call? 
                                                                                                                                           x




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   We must be wary of siloed approaches to increased mental health funding. Rather,
   governments can mobilize new resources and leverage existing funding streams by
   integrating mental health interventions into existing service delivery platforms
   across sectors.   (https://twitter.com/intent/tweet?
   text=governments+can+mobilize+new+resources+and+leverage+existing+funding+stre
   invest-mental-health-inclusive-and-resilient-recovery-covid-19/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)

   There are numerous potential cross-sectoral entry points that would align funding,
   service provision, and population needs:

               Experiences in Chile, Colombia, Ghana, and the United States demonstrate that
               national mandates to cover mental and substance use disorders prevent the
               use              of            preexisting          conditions           clauses
               (https://www.penguinrandomhouse.com/books/317536/a-common-struggle-
               by-patrick-j-kennedy-stephen-fried/) to deny health insurance coverage.  In
               Peru        (https://blogs.worldbank.org/health/paradigm-shift-peru-leading-way-
               reforming-mental-health-services), the inclusion of mental health services as
               part of the bene ts package o ered by the Integrated Health Insurance (SIS)
               scheme was an important step towards the achievement of mental health
               parity, and for helping vulnerable people access these services when needed
               without incurring high out-of-pocket expenditures. This measure was
               complemented by the development of a fee schedule to reimburse health
               facilities for services rendered, and a 10-year results-based budget allocation
               by the Ministry of Economy and Finance exclusively to support community-
               based mental health services.
             Projects funded under the World Bank Group’s $6 billion COVID-19 Global
             Health Emergency Response Program
             (https://www.worldbank.org/en/topic/health/coronavirus) in countries such as
             Bosnia and Herzegovina, Cambodia, Ecuador, India, Lesotho, Liberia, Morocco,
             Marshall Islands, Mongolia, Nigeria, Sri Lanka, and Turkey support psychosocial
             interventions to help people deal with negative psychological e ects associated
             with stressors such as lockdowns, self-isolation and quarantines, infection fears,
             inadequate information, job and nancial losses, and stigma and
             discrimination.     
             Existing funding streams for maternal and child health, such as those under the
             Global Financing Facility (GFF) in support of Every Woman, Every Child,
             (https://www.global nancingfacility.org/)can be leveraged to deal with maternal
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            depression, especially postnatal, and the associated stunting in children.  
            School-based interventions are critically important because 75 percent of
            mental and substance use disorders begin before age 25 and suicide is a
            leading cause of death among youth. Programs of social and emotional learning
            along with promotion of physical health, work and study support, and alcohol
            and other drug services, have a positive impact on healthy development, well-
            being, and academic performance. Integrating school and clinic-based services
            is an e ective approach to improve human capital
            (https://www.worldbank.org/en/news/press-release/2020/09/16/pandemic-
            threatens-human-capital-gains-of-the-past-decade-new-report-says) outcomes
            by investing earlier in life.
            Similarly, integrating mental health into wellness programs in the workplace
            (https://blogs.worldbank.org/health/case-physical-and-mental-wellness-
            programs-workplace) can mobilize  private companies to invest in health
            promotion activities such as cognitive-behavioral therapies to reduce stress.
            These programs generate signi cant bene ts for workers, their families, and
            employers, improving productivity and competitiveness, and tackling stigma
            surrounding mental disorders.
            Programs in fragile and con ict-a ected settings
            (https://blogs.worldbank.org/voices/ida-securing-more-resilient-future-fragile-
            and-con ict-a ected-settings) can be leveraged to mainstream integrated
            physical and mental health interventions
            (https://documents.worldbank.org/en/publication/documents-
            reports/documentdetail/916131486730755271/mental-health-among-
            displaced-people-and-refugees-making-the-case-for-action-at-the-world-bank-
            group) alongside other social services to address the needs of displaced
            populations and refugees who have been exposed to high levels of stress. For
            example, in the Horn of Africa
            (https://documents.worldbank.org/en/publication/documents-
            reports/documentdetail/483981467990370653/africa-horn-of-africa-emergency-
            health-and-nutrition-project), a World Bank Group-funded project supported
            counseling services for Somali women and children impacted by gender-based
            and sexual violence as part of a primary care package o ered in refugee camps
            in Kenya and Ethiopia. Likewise, in Afghanistan

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             distress-afghanistan) and Yemen (https://projects.worldbank.org/en/projects-
             operations/project-detail/P161809), psychosocial support services are provided
             to people who have personally experienced or witnessed traumatic events.
             Pro-health taxes (https://blogs.worldbank.org/health/taxes-tobacco-alcohol-
             and-sugar-sweetened-beverages-reduce-health-risks-and-expand- scal), such
             as those on tobacco, alcohol, and sugar-sweetened beverages can help expand
             the tax base and collect additional public revenue for priority social investments
             and programs, including mental health services at primary care and community
             levels, and reduce health risks associated with substance use
             disorders. Botswana, Colombia, Moldova,  Philippines
             (https://documents.worldbank.org/en/publication/documents-
             reports/documentdetail/491661505803109617/main-report), and Ukraine o er
             good examples of the use of this scal policy  for public resource mobilization
             and health objectives. 
             Microcredit schemes, such as Rise Asset Development in Canada
             (https://risehelps.ca/), which provides low-interest, small business loans,
             training, and mentorship to entrepreneurs with a history of mental health or
             addiction challenges (including former prisoners), facilitate reintegration
             (https://blogs.worldbank.org/health/mental-health-prisons-how-overcome-
             punishment-paradigm) into the community.
   As the saying goes, a crisis should not go to waste. During the COVID-19 pandemic
   and beyond, renewed e orts and dedicated funding are needed to achieve mental
   health parity across sectors. A sustained focus on mental health will contribute to a
   more resilient recovery and develop more equitable societies.  
   (https://twitter.com/intent/tweet?
   text=+A+sustained+focus+on+mental+health+will+contribute+to+a+more+resilient+rec
   invest-mental-health-inclusive-and-resilient-recovery-covid-19/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)


   HEALTH (/SEARCH?F[0]=TOPIC:297&F[1]=LANGUAGE:EN), COVID-19 (CORONAVIRUS) (/SEARCH?
   F[0]=SERIES:881&F[1]=LANGUAGE:EN)




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  Addressing Alcohol Use Disorders through Taxation: A
  Public Health and Economic Win-Win in the time of COVID-
  19
  Submitted by Patricio V. Marquez on Sun, 09/06/2020 - 11 05 AM




  Addressing Alcohol Use Disorders through Taxation: A
  Public Health and Economic Win-Win in the time of COVID-
  19
  Posted by Patricio V. Marquez on Sun, 09/06/2020 - 11 05 AM




   “Taxes should be levied not with the idea of lling the public treasury at whatever cost to public morality and e      ciency, but as method of reducing the
  consumption of alcohol”    
                                        ---Raymond B. Fosdick and Albert L. Scott, Toward Liquor Control (1933)


  For many of us who have experienced alcohol use disorders involving ourselves or family members, the
  remembrance of these events brings painful memories of behaviors that negate everything that we have done well,
  accomplished, or stand for; shattered dreams and aspirations; unintended damage to relationships with loved ones
  and friends; and feelings of guilt and frustration that the temptation to have “one more” cannot be controlled
  despite promises made of “never again.”

  In some cultures, like the one that I grew up in, high tolerance of heavy alcohol use and binge drinking was not only
  accepted but expected of men and peer-reinforced, both as a rite of passage from adolescence to adulthood, and
  later in life as a sustained behavior.  Common expressions, such as “por qué te vas, si todavía estás bien” (“why are you
  leaving the party if you are still sober”), clearly portray these deep-rooted social norms.

  Some may identify this condition as a social deviance, an outlier of what is considered “good behavior.”  But more
  than that, we need to be clear that alcohol abuse and dependency, with all their causes and manifestations, is a
  damaging “social disease” affecting not only the mental and physical well-being of individual people, but also the
  lives of others.  Let’s elaborate on this topic.
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  The Nature of Alcohol Use Disorders

  Alcohol use disorder (AUD), including alcoholism, is a chronic relapsing brain disorder
  (https://www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/alcohol-use-disorders), characterized
  by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. 
  The severity of the disorder is determined by speci c symptoms, including problems controlling drinking, being
  preoccupied with alcohol, continuing to use alcohol even when it causes problems, having to drink more to get the
  same effect, binge drinking, or having withdrawal symptoms (e.g., trouble sleeping, shakiness, irritability, anxiety,
  depression, restlessness, nausea, or sweating) when a person rapidly decreases or stops drinking. 

  The impact of alcohol consumption on chronic and acute health outcomes in populations is largely determined by
  two separate but related dimensions of drinking:  the total volume of alcohol consumed, and the pattern of
  drinking.  Moderate alcohol consumption (https:/   /health.gov/our-work/food-nutrition/2015-2020-dietary-
  guidelines/guidelines/) is up to 1 drink per day for women and up to 2 drinks per day for men. Patterns of drinking
  associated with AUD (https:/ /www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/moderate-binge-
  drinking) include:

      binge drinking, a pattern of drinking alcohol that brings blood alcohol concentration (BAC) to 0.08 percent (or
      0.08 grams of alcohol per deciliter - or higher). For a typical adult, this pattern corresponds to consuming 5 or
      more drinks (male), or 4 or more drinks (female), in about 2 hours.
      heavy alcohol use as more than 4 drinks on any day for men or more than 3 drinks for women.

  Alcohol Consumption

  A study in The Lancet (https:/ /www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32744-2/fulltext) that
  analyzes trends in alcohol intake in 189 countries from 1990–2017 and estimates the rates through 2030, shows
  that between 1990 and 2017, global adult per-capita consumption (consumption in L of pure alcohol per adult [≥15
  years]) in a given year) increased from 5.9 L to 6.5 L, and is predicted to reach 7.6 L by 2030. Globally, the prevalence
  of lifetime abstinence decreased from 46% in 1990 to 43% in 2017, albeit not a signi cant reduction, while the
  prevalence of current drinking increased from 45% in 1990 to 47% in 2017. The study forecast both trends to
  continue, with abstinence decreasing to 40% by 2030 (annualized 0·2% decrease) and the proportion of current
  drinkers increasing to 50% by 2030 (annualized 0·2% increase). In 2017, 20% of adults were heavy episodic drinkers
  (compared with 1990 when it was estimated at 18·5%), and this prevalence is expected to increase to 23% in 2030. 
  Overall, men (70%) are more likely to drink than women (30%).  The observed increase in alcohol use globally may be
  explained by increased purchasing power of consumers due to grow in per capita income, particularly in China and
  India.  

  Data compiled by Our World in Data (https:/   /ourworldindata.org/alcohol-consumption), show that while alcohol
  consumption across North Africa and the Middle East is particularly low — in some countries, close to zero, alcohol
  use across Europe is highest at around 15 liters per person per year in the Czech Republic, Lithuania, and Moldova
  (equal to around two bottles of wine per person per week), and high in  Germany, France, Portugal, Ireland, and
  Belgium – at around 12 to 14 liters. Outside of Europe, the only other country in this category of high per capita
  alcohol use is Nigeria. 

  When looking at consumption data within countries, it is observed that high-income people tend to drink more
  frequently.  While those in lower income or educational status groups often drink less overall, they are more likely to
  have lower-frequency, higher-intensity drinking patterns.



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  Data on alcohol expenditure from North America, Europe, and Oceania show that it typically ranges from 0.5
  percent up to 7.7 percent (in Ireland) of household expenditure.

  Globally, 107 million people or 1.8% of the total population are estimated to have an alcohol use disorder. The share
  of the population with alcohol use disorders across countries is shown in the map below, ranging from as low as 0.5
  percent to almost 5 percent of the population.

  Among youth, a study (https:/   /ghrp.biomedcentral.com/articles/10.1186/s41256-018-0070-2) that reviewed alcohol
  consumption patterns and alcohol-related social and health issues among 15–29-year olds in Asian countries, found
  that in a majority of the selected countries, over 15% of total deaths among young men and 6% among young women
  are attributable to alcohol use. Alcohol use among young people was also found to be associated with a number of
  harms, including stress, violence, injuries, suicide, and sexual and other risky behaviors.

  In Canada (https://www.partnershipagainstcancer.ca/topics/key-statistics-alcohol-consumption-largest-cities-
  canada/), approximately 80% of adults, aged 18 or older, consumed alcohol in the past year, with the proportion of
  the adult population with alcohol consumption rates above cancer guidelines ranging from 5% of adults in Toronto,
  Ontario to 15% of adults in Sherbrooke, Quebec (Canada’s Low-Risk Alcohol Drinking Guidelines for cancer
  recommends no more than 2 drinks per day for men and no more than 1 drink per day for women). 

  Mental health disorders are a major risk factor for developing alcohol dependency.  The results of a study
  (https://www.sciencedirect.com/science/article/abs/pii/S104727970700021X) on mental health and alcohol use in
  developing countries showed that the consumption of alcohol is heavily gendered and is characterized by a high
  proportion of hazardous drinking among men. Hazardous drinkers not only consume large amounts of alcohol, but
  also do so in high-risk patterns, such as drinking alone and binging, which are associated with depressive and
  anxiety disorders as well as suicide and domestic violence.  In the Americas
  (http://www.pvmarquez.com/legacy_to_overcome), in countries such as Bolivia, Canada, Ecuador, Mexico, Peru,
  and the United States, indigenous peoples, who account for some 13% of the region’s population, suffer substantial
  alcohol use-induced conditions yet have limited access to care and other interventions.




   

  Health Consequences

  According to the World Health Organization (https:/   /www.who.int/news-room/fact-sheets/detail/alcohol) (WHO),
  alcohol use is a risk factor in more than 200 disease and injury conditions. It is associated with the development
  of mental and behavioral disorders, including alcohol dependence, major noncommunicable diseases such as liver
  cirrhosis, some cancers, and cardiovascular diseases. A signi cant proportion of the disease burden attributable to
  alcohol consumption arises from unintentional and intentional injuries, including those due to traf c injuries,
  violence, and suicides, and fatal alcohol-related injuries tend to occur in relatively younger age groups. Also, there is


www.pvmarquez.com/alcoholuse                                                                                                                                 3/12
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  a causal relationship between harmful drinking and incidence of infectious diseases such as tuberculosis as well as
  the incidence and course of HIV/AIDS. Alcohol consumption by an expectant mother may cause fetal alcohol
  syndrome and pre-term birth complications, impacting human capital development.

  Worldwide (https:/ /www.who.int/news-room/fact-sheets/detail/alcohol), about 3 million deaths every year result
  from harmful use of alcohol, which represent 5.3 % of all deaths. More than three quarters of these deaths were
  among men. Overall, 5.1 % of the global burden of disease and injury is attributable to alcohol, as measured in
  disability-adjusted life years (DALYs), which re ect both mortality and morbidity.    

  WHO data (https:/   /www.who.int/substance_abuse/publications/global_alcohol_report/en/) for 2016 also show
  that of all deaths attributable to alcohol consumption worldwide, 28.7% were due to injuries, 21.3% due to digestive
  diseases, 19% due to cardiovascular diseases, 12.9% due to infectious diseases, and 12.6% due to cancers. 
  Additionally, alcohol use was responsible for 7.2% of all premature deaths (among persons 69 years of age and
  younger), with younger people aged 20–39 years old disproportionately affected (13.5% of all deaths among this
  group are attributed to alcohol use).

  The age-standardized alcohol-attributable burden of disease and injury
  (https://www.who.int/substance_abuse/publications/global_alcohol_report/en/) globally was 38.8 deaths and 
  1758.8 DALYs per 100 000 people, with the highest burden in the WHO African Region (AFR) (70.6 deaths and 3044
  DALYs per 100 000 people). This is in contrast to the level of alcohol consumption which was highest in WHO’s
  European Region (EUR). The alcohol-attributable burden of disease and injury in Africa was due, in part, to the large
  burden of disease caused by tuberculosis, cardiovascular diseases, digestive diseases, and injuries (to which alcohol
  is a contributing factor). This explains why Africa has the highest age-adjusted burden of disease and injury
  attributable to alcohol consumption. The age-standardized burden of disease and injury attributable to alcohol
  consumption was lowest in the Eastern Mediterranean Region (EMR) (7.0 deaths and 322 DALYs per 100 000
  people).  Data for the other regions are: Europe, 62.8 deaths and 2726.5 DALYs per 100 000 people; Americas, 34.1
  deaths and 1821.9 DALYs per 100 000 people; South East Asia, 36.8 deaths and 1718.3 DALYs per 100 000 people; and
  Western Paci c, 24.3 deaths and 1132.9 DALYs per 100 000 people.

  The proportions of all deaths and DALYs caused by alcohol consumption were highest in the European Region,
  where 10.1% of all deaths and 10.8% of all DALYs were attributable to alcohol consumption, and were lowest in the
  Eastern Mediterranean Region, where 0.7% of all deaths and 0.7% of all DALYs were attributable to alcohol
  consumption.  Data for the other regions are: Africa, 5.1% of deaths and 4.1% of DALYs; Americas, 5.5% of deaths and
  6.7% of DALYs; South East Asia, 4.6% of deaths and 4.6% of DALYs; and Western Paci c, 4.1% of deaths and 4.9% of
  DALYs.

  Social Impact

  Broader negative social impacts of alcohol use are re ected in the statistics for road traf c-related injuries and
  fatalities, violent crimes, and gender-based and sexual violence. 

  Drunk driving is an important risk factor
  (https:/ /openknowledge.worldbank.org/bitstream/handle/10986/27840/516670v20WP0P110Box345565B01PUBLIC1.p
  for all road users, and young drivers aged 18–25 are particularly at risk of crashing. As blood alcohol concentration
  (BAC) increases, so does the likelihood of crashing, particularly above a BAC of 0.04 grams per deciliter (g/dl).  WHO
  estimates that nearly 2 million people are killed on the world’s roads annually, with an additional 20-50 million
  people seriously injured. The share of all road traf c deaths attributed to alcohol consumption above the national
  legal limit for alcohol consumption was estimated in 2013 to vary from a high 57.5% in South Africa to a low of 3.8%

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  in China.   In 2014, alcohol-impaired driving fatalities
  (https:/ /crashstats.nhtsa.dot.gov/Api/Public/ViewPublication/812219) accounted for 31% percent of total driving
  fatalities in the United States.

  A recent World Bank Group report, “The High Toll of Traf c Injuries: Unacceptable and Preventable,”
  (https://openknowledge.worldbank.org/handle/10986/29129) showed that besides preventing loss of life of people
  and the resulting pain and misery for families and communities, there are signi cant long-term economic gains to
  be achieved from the adoption of simple, sustainable, affordable, and effective traf c safety policies and
  interventions, including hiking up taxes to increase the price of alcohol products and regulating their marketing and
  selling practices.  The estimated impact in an initial set of ve countries (China, India, Philippines, Tanzania, and
  Thailand) ranged from a 7% to 22% increase in GDP per capita over 24 years – that could be achieved through
  substantial reduction in road traf c injuries and deaths in line with the target set under the UN’s Sustainable
  Development Goals 2030 Agenda.  This nding sends a clear message
  (https://blogs.worldbank.org/health/preventable-traf c-injuries-and-deaths-hold-back-development-countries)
  to governments:  there is a signi cant economic loss associated with every year of inaction when LMICs fail to adopt
  effective policies and interventions to substantially reduce road traf c injuries and deaths.

  Research (https://www.tandfonline.com/doi/abs/10.1080/19371918.2013.759005) on the effects of alcohol abuse on
  families shows that alcohol abuse and addiction play a role in intimate partner violence, cause family nancial
  problems, impair decision-making skills, and contribute to child neglect and abuse.

  The share of all crimes which are considered to be alcohol-related (https:/    /ourworldindata.org/alcohol-
  consumption#alcohol-related-crime), including both offenses in which the alcohol consumption is part of the
  crime such as driving with excess alcohol, liquor license violations, and drunkenness offenses, and all those crimes
  in which the consumption of alcohol is thought to have played a role of some kind in the commission of the offense
  (e.g., assault, criminal damage, and other public order offenses), is estimated to vary signi cantly:  in some countries
  – including Iran, Chile, and Scandinavian countries – the share is well below 5%, while in the UK, it is over 50%.

  Additional country evidence illustrates the wider social and impact of AUD.  As documented back in the mid-2000s
  in the report “Dying Too Young,” (http://documents.worldbank.org/curated/en/867131468094164661/Main-report)
  alcohol abuse contributed signi cantly to the dramatic decrease in life expectancy among males and the shrinking
  of the total population experienced in Russia during rst decades of the post-Soviet period (1990-2000).     

  Are people drinking more amidst the COVID-19 pandemic?

  Alcohol misuse is already a public health concern in many countries, and it has the potential to further complicate
  the COVID-19 pandemic (https:/     /www.niaaa.nih.gov/directors-blog-alcohol-poses-different-challenges-during-
  covid-19-pandemic) in multiple ways.  Excessive alcohol consumption can in uence COVID-19 susceptibility and
  severity, as it both activates the immune system, causing in ammation, and interferes with the body’s immune
  response to viral and bacterial infections.  And, in a vicious cycle, the broad effects of the pandemic are also likely to
  lead to excessive alcohol consumption. As documented in a previous post
  (http://www.pvmarquez.com/mentalhealandthcovid-19), people are more likely to drink more as a coping
  mechanism "during times of uncertainty and duress", particularly in the face of raising unemployment and loss of
  income.  The COVID-19 crisis is not an exception. For example, with bars and restaurants closed in the United
  States, sales of alcohol in the United States (https://www.nielsen.com/us/en/insights/article/2020/rebalancing-
  the-covid-19-effect-on-alcohol-sales/) have spiked nearly 27% since the start of the pandemic, with consumers
  gravitating to larger pack sizes. 



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  Also, COVID-19 stress due to lockdown and isolation has the potential to increase the risk of developing AUD and of
  relapses among people struggling to overcome this disorder.  Studies have shown that there is a clear relationship
  between anxiety and AUD.  Both prolonged drinking and alcohol withdrawal
  (https://www.ncbi.nlm.nih.gov/books/NBK64178/) are associated with an increased incidence of anxiety; people
  with general anxiety and panic disorders
  (https://www.sciencedirect.com/science/article/abs/pii/S0887618508000856) often self-medicate their condition
  with alcohol; and people with anxiety who self-medicate with alcohol often develop AUD
  (https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1107248). 

  How to control this problem?

  The most cost-effective policies or “best buys” (https:/  /www.jsad.com/doi/abs/10.15288/jsad.2018.79.514?
  journalCode=jsad)  to reduce alcohol use include increasing taxes on alcoholic beverages, enacting and enforcing
  bans or comprehensive restrictions on exposure to alcohol advertising across multiple types of media, and enacting
  and enforcing restrictions on the retail availability of alcohol.

  Other effective interventions include the enactment and enforcement of drunk-driving laws and blood alcohol
  concentration limits via sobriety checkpoints. Indeed, the number of countries reporting the adoption of these
  measures increased substantially between 2008 and 2016   the majority (97) of countries studied by WHO
  (https://www.who.int/substance_abuse/publications/global_alcohol_report/en/) have a maximum permissible
  blood alcohol concentration (BAC) limit to prevent drunk driving at or below 0.05%; 37 countries have a BAC limit of
  0.08; and 31 countries have no BAC limits at all. Seventy countries (41%) reported using sobriety checkpoints and
  random breath-testing as prevention strategies, but 37 (22%) used neither strategy.

  Taxing alcohol

  As observed by Richard M. Bird
  (https://openknowledge.worldbank.org/bitstream/handle/10986/23464/Tobacco0and0al0ing0sin0and0virtue00.pdf
  sequence=1&isAllowed=y), excise taxes on alcohol as well as on tobacco have long been a dependable and signi cant
  revenue source in many countries globally.  In recent years, increased attention has been paid to the way in which
  such taxes may also be used to achieve public health objectives by reducing the consumption of products with
  adverse health and social impacts. 

  Alcohol taxation and pricing policies have public health and economic bene ts: 1) control of alcohol consumption
  and public health problems caused by alcohol consumption, 2) prevention of drinking initiation, and 3) tax revenue
  generation.

  Several types of alcohol excise taxation methods are employed around the world, including:  uniform tax methods –
  such as speci c taxation (where the tax is calculated based on the amount of ethanol a beverage contains), ad
  valorem taxation (where the tax is based on the price of the alcoholic beverage), and unitary taxation (where the tax
  is based on the volume of the alcoholic beverage) – and combination tax methods such as mixed speci c and ad
  valorem taxation and ad valorem with speci c oor taxation. These methods have different attributes that may be
  appropriate to different contexts and different alcohol control objectives
  (https://www.researchgate.net/pro le/Kevin_Shield/publication/318233753_The_need_for_alcohol_taxation_and
  need-for-alcohol-taxation-and-pricing-policies.pdf).  For example, speci c taxation may be appropriate for high-
  income countries that have a high prevalence of drinkers since it promotes consumption of beverages with low
  alcohol content instead of beverages with high alcohol content, resulting in a reduction in total alcohol
  consumption. Ad valorem with speci c oor taxation and mixed speci c and ad valorem taxation may be
  appropriate for low- and middle-income countries since they promote consumption of medium alcohol content
www.pvmarquez.com/alcoholuse                                                                                                                                 6/12
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  beverages, which are expected to reduce total alcohol consumption among heavy drinkers and prevent drinking
  initiation among young people. The government may also apply a minimum price measure to control problems
  caused by inexpensive alcoholic beverages.

  Hiking tax rates to increase the price of alcoholic beverages is one of the most cost-effective and cost-saving
  approaches to reducing alcohol consumption and harm. As such, it is important to note that alcohol and tobacco
  taxation may differ with respect to their public health goals. While there is no safe level of smoking, in terms of
  alcohol consumption, the public health goal is moderation (except in the case of road safety, where no level of drunk
  driving is safe). Hence, the public health goal for taxing alcohol beverages (https://www.worldcat.org/title/alcohol-
  consumption-and-taxation/oclc/20754456) is to limit the harm caused by alcohol consumption, either by reducing
  or preventing increases in the overall average consumption per person. 

  The WHO’s Global Strategy to Reduce the Harmful Use of Alcohol
  (https://www.who.int/publications/i/item/9789241599931) recommends that countries establish a system for
  speci c domestic taxation which may take into account the alcohol content of the beverage.  The strategy also
  encourages countries to review prices regularly in relation to in ation and income levels; to ban or restrict sales
  below cost and other price promotions; and to establish minimum prices for alcohol where applicable.  According to
  the ndings of the 2015 WHO Global Survey on Progress in Alcohol Policy
  (https://www.who.int/substance_abuse/publications/global_alcohol_report/en/), 59% of 164 reporting countries
  indicated that they had established or increased the excise tax on alcohol since 2010, covering 5 billion people.  

  The results of a study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764336/#pmed.1001963.ref011) that
  compared the scale and distribution across society of health impacts arising from alternative alcohol tax and price
  policy options have shown that, compared to taxation based on product value, alcohol-content-based taxation or
  minimum unit pricing would lead to larger reductions in health inequalities across income groups. The study also
  estimated that alcohol-content-based taxation and minimum unit pricing would have the largest impact on harmful
  drinking, with minimal effects on those drinking in moderation. 

  While the excise tax rate is an important factor in determining the price of alcoholic beverages, an important
  variable to in uence consumption, as is also the case in tobacco taxation, is the extent to which increases in excise
  taxes are passed along to consumers as opposed to being absorbed by rms, as people are sensitive to changes in
  the price of alcohol products. Pricing policies therefore can be used to in uence demand and reduce underage
  drinking, heavy drinking, and binge drinking. Consumer preferences and choice, per capita income variations,
  alternative sources of alcohol in the country or in neighboring countries, the presence or absence of other alcohol
  control policy measures, as well as opposition of industry groups, may in uence the effectiveness of this policy
  measure. To help realize the bene ts of alcohol tax policies, strengthened tax administration, including control of
  illicit tobacco and alcohol trade (https://documents.worldbank.org/en/publication/documents-
  reports/documentdetail/677451548260528135/confronting-illicit-tobacco-trade-a-global-review-of-country-
  experiences), plays a critical role.

  Health impact of alcohol taxation

  A recent study (https:/ /doi.org/10.15288/jsad.2018.79.514) provided evidence on the comparative cost-effectiveness
  of alcohol control strategies.    The results of the study showed that increasing alcohol excise taxes by 50% is the
  most cost-effective policy to reduce harmful alcohol use, as it has a low cost (< $0.10 per capita) and a highly
  favorable ratio of costs to effects (< $100 per healthy life year gained in both low- and high-income settings). This
  measure is more ef cient than alternative options in the same price category.  Availability and marketing
  restrictions are also highly cost-effective (< $100  per healthy life year gained in low-income settings and < $500 per

www.pvmarquez.com/alcoholuse                                                                                                                                 7/12
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  healthy life year gained in high-income settings), while enforcement of drunk-driving laws and blood alcohol
  concentration limits via sobriety checkpoints had cost-effectiveness ratios in the range of International (I) $1,500–
  3,000 and brief psychosocial treatments were <I$150 and <I$1,500 in low- and high-income settings, respectively.

  Different studies (https://www.who.int/substance_abuse/publications/global_alcohol_report/en/) also provide
  evidence that increasing the price of alcohol is associated with reductions in harmful use of alcohol and alcohol-
  related morbidity and mortality, including liver cirrhosis deaths, violence, teenage pregnancy, and sexually
  transmitted diseases.  There is also evidence that suggests that the bene ts of higher alcohol prices also extend to
  the education sector, increasing the likelihood of secondary school graduation as well as post-secondary enrollment
  and graduation.

  Another recently-published study (https:/  /gh.bmj.com/content/bmjgh/5/3/e002143.full.pdf) that simulated the
  health and economic effects of alcohol, as well as tobacco and sugar-sweetened beverages (SSB) over 50 years for
  30–79 years old populations, shows that alcohol taxation generate a health bene t of years of life gained  (YLG) over
  50 years of 227million and 547million for 20% and 50% price increases, respectively. It also shows that consumer
  expenditure increases by US$2958 billion and US$1549 billion over 50 years, and tax revenues increase by US$9428
  billion and US$17778 billion for the 20% and 50% price increases, respectively.

  Results from studies focusing on the State of Maryland (US) experience provide speci c evidence that alcohol tax
  increases are an effective strategy for reducing health risks.  One study
  (https://www.ajpmonline.org/article/S0749-3797(15)00627-3/fulltext) showed that after the sales tax rate for
  alcoholic beverages increased from 6% to 9% in 2011, on top of the existing state and federal excise tax rates that are
  collected from manufacturers or wholesalers of alcoholic beverages which are passed on directly to the consumer in
  the form of raised alcohol prices, per-capita alcohol consumption and sexually transmitted diseases were
  reduced. Gonorrhea rates, for example, decreased 24% during the 1.5-year post-increase period. This implied that
  an estimated 2,400 cases of gonorrhea were prevented, saving more than US$500,000 in direct medical expenses. 
  Another study showed that there was a signi cant though gradual annual reduction of 6% in the population-based
  rate of all alcohol-positive drivers, and a more pronounced 12% reduction for drivers aged 15–34 years following
  the 2011 alcohol sales tax increase. The ndings suggest that young drivers tend to be alcohol price-sensitive. The
  sales tax increase, which has also raised about US$70 million a year for health and education programs, has proved
  to be an important but often neglected intervention to reduce alcohol-impaired driving.

  In the case of China (https://www.worldbank.org/content/dam/Worldbank/document/NCD_report_en.pdf),
  modelling work has shown that for a few additional cents (US) or around 0.07 yuan per capita, a combination of anti-
  tobacco measures with interventions for controlling alcohol abuse, e.g., increasing tax and banning advertising,
  would help avert an additional 40 million DALYs lost annually.

  The experience of Russia since 2010 is illustrative of the potential signi cant impact of raising alcohol and tobacco
  taxes on good health outcomes. Over the past decade, life expectancy
  (https://www.thelancet.com/action/showPdf?pii=S0140-6736%2818%2931485-5) for men in Russia increased to
  65.4 years in 2016, up from 58 years in 2003, and among women it reached 76.2 years in 2016, up from 72 years in
  2003. A big factor (http://www.euro.who.int/en/countries/russian-federation/publications/tobacco-control-a-
  comprehensive-approach-at-country-level-in-the-russian-federation-2017) in this improvement was the effective
  measures adopted to control the consumption of alcohol and tobacco.

  It is worthwhile looking at the European Union (EU) experience, which shows that even countries in the same
  economic block governed by a partially restrictive legal framework enact very different alcohol taxation policies.  A
  recent study (https://onlinelibrary.wiley.com/doi/full/10.1111/add.14631) found only limited evidence that alcohol
  duties in the EU are designed to minimize public health harms by ensuring that drinks containing more alcohol are
www.pvmarquez.com/alcoholuse                                                                                                                                 8/12
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  taxed at higher rates.  The ndings of the study indicate that only 50% of EU Member States levy any duty on wine,
  and several levy duties on spirits and beer at or close to the EU minimum level. Duty rates are generally higher for
  spirits than other beverage types and are generally lowest in Eastern Europe and highest in Finland, Sweden,
  Ireland, and the United Kingdom.

  Public revenue impact of alcohol taxation

  When assessing the scal impact of alcohol taxation, it is important not only to focus on the generation of public
  revenue but also on the expenditures required to address the social consequences of alcohol use disorders. 

  This consideration is of great importance, as total alcohol tax revenue collection tends to account for only a small
  share of the total economic cost to the government of alcohol-related harm, and even a lower share of the total
  economic cost of excessive drinking.  For example, a CDC study (https:/   /www.cdc.gov/media/releases/2015/p1015-
  excessive-alcohol.html) showed that excessive drinking cost the United States US$249 billion in 2010, or US$2.05 per
  drink, a signi cant increase from US$223.5 billion, or $1.90 per drink, in 2006. Most of these costs were due to
  reduced workplace productivity, crime, and the cost of treating people for health problems caused by excessive
  drinking.  As shown by data from another on the situation in the United States
  (https://www.jsad.com/doi/10.15288/jsad.2019.80.408),  speci c excise taxes accounted for a weighted median of
  20.1% of total state alcohol tax revenue, and  the median total alcohol tax per drink (based on all federal and state
  taxes) was US$0.21, which accounted for 26.7% of the median cost to government and 10.3% of the median total
  economic cost of excessive drinking. 

  The heavy burden of alcohol-related conditions on the health system is illustrated by data from 100 emergency
  departments of 33 countries presented in a recent study (https:/    /movendi.ngo/reports/alcohols-healthcare-
  burden-during-covid%E2%80%9019-pandemic/).  In most countries, alcohol’s contribution is in the realm of 20% of
  all presenting injuries, while alcohol’s contribution to non‐injury emergency department admissions averages 11.5%.

  From a public revenue perspective, building on the experience in the Philippines
  (https://openknowledge.worldbank.org/handle/10986/24617) with the “Sin Tax Law” adopted at the end of 2012, 
  considerable attention has been paid in recent years to promoting alcohol and tobacco tax increases as a policy
  option to help mobilize additional resources to nance development priorities, particularly the expansion of
  universal health coverage schemes.  In large measure, the experience of the Philippines over 2013-2017 is one of the
  most compelling examples of ambitious national alcohol and tobacco tax reform. It involved a fundamental
  restructuring of the country’s tobacco excise tax structure, including reduction in the number of tax tiers;
  indexation of tax rates to in ation; and substantial tax increases that generated more than US$5.2 billion additional
  revenues or 1.1% of GDP in the rst 4 years of implementation, which expanded the scal space to increase the
  number of low-income families enrolled in the health insurance scheme from 5.2 million primary members in 2012
  to 15.3 million in 2017.

  Likewise, as part of a broad scal reform package approved by Colombia’s Congress on December 23, 2016, excise
  tax increases on alcohol and tobacco were adopted
  (http://documents1.worldbank.org/curated/en/491661505803109617/pdf/119792-REVISED-v2-
  OctFINALWBGTobaccoTaxReformFullReportweb.pdf) to achieve public health and revenue objectives. In addition,
  the scal reform law mandates the earmarking of these tax revenues to nance health insurance coverage and
  education programs at the departmental level.  Similar scal reforms were enacted over the 2016-2019 period in
  countries such as Armenia, Gabon, Lesotho, Montenegro, and Nigeria, with technical support from the World Bank
  Group.



www.pvmarquez.com/alcoholuse                                                                                                                                 9/12
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  The “win-win” scal/public health nature of raising taxes on alcohol is further illustrated by the experience of
  other countries.  In the United States (https://www.cbo.gov/budget-
  options/2018/54815#:~:text=Beginning%20in%202020%2C%20distilled%20spirits%20will%20be%20taxed,about%202
  federal collections from taxes on alcoholic beverages totaled about US$11 billion in 2017.  Distilled spirits are taxed at
  a at rate of US$13.50 per proof gallon (a proof gallon denotes a liquid gallon that is 50 percent alcohol by volume),
  which translates to about 21 cents per ounce of pure alcohol. Beer is generally  subject to a tax rate of US$18 per
  barrel, which is equivalent to about 10 cents per ounce of pure alcohol (under the assumption that the alcohol
  content of the beer is 4.5 percent), and the excise tax on wine that is no more than 14 percent alcohol is US$1.07 per
  liquid gallon, or about 6 cents per ounce of pure alcohol (assuming an alcohol content of 13 percent). As part of
  options for reducing the federal government de cit over 2019-2028, a Congressional Budget Of ce simulation
  showed that by increasing all taxes on alcoholic beverages to US$16 per proof gallon from current level and indexing
  for in ation would increase revenues by US$83 billion from 2020 through 2028, while reducing costs for society that
  are not re ected in the pretax price of alcoholic beverages---e.g.,  external costs including spending on health care
  that is related to alcohol consumption and covered by the public, losses in productivity stemming from alcohol
  consumption that are borne by entities or individuals other than the consumer, and the loss of lives and property
  from alcohol-related injuries and crime. 

  The above ndings provide a strong justi cation for raising excise taxes on alcoholic beverages to levels where
  revenues match or at least cover a larger share of the economic cost of alcohol use disorders.  If this is not done, the
  disparity that exists between alcohol-related costs to government and the collected alcohol tax revenue will be
  perpetuated, which is tantamount to a large taxpayer-funded subsidy of excessive drinking.
  (https://www.usnews.com/news/health-news/articles/2019-09-11/booze-taxes-dont-make-up-for-societal-
  costs-of-excess-drinking-study) 

  Is alcohol taxation a regressive policy measure?

  A common objection to increasing alcohol excise tax is that even if it is an effective public health measure, it is
  poorly focused, in effect punishing all drinkers regardless of whether their drinking is problematic. As eloquently
  argued by Prof. Philip J Cook of Duke University
  (https://press.princeton.edu/books/hardcover/9780691125206/paying-the-tab), in a landmark book on the cost
  and bene ts of alcohol control, alcohol taxation tends to be well focused on negative externalities of drinking.
  That is, in the case of a price increase per drink that results from raising taxes on alcohol, those who abstain (a
  signi cant proportion of most populations) would pay nothing and would be just a few extra dollars per year for
  light/moderate drinkers (the majority of those consuming alcohol). The bulk of the additional excise revenue
  would come from the top 15% of the drinkers (who average 8 or 9 drinks per day) who consume 75% of all the
  alcohol and consequently would pay 75% of a new tax. That is also the group that accounts for most of the alcohol-
  related harm, consequently yielding a well-targeted tax increase. Additionally, even if the direct effect of prices are
  on the consumption habits of relatively moderate drinkers, heavy drinkers can be affected indirectly. There is
  reliable evidence that alcohol consumers across the spectrum in uence each other. So, if alcohol prices affect the
  drinking patterns at the median, then the upper tail of the distribution will shift inward - in other words, a reduced
  prevalence of heavy drinking would be expected.

  Seizing the COVID-19 crisis to reduce public health risks and mobilize public funding

  The COVID-19 pandemic has impacted countries with an unprecedented double shock, public health and
  economic, that is constraining the scal capacity of countries in the short- and medium-term.  As argued in a
  previous post (https://blogs.worldbank.org/health/taxes-tobacco-alcohol-and-sugar-sweetened-beverages-
  reduce-health-risks-and-expand- scal), pro-health taxes, including excise tax increases on tobacco, alcohol, and
  sugar-sweetened beverages, are a potential tool to help alleviate the ongoing health crisis and contribute to
www.pvmarquez.com/alcoholuse                                                                                                                                 10/12
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  recovery.   While this scal measure can help reduce health risks associated with the onset of non-communicable
  diseases and injuries and their nancial and economic impacts, it can also help mobilize public revenue to expand
    scal space for health and other essential programs that bene t the entire population of countries.  Indeed, 
  projections presented in a World Bank Group report (https:/  /openknowledge.worldbank.org/handle/10986/31930)
  for the G-20 meeting in Osaka, Japan in 2019 showed that the substantial universal health coverage nancing gap in
  low- and lower-middle-income countries (now exacerbated by COVID-19), can be attenuated by excise tax increases
  on tobacco, alcohol, and sugar-sweetened beverages.  These pro-health taxes can help further mobilize public
  revenue while mitigating the affordability of these products by regularly adjusting the excise tax and sale tax
  increases in accordance with in ation and per capita income growth.

  It should be clear, however, that thus far governments have failed to take advantage of taxation
  (https://newbooksinpolitics.com/political/phishing-for-phools/) as a cost-effective and cost-saving method of
  alcohol control, despite the evidence that it could help generate signi cant public revenue to keep down taxes
  elsewhere.  In some measure this outcome is due to the in uence of powerful interest groups—from the alcohol
  industry to owners of bars and restaurants, as well as doubts about the harms of alcohol among the general public
  as alcohol use is associated with deep-rooted and well-accepted social and cultural norms and traditions. Dealing
  with this reality, active community engagement, as exempli ed by the work of organizations such as Mothers
  Against Drunk Driving (https:/ /www.madd.org/history/) (MADD), could be galvanized to lobby for the adoption of
  tax increases and other measures to moderate alcohol abuse and prevent ruining the lives of alcohol-dependent
  people and their loved ones, as well as of those people impacted or killed as a result of alcohol-impaired driving or
  acts of violence.

  As we move forward containing and mitigating the impact of the COVID-19 pandemic, the most significant global
  public health crisis of the past 100 years, we need to be clear that disease and injury prevention is not only a public
  health goal, but more importantly, a broad social goal that should matter to all of us since it is a key requirement for
  building healthy, resilient, and productive societies. Measures such as alcohol taxation, as shown by the evidence
  presented above, can contribute to this end by helping reduce the short- and long-term public health and economic
  harms caused by destructive drinking.

   

   

  Source of image: "Colorful drawing: father drinking alcohol and crying child", Stock photo ID:507843974.


   

   

   

   

   




                                                  
                                                         (https://twitter.com/pvmarquez1956)


www.pvmarquez.com/alcoholuse                                                                                                                                  11/12
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  Let’s not forget about Mental Health during COVID-19!
  Submitted by Patricio V. Marquez on Sat, 08/22/2020 - 09 42 AM




  Let’s not forget about Mental Health during COVID-19!
  Posted by Patricio V. Marquez on Sat, 08/22/2020 - 09 42 AM




  “Thus the rst thing that plague brought to our town was exile…….It was undoubtedly the feeling of exile—that sensation of a void within which never left us, the
  irrational longing to hark back to the past or else to speed up the march of time, and those keen shafts of memory that stung like re.”
  Albert Camus (1957 Nobel Prize Laureate for Literature), The Plague, 1947


  Growing numbers of infected people, loss of life, and an economic free-fall not experienced since World War II, are
  some of the casualties of the COVID-19 pandemic.  IMF estimates (https:/ /blogs.imf.org/2020/04/20/a-global-
  crisis-like-no-other-needs-a-global-response-like-no-other/) show that 170 countries will see income per capita
  go down, and World Bank Group projections (https:/   /blogs.worldbank.org/opendata/updated-estimates-impact-
  covid-19-global-poverty) suggest that rising unemployment and loss of income, including in some countries a
  signi cant drop in remittances, could push between 71 and 100 million people into extreme poverty. 

  Daily personal routines have been altered by social distancing measures adopted to prevent the spread of the novel
  coronavirus, impacting people in many different ways.  The lack of interpersonal contact with loved ones and peers
  is contributing to feelings of isolation and loneliness; detachment from our communities is depressing us; and fear
  of becoming infected or of loved ones falling ill worries and makes us anxious.  In large measure, a sense of being in
  “exile” has engulfed us as we drift through the sameness of days, feeling unmoored and uncertain about the
  repercussions of the pandemic.

  Given the intense disruption brought by COVID-19 to our everyday life, it is of great importance to understand how
  the pandemic is affecting mental well-being and what can be done to help people cope and deal with its
  consequences in the short- and medium-terms.  In answering this question, we need to learn from past crises as
  well as to look at the emerging evidence from the current pandemic.

  The Impacts of Unemployment and Loss of Income



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  The layoffs and job losses brought on by lockdowns have been enormous, particularly for people with only basic
  levels of education and in the poorer segments of society, while telework arrangements have protected the
  employment of highly skilled and educated people.  Across countries, ILO estimates
  (https:/ /news.un.org/en/story/2020/04/1061322) show that full or partial lockdown measures are affecting almost
  2.7 billion workers – four in ve of the world’s workforce. In particular, workers in sectors such as food and
  accommodation (144 million workers), retail and wholesale (482 million), business services and administration (157
  million), and manufacturing (463 million), which account for up to 37.5 per cent of global employment, are feeling the
  “sharp end” of the impact of the pandemic.  COVID-19 has had disproportionate effects on women
  (https:/ /blogs.imf.org/2020/07/21/the-covid-19-gender-gap/)and their economic status, since women are more
  likely than men to work in social sectors — such as service industries, retail, tourism, and hospitality, that require
  face-to-face interactions, and hence, are hit hardest by social distancing and mitigation measures.

  As discussed in a paper by researchers from the Urban Institute
  (https://www.urban.org/research/publication/consequences-long-term-unemployment/view/full_report), the
  experience from previous global crises, such as the Great Recession of 2008, shows than being out of work for six
  months or more is associated with lower well-being among the unemployed, their families, and their communities.
  While scal stimulus and targeted social transfer programs can help mitigate the consequences of long-term
  unemployment, a decline in family income due to a worker’s lack of earnings directly reduces the quantity and
  quality of goods and services the worker’s family can purchase and exacerbates stress as well. The erosion in the tax
  base used to fund essential public services, such as essential medical care, can negatively affect individuals and
  families by constraining access to these services when needed.

  Impact on Mental Health

  The devastating impact of COVID-19 disease on people’s physical health is well documented, with more than 22
  million people infected, almost 800,000 deaths (https://coronavirus.jhu.edu/), and many that survived infection left
  experiencing persistent symptoms long after hospital discharge. Much less understood is the impact of high levels
  of stress on people resulting from the adoption of social distancing measures to contain and mitigate COVID-19 and
  from the economic downturn and income loss to households.  The graph below depicts a COVID-19 physical and
  mental health impact timeline.




www.pvmarquez.com/mentalhealandthcovid-19                                                                                 2/6
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  Fear, pervasive anxiety, frustration, and anger
  (https://academic.oup.com/qjmed/article/113/8/531/5860841)experienced by adults and children can be
  overwhelming and aggravated by social isolation and loneliness (https:/ /www.nap.edu/catalog/25663/social-
  isolation-and-loneliness-in-older-adults-opportunities-for-the) among the elderly, who are a higher risk of
  developing severe symptoms or die from COVID-19 disease.  These negative psychological effects are associated
  with stressors (https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2930460-8) such as long
  duration of quarantines, infection fears, frustration, boredom, sadness, grief, inadequate supplies, inadequate
  information, nancial loss, and stigma and discrimination
  (https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30498-9/fulltext). Some of the symptoms of
  mental health problems include changes in sleep or eating patterns; dif culty sleeping or concentrating; worsening
  of chronic health problems and mental health conditions; and adoption of risky behaviors such as increase in
  tobacco use, alcohol abuse, and substance use.

  More speci cally, research in countries is showing how the pandemic is impacting the general population.  A health
  tracking poll (https://www.kff.org/coronavirus-covid-19/report/kff-health-tracking-poll-early-april-2020/)
  conducted in April 2020 in the United States indicates that an increasing share of people reported worrying about
  economic impacts, with more than half now reporting being worried that their investments will be negatively
  impacted for a long time (59%) and that they will be laid off or lose their job (52%), nearly half worried they will lose
  income due to a workplace closure or reduced hours (45%), more than half (53%) worried that they or a family will
  get sick from coronavirus, and nearly six in ten adults (57%) being worried they will put themselves at risk of
  exposure to coronavirus because they cannot afford to stay home and miss work.  More troubling, the results of the
  poll indicate that more than four in ten adults overall (45%) feel that worry and stress related to coronavirus have
  had a negative impact on their mental health, up from 32% in early March 2020.  Similarly, research
  (https://doi.apa.org/fulltext/2020-52963-001.html)that examined whether intolerance of uncertainty and coping
  responses in uence the degree of distress experienced by the U.K. general public during the COVID-19 pandemic,
  indicates that around 25% of participants demonstrated signi cantly elevated anxiety and depression, with 14.8%
  reaching clinical cutoff for health anxiety.  Further research from China
  (https://gpsych.bmj.com/content/33/2/e100213) found that 35% of people experienced mental distress, such as
   panic disorder, anxiety, and depression, during the rst month of the COVID-19 outbreak and that these levels
  continued as the disease spread over the following months.

  How are Lockdowns Impacting Children and Young Adults? 

  The Great Lockdown has affected close to 1 billion children and adolescents worldwide, upending their daily routine
  and isolating them from their social structures.  A recent study (https://psyarxiv.com/5bpfz/)examining the
  psychological impact on youth from Italy and Spain, shows that 85.7% of the parents perceived changes in their
  children´ s emotional state and behaviors during this period. The most frequent symptoms identi ed included
  dif culty concentrating (76.6%), boredom (52%), irritability (39%), restlessness (38.8%), nervousness (38%), feelings
  of loneliness (31.3%), uneasiness (30.4%), and worries (30.1%).  The study also reported that children of both
  countries used electronic devices more frequently, spent less time on physical activity, and slept more hours. 
  Moreover, when family coexistence became more dif cult, the situation was more serious, the level of stress was
  higher and parents tended to report more emotional problems in their children.  Death of parents or other family
  members due to COVID-19 may also spur a great amount of grief among children that would need to be dealt with.
   In addition, long-term school closures may further impact negatively the well-being of school-age children
  (https://www.cdc.gov/coronavirus/2019-ncov/downloads/considerations-for-school-closure.pdf) as they lose
  access to meal programs, academic support, physical and social activities, and reduced face-to-face engagement
  with peers.



www.pvmarquez.com/mentalhealandthcovid-19                                                                                     3/6
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  It has also been suggested (https:/ /theconversation.com/the-long-term-biological-effects-of-covid-19-stress-on-
  kids-future-health-and-development-140533) that stressors from the pandemic, such as reduced family income,
  food insecurity, parental stress, and child abuse, can negatively impact children’s developing brains, immune
  systems, and ability to thrive. While some effects will be immediate, many will surface decades from now
  (https://theconversation.com/the-long-term-biological-effects-of-covid-19-stress-on-kids-future-health-and-
  development-140533) in the form of mental, social, and physical health problems (e.g., higher risk of metabolic
  syndrome
  (https://journals.lww.com/psychosomaticmedicine/Abstract/2017/06000/Early_Life_Socioeconomic_Disadvantage
  and physical health problems in adulthood (https:/   /srcd.onlinelibrary.wiley.com/doi/abs/10.1111/cdep.12021)).  A
  related study in China (https:/ /onlinelibrary.wiley.com/doi/full/10.1111/jsr.13142?referringSource=articleShare) has
  highlighted the importance of the link between sleep, health, and family factors, even during a period in which
  families are confronted with dramatic lifestyle changes and grappling with heightened health concerns related to
  the pandemic. Disrupted and insuf cient sleep has been linked to immune system dysfunction (e.g., increase in
  cytokines, such as interleukin), impeding resilience to infection in young children during the COVID‐19 pandemic.

  Isolation and lack of interaction with other people are also negatively impacting the mental health of young adults
  ages 18-24.  Existing mental illness among adolescents may also be exacerbated by the pandemic, and with school
  closures, they may have limited access to mental health services.  Recent data from the CDC
  (https://www.baynews9.com/ /tampa/news/2020/08/15/cdc--young-adults-disproportionately-affected-by-
  mental-health-impacts-of-covid-19) illustrate this problem by showing that young adults in the United States are
  among the groups disproportionately affected by the mental health impacts of the COVID-19 pandemic, struggling
  with issues such as anxiety/depression (31%), trauma/stressor-related disorders (26%), starting or increasing
  substance use (13%), and seriously considering suicide (11%). Preliminary results of a study carried out by Uribe and
  team at the Ponti cia Universidad Javeriana (Personal communication with Miguel Uribe, June 2020) focusing on
  mental health and resilience in young adults in Bogota, Colombia during the COVID -19 lockdown, also evidence the
  high mental health toll that social distancing measures are having on young adults aged 18-24 years.  While 59% of
  males and 70% of females presented depressive symptoms, 47% of males and 56% of females had anxiety symptoms.
  Substance use and addiction (https:/  /www.cdc.gov/ncbddd/fasd/features/teen-substance-use.html), in particular,
  can have long-term impacts on young people, as they can affect brain development, occur more frequently with
  other risky behaviors, such as unprotected sex and dangerous driving, and contribute to the development of adult
  health problems, such as heart disease, high blood pressure, and sleep disorders.

  The daily attachment to laptops, desktops, and the multi-functional smartphone, which have become “virtual
  bridges” for interacting with the outside world during the pandemic, may pose additional risks, particularly to
  children and adolescents (http:/ /www.pvmarquez.com/digital%20media_impacts).  Hyper connectivity
  (http://www3.weforum.org/docs/WEFUSA_DigitalMediaAndSociety_Report2016.pdf) has the potential to further
  change patterns of social interaction, as online interaction may become a “new normal,” substituting for face-to-
  face interaction--essential to the give-and-take functioning of families, communities, and workplaces.  Digital
  media consumption may also facilitate bullying, harassment, social defamation, and hate speech because potential
  costs of such behavior are reduced and the ease of engaging in behaviors that harm others or ourselves is
  increased.  And, excessive digital media use can negatively in uence the development of cognitive (thinking,
  imagining, reasoning, and remembering abilities) and behavioral (reactions or actions that we take in response to
  stimuli present in our environment) skills and even mental and physical health.

  Impact on Frontline Health Workers

  In many countries, as COVID-19 cases surged, hospitals were overwhelmed, and work demands on frontline health
  care workers increased signi cantly, particularly in facilities with lower physician-or nurse-to-patient densities.  As
  a result, they are at increased risk of burnout and suffer from mental health issues
www.pvmarquez.com/mentalhealandthcovid-19                                                                                   4/6
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  (https://blogs.worldbank.org/health/supporting-mental-health-and-resilience-frontline-covid-19-coronavirus-
  health-care-workers), including depression and substance use.

  Risk of Suicides

  Suicide is a terminal outcome in the spectrum of mental health problems.   Accumulated evidence from countries
  around the world indicates that global crises, that lead to severe social and economic disruptions, similar to those
  caused now by the COVID-19 pandemic, are associated with increases in suicide, particularly in males of working
  age.  This occurs (https://pubmed.ncbi.nlm.nih.gov/24903684/) as the result of the negative effects of
  unemployment and job insecurity, as well as effects of nancial loss, bankruptcy, and home repossession on
  individuals and households, which may lead directly or indirectly to mental health problems such as depression,
  anxiety, and binge drinking and then to suicidal behavior.

  A study (https:/ /jech.bmj.com/content/73/4/311#article-bottom)that estimated what the suicide rates would have
  been during and one year after economic/ nancial crises of the 1970-2011 period in 21 Organization for Economic
  Co-operation and Development (OECD) countries if the suicide rates had followed the pre-crisis trends, found that
  all the crises led to excess suicides. Among males, the excess suicide rate (per 100 000 persons) varied from 1.1 to 9,
  and among females, from 0 to 2.4.  In terms of actual numbers, these crises caused more than 60,000 excess
  suicides in OECD countries. Another study (https:/   /journals.sagepub.com/doi/pdf/10.1177/0020764019879946?
  casa_token=4hQ4Y4FwCiMAAAAA 6w3FYw1j44NqzVbCOIlBGycQgkT_SysZxVSweojU7BSaNLhngL8vMn0pmCJbaVBugT
  that after the Great Recession of 2008 in the United States, the number of suicides increased due to the negative
  effect of the crisis on the mental health of individuals and the decrease in their future expectations.  These ndings
  are corroborated by studies done in Ireland (https:/  /pubmed.ncbi.nlm.nih.gov/26082406/), that showed that ve
  years of economic recession and austerity had a signi cant negative impact on rates of suicide in men and on self-
  harm in both sexes, and in Greece (https:/  /bmjopen.bmj.com/content/5/3/e007295), that found a clear increase in
  suicides among persons of working age that resulted from the economic crisis of 2011-2013.

  What to Do?

  While a vaccine and new diagnostics and therapies are on the horizon, it seems that we are at the cusp of a
  transition from a world that we knew well at the beginning of 2020 and that in many ways has now been shattered,
  to a yet unknown “new normal”.   

  Should we despair, or use this time as a “window of opportunity” to re ect, learn from the fact that no country, not
  even the richest one in the world, was prepared to deal with the onslaught of the fast-spreading novel coronavirus,
  and perhaps start thinking on how to build better for the long term?  Looking at the glass half full, we will discover
  that not everything is lost.  As human beings we have the capacity to assess reality, learn from past experiences and
  accumulated knowledge, and chart a path forward.

  The mental health toll of the COVID-19 pandemic is only beginning to show itself.  Although we cannot predict the
  scale of its impact, lessons from past crises can offer guidance on how to mitigate and address this challenge.

  Moving forward, it is crucial that we ensure that along with health and economic emergency response programs,
  social and psycho-social support interventions are included to provide required support to people in need, both
  those already suffering from mental disorders pre-pandemic and those newly affected.  This would require the
  allocation of resources targeted to develop effective communication to the population and improve the quality and
  quantity of mental health services integrated as part of primary health care and social support service delivery
  platforms at the community level.  It will be of critical importance that these platforms include mechanisms for
  surveillance, reporting, and intervention
www.pvmarquez.com/mentalhealandthcovid-19                                                                                  5/6
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  (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2764404), particularly to track and address
  gender and domestic violence and child abuse during lockdowns, and that services delivered be organized following 
  stepped-care approaches (https:/   /jamanetwork.com/journals/jamapsychiatry/fullarticle/2656183)—the practice of
  delivering the most effective, least resource-heavy treatment to people in need, and then stepping up to more
  resource-heavy treatment based on patients’ needs.  Levering information technology will facilitate the provision of
  online mental health and peer-to-peer support services while helping overcome stigma barriers, particularly among
  adolescents. 

  Monitoring and additional research (https://www.nytimes.com/2020/08/21/opinion/covid-depression-
  boredom.html?referringSource=articleShare) are also needed to track and understand the long-term mental health
  impacts of the COVID-19 pandemic, to guide action on the basis of evidence.

  Finally, it is important to keep in mind that while some people may require medication and social support to deal
  with fear, loneliness, or grief (https://www.nytimes.com/2020/04/09/opinion/sunday/coronavirus-depression-
  anxiety.html?action=click&module=RelatedLinks&pgtype=Article), we need to avoid rushing to medicalize the
  response to “normal unpleasant emotions” such as feeling bored and confusion during lockdowns.  Although these
  feelings may be intolerable sometimes, they “do not need medical treatment any more than everyday unhappiness
  requires an antidepressant” (https:/   /www.nytimes.com/2020/08/21/opinion/covid-depression-boredom.html?
  referringSource=articleShare).

    

   

  Image Credit: Srdjanns74, Stock Photos  




                                            
                                                 (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/mentalhealandthcovid-19                                                                                 6/6
1/12/2021            Taxes on tobacco, alcohol, and sugar-sweetened beverages reduce health risks and expand fiscal space for Universal Health Coverage post-COVID 19


            Learn how the World Bank Group is helping countries with COVID-19 (coronavirus).                                   Find Out 




                           Publish d on Inv stin in H                                                      lth (/h                lth)


   T x s on tob cco, lcohol, nd su r-
   sw t n d b v r     s r duc h lth
   risks nd xp nd fisc l sp c for
   Univ rs l H lth Cov r     post-COVID
   19
   PATRICIO V. MARQUEZ (/TEAM/PATRICIO-V-MARQUEZ) & SHEILA DUTTA (/TEAM/SHEILA-
   DUTTA) | AUGUST 11, 2020
   This page in: English


                                      
                                          3




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         “If we want to improve global health, we need to tax the things that are killing us.
         Taxing things that are bad for your health, like tobacco, over things like savings
         and income, is as close to a free lunch as you can get in economics. The economic
         rationale for taxing these products is strong if we want to save lives and make a
         better, healthier world.” (https://www.bloomberg.org/program/public-
         health/who-global-ambassador/#task-force- scal-policy-health)

         LARRY SUMMERS, former Secretary of the U.S. Treasury and Director of the
         National Economic Council, and former World Bank Group Chief Economist
         (2019)


   Seven months after the rst cases of a new coronavirus (COVID-19) were reported in
   China, the pandemic’s toll continues to increase, despite global containment and
   mitigation e orts. People of any age with certain underlying medical conditions
   (https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-
   medical-conditions.html?
   CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-
   ncov%2Fneed-extra-precautions%2Fgroups-at-higher-risk.html), such as
   cardiovascular diseases, cancer, obstructive pulmonary diseases, and obesity and
   diabetes, are at increased risk for severe illness and death from COVID-19.  Tobacco
   use, alcohol abuse, and consumption of unhealthy foods (such as sugar sweetened
   beverages) are three leading risk factors for the development of these chronic health
   conditions.
   Pre-existing global health disparities, magni ed during the pandemic, re ect deep-
   rooted inequalities in income, wealth, and voice. To address these challenges,
   countries need to maintain essential health services to address concurrent health
   needs, and particularly the needs and service delivery gaps targeting the most
   vulnerable populations. Urgent steps are required to prevent a secondary global
   health crisis, with many countries already reporting life-threatening health service
   disruptions.  (https://twitter.com/intent/tweet?
   text=Urgent+steps+are+required+to+prevent+a+secondary+global+health+crisis%2C+w
   threatening+health+service+disruptions.&url=https://blogs.worldbank.org/health/taxes
   tobacco-alcohol-and-sugar-sweetened-beverages-reduce-health-risks-and-expand-
    scal/?cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) There are particular
   gaps with respect to maternal, infant, and child health; prevention and treatment of
   other infectious diseases such as TB, malaria, HIV/AIDS, and noncommunicable
   diseases.
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   Looking forward, as noted by the Dean of the Johns Hopkins Bloomberg School of
   Public Health (https://magazine.jhsph.edu/2020/lets- x-things-good), "we must start
   talking now about the need to invest for the long term," building upon the “brutal
   lessons” from the COVID-19 pandemic. This observation brings to the fore once
   again the imperative of universal health coverage (UHC). 
   Up to now, the UHC e ort has largely focused on ensuring that medical care is
   accessible and a ordable. The time has come to give equal importance to
   disease prevention, health promotion, and emergency preparedness as part of
   an integrated framework for action to achieve UHC.    
   (https://twitter.com/intent/tweet?
   text=%3Cstrong%3EThe+time+has+come+to+give+equal+importance+to+disease+prev
   tobacco-alcohol-and-sugar-sweetened-beverages-reduce-health-risks-and-expand-
    scal/?cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)
   Taxation on tobacco, alcohol, and sugar-sweetened beverages are e ective but
   underused policies of disease prevention and health promotion
   (https://www.bbhub.io/dotorg/sites/2/2019/04/Health-Taxes-to-Save-Lives.pdf), that
   could also help mobilize additional government revenue to fund investments and
   programs that bene t the entire population and enhance equity. Let’s explain the
   win-win-win nature of this policy.

   Raising taxes on tobacco, in particular, can do more to reduce premature mortality
   than any other single health policy. The evidence
   (https://documents.worldbank.org/en/publication/documents-
   reports/documentdetail/491661505803109617/main-report) across a wide range of
   countries shows that a 50% increase in cigarette price typically leads to a 20% decline
   in cigarette consumption. Lowering consumption reduces tobacco-attributable
   sickness and death: about half of this e ect comes from current smokers quitting
   and the other by reducing smoking initiation among young people.
   Taxing alcohol
   (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951962/pdf/2270.pdf) and sugar-
   sweetened beverages
   (https://www.worldbank.org/en/topic/nutrition/publication/obesity-health-and-
   economic-consequences-of-an-impending-global-challenge) helps to reduce
   consumption and prevent the onset of related chronic diseases such as
   cardiovascular diseases, cirrhosis of the liver, obesity and diabetes. Moreover, taxing
   to increase the price of alcohol products, along with strict enforcement of drink-drive
   laws, can help reduce the high human and economic cost of road tra c injuries,
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   fatalities (https://www.worldbank.org/en/programs/global-road-safety-
   facility/publication/the-high-toll-of-tra c-injuries-unacceptable-and-preventable),
   and domestic violence.  
   Emerging evidence (https://openknowledge.worldbank.org/handle/10986/34082)
   reported by the World Bank consistently identi es net positive economic impacts
   from sugar-sweetened beverages taxes, including overall employment and
   productivity gains, and increased government spending.
   To help realize the bene ts of pro-health tax policies, strengthened tax
   administration, including control of illicit tobacco and alcohol trade, play a critical
   function (https://documents.worldbank.org/en/publication/documents-
   reports/documentdetail/677451548260528135/confronting-illicit-tobacco-trade-a-
   global-review-of-country-experiences).
   Even as they lower consumption and improve public health, tobacco, alcohol, and
   sugar-sweetened beverage taxes can substantially boost government revenues.  
   (https://twitter.com/intent/tweet?
   text=Even+as+they+lower+consumption+and+improve+public+health%2C+tobacco%2C
   sweetened+beverage+taxes+can+substantially+boost+government+revenues.+&url=ht
   tobacco-alcohol-and-sugar-sweetened-beverages-reduce-health-risks-and-expand-
    scal/?cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) This is of critical
   importance during COVID-19, as policymakers must maintain their public health
   responses while also mobilizing domestic revenue for investment in future pandemic
   preparedness and other essential health services. Adoption of policies that reduce
   future health risks has been found to (https://blogs.imf.org/2020/07/10/ scal-
   policies-for-a-transformed-world/) contribute to public trust, thereby helping
   economic activity and reducing strains on public nances. Investing in stronger
   health systems for all can also contribute to tackling rising poverty and inequality.
   Projections presented in a World Bank Group report for the G-20 meeting in Osaka,
   Japan in 2019 (https://openknowledge.worldbank.org/handle/10986/31930) showed
   that the substantial UHC nancing gap in low- and lower-middle-income countries
   (now exacerbated by COVID-19), can be attenuated by excise tax increases on
   tobacco, alcohol, and sugar-sweetened beverages. These calculations showed that a
   50% increase in prices for these products could generate additional revenues of
   approximately $24.7 billion in 54 low- and middle-income countries by 2030.




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   These health tax increases would have the additional advantage of reducing future
   health care costs by curbing the growth of the non-communicable diseases that
   tobacco, alcohol, and sugar-sweetened beverages can cause. Importantly, the
   revenue raised can additionally bene t poorer households
   (https://documents.worldbank.org/en/publication/documents-
   reports/documentdetail/893811554737147697/is-tobacco-taxation-regressive-
   evidence-on-public-health-domestic-resource-mobilization-and-equity-
   improvements) when it is used progressively. Elimination of fossil fuel subsidies
   (https://openknowledge.worldbank.org/handle/10986/31930), which impose large
    scal costs while adding to negative environmental and health impacts, could also
   help expand scal space for health. 
   Pro-health taxes are a potential tool to help alleviate the ongoing health crisis and
   contribute to recovery.   (https://twitter.com/intent/tweet?text=Pro-
   health+taxes+are+a+potential+tool+to+help+alleviate+the+ongoing+health+crisis+and+
   tobacco-alcohol-and-sugar-sweetened-beverages-reduce-health-risks-and-expand-
    scal/?cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)  As such, they should be
   considered essential components of health and scal policy building support of
   healthier and more resilient societies. 




   Authors




                                                                                                              
   (/team/patricio-v-marquez) (/team/patricio-v-marquez)
   P tricio V. M rqu                       (/t       m/p tricio-v-m rqu )
                                                                                                                                                                 x




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  While waiting for a COVID-19 vaccine, it’s time to
  focus on gaps in vaccine distribution, cold chain,
  and uptake
  Submitted by Patricio V. Marquez on Sun, 07/26/2020 - 11 12 PM




  While waiting for a COVID-19 vaccine, it’s time to
  focus on gaps in vaccine distribution, cold chain,
  and uptake
  Posted by Patricio V. Marquez on Sun, 07/26/2020 - 11 12 PM




  Patricio V. Marquez, Betty Hanan, and Sheila Dutta
   

  As the world waits anxiously for a COVID-19 vaccine to become available, countries have a “window
  of opportunity” to focus on existing gaps in vaccine distribution and cold chain systems and
  vaccination demand and uptake constraints.  If these gaps are addressed in a timely way, it will
  facilitate widespread administration, not only of a new COVID-19 vaccine, but will also help revamp
  the delivery of routine vaccines, particularly those for children, that are part of the Expanded
  Program on Immunization (EPI).  The latter task is of critical importance since over the past 4-6
  months, national immunization programs around the world have been disrupted due to the severe
  health system constraints and physical distancing measures in place to mitigate the ongoing

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  COVID-19 pandemic (Abbas, Procter, van Zandvoort, Clark, Funk, Mengistu, Hogan, Dansereau, Jit,
  Flasche, LSHTM CMMID COVID-19 Working Group 2020
  (https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30308-9/fulltext)).

  The importance of vaccines and vaccination

  The development of vaccines is a long, risky, and costly endeavor.  On average, it takes 10.7 years to
  develop a new vaccine, and there is only a 6% success rate for vaccine research—from start to nish
  (Kuchler (https:/ /www.ft.com/hannah-kuchler), H.  (https:/ /www.ft.com/content/1467b1da-28a5-
  47d4-a5e2-a6f4b68484c3)Financial Times. Big Read. Medical Science, 2020
  (https://www.ft.com/content/1467b1da-28a5-47d4-a5e2-a6f4b68484c3)).  Indeed, determining that
  a vaccine is safe and effective takes time. 

  The drive and race for a COVID-19 vaccine has picked up with the recent announcement of
  promising results of ongoing trials conducted in different countries (Jackson, Anderson, Rouphael,
  Roberts, Makhene, et al. 2020 (https:/    /www.nejm.org/doi/10.1056/NEJMoa2022483); F
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext)olegatti,
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#) 
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext)Ewer, 
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#)Aley, 
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#)Angus, 
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#)Becker, 
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext#)Belij-
  Rammerstorfer, et al. (https:/  /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31604-4/fulltext#) 2020 (https:/      /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31604-4/fulltext); Zhu,  (https:/    /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31605-6/fulltext)Guan,  (https:/     /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31605-6/fulltext#)Li,  (https:/    /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31605-6/fulltext#)Huang,  (https:/      /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31605-6/fulltext#)Jiang,  (https:/     /www.thelancet.com/journals/lancet/article/PIIS0140-
  6736(20)31605-6/fulltext#)Hou, et al.
  (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31605-
  6/fulltext#) 2020).  While there is hope that a COVID-19 vaccine will be available in 12 to 18 months
  or earlier if the trials are successful, a lot of uncertainty still clouds that optimistic scenario.    

  While vaccines are important, as experts have observed, what matters is vaccination; that is, the
  administration of a vaccine to people to help their immune systems develop protection from a
  disease. Immunization programs often serve as the entry point for primary health care in many
  countries, often providing the only access to mothers and young children on a regular basis (CDC,
  2020 (https://www.cdc.gov/globalhealth/immunization/default.htm)). Vaccination not only
  protects those immunized but can reduce the risk of disease among those not immunized in a
  community through the development of “herd immunity.” The impact of vaccines in reducing
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  vaccine-preventable disease morbidity and mortality is enormous: for example, in low-income
  countries, 23.3 million deaths are estimated to have been averted over 2011-2020 (CDC, 2020
  (https://www.cdc.gov/globalhealth/infographics/immunization/global_impact_of_vaccines.htm)).  

  COVID-19 is disrupting life-saving immunization services in both rich and poor countries, putting
  millions of children at risk from vaccine-preventable diseases like diphtheria, measles, and polio.
  According to UNICEF, this situation is due in large measure to a massive backlog in vaccine
  shipments due to unprecedented logistical constraints related to COVID-19 mitigation measures
  including lockdowns in some countries (UNICEF, 2020 (https:/    /www.unicef.org/press-
  releases/geneva-palais-brie ng-note-impact-covid-19-mitigation-measures-vaccine-supply-
  and)).  It is estimated that vaccination saves between 2 to 3 million lives a year (CDC, 2020
  (https:/ /www.cdc.gov/globalhealth/infographics/immunization/global_impact_of_vaccines.htm)).  

  Considerations for Strengthening/Reinstating Immunization Services

  While the global effort nowadays is centered on containing the spread of the coronavirus and the
  resulting disease (COVID-19) and mitigating its social and economic impact, it is of critical
  importance to also maintain essential health service delivery to address other health needs of the
  population and prevent excess morbidity and mortality in a society (Marquez, Wang, and Ndebele
  2020 (http://pvmarquez.com/essentialhealthservices)).

  Guidelines put forward by WHO can help adopt a balanced response at national, regional, and local
  levels (WHO, June 2020 (https:/ /www.who.int/publications/i/item/covid-19-operational-
  guidance-for-maintaining-essential-health-services-during-an-outbreak)). WHO advises that,
  where immunization services are constrained or suspended, countries should reinstate their
  immunization services, once local transmission of the COVID-19 virus has declined (WHO, March
  2020 (https://www.who.int/publications/i/item/guiding-principles-for-immunization-activities-
  during-the-covid-19-pandemic-interim-guidance)). WHO also notes that if resources for “catch-up”
  immunization campaigns are limited, priority should be given to outbreak-prone diseases such as
  measles, polio, diphtheria, and yellow fever.   

  Vaccine Logistics, Cold Chain, Tracking, and Communication

  Building and sustaining safe and effective immunization programs are essential components of
  health delivery systems.  Successful programs are built on functional, end-to-end supply chain and
  logistics systems. The role of the supply chain is to ensure effective vaccine storage, handling, and
  stock management; rigorous temperature control in the cold chain; and maintenance of adequate
  logistics management information systems. The ultimate goal is to ensure the uninterrupted
  availability of quality vaccines from manufacturer to service-delivery levels, so that opportunities to
  vaccinate are not missed because vaccines are unavailable (WHO, accessed on July 26, 2020
  (https://www.who.int/immunization/documents/IIP2015_Module2.pdf)).  


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  The maintenance of cold chain is essential for vaccine effectiveness  (WHO, accessed on July 26,
  2020 (https://www.who.int/immunization/documents/IIP2015_Module2.pdf)).  A cold chain is a
  temperature-controlled supply chain from the point of manufacture to the point of use. It involves
  an uninterrupted series of refrigerated production, storage, and distribution activities, along with
  associated equipment and logistics, including uninterrupted access to electrical or solar energy, to
  maintain the vaccines within a low-temperature range to ensure their potency.  

  Maintaining the cold chain requires that vaccines and diluents be consistently transported and
  stored between 2-8◦C at all stages, including in primary/central/intermediate vaccine stores and
  health facilities and also during outreach immunization sessions (WHO, accessed on July 26, 2020
  (https://www.who.int/immunization/documents/IIP2015_Module2.pdf)).  In addition to
  temperature sensitivity, some vaccines (e.g., BCG and measles) also are sensitive to light. Any loss of
  potency due to heat or light is cumulative, permanent, and irreversible, meaning that the vaccine is
  rendered ineffective. 

  Tracking and monitoring vaccine coverage is also critical, as data and information inform decision-
  making and outreach priorities.  To this end, well-established arrangements need to be in place to
  record and report every vaccine dose administered, adverse effects, and assess the population
  served.

  Cold Chain Challenges and Solutions

  Some cold chain challenges that merit immediate review and attention include insuf cient and sub-
  optimal cold chain capacity that hampers availability of safe vaccines; limited freezing and storage
  capacity; inadequate temperature monitoring and maintenance systems; and costs.

  As assessed in different countries, often cold chain systems are unable to ensure availability of safe
  and potent vaccines (Ashok
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub#!), 
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub)Brison
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub#!), and 
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub)LeTallec
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub#!), 2017
  (https://www.sciencedirect.com/science/article/pii/S0264410X16307307?via%3Dihub)).  To
  address key performance gaps, the authors recommend the following actions: (i) development of an
  accurate picture of cold chain capacity gaps based on current and future needs (including in-
  country piloting of new equipment and a full understanding of equipment trade-offs); (ii)
  improvement of planning and programming (particularly to ensure that vaccination covers hard-to-
  reach populations); (iii) mobilization of resources to adequately fund programs; and (iv) effectively
  monitoring the cold chain during implementation. In addition, to control temperature variations



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  and equipment failures, the introduction of temperature monitoring and control devices and
  practices is recommended, in addition to strengthening human resources for equipment repair and
  the availability of spare parts.

  Well-trained vaccinators at vaccination sites are also critical for the delivery of this intervention. 
  Hence, strengthening health workers’ knowledge, skills, and practices is of upmost importance for
  the effective administration of vaccines.  Human resources are the backbone of any system and the
  key enabler for all other functions to perform effectively. It is no different with vaccination
  programs, and more so in the current environment in which there is a need to have ready capacity
  to manage the introduction and administration of a potential new COVID-19 vaccine, while at the
  same time revamping the delivery of existing EPI vaccines.   

  Ensuring demand and uptake of vaccines, as well as their affordability

  It should be clear that the ready availability of vaccines will not automatically generate their
  demand and uptake in all population groups.  This reality re ects a lack of trust in government
  action and in some cases is the result of misinformation campaigns that are not backed by scienti c
  evidence. So, serious community outreach and engagement to provide transparent information
  about the importance of vaccines needs to be mounted to protect people, particularly the most
  vulnerable. The communications effort, however, needs to address knowledge, attitudes, and beliefs
  about vaccination particular to the social and cultural characteristics of different societies.   

  Another option for increasing vaccine uptake is to require it. As observed in a recent article (Mello,
  Silverman, and Omer, 2020 (https:/  /www.nejm.org/doi/full/10.1056/NEJMp2020926)), mandatory
  vaccination has proven effective in ensuring high childhood immunization rates in many high-
  income countries. However, except for in uenza vaccination of health care workers, mandates have
  not been widely used for adults.  The operationalization of a vaccination mandate, for example for
  some high-risk groups such as health workers, the elderly, and those with preexisting conditions,
  would require that (i) the supply of the vaccine is suf cient to cover the population groups for
  which a mandate is being considered; (ii) available evidence about the safety and ef cacy of the
  vaccine has been transparently communicated; and (iii) established infrastructure to provide access
  to vaccination without nancial or logistic barriers, compensation to those who suffer adverse
  effects from a required vaccine, and real-time surveillance of vaccine side effects.

  It is also important that countries implement effective communication strategies to allay concerns
  and re-establish the demand for vaccinations within communities.The need to build public trust
  requires that state of cials implement vaccination policy through transparent and inclusive
  processes, involving local health of cers, health professional and hospital associations,
  representatives of high-risk population groups, and groups concerned about vaccine safety.  As was
  observed during the Ebola response in West Africa in 2014-2015, building trust by engaging citizens
  and community leaders is critical to the success of delivering health services (UNDP, UN Agencies,
  World Bank Group, European Union, and African Development Bank, in consultation with the
www.pvmarquez.com/vaccinationsystems                                                                                                                              5/8
1/12/2021                While waiting for a COVID-19 vaccine, it’s time to focus on gaps in vaccine distribution, cold chain, and uptake | Patricio V. Marquez

  African Union and (https://www.undp.org/content/undp/en/home/librarypage/crisis-
  prevention-and-recovery/recovering-from-the-ebola-crisis---full-report.html)Economic
  Community of West African States and Mano River Union
  (https://www.undp.org/content/undp/en/home/librarypage/crisis-prevention-and-
  recovery/recovering-from-the-ebola-crisis---full-report.html), 2015
  (https://www.undp.org/content/undp/en/home/librarypage/crisis-prevention-and-
  recovery/recovering-from-the-ebola-crisis---full-report.html)). 

  Finally, equitable access to and utilization of vaccines is of paramount importance, particularly for
  ensuring that all countries, including the poorest, have equal access to a new COVID-19
  vaccine once they become available. A key question that needs to be clari ed across the world,
  therefore, is how to make the new COVID-19 vaccines available free of charge or affordable to large
  segments of the world population that lack or have limited access to essential public health services
  and related nancial protection arrangements, such as social health insurance coverage.

  This issue merits careful consideration and assessment of options given the negative impact of the
  pandemic on countries’ macroeconomic situation, which might cascade down to health
  systems. Indeed, World Bank Group's 
  (https://openknowledge.worldbank.org/handle/10986/33748)baseline forecast envisions a
  5.2% contraction in global GDP in 2020—the deepest global recession in eight decades, despite
  unprecedented policy support. Per capita incomes in the vast majority of emerging market and
  developing economies (EMDEs) are expected to shrink in 2020, tipping many millions back into
  poverty.  Under the baseline scenario, World Bank Group estimates show that COVID-19 will push
  more than 70 million people into extreme poverty, measured at the international poverty line of
  $1.90 per day (Gerszon Mahler, Lakner, Castaneda Aguilar, Wu 2020
  (https://blogs.worldbank.org/opendata/updated-estimates-impact-covid-19-global-poverty)).
  Tighter scal space and shrinking revenue for employment-based insurance schemes may enlarge
  the nancial gap for investing in the health system. 

  One option that should be considered for expanding the tax base and mobilizing additional scal
  resources for health, while helping reduce associated health risks, is the adoption of higher tax
  rates for tobacco and alcohol products, introducing or hiking taxes on sugary drinks, and phasing
  out fuel subsidies. There is signi cant accumulated experience in different countries of the world
  on the use of pro-health taxes, particularly to reduce tobacco use, and evidence on the positive
  health, scal, and equity gains that are generated by this policy measure.

  Looking forward

  While the world is going through a “perfect storm” caused by the coronavirus, we should not
  despair.  We have evidence that proper application and population acceptance of basic public
  health measures, such as testing, isolation of those infected, contact tracing, quarantines for those
  people suspected of having being exposed to the virus, use of a cloth face covering
www.pvmarquez.com/vaccinationsystems                                                                                                                              6/8
1/12/2021                While waiting for a COVID-19 vaccine, it’s time to focus on gaps in vaccine distribution, cold chain, and uptake | Patricio V. Marquez

  (https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-
  coverings.html) in public spaces, hand hygiene, and social distancing provisions, help prevent the
  spread of the coronavirus. 

  Also, recent developments in treatments, such as antivirals (Remdesivir), glucocorticoids
  (dexamethasone), and antibodies (blood injections from patients who have recovered from COVID-
  19), are showing that they can help improve outcomes for COVID-19 patients
  (Beigel,Tomashek, Dodd, Mehta, Zingman, et al. 2020
  (https://www.nejm.org/doi/full/10.1056/NEJMoa2007764?
  query=recirc_curatedRelated_article); The RECOVERY Collaborative Group 2020
  (https://www.nejm.org/doi/full/10.1056/NEJMoa2021436?
  query=recirc_mostViewed_railB_article); Casadevall and Pirofski 2020
  (https://www.jci.org/articles/view/138003)).

  Even if a COVID-19 vaccine is only 60% or 70% effective, it could have a signi cant impact in
  reducing the contagiousness of the virus.  Similarly, revamping and expanding the coverage of
  essential health services will help address the larger health needs to the population, and reduce the
  risk of the onset of other vaccine-preventable infectious diseases.  

  History is full of examples that suggest that the prevention, containment, mitigation, and
  eventual suppression of COVID-19 is possible if political commitment, the alignment of
  resources, and determined scienti c, technological and operational efforts converge around a
  common objective.  Indeed, as told by Dr. William Foege in “House on Fire”
  (https://www.goodreads.com/book/show/9772046-house-on- re), his memoire about the ght to
  eradicate smallpox in the 1960s and 1970s, well-structured and supported programs such as the one
  for smallpox eradication illustrates that “humanity does not have to live in a world of plagues,
  disastrous governments, con ict, and uncontrolled health risks” because “the coordinated action of
  a group of dedicated people can plan for and bring about a better future.”

  Source: Top Image by Katja Fuhlert (https://pixabay.com/users/kfuhlert-977338/?
  utm_source=link-
  attribution&utm_medium=referral&utm_campaign=image&utm_content=1215279) from Pixabay
  (https://pixabay.com/?utm_source=link-
  attribution&utm_medium=referral&utm_campaign=image&utm_content=1215279) 

   

   




www.pvmarquez.com/vaccinationsystems                                                                                                                              7/8
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www.pvmarquez.com/vaccinationsystems                                                                                                                              8/8
1/12/2021                              Improving Health Services: A Global Imperative Amidst COVID-19 | Patricio V. Marquez




   Improving Health Services: A Global
   Imperative Amidst COVID-19
   Submitted by Patricio V. Marquez on Mon, 06/22/2020 - 06 54 PM




   Improving Health Services: A Global
   Imperative Amidst COVID-19
   Posted by Patricio V. Marquez on Mon, 06/22/2020 - 06 54 PM




   Patricio V. Marquez and Lani Rice Marquez


       "If you can't describe what you are doing as a process, you don't know what
   you're doing”

                W. Edwards Deming, 1900-1993


www.pvmarquez.com/qualityimprovement                                                                                          1/5
1/12/2021                              Improving Health Services: A Global Imperative Amidst COVID-19 | Patricio V. Marquez

   Although “back to normal” in all spheres of life is still a distant aspiration
   worldwide after six months of relentless coronavirus (COVID-19) onslaught,
   restoring routine health services is a task that cannot wait. The diversion of
   health care resources to contain and mitigate the COVID-19 pandemic,
   coupled with a fear of health facilities among the population amid
   lockdowns, has disrupted the delivery and utilization of services in different
   parts of the world. 

   In the absence of a vaccine or effective treatment, the immediate priority is
   to halt the spread of the deadly coronavirus through public health action,
   including: testing and contact tracing to stop cases from becoming clusters
   and outbreaks; isolation of infected people from people who are not sick;
   quarantine to separate and restrict the movement of people believed to have
   been exposed to the coronavirus to monitor if they become sick; and social
   distancing measures and wearing face masks in public spaces for the general
   population.  The restoration and strengthening of health system capacity,
   however, are equally essential tasks that should be planned and
   implemented to ensure that critically ill patients receive appropriate care
   and to reduce the overall impact of the pandemic.  A false dichotomy
   between COVID-19 emergency response and health system strengthening
   priorities needs to be avoided.

   The question that merits consideration, then, is how can quality
   improvement be at the core of restoring health services?  Does
   improvement happen only by increasing providers’ knowledge and use of
   new tools, technologies, and medicines to prevent disease and diagnose and
   treat patients?  Or is improvement a process that requires sustained effort
   and participation of all actors involved in the delivery of services? 

   To answer these questions, a new open-access book "Improving Health
   Care in Low-and Middle-Income Countries
   (https://www.springer.com/us/book/9783030431112)" offers an

www.pvmarquez.com/qualityimprovement                                                                                          2/5
1/12/2021                              Improving Health Services: A Global Imperative Amidst COVID-19 | Patricio V. Marquez

   interesting perspective rooted in the work of W. Edwards Deming, who
   proposed in the 1950s that eliminating delays, duplications, and errors
   would result in higher quality products and services at lower unit costs. 
   Deming’s ideas were initially embraced and applied with good results in
   Japan to manufacture automobiles, electronic appliances, and other
   consumer goods, and were later adapted by Don Berwick and others in the
   United States and other countries in the 1990s for improving health care.    

   “Improvement”, therefore, as suggested by the book authors, should be
   understood as “a directed effort to take what we know can improve health –
   proven, high-impact interventions like active management of the third stage
   of labor or keeping newborns warm – and ensure that those are implemented
   reliably, in different contexts, every time, for every patient who needs them.”
    The country case studies from Africa, Eastern Europe, South Asia, and Latin
   America and the Caribbean presented in the book illustrate how a persistent
   effort to identify gaps in care, propose changes to address those gaps, and
   test the effectiveness of the changes can measurably improve health
   processes and outcomes.

   Overall, one can infer from the book that there is no “best way” to improve
   health care.  Rather, it is clear that engagement of health workers is the
   critical element for improving care at different levels of the health system—
   community, health center, district hospital, and referral hospital and for a
   wide variety of health conditions--prevention of mother-to-child
   transmission of HIV, tuberculosis-HIV co-infection, nutrition and health
   promotion for pregnant women and children under two, maternal mortality,
   and antimicrobial resistance due to overuse of antibiotics.

   Indeed, key to success in all country case studies is a dedicated focus of
   improvement teams on reaching explicit standards, identifying gaps in
   meeting standards and taking action to address the gaps, including
   brainstorming and thinking through new ways of improving adherence to
www.pvmarquez.com/qualityimprovement                                                                                          3/5
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   standards. Some approaches introduced rewards for meeting standards, but
   similar improvements in care were achieved by simply informing health
   workers of gaps in care without explicit rewards for quality. 

   Measurement is a critical part of testing and implementing changes.  The
   development of data analysis skills among health workers, therefore, is
   critical for the quality improvement process, particularly looking at changes
   in data in a simple or intuitive way to allow improvement teams to easily
   understand what worked—and what didn't.

   Building in mechanisms to share learning across teams as they tested
   different approaches improved the impact of quality improvement efforts in
   many cases, as effective ways for improving care were shared among teams
   and scaled up to more sites.

   Teams were able to achieve better improvement results with strong support
   structures around them, including management support, to help them
   address system-level problems that are beyond the reach of individual
   teams. Many of the cases also emphasize the value of coaching support to
   help teams to translate standards into practice and for intervening in the
   particular care area.

   A pilot approach can be useful to demonstrate results on a small scale
   before scaling up to multiple sites.  Results at pilot sites can help create
   buy-in and political support for the improvement at the political and
   administrative level of the health system, which in turn can strengthen the
   efforts at the service delivery level.

   Benchmarking or comparing performance between facilities and districts,
   while providing facility-speci c feedback, can stimulate efforts of teams
   to modify practices.  Indeed, health workers can be motivated by evidence


www.pvmarquez.com/qualityimprovement                                                                                          4/5
1/12/2021                              Improving Health Services: A Global Imperative Amidst COVID-19 | Patricio V. Marquez

   of how their practices deviate from the established practices or from the
   mean performance of other facilities in the same region.

   It should be clear, however, that the medium- and long-term sustainability
   of quality improvement efforts and their achievements will depend on their
   institutionalization through policies, organizational and institutional
   arrangements, performance management processes, and adequate and
   predictable funding allocations. This will support the establishment of a
   “quality improvement culture” that is ingrained at all levels of the health
   system.  The engagement of frontline teams, following clearly de ned
   standards of work for the delivery of safe, effective, and ef cient health
   care, that is monitored and adjusted as a team responsibility, would be key
   to sustain performance and contribute to improving the health conditions of
   the population.  If this is done, it would help rebuild trust and con dence in
   health services after the COVID-19 crisis has ended.

   Picture:  Picture of Quality Improvement (QI) Teams in Uganda, URC.




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www.pvmarquez.com/qualityimprovement                                                                                          5/5
1/12/2021                            Sustaining Essential Health Services during the Covid-19 Pandemic: A Social Imperative | Patricio V. Marquez




  Sustaining Essential Health Services during the Covid-19
  Pandemic: A Social Imperative
  Submitted by Patricio V. Marquez on Mon, 06/15/2020 - 08 44 PM




  Sustaining Essential Health Services during the Covid-19
  Pandemic: A Social Imperative
  Posted by Patricio V. Marquez on Mon, 06/15/2020 - 08 44 PM




                Patricio V. Marquez, Huihui Wang, Lydia Ndebele

  Background
  The COVID-19 pandemic is currently affecting 188 countries and territories across all regions. In all but a handful
  of countries, COVID-19 exploited weaknesses across health system platforms, pointing out strong need for resilient
  health systems. Under-resourced surveillance platforms were unable to promptly detect community spread until
  viral circulation was already widespread. Insuf cient stockpiling, contingency planning, and coordination across
  regional, national, and international public health platforms led to shortages of essential supplies and equipment,
  sparking bidding wars and leaving health workers without appropriate protective gear. Hospital platforms were
  overwhelmed and stressed beyond capacity, with fragmentation hampering the ef cient ow of patients, staff, and
  equipment.

  For countries that had weaker health systems and less resources, the impact can be both signi cant and long-
  lasting.  COVID-19 may affect countries’ journey to Universal Health Coverage and the Sustainable Development
  Goal 3 through several pathways:


  1.  Increased morbidity and mortality directly attributed to COVID-19
      As of June 16, 2020, there have been close to 8 million con rmed cases of COVID-19 and more than 434,000
      deaths (JHU&M 2020). Since testing capacity lags in most countries, the number of new cases is likely to be
      underestimated. Similarly, mortality data should also be interpreted with caution, as many countries show
      signi cant underreporting of COVID-19- related deaths (Table 1). Differences in data collection, as well as delays
      in death registrations, contribute to the problem.


www.pvmarquez.com/essentialhealthservices                                                                                                           1/8
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       Unexplained deaths provide a proxy for underreporting. They are estimated as the difference between
       observed deaths and the projected number of deaths based on historical and seasonal trends. The difference may
       be attributed to COVID-19 or to other factors, such as a shortage or lack of essential medical services for other
       conditions. While it is not possible to know the true death toll of COVID-19, it is clear that in some countries
       daily deaths have reached rates 50% or higher than the historical average for periods of time. 
                                                              Table 1. COVID-19 underreported deaths




  Source:  For all cases, except Mexico, The New York Times “74000 missing deaths: tracking the true toll of the coronavirus outbreak.” Updated May 19. For México City Nexos:
  “¿Qué nos dicen las actas de defunción de la CDMX?”, May 25, 2020.

       Based on currently available information and clinical expertise, older adults and people of any age who have
       serious underlying medical conditions might be at higher risk for severe illness from COVID-19 (CDC 2020),
       particularly those with weakened immune systems.  People with chronic lung disease or moderate to severe
       asthma, serious heart conditions, who are immunocompromised (many conditions can cause a person to be
       immunocompromised, including cancer treatment, smoking, bone marrow or organ transplantation, immune
       de ciencies, poorly controlled HIV or AIDS, and prolonged use of corticosteroids and other immune weakening
       medications), severe obesity (body mass index [BMI] of 40 or higher), diabetes, chronic kidney disease
       undergoing dialysis, and liver disease.   Conditions such as ischemic heart disease, stroke, lower respiratory
       infections, chronic obstructive pulmonary disease (COPD), HIV/AIDS, tuberculosis, are already among the ten
       leading causes of premature death in the world, accounting for more than 1 million deaths each in 2017 (IHME
       2018). 
       As the rst country to be impacted, China’s reported data provides insights into the biology, epidemiology,
       and clinical characteristics of COVID-19 (Guan, Ni, Hu, Liang, et al 2020). A higher prevalence of smoking
       among men, often resulting in compromised lung function, may help explain their higher COVID-19 fatality rate. 
       Tobacco use also contributes to the onset of co-occurring conditions such as cardiovascular diseases, lung
       cancer, COPD, and diabetes, which are more prevalent among males, and which also increase the risk of disease
       severity and death among COVID-19 patients.  Data from Italy also shows that a high proportion of COVID-19
       patients had a history of smoking and high rates of COPD and heart disease (Boccia, Ricciardi, Ioannidis 2020).
       The Middle East and North Africa (MENA) region is also facing an increased pressure on health systems from
       COVID-19 (coronavirus), with over 200,000 con rmed cases and almost 10,000 deaths reported, on top of a high
       and growing burden of non-communicable diseases (NCDs) (Duran and Menon 2020). 
       Sub-Saharan African countries can be potentially hit hard with a large number of people are at higher risk of
       infection due to preconditions: about 26 million live with HIV
       (https://www.unaids.org/sites/default/ les/media_asset/UNAIDS_FactSheet_en.pdf) and 2.5 million fall ill
       from tuberculosis (https://www.afro.who.int/health-topics/tuberculosis-tb) annually, while South Africa and
       Namibia have high mortality rates from NCDs (Marquez and Farrington 2013). As experienced by some high-
       income countries, people in low- and middle-income countries (especially the poor) may refrain themselves
       seeking care or getting tested due to nancial barriers, which in turn will worsen the pandemic.
       Simultaneous epidemics are overwhelming public health systems in different countries that had few
       resources to begin with.  In some countries, the threat of dengue fever is being taken as seriously as COVID-19.
       For example, in Central America, Honduras has seen a steep climb in COVID-19 cases in the midst of a dengue

www.pvmarquez.com/essentialhealthservices                                                                                                                                        2/8
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      fever outbreak. San Pedro Sula, the business capital where gang violence makes Honduras one of the deadliest
      countries in the world, is also now the epicenter of a COVID-19 outbreak (Gannon 2020).  In Singapore dengue
      infections may for 2020 exceed the all-time high of 22,170 set in 2013 (Goodman 2020), while in the state of Mato
      Grosso do Sul in Brazil, health authorities are dealing with additional dengue fever cases, bringing the total this
      year so far to 61,604 con rmed cases. (Newsdesk 2020). In Pakistan, the country’s toll of above 139,000
      coronavirus cases surpasses that of neighboring China with 84,000 con rmed cases, and more than 2,600 people
      in Pakistan have already died.  At the same time, Pakistan continues to suffer some of the world’s worst outbreaks
      of infectious diseases, with  4.3 million cases of malaria annually, and is also one of the top 10 countries for new
      cases of tuberculosis each year, and is one of only three countries, including Afghanistan and Nigeria, where
      polio is still endemic (Gannon 2020).  Meanwhile, in the Democratic Republic of Congo (DRC), a new outbreak of
      Ebola in Equateur Province is now compounding the public health challenge posed by COVID-19 pandemic, with
      more than 4,000 con rmed cases reported (Schlein, 2020).

  2.  Increased morbidity and mortality due to interruption of essential
  service delivery associated with COVID-19 containment measures
      During the 2014-2015 Ebola epidemic in West Africa, it was observed an upsurge in mortality and morbidity
      from other diseases and conditions (Bietsch, K, Williamson, J, and Reeves M. 2020; Camara BS et al. 2017; Hall KS
      et al. 2020; Sochas, L, Channon, AA, and Nam, S. 2017), and this is happening again during the COVID-19
      pandemic. Shortage of health workers is exacerbated as many of them are diverted to managing COVID-19 cases,
      or hampered by lack of protective gears, or advised to discontinue service delivery. Local or national lockdowns,
      along with the consequences of physical distancing, travel restrictions, disruptions on the supply chain for
      contraceptive commodities, and the fear of health facilities among pregnant women, may risk undermining or
      reversing the progress made in the past decade to improve the access to and quality of sexual and reproductive
      health services and reduce unwanted teenage pregnancy and maternal mortality.  Consequently, women and
      children are affected disproportionately, especially those living in fragile contexts. For example:
      Increased unmet need for modern contraceptive: Initial estimates show that a 10% proportional decline in use
      of short- and long-acting reversible contraceptive methods in LMICs due to reduced access would result in an
      additional 49 million women with an unmet need for modern contraceptives and an additional 15 million
      unintended pregnancies over the course of a year ((Riley, Sully, Ahmed, and Biddlecom 2020).
      Additional maternal and newborn deaths: An additional 1.7 million women who give birth and 2.6 million
      newborns would experience major complications but would not receive the care they need, resulting in an
      additional 28,000 maternal deaths and 168,000 newborn deaths (Riley, Sully, Ahmed, and Biddlecom 2020).
      Wide-spread interruption of immunization program: A recent report by WHO (2020) indicates that since March
      2020, routine childhood immunization services have been disrupted on a global scale that may be unprecedented
      since the inception of expanded programs on immunization (EPI) in the 1970s. More than half (53%) of the 129
      countries where data were available reported moderate-to-severe disruptions, or a total suspension of
      vaccination services during March-April 2020.  Many countries have temporarily suspended preventive mass
      vaccination campaigns against diseases like cholera, measles, meningitis, polio, tetanus, typhoid and yellow fever,
      due to risk of transmission and the need to maintain physical distancing during the early stages of the COVID-19
      pandemic.  Measles initiatives, for example, have been suspended in 27 countries, including Chad and Ethiopia,
      and polio programs are on hold in 38, including Pakistan and the Democratic Republic of Congo (Hoffman
      2020).  The problem of slipping vaccine rates is not limited to developing countries. The Centers for Disease
      Control and Prevention (CDC) reported drop in visits and fewer vaccine doses being administered in the United
      States, leaving children at risk for vaccine-preventable diseases (Santoli, Lindley, DeSilva, et al 2020).
      Transport delays of vaccines are exacerbating the situation. UNICEF has reported a substantial delay in planned
      vaccine deliveries due to the lockdown measures and the ensuing decline in commercial ights and limited
      availability of charters (UNICEF 2020). This particularly affects countries in FCV areas where immunization
      delivery relies heavily on community outreach and campaign programs most of which are put on hold due to
      social distancing requirements. As a result, at least 80 million children under one at risk of diseases such as
      diphtheria, measles and polio as COVID-19 disrupts routine vaccination efforts (WHO 2020, 1). 

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      In addition to physical health, mental health for all and especially the displaced also needs to be prioritized.
      COVID-19 Exposed by the coronavirus crisis, everyone is affected mentally through losses such as the death of
      loved ones, illness, diminished life’s savings, or in being con ned, having to forgo life’s signi cant occasions,
      transitions, plans, or experiences. For displaced communities – for example refugees or asylum seekers – the
      mental health fallout will be signi cantly more acute, while their access to health care reduces (Marquez 2017). In
      Afghanistan, for example, which is in the midst of a displacement and refugee crisis (more than 400,000 IDPs;
      505 000 refugees returning from Iran), one can anticipate a rapid exacerbation of these challenges (Pierre-Louise
      2020). To restore economic activity in the aftermath of the pandemic, besides nancial and physical well-being
      efforts are needed to address mental health of individuals and communities.

  3. Uncertain nancing prospects for health system accompanied by
  growing demand to look after the poor
      While countries are mobilizing all potential resources for health system to ght against the pandemic, the
      negative impact on countries’ macroeconomic situation might cascade down to health system. Indeed, World
      Bank estimates indicate that as many as 90% of the 183 economies are expected to suffer from falling levels of
      GDP in 2020.  Tighter scal space and shrinking revenue for employment-based insurance schemes may enlarge
      the nancial gap for investing in health. Furthermore, the World Bank estimates that under a baseline scenario
      with global growth contracting by about 5% in 2020, and downside scenario with a global growth contraction of
      8% in 2020, COVID-19 will push 71 million into extreme poverty, measured at the international poverty line of
      $1.90 per day (Gerszon Mahler, Lakner, Castaneda Aguilar, Wu 2020). With the downside scenario, this increases
      to 100 million people. 
      These scenarios pose signi cant nancing challenges for ensuring population access to essential services.  If
      not well managed, countries may be pushed to a situation in which the relative importance of out-of-pocket
      payments may rise, a mechanism deemed most inequitable and least ef cient, and that poses a high risk of
      impoverishment to the population. Even before the pandemic, the incidence of catastrophic health expenditure
      (SDG indicator 3.8.2), de ned as large out-of-pocket spending in relation to household consumption or income,
      increased continuously between 2000 and 2015 (WHO/WBG 2020). In 2015, 926.6 million people incurred out-
      of-pocket health spending exceeding 10% of their household budget (total consumption or income), and 208.7
      million incurred out of pocket health spending that even exceeded 25% of the household budget (WHO/WBG
      2019). These people lived mostly in Asia (70%–76%), about 45% in lower-income countries and 41%–43% in
      upper-middle-income countries. Asia, and Latin America and the Caribbean had the highest percentage of their
      2015 population with catastrophic health spending as tracked by SDG indicator 3.8.2, while North America and
      Oceania had the lowest.
      In 2015, out-of-pocket health spending contributed to pushing more people below the poverty line: 89.7 million
      people (1.2%) were pushed into extreme poverty (below $1.90 per person per day in 2011 purchasing power parity
      terms), while 98.8 million (1.4%) were pushed below $3.20 per person per day and 183.2 million were pushed into
      poverty de ned in relative terms (below 60% of median daily per capita consumption or income in their country)
      (WHO/WBG 2019).

  4.  What to Do?
  As the COVID-19 continues to evolve, it is imperative that countries adopt measures to balance the demands of
  responding directly to COVID-19, while simultaneously engaging in strategic planning and coordinated action to
  maintain the delivery of routine essential health services, mitigating the risk of system collapse (WHO 2020,2).
  Travel restrictions and lockdowns, people putting off seeking needed health care for any number of conditions from
  fear of becoming infected with COVID-19 in a health facility, disruptions in the global supply chain of essential
  personal protective equipment, medicines and medical materials, demand solutions beyond the usual way of
  operating to be able to continue caring for patients affected by concurrent conditions.




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  To ensure continuity of routine essential health services to meet all the health needs of the population, innovative
  approaches have been launched in different countries.  Some of them are presented below.

      Use of family medicine and integrated networks at all three levels of care, as done in Costa Rica (Macaya 2020),
      as well as in Cuba and in the Kerala State in India, where  the whole organization of the health care system is
      geared to be in close touch with the population, identify health problems as they emerge, and deal with them
      immediately along a care continuum (Augustin 2020; Shailaja, K.K., Teacher, and  Khobragade, RN, 2020).  In these
      countries, the primary health care system acts as the entry point to the integrated health system, facilitating
      early identi cation and timely referral of cases to higher levels of care for appropriate management.
      Improving the equity of health nancing and service delivery.  Available data from the United States show the
      estimated average cost for possible procedures that might occur for COVID-19 treatment and the signi cant
      disparity between people with health insurance and those who lack insurance or have limited access to publicly-
      funded health services. For people with health insurance who have met the required deductible, they would need
      to pay only the co-pay or co-insurance, while the insurance plan would pay the remaining balance. In the case of
      people without insurance, they would have to pay 100% of the price of COVID-19-related medical costs, which
      could set a patient and his/her family back nancially (Abrams 2020). While health systems, nancial protection
      arrangements, and medical cost structures vary from country to country, it should be clear that in countries
      without universal health coverage, the nancial impact of COVID-19 on the population, particularly low-income
      groups, could be signi cant or even catastrophic if adequate provisions are not taken to offer nancing
      protection to the population. In the MENA region, for example, to mitigating the direct and indirect impacts of
      COVID-19, particularly for the most vulnerable populations, the elimination of user fees and copayments has
      been proposed for all health services (Duran and Menon 2020). 
      Drone delivery is changing the face of global logistics. The experience in Rwanda’s health system is
      noteworthy.  Beginning in 2017, Rwanda, in partnership with California-based robotics company Zipline
      International Inc., became the rst country in the world to incorporate drone technology into its health care
      system for delivering blood and medical supplies to hospitals across its Southern and Western provinces
      (Marquez 2019).  Establishment of drone delivery systems for transporting samples from remote areas to test
      centers during the COVID-19 pandemic has also been initiated in Ghana, alongside the distribution of drugs and
      blood products (Nsiah Asare 2020).
      Increasing the availability of telemedicine for ambulatory services. This use of this technology helps to provide
      online infection prevention and control trainings for care home workers, running health promotion campaigns
      on social media, to managing WhatsApp groups of traditional healers (MSF 2020).  Telemedicine can play a
      critical role in ensuring that patients continue to receive non-urgent care, particularly those with chronic
      conditions.
      Engagement of community health workers and mobile health teams. To minimize the negative impact of the
      reduction of recommended number of antenatal consultations for pregnant women in clinics, the engagement of 
      trusted people in their communities is critical to ensure that women can still receive the care they
      need. Community personnel can help identify when a woman needs to go to hospital because of complications
      (MSF 2020), or help organize service delivery by mobile teams, particularly to cover hard to reach rural areas. 
      Distribution of essential drugs to patients for longer periods (one to six months depending on the person’s
      health condition) so that they do not have to visit a health facility as often for follow up care for HIV,
      tuberculosis, hepatitis C and non-communicable diseases.  At the same time, measures adopted to ensure that
      patients receive follow-up through phone consultations, messaging apps and peer support networks (MSF 2020).
      Use of smartphones for ‘video observed therapy’, for example for patients with multidrug-resistant tuberculosis
      (MDR-TB), so they can lm themselves taking their medication and send the video to be checked by a nurse (MSF
      2020).
      Use of telephone hotlines for the provision of consultations by counselors and psychologists for patients with
      mental disorders. This approach also helps to reduce the fear of stigma and discrimination that hinders service
      demand and utilization (MSF 2020). 

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      Planning efforts are needed to ramp up vaccinations for every missed child when the pandemic Covid-19 ends,
      and to make advance provisions to ensure that when the COVID-19 vaccine is available, it reaches those most in
      need. 
      Looking into the future, the global spread of COVID-19 clearly signals the need, hopefully once and for all, for
      building and maintaining strong and sustainable public health and medical institutions and systems in
      countries.  This needs to be complemented by effective cross sectoral interface between environment,
      veterinary and public health services to anticipate, prevent, and control the emergence of new infectious
      pathogens of animal origin, the resurgence of known infectious diseases, and the ominous threat of anti-
      microbial resistance.  This task is of priority importance where health systems are weaker, living conditions often
      more overcrowded, and populations most vulnerable.
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                                                  
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1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?


            Learn how the World Bank Group is helping countries with COVID-19 (coronavirus).                               Find Out 




                          Publish d on Inv stin in H                                                      lth (/h            lth)


   H v South nd C ntr l Am ric
   b com th n w coron virus (COVID-19)
    pic nt r?
   PATRICIO V. MARQUEZ (/TEAM/PATRICIO-V-MARQUEZ), SANTIAGO HERRERA AGUILERA (/TEAM/SANTIAGO-
   HERRERA-AGUILERA) & LUIGI BUTRON CALDERON (/TEAM/LUIGI-BUTRON-CALDERON) | JUNE 03, 2020
   This page in: English


                                     
                                         6




         “There have been as many plagues as wars in history; yet always plagues and wars take people

    equally by surprise.” - Albert Camus (1957 Nobel Prize Laureate for Literature), La Peste, Vintage, 1947




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1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?

   The coronavirus (COVID-19) pandemic has hit the entire world with devastating
   e ects, both through lives lost (more than 370,000 deaths
   (https://coronavirus.jhu.edu/)) and a severe economic downturn
   (https://www.imf.org/en/Publications/WEO/Issues/2020/04/14/weo-april-2020).
   Although the aggregate number of new cases has stabilized somewhat (Figure 1), the
   tide has fallen in some places and risen in others, shifting the pandemic’s epicenter
   from region to region. The latest data suggest that some South and Central
   American countries have become the new COVID-19 epicenter 
   (https://twitter.com/intent/tweet?
   text=The+latest+data+suggest+that+some+South+and+Central+American+countries+ha
   19+epicenter&url=https://blogs.worldbank.org/health/have-south-and-central-
   america-become-new-coronavirus-covid-19-epicenter/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) , with daily infections in the
   region now exceeding those in the United States and Europe
   (https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200602-
   covid-19-sitrep-134.pdf?sfvrsn=cc95e5d5_2) (Figure 2). 

            Figure 1. Daily confirmed new cases worldwide                                  Figure 2. Daily confirmed new cases by region

                               (Number of cases)                                                              (Percent of total cases)




     Note: Data as of May 25. Source: Prepared by authors using Our World in

     Data.


   The situation in the region

   More than 70 days into the pandemic, new cases keep rising sharply in some
   countries in South and Central America (Figure 3). There are now more than 1 million
   COVID-19 cases here, half of them in Brazil (https://www.who.int/docs/default-
   source/coronaviruse/situation-reports/20200602-covid-19-sitrep-134.pdf?
   sfvrsn=cc95e5d5_2), which has surpassed Russia, the United Kingdom, and Spain to

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1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?

   reach the second highest number of cases in the world. More than 50,000 people
   have died across the region.  Countries that adopted late or lax social distancing,
   such as Brazil and Mexico, are now seeing higher rates of infection. Other countries
   that had stabilized the growth of new cases and relaxed their lockdowns, such as
   Chile and Peru, have seen surges of new cases. Costa Rica and Uruguay are outliers,
   as their cases seem to have leveled o . 



            Figure 3. Daily confirmed new cases (7-day moving average): South and Central American
                                                                 countries




   Note: Data as of May 25. Source: Prepared by authors using Our World in Data.




   Since testing capacity lags behind other regions, the number of new cases is likely to
   be underestimated. Similarly, mortality data should also be interpreted with caution,
   as many countries show signi cant underreporting of COVID-19- related deaths
   (Table 1).
   Unexplained deaths provide a proxy for underreporting. They are estimated as the
   di erence between observed deaths and the projected number of deaths based on
   historical and seasonal trends. The di erence may be attributed to COVID-19 or to
   other factors, such as a shortage or lack of essential medical services for other
   conditions. In Ecuador, Chile, and Mexico, the unexplained deaths are 4 to 5 times
   the reported deaths. In Brazil and Peru, the factor is somewhat smaller, around 2
   times.

   Table 1. COVID-19 underreported deaths




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   epicenter
1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?




   What explains Latin America’s vulnerability?
   Experts (https://www.cnn.com/2020/05/30/americas/latin-america-covid-19-
   epicenter-intl/index.html) suggest that poverty and the region’s high levels of
   inequality (https://blogs.worldbank.org/developmenttalk/inequality-and-social-
   unrest-latin-america-tocqueville-paradox-revisited) have contributed to the relative
   ine ectiveness of lockdowns. The average Gini coe cient, which measures the
   distribution of income or consumption expenditure within a country, was estimated
   at 0.51 in 2017 – the highest level of inequality in the world (Figure 4). In particular,
   the region has many informal workers (about 140 million people, or 55% of total
   workers), who must continue to work every day to earn a living, for example in
   marketplaces, cleaning houses, or as street vendors. These workers are unlikely to
   have much savings or to receive support from social protection programs at a level
   that would allow them to feed their families while adhering to social distancing
   measures.

   The vulnerability of people in large metropolises such as Sao Paulo and Mexico City is further
   increased by poor living conditions. Millions are crowded in densely packed neighborhoods, with
   large families often sharing a single room and many lacking access to clean water, basic
   sanitation, and health services. Some households are forced to shop for food every day in
   crowded markets because they do not have a refrigerator or lack electricity, putting them at
   higher risk of becoming infected.

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1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?




   Figure 4. Income inequality in selected Latin American countries, 2000-2017:
   Gini coe cients




   Meanwhile, the ongoing economic downturn caused by COVID-19 is taking a severe
   toll on the ability of migrant workers to send money home. In South and Central
   American countries, the decline in remittance ows
   (https://www.worldbank.org/en/news/press-release/2020/04/22/world-bank-
   predicts-sharpest-decline-of-remittances-in-recent-history) has been estimated at
   20%.  Remittances are a vital source of income in some countries such as Ecuador
   and El Salvador, as they help the poorest communities a ord food, health care, and
   basic needs.




https://blogs.worldbank.org/health/have-south-and-central-america-become-new-coronavirus-covid-19-epicenter                         5/11
1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?
   The situation has been further aggravated by high debt burdens and signi cant
   budget de cits, which have reduced investment in public health systems and
   undermined their capacity to care for the sick.

   What is the World Bank doing?
   The World Bank is supporting COVID-19 health-relatd emergency responses in 19
   Latin American and Caribbean countries. To date, 15 new COVID-19 health
   operations are underway in 13 countries, amounting to $965 million. In addition,
   resources allocated to existing World Bank projects are being redeployed, including
   through restructuring ($176 million) and activating emergency provisions ($18.5
   million).

   Given the severity of the pandemic, the World Bank Group is committed to providing
   $160 billion (https://www.worldbank.org/en/about/what-we-do/brief/world-bank-
   group-operational-response-covid-19-coronavirus-projects-list) over 15 months to
   help countries across the globe address the health, economic, and social impacts of
   COVID-19. Emergency operations now reach 100 countries with emergency
   containment and mitigation activities. Health operations also support governments
   in strengthening their longer-term health system capacity to prevent the
   reemergence of COVID-19 and other pathogens of animal origin, and to provide
   essential services for other conditions.

   What lessons are emerging?
   In the landmark book “This Time is Di erent. Eight Centuries of Financial Folly”
   (https://wc a.harvard.edu/publications/time-di erent-eight-centuries- nancial-folly),
   Carmen Reinhart, the World Bank Group’s newly appointed chief economist
   (https://www.worldbank.org/en/news/press-release/2020/05/20/carmen-reinhart-
   appointed-as-world-bank-group-chief-economist), and her co-author, Kenneth
   Rogo , noted that “long spans of history catch sight of ‘rare’ events that are all too
   often forgotten, although they turn out to be far more common and similar that
   people seem to think.”
   This observation is apt in the context of COVID-19, which illustrates a collective failure to prepare
   adequately for outbreaks of infectious diseases. As we saw in West Africa with Ebola, with the
   Zika virus in Brazil and other countries, with SARS in East Asia and Canada, and with avian
   influenza globally, novel viruses can spread quickly across borders and wreak havoc on
   unsuspecting populations, countries, and regions. The challenge is continuing to grow with the
   increased movement of goods, services, and people across the world.


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1/12/2021                                         Have South and Central America become the new coronavirus (COVID-19) epicenter?

   Learning from what did or didn’t work well in past health crises will help countries in
   rapidly detecting and responding to future infectious disease outbreaks.  
   (https://twitter.com/intent/tweet?
   text=Learning+from+what+did+or+didn%E2%80%99t+work+well+in+past+health+crises
   south-and-central-america-become-new-coronavirus-covid-19-epicenter/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) Rebuilding better and
   sustaining essential health services for all is a global public good and should be a
   priority. Indeed, the COVID-19 pandemic should serve as a catalyst for institutional
   reform and for improving nancing to boost the capacity and performance of health
   systems.  (https://twitter.com/intent/tweet?text=the+COVID-
   19+pandemic+should+serve+as+a+catalyst+for+institutional+reform+and+for+improvin
   south-and-central-america-become-new-coronavirus-covid-19-epicenter/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)
   Now, more than ever, countries need to collaborate across sectors to reduce social
   and economic vulnerabilities.  We must address not just the symptoms of ill health,
   but the root causes of disease and premature mortality. 
   (https://twitter.com/intent/tweet?
   text=We+must+address+not+just+the+symptoms+of+ill+health%2C+but+the+root+cau
   south-and-central-america-become-new-coronavirus-covid-19-epicenter/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)


   HEALTH (/SEARCH?F[0]=TOPIC:297&F[1]=LANGUAGE:EN), BRAZIL (/SEARCH?F[0]=COUNTRIES:60&F[1]=LANGUAGE:EN),
   LATIN AMERICA & CARIBBEAN (/SEARCH?F[0]=REGIONS:277&F[1]=LANGUAGE:EN), COVID-19 (CORONAVIRUS) (/SEARCH?
   F[0]=SERIES:881&F[1]=LANGUAGE:EN)




   Authors




   (/team/patricio-v-marquez) (/team/patricio-v-marquez)
   P tricio V. M rqu                      (/t       m/p tricio-v-m rqu )
https://blogs.worldbank.org/health/have-south-and-central-america-become-new-coronavirus-covid-19-epicenter                         7/11
1/12/2021                                             Tobacco use and coronavirus (COVID-19): A deadly but preventable association


            Learn how the World Bank Group is helping countries with COVID-19 (coronavirus).                                  Find Out 




                                            Publish d on Voic s (/voic s)


   Tob cco us nd coron virus (COVID-
   19): A d dl but pr v nt bl
    ssoci tion
   PATRICIO V. MARQUEZ (/TEAM/PATRICIO-V-MARQUEZ) | MAY 27, 2020
   This page in: English


                                      




    Initial evidence suggests smoking is also a risk factor for COVID-19, with smokers having 1.91 times the odds of progression
    in COVID-19 severity compared to non-smokers. Photo: © ilkercelik/shutterstock




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   As we mark World No Tobacco Day on May 31, let’s consider the impact of tobacco
   use on coronavirus (COVID-19) outcomes.  (https://twitter.com/intent/tweet?
   text=As+we+mark+World+No+Tobacco+Day+on+May+31%2C+let%E2%80%99s+conside
   19%29+outcomes.&url=https://blogs.worldbank.org/voices/tobacco-use-and-
   coronavirus-covid-19-deadly-preventable-association/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) The virus has infected more
   than 5.5 million people in 188 countries and territories
   (https://coronavirus.jhu.edu/map.html), killing more than 350,000.
   Tobacco use is causally linked (https://www.surgeongeneral.gov/library/reports/50-
   years-of-progress/full-report.pdf) to diseases of nearly all organs of the body. Studies
   (https://www.nejm.org/doi/full/10.1056/NEJMra1308383) in various countries have
   found that middle-aged smokers have two to three times the mortality rate of non-
   smokers of similar age, reducing lifespan by an average of 10 years. Smoking and e-
   cigarette use increase the risk and severity of pulmonary infections because of
   damage to upper airways, lung in ammation, and reduced lung and immune
   function.  (https://twitter.com/intent/tweet?text=Smoking+and+e-
   cigarette+use+increase+the+risk+and+severity+of+pulmonary+infections+because+of+
   use-and-coronavirus-covid-19-deadly-preventable-association/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank)  

   It shouldn’t surprise us, then, that initial evidence
   (https://academic.oup.com/ntr/advance-article/doi/10.1093/ntr/ntaa082/5835834)
   suggests smoking is also a risk factor for COVID-19, with smokers having 1.91 times
   the odds of progression in COVID-19 severity compared to non-smokers. 
   (https://twitter.com/intent/tweet?text=smoking+is+also+a+risk+factor+for+COVID-
   19%2C+with+smokers+having+1.91+times+the+odds+of+progression+in+COVID-
   19+severity+compared+to+non-
   smokers.&url=https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-
   covid-19-deadly-preventable-association/?



https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-covid-19-deadly-preventable-association                               2/7
1/12/2021                                             Tobacco use and coronavirus (COVID-19): A deadly but preventable association

   id=10.1371/journal.pone.0233147) showing that infection was associated with
   substantially higher severity and mortality rates in patients with chronic obstructive
   pulmonary disease (COPD) and among current smokers.




    
   M n r               t hi h r risk of COVID-19 pro r ssion
   Data from China, the rst country to be a ected, provides insights into the biology,
   epidemiology, and clinical characteristics of COVID-19. The sex distribution of
   a ected patients shows a male predominance of cases. Chinese researchers
   reported (https://www.nejm.org/doi/full/10.1056/NEJMoa2002032?
   query=recirc_mostViewed_railB_article) in the New England Journal of Medicine that
   58.1% of patients across 30 provinces were male. Also, among the initial 425 cases
   that occurred in Wuhan, 56% were male. Moreover, an article
   (https://jamanetwork.com/journals/jama/fullarticle/2762510) published at the
   Journal of the American Medical Association noted that death rates among infected
   men, particularly in their late 40s and older, have exceeded those among women.
   In previous outbreaks of coronaviruses, such as SARS and MERS, men were also
   disproportionally a ected. In Hong Kong in 2003, researchers found
   (https://jamanetwork.com/journals/jama/fullarticle/2762510) that men with SARS
   had a 50 percent higher risk of death than women.
   Wh t xpl ins this discr p nc ?
https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-covid-19-deadly-preventable-association                               3/7
1/12/2021                                             Tobacco use and coronavirus (COVID-19): A deadly but preventable association

   A higher prevalence of smoking among men, often resulting in compromised lung
   function, may help explain
   (https://jamanetwork.com/journals/jama/fullarticle/2762510) their higher COVID-19
   fatality rate.
   Tobacco use also contributes to the onset of co-occurring conditions such as
   cardiovascular diseases, lung cancer, COPD, and diabetes. These are more prevalent
   among males and also increase the risk of disease severity and death among COVID-
   19 patients.  (https://www.cdc.gov/coronavirus/2019-ncov/need-extra-
   precautions/people-at-higher-risk.html)

   Data presented in the New England Journal of Medicine article further illustrates the
   impact that smoking has on COVID-19 progression and mortality in China: 
            Among those severely a ected by the disease, 16.9% were current smokers and
            5.2% former smokers.
            Among patients who were admitted to an intensive care unit, put on ventilation,
            or died, 25.8% were current smokers and 7.6% were former smokers.
   Data from Italy
   (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2764369)
   similarly shows that a high proportion of COVID-19 patients had a history of smoking
   and high rates of COPD and heart disease. Researchers in Indonesia
   (https://www.channelnewsasia.com/news/asia/covid-19-fatality-rate-highest-asia-
   indonesia-12669500) have also found that the high prevalence of smoking among
   men (one of the world’s highest) is contributing to the high COVID-19 fatality rate in
   the country.

   Th          pid mic of tob cco us in Chin
   China has the largest smoking population in the world, with around 316 million adult
   smokers representing nearly one-third of smokers and 40% of tobacco consumption
   globally. While the prevalence of smoking in women is relatively low at 1.9%, an
   estimated 48.4% (https://data.worldbank.org/indicator/SH.PRV.SMOK.MA?
   view=chart) of men are smokers.

   In 2010, an estimated 1.2 million premature deaths were attributable to smoking in
   China, and the three leading causes of death (stroke, heart disease, and COPD) were
   linked to tobacco use. A recent study
   (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546632/pdf/tlcr-08-S1-S21.pdf)



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1/12/2021                                             Tobacco use and coronavirus (COVID-19): A deadly but preventable association

   also nds China in the midst of a lung cancer epidemic on an unprecedented scale,
   driven largely by tobacco use and accounting for 21.7% of the country’s total cancer
   mortality in 2015.
   How do s smokin                          ff ct lun h                 lth nd COVID-19 risk?
   As explained in the 2004 U.S. Surgeon General Report
   (https://www.ncbi.nlm.nih.gov/books/NBK44695/):

   “Toxins in tobacco smoke harm the body from the moment they enter through the
   mouth and nose. They damage tissue and cells all the way to the lungs. When
   cigarette smoke is inhaled, chemicals from the smoke are absorbed in the lungs. As a
   result, smoking causes lung diseases…  makes chronic lung diseases more severe;
   and increases the risk for respiratory infections…. Although the lung has ways to
   protect itself from injury by inhaled agents, these defenses are overwhelmed when
   cigarette smoke is inhaled repeatedly over time. After years of exposure to cigarette
   smoke, lung tissue becomes scarred, loses its elasticity, and can no longer exchange air
   e ciently.” 

   There is su cient evidence to infer a causal relationship between smoking and
   acute respiratory illnesses, including pneumonia. 
   (https://twitter.com/intent/tweet?
   text=There+is+su cient+evidence+to+infer+a+causal+relationship+between+smoking
   + use-and-coronavirus-covid-19-deadly-preventable-association/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) Not only is smoking the
   predominant underlying cause, but it might increase the frequency or severity of
   infections. For example, a recent study
   (https://journals.lww.com/epidem/Abstract/2019/05000/Smoking_and_In uenza_associ
   showed that smoking was consistently associated with a higher risk of hospital
   admission for in uenza. Researchers
   (https://www.atsjournals.org/doi/10.1164/rccm.202003-0693LE) have also suggested
   that it could cause an increase in the ACE2 protein in the lungs, the molecule that the
   coronavirus uses to infect human cells, facilitating viral dissemination and possibly
   resulting in a higher rate of morbidity in COVID-19 patients.

   Wh t to do?
      Besides monitoring smoking and e-cigarette use, governments have an obligation to
      address smoking in their strategies to contain and mitigate the impact of COVID-19. 




https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-covid-19-deadly-preventable-association                               5/7
1/12/2021                                             Tobacco use and coronavirus (COVID-19): A deadly but preventable association

   19.&url=https://blogs.worldbank.org/voices/tobacco-use-and-coronavirus-covid-19-
   deadly-preventable-association/?
   cid=SHR_BlogSiteTweetable_EN_EXT&via=worldbank) The most cost-e ective policy
   measure (http://documents.worldbank.org/curated/en/491661505803109617/Main-
   report) for tobacco control is taxation, so governments must act boldly and swiftly to
   raise taxes on cigarettes and e-cigarettes. This has been shown to reduce and
   prevent tobacco use, particularly among youth, and hence to improve health and
   reduce the risk of premature mortality. Taxation would also help to expand the tax
   base and mobilize additional public revenue for economic recovery initiatives after
   the pandemic subsides.
   RELATED
   The World Bank Group and COVID-19 (https://www.worldbank.org/en/who-we-
   are/news/coronavirus-covid19)


   GENDER (/SEARCH?F[0]=TOPIC:295&F[1]=LANGUAGE:EN), HEALTH (/SEARCH?F[0]=TOPIC:297&F[1]=LANGUAGE:EN), CHINA
   (/SEARCH?F[0]=COUNTRIES:74&F[1]=LANGUAGE:EN), HONG KONG SAR (/SEARCH?
   F[0]=COUNTRIES:127&F[1]=LANGUAGE:EN), THE WORLD REGION (/SEARCH?F[0]=REGIONS:280&F[1]=LANGUAGE:EN),
   COVID-19 (CORONAVIRUS) (/SEARCH?F[0]=SERIES:881&F[1]=LANGUAGE:EN)




   Authors




                                                                                                            
   (/team/patricio-v-marquez) (/team/patricio-v-marquez)
   P tricio V. M rqu                       (/t       m/p tricio-v-m rqu )
   Senior Associate, Johns Hopkins University Bloomberg School of Public Health


      MORE BLOGS BY PATRICIO (/TEAM/PATRICIO-V-MARQUEZ)
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1/12/2021                        Social distancing in the time of COVID-19 in Latin America and the Caribbean: Costs and Benefits | Patricio V. Marquez




  Social distancing in the time of COVID-19 in Latin America
  and the Caribbean: Costs and Bene ts
  Submitted by Patricio V. Marquez on Thu, 05/14/2020 - 07 37 PM




  Social distancing in the time of COVID-19 in Latin America
  and the Caribbean: Costs and Bene ts
  Posted by Patricio V. Marquez on Thu, 05/14/2020 - 07 37 PM




   

  Patricio V. Marquez, Santiago Herrera, and Luigi Butron Calderon

  May 14, 2020

  Since December 2019, following the diagnosis of the initial cases in Wuhan, Hubei Province, China, the number of
  the coronavirus disease (COVID-19) cases outside China increased exponentially. As of May 14, 2020, the global
  pandemic has resulted in over 4.4 million con rmed cases and 301,370 con rmed deaths in 188 countries/regions
  (Johns Hopkins University Coronavirus Resource Center & Medicine 2020). Data from WHO show that 26.4 percent
  of the total 1.8 million con rmed cases and 26 percent of the total 109,121 con rmed deaths in the Americas are from
  countries in Latin America and the Caribbean (LAC)--the bulk of con rmed cases and deaths are from the United
  States (WHO 2020).

  Limiting face-to-face contact with others is the best way to reduce the spread of COVID-19 (CDC 2020).  As such,
  social distancing is one of the best tools to avoid being exposed to this virus and slowing its spread locally, within
  countries, and across the world.  People are reminded to stay at least 6 feet away from other people, not to gather in
  groups, stay out of crowded places, and avoid mass gatherings.  Social distancing is especially important for people
  who are at higher risk (https:/  /www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-at-higher-
  risk.html) for severe illness from COVID-19.



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1/12/2021                            Social distancing in the time of COVID-19 in Latin America and the Caribbean: Costs and Benefits | Patricio V. Marquez

  Contrary to what some people believe, the practice of “physical and social distancing” is not something new; it has
  been around for centuries as a common public health tool to control the spread of infectious pathogens into the
  population. 

  Social Distancing Measures are Centuries Old

  The history of public health in LAC offers multiple examples of the use of this tool. Since colonial times, outbreaks of
  disease were common in these countries, largely the result of maritime trade and export of agricultural products
  and minerals that helped integrate the countries in this region into the world economy.  The smallpox epidemic in
  Hispaniola (now the Dominican Republic and Haiti), registered as the rst one in the colonial period, spread to
  neighboring islands and countries, leaving a toll of thousands of victims. 

  In the sixteenth and following Centuries, epidemics of different kinds made devastating sweeps across the
  Americas.  As the spread of disease largely re ected the maritime basis for trade among the colonies, and between
  the colonies and mercantile powers, such as Spain and Portugal, the principles of isolation and con nement (“social
  distancing”) followed in Europe to control disease outbreaks were also applied in the region.  In practice, beginning
  in Hispaniola in 1519, in accordance with the 1423 Venetian quarantine control system, measures to cope with
  epidemics centered on the detention of ships and the isolation of their crews and passengers outside the harbors
  until suf cient time had elapsed without the outbreak of “pestilences.”  The latter years of the 19th Century and the
  early 20th Century saw various attempts by the Latin American and Caribbean countries and the United States to
  adopt uniform quarantine regulations at different international conferences, under the aegis of the newly
  established Pan American Sanitary Bureau in 1902 (now PAHO/WHO). These sought to remove barriers to steam
  navigation and to codify new preventive measures into specific health legislation and programs based on the great
  microbiological discoveries of Pasteur, Koch, and Klebs that had revolutionized public health practice in Europe.

  Social Distancing in the Times of COVID-19

  We should not be surprised, therefore, that in the absence of a vaccine or known therapies for COVID-19, and due to
  low testing capacity and ability to do contact-tracing, governments in LAC countries as elsewhere have been forced
  to impose once again strict social distancing measures to contain and mitigate the impact of the corona virus.  

  As such, the timing and severity of social distancing measures is key in containing the COVID-19 pandemic.  The
  graphs that we have prepared below illustrate how this has happened in LAC, using the Stringency Index developed
  by the University of Oxford Coronavirus Government Response Tracker team, to capture variation in containment
  and closure policies (Petherick, Kira, Angrist, Hale, Phillips, and Webster 2020). In general, government responses
  have become more stringent over the course of the outbreak, and it should be expected that the stringency of
  response measures broadly tracks the spread of the disease. However, variation can be seen across countries.  The
  rate at which such measures are adopted plays a critical role in stemming the infection. 

  In the country-speci c graphs in Figure 1, the speed of the policy response is proxied by the number of days after
  the 100th case is con rmed (horizontal axis, with zero representing the day the 100th case was reported). In LAC,
  countries such as Argentina, Colombia, Costa Rica, El Salvador, and Paraguay, are good examples of preemptive
  policy action, while Mexico and Brazil illustrate a delayed social-distancing response.  As a comparison with other
  regions, Figure 1 shows that South Korea’s stringency index was moving up signi cantly before reaching the 100th
  case, while the UK ramped it up after that.

  Figure 1. Reported number of con rmed cases and stringency index (con rmed cases in log scale), by country




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  Economic Cost of the COVID-19 Pandemic

  The COVID-19 pandemic is in icting high human costs worldwide. Transmissibility and severity are the two most
  critical factors that determine the effect of the pandemic. Protecting lives and allowing health care systems to cope
  have required isolation, lockdowns, and widespread closures to slow the spread of the coronavirus. The health crisis
  is therefore having a severe impact on economic activity.  IMF projections indicate that the global economy is
  expected to contract sharply by –3 percent in 2020, much worse than during the 2008–09 nancial crisis (IMF
  2020).

  In LAC, social distancing has reduced mobility among citizens and impacted economic activity.  Individual mobility
  is measured by Google data based on the history of cell phone locations to reveal if citizens have reduced their
  mobility. Using the individual mobility data as an indicator of economic activity, it can be inferred that mobility has
  decreased considerably across all the LAC countries listed in Figure 2 below. The combined index of Google mobility
  is negatively correlated with the stringency index of social distancing (i.e., the relationship between these two
  variables shows that as social distancing measures became more stringent, mobility decreased) (Figure 3).

  Overall, economic activity in LAC is faltering.  IMF projections point to severe economic slowdowns or outright
  contractions in LAC:  a negative growth forecast for the region as a whole of –5.2 percent; with Brazil’s growth
  forecast at –5.3 percent and Mexico’s at –6.6 percent (IMF 2020).




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  While the economic cost of the pandemic is signi cant, it is important to highlight that social distancing should be
  interpreted as the price society must pay due to imperfect information about which individuals carry the virus and
  the lack of adequate health care systems to manage the patient peak loads.  Hence, countries that have ample
  testing and contact-tracing capacity as well as ample health-care facilities, can afford less restrictive social
  distancing. As shown in Figure 4 below, LAC countries have very low testing compared to the rest of the world,
  therefore, they are being forced to adopt more stringent social distancing measures.  The pandemic is also hitting
  the region after a long economic stagnation, which led several countries to slash health care budgets, which further
  aggravated lack of or limited preparedness.




  Excess Deaths Better Gauges the COVID-19 Toll

  Although worldwide, 3.4 percent of the people con rmed as having been infected have died, WHO has been careful
  not to describe this gure as a case fatality rate or death rate.  This is because during an evolving epidemic it can be
  misleading to look simply at the estimate of deaths divided by cases to date.  Given the large number of
  asymptomatic cases, the denominator cannot be estimated without widespread testing. And there is substantial
  evidence that the number of deaths is underreported, as case fatality perhaps only re ects deaths in health
  facilities.  In addition, to better gauge the pandemic’s toll, one also needs to include not only deaths from COVID-19,
  but also those from other causes, including people who could not be treated as hospitals became overwhelmed with
  patients, or those who did not seek treatment because they were afraid of being infected with the coronavirus.  

  For instance, in Ecuador the number of deaths reported in the period March-April 2020 exceeded the normally
  reported number for those months by more than 8,000 cases, while the COVID19 reported deaths were only 1,561,
  suggesting signi cant underreporting (Table 1). In Guayaquil, a port city in Ecuador, the sudden spike in fatalities in


pvmarquez.com/socialdistancing                                                                                                                           4/7
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  April 2020 was comparable to what New York City experienced during its worst month: more than ve times the
  number of people died than in previous years (Kurmanaev, Andreoni, Casado, and Taj 2020).  

  From an economic perspective, it should be clear that excess mortality and morbidity across population groups have
  the potential to undermine and reverse human capital development achieved in countries in recent decades.

   




  Bene ts of Social Distancing Measures

  COVID-19 infections have been growing exponentially in many countries across the world, with the doubling time
  remaining between 2 and 4 days in several countries like the United States. This exponential growth is fueled by the
  presence of three conditions: (i) there is at least one infected person in the population pool; (ii) regular contact
  between infected and uninfected members of the population occurs; and (iii) there are large numbers of uninfected
  potential hosts among the population. Exponential growth is so powerful, not because it is necessarily fast, but
  because it is relentless (Siegel 2020). Without introducing a factor to suppress it, such as stringent social distancing
  measures, exponential growth becomes a near impossible challenge, because it doubles its presence in the
  population in a given amount of time.

  Hence, it should be clear that while social distancing measures are disrupting economic activity, they help prevent
  the spread of the corona virus and save lives, tilting the cost-bene t analysis in their favor (Thunstrom, et al. 2020). 

  We used recent literature to estimate the impact of isolation and contact-tracing on the number of infections in the
  course of one month, taking into account that the number of lives saved will depend on the fatality rate that varies
  by country. The estimation of the number of potential infections is based on key parameter assumptions: a) the
  degree of contagiousness, measured by the parameter Ro; b) the extent of social isolation; c) the ability to do contact
  tracing, and d) the speed with which the self-isolation takes place after the symptoms manifest.

  The degree of contagiousness changes over time as shown by Arroyo et al. (2020). Hence, we assume different
  values for the parameter, based on the LAC data. The degree of isolation can uctuate from zero (ignorance of any
  restrictions) to 100% (complete isolation going out to only to purchase groceries).  Using an online tool that
  implements the Hellwell et al. model (IFLscience 2020), we estimate the number of lives saved, based on different
  fatality rates, from 3.4% (cited by WHO) to 5% (a common rate in LAC).  These back-of-the envelope estimations
  show that the bene ts--the number of lives saved--increase with stringency and with assumptions of
  infectiousness (Tables 2 and 3).

pvmarquez.com/socialdistancing                                                                                                                           5/7
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  The level of contagiousness, which changes over time (Arroyo et. al. 2020), is not completely exogenous, as it is
  correlated with the stringency social distancing as measured by the stringency index of the Oxford COVID-19
  Government Response Tracker. There is a high negative correlation between the two independent sources of data.
  In fact, the purpose of the social distancing measures is to reduce the value of Ro, and the high negative correlation
  indicates that the measures have been effective.

  What Next?

  It should be clear to all that in the absence of vaccines and cures, social distancing measures are a critical tool to
  help suppress transmission of the coronavirus below the basic reproduction number of 1.0 (Ro), which is necessary
  to rapidly reduce case incidence, keep cases to low levels, and maintain that situation over time.   

  As warned by different international experts, if countries reopen their economies too soon without ensuring that
  they have in place critical testing capacity, ability to trace the contacts of those infected, and adequately prepared
  medical care services to deal with a surge of severe cases in the event of a resurgence, the consequences would be
  dire.  With deaths now declining, governments are trying to restart their economies, by gradually releasing the
  lockdown. But, local authorities’ fear of a new outbreak is pushing back central governments’ reopening decisions--
  in Ecuador, for example, only two of the country’s 221 cities have moved toward relaxing the quarantine nearly a
  week later after the central government announced the reopening.

  As observed by leading global experts, the COVID-19 pandemic is a stark remainder of the ongoing challenge of
  emerging and reemerging infectious diseases and the need for constant disease surveillance, prompt diagnosis, and
  robust research to understand the basic biology of new organisms and our susceptibilities to them, as well as to
  develop effective countermeasures to control them (Fauci, Lane, Clifford, and Red eld 2020). 

  Looking into the future, the global spread of COVID-19 clearly signals the need, hopefully once and for all, for
  building and maintaining strong and sustainable public health and medical institutions and systems, and an effective
  cross sectoral interface between environment, veterinary and public health services to anticipate, prevent, and
  control the emergence of new infectious pathogens of animal origin, the resurgence of known infectious diseases,
  and the ominous threat of anti-microbial resistance.  This task is of priority importance where health systems are
  weaker, living conditions often more overcrowded, and populations most vulnerable. If this is not done, as the
  COVID-19  pandemic is demonstrating now, the risk posed by novel infectious diseases that can emerge in any part
  of the world at any time, causing massive social and economic disruptions, will continue to threaten the entire
  global community.  

  Note: *The Stringency Index collects publicly available information on 17 indicators of government responses. Eight of the policy indicators record information on
  containment and closure policies, such as school closures and restrictions in movement. Four of the indicators record economic policies, such as income support to citizens or
  provision of foreign aid, and ve indicators record health system policies such as the COVID-19 testing regime or emergency investments into healthcare.  The index has a
  numeric value ranging from 0 (less stringent) to 100 (more stringent). https://www.bsg.ox.ac.uk/research/research-projects/coronavirus-government-response-tracker
  (https://www.bsg.ox.ac.uk/research/research-projects/coronavirus-government-response-tracker).
  Source of Picture: Image Covid-19 | New Scientist
  About the authors: Patricio V. Marquez, Former Lead Public Health Specialist, World Bank Group, Santiago Herrera, Lead Economist, Macroeconomics, Trade and Investment,
  LAC Region, World Bank Group, and Luigi Butron Calderon, Research Assistant (consultant), Macroeconomics, Trade and Investment, LAC Region, World Bank Group
  This note is a product of work done by the authors, and the ndings, interpretations, and conclusions expressed in this post do not necessarily re ect the views of the World Bank
  Group, the Executive Directors of the World Bank Group or the governments they represent. 


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1/12/2021                        Social distancing in the time of COVID-19 in Latin America and the Caribbean: Costs and Benefits | Patricio V. Marquez
   

  Sources
  Arroyo Marioli, F, Bullano, F, and Rondon-Moreno, C. 2020. “Dynamics of Transmi…
  (https://www.medrxiv.org/content/10.1101/2020.04.19.20071886v1)
  Blavatnik School of Government, University of Oxford. University of Oxford Cor…
  (https://www.bsg.ox.ac.uk/research/research-projects/coronavirus-government-response-tracker)
  Centers for Disease Control and Prevention (CDC). 2020. “Coronavirus Disease 2…
  (https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/social-distancing.html)
  IFLscience. “Calculator Shows How Your Social Distancing Saves People.” Mar 30…
  (https://www.i science.com/health-and-medicine/online-calculator-shows-how-many-lives-your-
  socialdistancing-may-save/)
  Fauci, AS, Lane, Clifford, L, and Red eld, RR. 2020. “Covid-19---Navigating th…
  (https://www.nejm.org/doi/full/10.1056/NEJMe2002387?query%3DRP=)
  International Monetary Fund. 2020. “World Economic Outlook, April 2020 The Gr…
  (https://www.imf.org/en/Publications/WEO/Issues/2020/04/14/weo-april-2020)
  Hellewell, J, Abbott, S, Gimma, A, Bosse, NI, Jarvis, CI, Russell, TW, Munday,…
  (https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30074-7/fulltext)
  Johns Hopkins University & Medicine Coronavirus Resource Center. “COVID-19 Map”…
  (https://coronavirus.jhu.edu/map.html)
  Kurmanaev, A, Andreoni, M, Casado, L, and Taj, M. 2020. “Latin America’s Outbr…
  (https://www.nytimes.com/2020/05/12/world/americas/latin-america-virus-death.html?
  referringSource=articleShare)
  Petherick, A, Kira, B, Angrist, N, Hale, T, Phillips, T, and Webster, S. 2020…
  (https://www.bsg.ox.ac.uk/research/publications/variation-government-responses-covid-19)
  Siegel, S. 2020. “Why 'Exponential Growth' Is So Scary for the COVID-19 Corona…
  (https://www.forbes.com/sites/startswithabang/2020/03/17/why-exponential-growth-is-so-scary-for-the-
  covid-19-coronavirus/#744a71114e9b)
  ThunströmL, NewboldS, FinnoffD, AshworthM, ShogrenJF. The bene ts and costs of…
  (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3561934)
  Weiss, RA, and McMichael, AJ. 2004. “Social and environmental risk factors in …
  (https://www.nature.com/articles/nm1150)
  WHO Coronavirus disease (COVID-19) Situation Report – 115 Data, May 14 2020 (https://www.who.int/docs/default-
  source/coronaviruse/situation-reports/20200514-covid-19-sitrep-115.pdf?sfvrsn=3fce8d3c_6)
  Image Covid-19 | New Scientist (https:/   /www.bing.com/images/search?
  view=detailV2&ccid=3cwl5OI9&id=9658B910E1B8479D840DA78F754EE538D2F2C78F&thid=OIP.3cwl5OI9IgTFZdVCNB3e
  content/uploads/2020/02/11165812/c0481846-wuhan_novel_coronavirus_illustration-
  spl.jpg&exph=800&expw=1200&q=free%20covid-
  19%20pictures&simid=607991704663294897&selectedindex=0&ajaxhist=0&vt=0&eim=1&sim=11)




                                                   
                                                          (https://twitter.com/pvmarquez1956)




pvmarquez.com/socialdistancing                                                                                                                           7/7
1/12/2021               Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez




   Do BCG Vaccinated People Have Some
   Immunity Advantage Over Non-
   Vaccinated People?
   Submitted by Patricio V. Marquez on Tue, 04/21/2020 - 03 24 PM




   Do BCG Vaccinated People Have Some
   Immunity Advantage Over Non-
   Vaccinated People?
   Posted by Patricio V. Marquez on Tue, 04/21/2020 - 03 24 PM




   Second Installment of Preliminary Interrogation by Patricio V. Marquez, Albert
   Figueras, Allison Ross, Giovanni S. Marquez, and Jaime Bayona

www.pvmarquez.com/bcg                                                                                                             1/9
1/12/2021                Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez
   “…government and municipal o cials were putting their heads together. So long as each individual doctor
   has come across only two or three cases, not one had thought of taking action.  But it was merely a matter
   of adding up the gures and, once this had been done, the total was startling.  In a very few days the
   number of cases had risen by leaps and bounds, and it became evident to all observers of this strange
   malady that a real epidemic had set in.” 
   Albert Camus, The Plague, 1947


   In this post, we build upon the preliminary interrogation described in our
   previous post “Searching for Evidence in the COVID-19 Era: The BCG Case”
   (“Searching for Evidence in the COVID-19 Era: The BCG Case”, April 18,
   2020, http://pvmarquez.com/bcgcovid19
   (http://pvmarquez.com/bcgcovid19)).  

   The objective in this post is to present the results of a rapid statistical
   analysis that we conducted to assess a hypothesis that has been put forward
   by some researchers about the association between COVID-19 reported
   deaths and Bacillus Calmette–Guérin (BCG) vaccination policy in countries.

   The BCG vaccine, rst administered to a human in 1921, is one of the most
   widely used of all current vaccines, covering >80% of neonates and infants
   in countries where it is part of the national childhood immunization
   program. The BCG vaccine has a documented protective effect against
   meningitis and disseminated TB in children (disseminated TB is a contagious
   mycobacterial infection in which mycobacteria have spread from the lungs
   to other parts of the body through the blood or lymph system) (WHO 2020).
    

   Overall, BCG vaccine ef cacy is estimated to be about 51 percent in
   preventing any TB disease and up to 78 percent in protecting newborns
   from disseminated or meningeal TB (Canadian Immunization Guide 2014).
   The BCG vaccine is also of proven ef cacy in the control of leprosy.  

   The duration of BCG vaccine protection is not well-established, although
   one study demonstrated a protective effect for as long as 60 years
   (Nguipdop-Djomo, Heldal, Cunha Rodrigues, Abubakar, and Mangtani 2015).
www.pvmarquez.com/bcg                                                                                                              2/9
1/12/2021               Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez

   The BCG vaccine, however, will not prevent the development of active TB in
   individuals who are already infected with M. tuberculosis.

   If processes for early identi cation and treatment of latent TB infection are
   not available, it is recommended that BCG vaccine may be considered for
   workers (such as health care workers, laboratory workers, prison workers
   and those working in shelters for the homeless) who may be repeatedly
   exposed to persons with untreated, inadequately treated or drug-resistant
   active TB, in conditions where protective measures against infection are not
   feasible (Canadian Immunization Guide 2014). 

   BCG vaccination policies vary across countries. Countries with high TB
   prevalence tend to have universal BCG vaccination policies, while those with
   lower TB burden tend to vaccinate only high-risk groups (SAGE Working
   Group on BCG Vaccines and WHO Secretariat 2017). Among 180 countries
   with available data, 157 countries recommend universal BCG vaccination,
   while 23 countries have either stopped BCG vaccination (due to a reduction
   in TB incidence), or never recommended mass BCG immunization and
   instead favored selective vaccination of “at risk” groups (Zwerling, Behr,
   Verma, Brewer, Menzies, Pai 2011). For example, BCG vaccination in the
   latter group of countries may be considered in exceptional circumstances,
   such as for infants in high risk communities, for persons at high risk of
   repeated exposure, for certain long-term travelers to high prevalence
   countries, and in infants born to mothers with infectious TB disease.

   As noted in our previous post, different studies involving the BCG vaccine
   have found that it provides heterologous or "nonspeci c immunological
   effects" by altering immune response to pathogens other than
   Mycobacterium tuberculosis.  The BCG vaccine has been found to reduce
   non-TB respiratory infection, sepsis, and all-cause mortality among young
   children, and it may prevent upper respiratory tract infections among the


www.pvmarquez.com/bcg                                                                                                             3/9
1/12/2021                Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez

   elderly. Although the mechanism, magnitude, and duration of these
   nonspeci c effects remain uncertain, some researchers speculate that BCG
   vaccination could moderate the severity of COVID-19 infections.

   Results of an Additional Analysis

   Data and Information Used.  Our team conducted an initial, limited, analysis
   of the available data and information.  Data on country population size were
   obtained from the World Bank Data Bank; data on COVID-19 deaths were
   from the Johns Hopkins University Center for Systems Science and
   Engineering (CSSE) database, and information on BCG vaccination policies,
   by country, was from the BCG World Atlas. COVID-19 deaths per capita was
   calculated using Johns Hopkins CSSE death counts and World Bank
   population estimates; the data were then logarithmically transformed to
   ensure normality.

   Summary of Results

            An analysis of variance (ANOVA), including both small states and low-
            income countries, was conducted. Countries were divided into four
            groups according to four different types of BCG vaccination policy (no
            policy at all, universal BCG vaccination policy, previous BCG vaccination
            policy, and policy to vaccinate certain high-risk groups). The analysis
            showed that there is a statistically signi cant difference in the mean
            number of deaths per 1,000 people between country groups (p < .01).
            A second ANOVA was conducted excluding small states and low-income
            countries. Countries were also divided into four groups according to the
            four different types of BCG vaccination policy (no policy at all, universal
            BCG vaccination policy, previous BCG vaccination policy, and policy to
            vaccinate certain high-risk groups). The analysis showed that there is a
            statistically signi cant difference in the mean number of deaths per
            1,000 people between country groups (p < .01).

www.pvmarquez.com/bcg                                                                                                              4/9
1/12/2021                Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez

            A two-sample t-test assuming equal variances was conducted, testing
            the difference in mean COVID-19 deaths per 1,000 population between
            countries with a universal BCG vaccination policy and countries without
            it (including no policy, only high-risk groups, and previous universal
            policy) was conducted. The test included small states and low-income
            countries and showed that there is a statistically signi cant difference in
            the mean number of deaths per 1,000 people between the two groups (p
            < .01).
            Finally, another two-sample t-test assuming equal variances, testing the
            difference in mean COVID-19 deaths per 1,000 population between
            countries with a universal BCG vaccination policy and countries without
            (including no policy, only high-risk groups, and previous universal policy)
            was conducted. In this case, small states and low-income countries were
            excluded. The results similarly showed that there is a statistically
            signi cant difference in the mean number of deaths per 1,000 people
            between the two groups (p < .01).

   In conclusion, the results of our initial analyses show statistically signi cant
   correlations, both when small states and low-income countries were
   included and when they were excluded from the analyses.

   Despite the interesting results that we obtained, substantial doubts arise
   and should be taken into account when further assessing the plausibility of
   the hypothesis:

            At present, there are a lot of questions about how different countries are
            reporting COVID-19 deaths. It seems that some countries only count
            deaths occurring in hospitals but not those happening in nursing homes,
            prisons, or at home (because testing was not done to con rm the
            diagnosis).  Moreover, large number of countries are facing supply-side
            challenges related to the availability of test kits for case detection and
            contact tracing.  The latter may have a confounding effect on the
            observed results.

www.pvmarquez.com/bcg                                                                                                              5/9
1/12/2021                Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez

            BCG vaccination policies and practices vary across time and countries. 
            For example, it is possible that a country with an 'only high-risk group'
            vaccination policy at present had a 'universal vaccination policy' up to
            1960. In cases like this, there are differences in previous BCG vaccination
            coverage according to age groups. A proper analysis should take into
            account these inter- and intra-country differences.  In addition, the use
            of different BCG vaccine strains in different countries and even within
            the same countries may also have a confounding effect.  Currently, ve
            main strains account for more than 90 percent of the vaccines in use
            worldwide with each strain possessing different characteristics, and
            there is no standardized production of BCG vaccine between
            manufacturers (WHO 2012).
            The role of additional factors that have not yet been assumed,
            investigated, or con rmed. For example, since the primary function of
            the respiratory system--to supply oxygen to all the parts of the body--is
            especially affected among COVID-19 infected individuals (probably
            because of multiple clotting in the lungs), does the decreased respiratory
            capacity observed among cigarette smokers play a major role in the
            clinical evolution of COVID-19 disease, increasing the risk of disease
            severity and death among COVID-19 infected individuals? As discussed
            on a previous post, cigarette smoking makes chronic lung diseases more
            severe and increases the risk for respiratory infections (“Does Tobacco
            Smoking Increases the Risk of Coronavirus Disease (Covid-19) Severity?
            The Case of China” of March 3, 2020, http:/ /pvmarquez.com/Covid-19
            (http://pvmarquez.com/Covid-19)).

   The Way Forward

   Many clinical trials with different drugs treat COVID-19 disease patients are
   currently being conducted in many countries. Antivirals (lopinavir/ritonavir,
   lopinavir), monoclonal antibodies (tocilizumab) and other agents affecting




www.pvmarquez.com/bcg                                                                                                              6/9
1/12/2021               Do BCG Vaccinated People Have Some Immunity Advantage Over Non-Vaccinated People? | Patricio V. Marquez

   the immune response (hydroxychloroquine and chloroquine) are being
   tested. Different treatments are also being tested as preventive measures in
   non-positive patients.

   It should be clear, however, that research to nd an effective vaccine is one
   of the most promising ways to suppress the pandemic (not the present
   wave, but future waves that may happen).

   At this stage, it is crucial to try to understand sets of factors and their
   interactions, e.g., risk factors, protective factors, and infection periods.
    Within this framework, the BCG hypothesis could be useful. There is a
   plausible hypothesis: vaccinated people could show some immunity
   advantage over non-vaccinated people (based on previous studies on the
   nonspeci c effects of BCG on the immune response as described in our
   above-mentioned previous post of April 18, 2020).

   Conducting more accurate analyses, including evaluating differences in BCG
   vaccination among infected people, recovered patients, and positive but
   asymptomatic patients, should be of high interest, not only to understand
   how COVID-19 interacts with people but also to inform the development of
   a vaccine (or to understand potential failures or successes of future
   vaccines).  Another avenue of analysis that may offer some clarity on this
   inquiry is related to the fact that some medical personnel working in
   develop countries, such as the United States (without BCG), are actually
   coming from low-and middle-income countries where BCG policy is in
   place. Hence, a question that may need to be analyzed is whether there are
   differences in terms of severity of COVID-19 disease among infected doctors
   and nurses based on the country of origin of medical personnel that
   emigrated and those who emigrated and are working in medical facilities in
   developed countries?



www.pvmarquez.com/bcg                                                                                                             7/9
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   At this point, it is crucial is to ensure that decisions taken on BCG
   vaccination are taken based on the available information for several reasons:

            First, because it takes several weeks to develop the alleged positives
            effects of BCG on immunity after vaccination (so, it would not be useful
            for the present wave).
            Second, because of the low availability of BCG vaccines and their low
            production rate
            (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777639/).
            Third, and most important, because the hypothesis has to be tested with
            more appropriate epidemiological and clinical methods before a causal
            relationship can be ascertained.

    

    

    

    

    
   Sources
   Government of Canada. 2014. “Bacille Calmette-Guérin (BCG) vaccine:
   Canadian Im… (https://www.canada.ca/en/public-
   health/services/publications/healthy-living/canadian-immunization-
   guide-part-4-active-vaccines/page-2-bacille-calmette-guerin-
   vaccine.html)
   Nguipdop-Djomo, P, Heldal, E, Cunha Rodrigues, L, Abubakar, I, Mangtani, P.
   20… (https://www.thelancet.com/journals/laninf/article/PIIS1473-
   3099(15)00400-4/fulltext)
   WHO. 2020. “BCG vaccine”. (internet site).
   (http://www9.who.int/biologicals/areas/vaccines/bcg/en/)
www.pvmarquez.com/bcg                                                                                                              8/9
1/12/2021                                                Searching for Evidence in the COVID-19 Era: The BCG Case | Patricio V. Marquez




  Searching for Evidence in the COVID-19 Era: The BCG Case
  Submitted by Patricio V. Marquez on Fri, 04/17/2020 - 10 41 PM




  Searching for Evidence in the COVID-19 Era: The BCG
  Case
  Posted by Patricio V. Marquez on Fri, 04/17/2020 - 10 41 PM




  A Preliminary Interrogation Conducted by Patricio V. Marquez [1], Albert Figueras [2],Allison
  Ross [3],Giovanni S. Marquez [4], and Jaime Bayona [5]

   

  “A pestilence is not a thing made to man’s measure; therefore, we tell ourselves that pestilence is a mere bogy of the mind, a bad dream that will pass away.  But it does not
  always pass away and, from one bad dream to another, it is men who pass away, and the humanists rst of all, because they have not taken their precautions.”
  Albert Camus, The Plague.  Vintage, 1947. 
  “For the rst time in history, we face the risk of a global decline. But we are also the rst to enjoy the opportunity of learning quickly from developments in societies anywhere
  else in the world today, and from what has unfolded in societies at any time in the past.”
  Jared Diamond. Collapse. How societies choose to fail or succeed. Penguin, 2005.
   



  Across the world, the spread of the novel coronavirus disease (COVID-19) has been rapidly altering life as we
  know it. With more than 2.2 million reported cases and more than 150,000 deaths as of April 17, 2020 (Johns
  Hopkins Center for Systems Science and Engineering 2020), social distancing policies, including widespread
  lockdowns, have been adopted out of societal fear of the high transmissibility, often by asymptomatic people,
  and severity of a virus that transcends national boundaries. The global economy is experiencing an exceptional
  negative shock as a result of COVID-19 massive layoffs and unemployment, supply chain and market disruption
  directly affecting economic production, and the nancial impact on rms and nancial markets has been hard.
  All this on top of the severe negative impact on human capital, including lives, learning, basic well-being, and
  future productivity (World Bank/International Monetary Fund 2020).  Still, despite its enormous health, social,
  and economic impact, much about the disease is currently unknown.


www.pvmarquez.com/bcgcovid19                                                                                                                                                         1/4
1/12/2021                            Searching for Evidence in the COVID-19 Era: The BCG Case | Patricio V. Marquez

  Given the novelty of COVID-19 and its clinical manifestations (Fauci, Lane, Clifford, and Red eld, 2020), as well
  as the speed at which the pandemic is progressing, we are constantly learning and revising our understanding of
  the virus and how to contain and mitigate its spread and impact, and hoping for eventual suppression. The
  global scienti c community is conducting signi cant research into transmission methods, potential treatments,
  and vaccine candidates, resulting in a plethora of information, in some cases con icting, for the general public to
  sort through.

  One such nding has been the association between a country's COVID-19 reported cases and deaths and its
  Bacillus Calmette–Guérin (BCG) vaccination policy. BCG usually is given to newborns, protecting them
  especially against severe forms of TB (e.g., TB meningitis, disseminated TB).  However, vaccination policies vary
  country to country. Countries with high TB prevalence tend to have universal BCG vaccination policies, while
  those with lower TB burden tend to vaccinate only high-risk groups (SAGE Working Group on BCG Vaccines and
  WHO Secretariat 2017).

  According to a preprint, ecological study* (Miller et al. 2020), countries without universal policies of BCG
  vaccination (e.g., Italy, United States) have been more severely affected by COVID-19 compared to countries with
  universal and long-standing BCG policies. It is also shown in this study that countries that have had a late start
  of universal BCG policy (e.g., Iran, 1984) have high COVID-19 mortality, consistent with the idea that BCG
  protects the vaccinated elderly population. The results of another ecological study not yet published also show
  that COVID-19-attributable mortality among BCG-using countries was 5.8 times lower than in non-BCG-using
  countries (Shet et al. 2020). Accordingly, the authors of both studies have hypothesized that BCG vaccination
  might offer some protection against COVID-19, reducing the severity of the disease. Data from another study
  not yet peer reviewed corroborates the observation that universal BCG vaccination has a protective effect on the
  course of COVID-19, probably preventing progression to severe disease and death (Dayal and Gupta 2020). 

  Since its introduction in the 1930s, epidemiological studies have shown that BCG also protects against childhood
  mortality independent of its effect on TB.  More speci cally, the studies involving the BCG vaccine have found
  that it provides heterologous or "nonspeci c immunological effects," altering immune response to pathogens
  other than Mycobacterium tuberculosis (Iglesias and Martin 2015). The ndings suggest that BCG at birth has
  bene cial nontargeted effects on general infant morbidity and mortality in low-income countries--a BCG scar is
  associated with better survival and 50 percent mortality reduction due to pneumonia in vaccinated
  children (Roth, Garly, Jensen, Nielsen, Aaby 2006). Besides reducing non-TB respiratory infection, other studies
  show that the BCG vaccine reduces sepsis, and all-cause mortality among young children (de Castro, Pardo-
  Seco, and Martinón-Torres 2015; Higgins, JPT, Soares-Weiser, K, López-López, JA, Kakourou, A, Chaplin, K,
  Christensen, H, et al. 2016).  It is also shown that BCG prevents upper respiratory tract infections among the
  elderly (Wardhana, Sultana, Mandang, and Jim 2011).

  Although the mechanism, magnitude, and duration of these nonspeci c effects remain uncertain, a study
  showed that BCG induces adaptive or trained immunity and nonspeci c protection from infections through
  epigenetic reprogramming of innate immune cells (Kleinnijenhuis, Quintin, and Preijers 2012).  The innate
  immune response in a person’s organism is initiated when cells of the innate immune system, including PMNs,
  monocytes, macrophages, and DCs, encounter pathogens.  Some researchers now speculate that BCG
  vaccination could moderate the severity of COVID-19 infections (Dayal and Gupta 2020; Hegarty, Kamat,
  Za rakis, Dinardo 2020).




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  While two of the above-mentioned ecological studies (Miller et al. 2020; Shet et al. 2020) observed an
  association between national vaccination policies and country-level deaths, it should be clear, however, that this
  relationship does not imply causation between the exposure and the disease. Uncontrolled confounding
  variables could instead explain the association, including the fact that low and middle-income countries tend to
  have both universal BCG policies and lower capacities to test for COVID-19. Additionally, it should be taken into
  account that many countries have changed their BCG policies in the past 50 years, so even within a country,
  immunization is not uniform (i.e., it can be different according to age).

  Given what we know now, BCG vaccinations cannot prevent COVID-19 infections or reduce their severity, but
  the association is worth evaluating in greater depth. Additional research could provide more accurate
  characterizations of the relationship between vaccination and disease occurrence, accounting for variables like
  population demographics, testing capacity, and epidemic timelines that affect national ecological studies.

  Two randomized control trials are currently underway in Australia and the Netherlands to evaluate whether BCG
  vaccination reduces COVID-19 incidence among healthcare workers (Murdoch Children’s Research Institute
  2020; UMC Utrecht 2020).  Perhaps the results of these trials will help provide much needed evidence on what
  works in the ght against the novel coronavirus, contributing with additional insights into the mechanisms of
  disease and host response.

  We should keep an eye on the outcome of these trials, while recognizing that rushing to promote novel
  treatments before evidence of their ef cacy and safety has been established can do public health more harm
  than good.

   

  Note.  * Ecological studies are studies of risk-modifying factors on health or other outcomes based on populations de ned either geographically or temporally.  The study by
  John Snow in 1984, regarding a cholera outbreak in London is considered the rst ecological study to solve a health issue. He used a map of deaths from cholera to determine
  that the source of the cholera was a pump on Broad Street.

  About the authors:
  [1] Consultant, World Bank Group (WBG) COVID-19 Global Emergency Response Program, and former Lead Public Health Specialist, WBG
  [2] Director, Fundació Institut Català de Farmacologia (Catalan Pharmacology Institute), a collaborating center of the Department of Clinical Pharmacology of the
  Hospital Vall d'Hebron, and associated center of the Department of Pharmacology, Therapeutics and Toxicology at the Autonomous University of Barcelona (UAB), and a
  WHO Collaborating Center for Research and Training in Pharmacoepidemiology.  Barcelona, Spain
  [3] WBG Intern, and Graduate Student, Global Health Program, Georgetown University, Washington, D.C.
  [4] Former Technical O cer, PAHO/WHO, WHO AFRO, and WHO EMRO (Health Systems, Expanded Programme on Immunization and Health Emergencies in Barbados, USA,
  Haiti, Pakistan, and Nigeria)
  [5] Senior TB/Health Specialist, WBG



   
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  (https://academic.oup.com/cid/article/60/11/1611/356084)
  Higgins, JPT, Soares-Weiser, K, López-López, JA, Kakourou, A, Chaplin, K, Chris…
  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063034/)
  Iglesias, M-J, and Martin, C. 2015. “Nonspecific Beneficial Effects of BCG Vacci…
  (https://academic.oup.com/cid/article/60/11/1620/356166)
  Johns Hopkins Center for Systems Science and Engineering (internet site).
  (https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6)
  Kleinnijenhuis, J, Quintin, J, Preijers, F, Joosten, LAB, Ifrim, DC, Saeed, …
  (https://doi.org/10.1073/pnas.1202870109)
  Miller, A, Reandelar, MS, Fasciglione, K, Roumenova, V, Li, Y, and Otazu, GH. …
  (https://www.medrxiv.org/content/10.1101/2020.03.24.20042937v1)

www.pvmarquez.com/bcgcovid19                                                                                                                                                     3/4
1/12/2021                       Searching for Evidence in the COVID-19 Era: The BCG Case | Patricio V. Marquez

  Murdoch Childrens Research Institute. "BCG Vaccination to Protect Healthcare Wo…
  (https://clinicaltrials.gov/ct2/show/NCT04327206.)
  SAGE Working Group on BCG Vaccines and WHO Secretariat. 2017. "Report on BCG …
  (https://www.who.int/immunization/sage/meetings/2017/october/1_BCG_report_revised_version_online.pdf)
  Shet, A, Ray, D, Malavige, N, Santosham, M, Bar-Zeev, N. 2020. "Differential…
  (https://www.medrxiv.org/content/10.1101/2020.04.01.20049478v1)
  UMC Utrecht. "Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Thr…
  (https://clinicaltrials.gov/ct2/show/NCT04328441)
  Wardhana, DEA, Sultana A, Mandang VV, Jim E. 2011. “The ef cacy of Bacillus Ca…
  (https://www.ncbi.nlm.nih.gov/pubmed/21979284)
  World Bank/International Monetary Fund. WB/IMF Spring Meetings 2020. “Develop…
  (https://www.worldbank.org/en/news/press-release/2020/04/17/world-bankimf-spring-meetings-2020-
  development-committee-communique)




                                
                                      (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/bcgcovid19                                                                                     4/4
1/12/2021                         How to Prevent Jails and Prisons from Becoming New Hotspots for the Spread of COVID-19? | Patricio V. Marquez




  How to Prevent Jails and Prisons from Becoming New
  Hotspots for the Spread of COVID-19?
  Submitted by Patricio V. Marquez on Mon, 04/13/2020 - 05 11 PM




  How to Prevent Jails and Prisons from Becoming New
  Hotspots for the Spread of COVID-19?
  Posted by Patricio V. Marquez on Mon, 04/13/2020 - 05 11 PM




  Recent newspaper articles have reported on the potential role of jails and prisons as “ampli ers” of the coronavirus
  pandemic (Ransom and Feuer 2020; Flagg and Neff 2020). For example, data from New York City jails show that 36
  out of 1,000 inmates tested positive for the virus versus 4 out of 1,000 people in the city at large (The Legal Aid
  Society 2020).  Additional information indicates that 23 states across the United States have reported cases in
  correctional facilities (Coppola and Pettersson 2020).

  The gravity of this challenge in the rest of the world is evidenced by the fact that more than 10.3 million people are
  held in penal institutions at any given time and more than 30 million people pass through prisons each year
  (Walmsley 2015; Subramanian, Henrichson, and Kang-Brown, 2015).  In addition, there is a large workforce, both
  within institutions and in community supervision.  With thousands of people owing in and out of jails and prisons
  every week, this is a great risk not only for the detained population that could be hard hit by the coronavirus
  pandemic, but also for correctional workers, families of released inmates, and surrounding communities (The
  Marshall Project 2020). 

  Facilitating Factors in Jails and Prisons 

  Jails are transient, local level facilities, for the newly arrested, those awaiting trial or sentencing, those who have not
  yet been convicted of a crime, and people serving shorter sentences.  Prisons are run by states or central
  governments and are for those convicted of crimes and serving longer sentences. The people who are incarcerated
  are among the most vulnerable in society, often from low income and marginalized backgrounds (e.g., racial

www.pvmarquez.com/prisoncovid19                                                                                                                   1/7
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  minorities, undocumented migrants).  The vulnerability of prisoners is further exacerbated by restricted movement,
  rampant overcrowding, poor hygiene, sanitation, and ventilation, and limited medical care in the facilities (Akiyama,
  Spaulding, and Rich 2020).  

  Besides the sheer number of incarcerated people, often a “veil of oblivion” surrounds the dire conditions of jails and
  prisons, which make them potential host spots for the spread of COVID-19 because of the ease with which it
  transmits in congregate settings. 

  Another factor that may facilitate the rapid spread of COVID-19 in jails and prisons is the large share of those
  incarcerated who are older adults affected by underlying chronic health conditions, including both infectious
  diseases such as HIV, hepatitis C, and tuberculosis, and noncommunicable diseases such as chronic lung disease,
  moderate to severe asthma, serious heart conditions, diabetes, chronic kidney disease, and liver disease, all of which
  make them at higher risk of developing severe COVID-19 disease and having poor outcomes of infection (CDC (1)
  2020). 

  Health risk factors that make respiratory diseases like COVID-19 more dangerous are far more common in the
  incarcerated population than in the general population, such as the high prevalence of cigarette smoking.  As
  documented, cigarette smoking may help explain the negative progression and adverse outcomes of COVID-19 in
  China among men, who are far more likely to smoke than women  (Marquez 2020; Vardavas and Nikitara 2020).  In
  other countries such as Italy and South Korea, with sizable outbreaks of COVID-19,  smoking rates in countries
  remain high at approximately 19-27 percent of the population (Simons, Perski,Brown 2020).

  An additional factor that further compounds the poor health and social conditions in the penal system is evidenced
  by country data that shows that as many as half the people in jails and prisons have a mental disorder, which could
  be aggravated by the fear of becoming severely ill or dying if infected with COVID-19 because of their age or health
  conditions, and by other stressors such as frustration, boredom, inadequate supplies, and inadequate information
  (Brooks, Webster, Smith, et al. 2020; Marquez, 2018).  For example, as described in Alisa Roth's gripping book Insane
  (2018), although the overall number of people behind bars in the United States has decreased in recent years, the
  proportion of prisoners with mental illness has continued to go up. Data in the book indicate that in Michigan about
  50 percent of people in county jails have a mental illness, and nearly 25 percent in state prisons do. This situation
  tends to be more pronounced among women prisoners: one study by the US Bureau of Justice Statistics found that
  75 percent of women incarcerated in jails and prisons had a mental illness, as compared to just over 60 percent of
  men.  De facto, as observed by Roth, jails and prisons, not only in the United States but across the world, have
  become “warehouses for the mentally ill”, who tend to be among the most disadvantaged members of society, fare
  worse than others, and who are susceptible to medical neglect and abuse, since ultimately the mission of jails and
  prisons is punishment, not medical care. 

  Limited Resources in Jails and Prisons

  What should be of concern is that in different countries across the world, penitentiary facilities often struggle with
  limited resources to provide basic levels of healthcare and psychological support services to inmates.  So, it is not a
  far-fetched idea to assume that the risk of an exponential spread of COVID-19 infection in jails and prisons is real as
  it will be greatly facilitated by the overcrowded and unsanitary conditions and the disease burden in these facilities.
  The urgency for taking early and decisive action in correctional facilities is best illustrated by COVID-19 outbreaks
  that have occurred in other con ned settings, such as in the long-term care skilled nursing home in King County,
  Washington, where ineffective infection control and prevention procedures and staff members working in multiple
  facilities contributed to intra- and inter-facility spread in the community (McMichael, Clark, Pogosjans, et al. 2020).
  In addition, dozens of nursing homes across 42 states in the United States have suffered outbreaks (Coppola and
  Pettersson 2020).  Another warning sign of what could happen in the face of inaction in jails and prisons is the
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  COVID-19 outbreaks on cruise ships, which are often settings for infectious disease transmission because of their
  closed environment and contact between travelers from many countries.  As documented, more than 800 cases of
  laboratory-con rmed COVID-19 cases occurred during outbreaks on three cruise ship voyages, and cases linked to
  several additional cruises have been reported across the United States (Moriarty, Plucinski, Marston, et al. 2020).
  Places of worship could also become loci of infection if religious institutions facilitate the congregation of large
  number of people by not closing services. 

  While case detection, contact tracing, medical isolation, quarantines, and social distancing, along with basic
  sanitation measures such as hand washing, are critical measures  to “ atten the curve” of the COVID-19 pandemic
  among the civilian population, the adoption of these measures in the closed environment of jails and prisons
  presents signi cant challenges. Given the nature and characteristics of these facilities, it would be dif cult or
  impossible for most incarcerated people to follow guidelines on social distancing, since they are living in
  overcrowded quarters, interact in dining halls,  and sleep in rows of beds in a common room, have two or more
  people in a single cell, and have to use group showers and bathrooms that serve dozens, often without running
  water, with broken sanitation services, and lacking soap, towels to dry hands, and other supplies for disinfecting
  surfaces (Flagg and Neff 2020). 

  Since these dire conditions are typical of jails and prison systems across the world, it is imperative that allocation of
  required resources for supporting prevention, containment, and mitigation activities in these settings be included as
  part of country-wide emergency response strategies to prevent that these facilities become “transmission centers”
  for COVID-19. If widespread COVID-19 outbreaks occur in jails and prisoners, a large number of patients at once
  may overwhelm the often-constrained capacity of the healthcare services in the penitentiary system but also of
  referral hospitals in the community where the very sick and dying will be transferred.

  Policy and Institutional Measures to Minimize COVID-19 Risk

  Different observers and organizations have highlighted possible actions that if effectively implemented could help
  inhibit the spread of this highly infectious virus among those already incarcerated, prison guards, correctional staff,
  and administrators, and among people on probation or parole, who are in regular contact with the penal system
  (Prison Policy Initiative 2020; CDC (2) 2020; American Correctional Association Resources 2020; Markham 2020).
  Some of the proposed actions include the following:

  Release people from jails and prisons following depopulation and de-incarceration policies and strategies.  As
  noted above, jails and prisons house large numbers of people with chronic health conditions and diseases that make
  them more vulnerable to COVID-19.  One way to protect these vulnerable populations is to reduce overcrowding in
  correctional facilities by releasing inmates charged with low-level, non-violent crimes and elderly and in rm
  inmates, and by focusing on preventing people with health issues who are charged with non-violent offenses from
  going into the prison system in the rst place, for example, by allowing the posting of personal bonds. Different
  states in the United States such as California, Ohio, New Jersey, and Texas have undertaken the controlled release of
  low-level offense prisoners and have pushed for the “compassionate release” of inmates over age 50 facing
  nonviolent charges (Tamkin 2020; Williams, Weiser, and Rashbaum 2020). In other countries, such as Iran, 54,000
  prisoners have been temporarily released to combat the COVID-19 spread (BBC 2020). The adoption of these
  measures would in turn help to reduce the risk of unrest and rioting by prisoners who fear being the last in line to
  be tested and at high risk of being infected as recently seen in several countries such as Brazil, Colombia, France,
  Italy and Venezuela (Turkewitz 2020; Amante 2020). The pandemic also offers the opportunity to release political
  prisoners on humanitarian grounds.




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  Reduce jail and prison admissions.   This action will help slow down the rapid movement of people in and out of jails
  and prisons, while also facilitating the reduction of the incarcerated population.  Rather than arresting and locking
  up more people in jail and prisons for misdemeanors and nonviolent felony offenses, and in some countries, for
  nonviolent immigration or drug charges, public of cials have started to order the police to issue citations and to
  strike plea deals to resolve cases quickly (Gillispie 2020).  There are other innovative approaches that could be used
  during the pandemic.  For example, as reported in an article in The Financial Times, approaches being implemented
  with good results in the United States, such as the “judge-led therapy programs”, offer non-violent offenders with
  mental and substance use disorders the opportunity to avoid jail, by agreeing to intensive mentoring and support
  (Waldmeir 2018).  Among the vast majority of offenders who opt for this alternative approach, where they are
  connected with housing and other services, it has been reported that recidivism is low, patients get the support they
  need, and the judicial system saves a signi cant amount of funds that could be directed to improve the health and
  sanitary conditions in jails and prisons.

  Reduce or suspend visitation by community members, limit visits by legal representatives, and reduce facility
  transfers for incarcerated persons.   As observed in a recent article, physical contact between staff and the
  incarcerated is often unavoidable: while of cers ngerprint, handcuff and supervise prisoners, as well as escort
  them to court and drive them to medical appointments, many other people also ow in and out of jails, like family
  members who visit; volunteers who counsel or teach or preach; contractors who stock vending machines; and
  lawyers who meet their clients (Flagg and Neff 2020).   The adoption of social distancing actions to limit visits,
  services, and vendors, and by moving to online and phone communication, is a required disease prevention measure
  to reduce the risk of asymptomatic cases spreading COVID-19 in jails and prisons.

  Improve capacity for infection prevention and control, and well as care and treatment, in the penitentiary health
  system.  This would require that the penitentiary facilities have in place health promotion and disease prevention
  measures, the capacity to monitor the onset of infectious diseases, test individuals who present COVID-19
  symptoms (e.g., fevers, coughs, and symptoms of respiratory illness) and have a known exposure to the virus, record
  and report to national health department positive COVID-19 cases, and conduct epidemiological investigations to
  identify individuals who may have had close contact with infected individuals (CDC (2) 2020).  Prison health services
  need to also medically isolate suspected and con rmed cases from the prison general population, follow up the
  progression of the infection by taking the temperatures of inmates who are elderly, are considered at risk for the
  virus, or are in medical isolation, and treat or refer to specialized facilities patients with severe COVID-19 disease
  and other co-occurring chronic health conditions in accordance with national standards.  Additional measures
  include medical screenings for all staff entering a prison, including temperature checks with no-touch
  thermometers and denial of entry to a prison to anyone with a temperature of 100 degrees or more, has symptoms
  of respiratory illness, or who has been exposed in the past 14 days to anyone who is suspected or diagnosed with
  COVID-19. A 14-day quarantine period, in addition to previously noted medical screening, could be instituted for all
  incoming prisoners to prevent the introduction of COVID-19 into the prison system.  The use of washable masks
  should also be promoted in all sites where there have been reported COVID-19 cases, as well as ensuring the
  availability of personal protective equipment, face shields and masks, and protective gowns for prison health
  workers and other staff in direct contact with infected inmates, as well as establishing designated rooms to separate
  infected people from other inmates. A comprehensive response that connects correctional facilities and the
  community is of great importance for managing transition in the care of people to and from the community given
  the “revolving door” nature of jails and prisons.

  Eliminate medical co-pays.  In countries where universal nancial protection in health is lacking or limited such as
  in the United States, incarcerated people are expected to make copayments for physician visits, medications, and
  testing.  As observed among the civilian population, the imposition of medical copayments becomes a barrier that
  discourages demand and utilization of needed medical services, which in turn will only help increase the tally of
  infected cases within the facility’s inmate population and security and administrative personnel.
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  Way Forward

  The impact of the adoption of the measures described above would have dual bene ts:  on one hand, it would help
  prevent the spread of COVID-19 among inmates and penitentiary system workers, and hence among their families
  and surrounding communities, that could undermine efforts to atten the curve in countries. It would also help
  contain a resurgence of the virus during the suppression phase of the pandemic.   And, on the other hand, it would
  help advance prison reform by depopulating jails and prisons in combination with the provision of health care,
  rehabilitation, education and skills development, and social support programs as an alternative to incarceration.  A
  glimmer of hope? Yes, but one that is possible if political commitment and public and private efforts push forward
  these policy choices as part of a multisectoral strategy for human capital development, and as a moral imperative in
  society to offer vulnerable people a second chance for rebuilding their lives. 

   

  Picture 1 Inside the Prison Industrial Complex, Guess Contributor. 
  https://www.patheos.com/blogs/rhetoricraceandreligion/2015/09/inside-the-prison-industrial-complex.html

  Picture 2 “Detainees in Manila City Jail, where most are still awaiting trial, and may stay for months or even years
  before that happens.” By Hannah Reyes Morales for The New York Times
  https://www.nytimes.com/2019/01/07/world/asia/philippines-manila-jail-overcrowding.html
  (https://www.nytimes.com/2019/01/07/world/asia/philippines-manila-jail-overcrowding.html) 

   
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  Walmsley, R. “World Prison Population List.” Eleventh Edition. Institute for Cr…
  (https://www.prisonstudies.org/sites/default/ les/resources/downloads/world_prison_population_list_11th_editi
  Williams, T, Weiser, B, and Rashbaum, WK. 2020. “‘Jails Are Petri Dishes’: Inm…
  (https://www.nytimes.com/2020/03/30/us/coronavirus-prisons-jails.html)




www.pvmarquez.com/prisoncovid19                                                                                                                   6/7
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  Does Tobacco Smoking Increases the Risk of Coronavirus
  Disease (Covid-19) Severity? The Case of China
  Submitted by Patricio V. Marquez on Tue, 03/03/2020 - 02 20 PM




  Does Tobacco Smoking Increases the Risk of Coronavirus
  Disease (Covid-19) Severity? The Case of China
  Posted by Patricio V. Marquez on Tue, 03/03/2020 - 02 20 PM




  Since December 2019, when Covid-19 emerged in Wuhan city and subsequently spread across China causing varying
  degrees of illness, the virus has now infected 92,100 people in at least 70 countries.  Data reported from China
  provide insights into the biology, epidemiology, and clinical characteristics of Covid-19.  

  Men are at higher risk of Covid-19

  When assessing the data on the personal characteristics of affected patients, the sex distribution of the disease
  clearly shows a male predominance of Covid-19.  Indeed, as reported by Chinese researchers in the New England
  Journal of Medicine, (Guan, Ni et al 2020), among a sample of 1099 patients, with laboratory-con rmed disease, from
  552 hospitals in 30 provinces, autonomous regions, and municipalities in China through January 29, 2020,  the
  median age of patients was 47 years and 58.1 percent of the patients were male.  Also, among the initial 425 cases
  of that occurred in Wuhan, Hubei Province, China, in December 2019 and January 2020, the median age was 59 years
  and 56 percent were male (Li, Guan, et al 2020).   Moreover, an article published at the Journal of the American
  Medical Association (JAMA), noted that the death rates among men infected with the coronavirus, particularly
  those in their late 40s and older, have exceeded those among women (del Rio and Malani 2020).

  In previous coronavirus outbreaks, such as the SARS and MERS outbreaks, men were also disproportionally
  affected.  In Hong Kong in 2003, for example, men with SARS had a 50 percent excess risk of death than females
  (Leung, Hedley, et al 2004).

  What explains this discrepancy?   

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  While that cause is not known, it is suggested that a higher prevalence of tobacco smoking among Chinese men,
  often resulting in compromised lung function, may help explain it (del Rio, Milani 2020).  Tobacco use also
  contributes to the onset of other co-occurring conditions such as cardiovascular diseases, lung cancer, chronic
  obstructive pulmonary disease (COPDs), and diabetes, which are more prevalent among males and account for a
  signi cant share of the total disease burden in China (Wang, Marquez, Langenbrunner 2011).   The existence of pre-
  existing conditions increases the risk of disease severity and death among Covid-19 patients, similar to the
  situation with in uenza (Fauci, Lane, Red eld 2020).

  Data presented in above-mentioned New England Journal of Medicine article (Guan, Ni, et al 2020), further
  illustrate the relative impact that tobacco smoking has on the spectrum of the Covid-19 progression and mortality in
  a nationwide sample of 1099 Covid-19 patients, with laboratory-con rmed diseases: 

      12.6% of patients were current smokers, and 1.9% former smokers.
      Among those that developed a severe disease (N=173), 16.9% were current smokers and 5.2% former smokers.
      Among patients with presence of primary composite end point (admission to an intensive care unit, the use of
      mechanical ventilation, or death) (N=67), 25.8% were current smokers and 7.6% former smokers.

  The epidemic of tobacco use in China

  We should not be surprised by the role of tobacco smoking in explaining the difference in the sex distribution and in
  the severity of Covid-19 in China.  China has the largest smoking population in the world, with around 316 million
  adult smokers, and accounts for nearly one-third of smokers and 40 percent of tobacco consumption worldwide. 
  While the prevalence of smoking in women is still relatively low at 1.9 percent, among males, the prevalence was
  estimated at 48.4 percent in 2016 (World Bank Development Indicators).  Smoking prevalence also varies across
  cities and provinces within China.

  Since the lung is an organ directly affected by cigarette smoking, various respiratory diseases including lung
  cancer, chronic obstructive pulmonary disease, interstitial lung diseases, and bronchial asthma, are caused and
  worsened by cigarette smoking not only in the case of active smoking but also in the case of passive smoking. In
  2010, an estimated 1.2 million premature deaths were attributable to smoking in China, and the three leading causes
  of death (stroke, ischemic heart disease, and chronic obstructive pulmonary disease) were linked to tobacco
  consumption. As documented in a recent study, China is in the midst of a lung cancer epidemic on an
  unprecedented scale, and tobacco smoke exposure is the primary factor driving current lung cancer trends
  (Parascandola and Xiao, 2019). Lung cancer is now the most commonly diagnosed cancer and the leading cause of
  cancer mortality in China. In 2015, there were an estimated 733,000 new lung cancer cases (17 percent of total
  cancer incidence) and 610,000 deaths (21.7 percent of total cancer mortality) in China.

  How does smoking affect lung health?

  Acute respiratory illnesses are divided into those that include the upper respiratory tract (nose and pharynx) and
  larynx, and those that include the lower respiratory tract (below the larynx). In people with normal immune systems,
  viruses account for most cases of upper respiratory syndromes (Gwaltney 1995c): acute bronchitis (Gwaltney 1995a,
  as cited in U.S. Department of Health and Human Services 2004), bronchiolitis (Hall and Hall 1995, as cited U.S.
  Department of Health and Human Services 2004), and a majority of pneumonia cases (Marrie et al. 1989, as cited in
  U.S. Department of Health and Human Services 2004). Bacteria can cause pharyngitis (Gwaltney 1995b, as cited in
  U.S. Department of Health and Human Services 2004) and some pneumonias (Marrie et al. 1989, as cited in U.S.
  Department of Health and Human Services 2004).

  As clearly explained in the 2004 US Surgeon General Report (U.S. Department of Health and Human Services. 2004),
www.pvmarquez.com/Covid-19                                                                                                                                 2/5
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  “Toxins in tobacco smoke harm the body from the moment they enter through the mouth and nose.  They damage
  tissue and cells all the way to the lungs.  When cigarette smoke is inhaled, chemicals from the smoke are absorbed in
  the lungs. As a result, smoking causes lung diseases, including the majority of cases of chronic obstructive
  pulmonary disease (COPD); makes chronic lung diseases more severe; and increases the risk for respiratory
  infections.  Genetic factors make some people more susceptible to lung disease from smoking.  Although the lung
  has ways to protect itself from injury by inhaled agents, these defenses are overwhelmed when cigarette smoke is
  inhaled repeatedly over time. After years of exposure to cigarette smoke, lung tissue becomes scarred, loses its
  elasticity, and can no longer exchange air ef ciently.” 

  The evidence is suf cient to infer a causal relationship between smoking and acute respiratory illnesses,
  including pneumonia, in persons without underlying smoking-related chronic obstructive lung disease. In the
  case of acute respiratory illnesses, it is presumed an infection is the predominant underlying cause, but smoking
  might act to increase the frequency or severity of infections. A systematic review and meta-analysis, showed that
  smoking was consistently associated with higher risk of hospital admissions after in uenza infection (Han, Ran, et al
  2019). 

  As reported in the 2004 US Surgeon General report (U.S. Department of Health and Human Services. 2004), there
  are several U.S. population-based studies that provide evidence of a link between cigarette smoking and acute lower
  respiratory tract infections. A population based, case-control study of 205 cases of community acquired pneumonia
  (Almirall et al. 1999a, b) reported an attributable risk of 23.0 percent for a history of ever smoking. The US Centers
  for Disease Control and Prevention sponsored a case-control study of invasive pneumococcal disease based on a
  population surveillance system (Nuorti et al. 2000), showed among cases for which pneumonia is likely to have been
  the main diagnosis, the population attributable risk estimate for smoking was 51 percent, compared with 14 percent
  for chronic illnesses. The authors estimated that reducing the prevalence of smoking to 15 percent among persons
  aged 18 through 64 years would prevent 4,000 cases per year of invasive pneumococcal disease in the United States.
  Of particular interest in this study was the observation that after 10 years of smoking cessation, the risk of invasive
  pneumococcal disease reached that of nonsmokers.

  What to do?

  The initial data from the Covid-19 outbreak in China, shows that smoking among men may explain the difference
  in the sex distribution of the disease, as well as in its severity.  This on top of existing evidence on the high human
  toll and economic impact of tobacco-attributable diseases in China, which as co-occurring conditions further
  impact negatively Covid-19 patients.

  Governments have an obligation and the means to protect their population’s wellbeing by adopting population-
  based disease prevention measures (for example, scal and regulatory measures), in addition to providing
  medical care to those persons who fall ill.  In the case of tobacco control, the most cost-effective policy measure
  is to control and prevent tobacco use, is tobacco taxation (Marquez and Moreno-Dodson 2017).  On the basis of the
  Covid-19 experience, and building upon the 2015 tobacco tax increase, it would be of paramount importance for the
  government in China to act boldly and swiftly to reform tobacco taxation for health and scal gains, as well as to
  promote human capital development.

  While the 2015 tobacco tax increase has generated measurable public health and scal bene ts, the price of
  cigarettes in China continues to be low and increasingly affordable for a population that enjoys rapid wage
  increases (Marquez and Zheng 2016; Zheng, Hu, Wang, and Marquez, 2017). If the ultimate goal is to help smokers
  quit and prevent the next generation from getting addicted to smoking cigarettes and hence signi cantly reduce
  health risks, then additional tobacco tax policy reforms are urgently needed in China, especially for re-orienting the
  excise tax structure towards speci c excise taxes at the retail level in the medium-term and towards a uniform tax
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  system at the retail level in the long-term.  A recent study estimated that a 50 percent increase in tobacco price
  through excise taxes would lead over 10 years to 5.3 million years of life gained and would reduce expenditures on
  tobacco-related disease treatment by US$2.4 (Verguet, Gauvreau, Mishra, MacLennan, Murphy, Brouwer,  Nugent,
  Zhao, Jha, Jamison  2015).

  Looking into the future, as evidenced in a World Bank study “Toward a Healthy and Harmonious Life in China:
  Stemming the Rising Tide of Non-Communicable Diseases” (Wang, Marquez, Langenbrunner 2011), with stronger
  tobacco control measures including steeper tobacco tax increases, the rapid rise in China's non-communicable
  diseases, that compound the impact of infectious diseases as we are now witnessing with Covid-19, can be halted,
  resulting in major gains for people’s health and the country’s social and economic development. 

  However, if an effective response is not mounted in China to control and reduce tobacco use after overcoming
  Covid-19, the disease burden posed by these conditions will aggravate the economic and social impact of the
  expected population explosion of older citizens and smaller workforce in China. And, a reduced ratio of healthy
  workers to sicker, older dependents, will certainly increase the odds of a future economic slowdown and pose a
  signi cant social challenge in China. 

   

  Sources of Photos: 

  First Photo:  Mark Schiefelbein/Associated Press, as published in the NYT on March 3 2020

  Second Photo: Agence France-Presse, Getty Images, as published in the NYT on March 3 2020

   
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  population-based-case-control-study/)
  Almirall J, González CA, Balanzó X, Bolíbar I. 1999b. “Proportion of community-…
  (https://journal.chestnet.org/article/S0012-3692(15)38022-3/fulltext)
  Del Rio, C., and Malani, P.N. 2020. “Covid-19-New Insights on a Rapidly Changi…
  (https://jamanetwork.com/journals/jama/fullarticle/2762510)
  Fauci, AS., Lane, HC, M.D., and Red eld, RR. 2020. “Covid-19 — Navigating the …
  (https://www.nejm.org/doi/full/10.1056/NEJMe2002387?query=recirc_curatedRelated_article)
  Guan, W, Ni, Z, Hu, Y, et al. 2020. Clinical characteristics of coronavirus di…
  (https://www.nejm.org/doi/full/10.1056/NEJMoa2002032?query=recirc_mostViewed_railB_article)
  Han, L, Ran, J, Mak, Y-W; Suen, LK-; Lee, P, et al. 2019. “Smoking and In uen…
  (https://journals.lww.com/epidem/Abstract/2019/05000/Smoking_and_In uenza_associated_Morbidity_and.15.as
  Leung, G.M, Hedley, A.J, Ho, L.M, Chau, P, et al. 2004. “The epidemiology of s…
  (https://www.ncbi.nlm.nih.gov/pubmed/15520422)
  Li, Q, Guan, X, Wu, P, et al. 2020. Early transmission dynamics in Wuhan, Chin…
  (https://www.nejm.org/doi/full/10.1056/NEJMoa2001316)
  Marquez, PV, and Zheng, R. 2016. “China’s 2015 tobacco tax adjustment: a step i…
  (https://blogs.worldbank.org/health/china-s-2015-tobacco-tax-adjustment-step-right-direction)
  Marquez, PV, and Moreno-Dodson, B. 2017. “Tobacco tax reform at the crossroads …
  (http://documents.worldbank.org/curated/en/491661505803109617/Main-report)
  Nuorti JP, Butler JC, Farley MM, Harrison LH, McGeer A, Kolczak MS, Breiman RF…
  (https://www.nejm.org/doi/full/10.1056/NEJM200003093421002)

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1/12/2021                    Does Tobacco Smoking Increases the Risk of Coronavirus Disease (Covid-19) Severity? The Case of China | Patricio V. Marquez

  Parascandola M, Xiao L. 2019. “Tobacco and the lung cancer epidemic in China.” …
  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546632/pdf/tlcr-08-S1-S21.pdf)
  U.S. Department of Health and Human Services. 2004. “The Health Consequences of…
  (https://www.ncbi.nlm.nih.gov/books/NBK44695/)
  Verguet, S, Gauvreau, CL, Mishra, S., MacLennan, M, Murphy, SM, Brouwer, ED, Nu…
  (https://www.thelancet.com/pdfs/journals/langlo/PIIS2214-109X(15)70095-1.pdf)
  Wang, S, Marquez, PV, Langenbrunner, J. 2011. “Toward a Healthy and Harmonious …
  (http://documents.worldbank.org/curated/en/618431468012000892/pdf/634260WP00Box30of cial0use0only090.pd
  World Bank Development Indicators. Accessed at: (https:/  /data.worldbank.org/indicator/SH.PRV.SMOK.MA?
  view=chart)
  Zheng, R, Hu, X, Marquez, PV, Wang Y. 2017. “Cigarette affordability in China: …
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  The Unpredictable Social and Economic Cost of
  the Coronavirus (Covid-19) Outbreak
  Submitted by Patricio V. Marquez on Thu, 02/27/2020 - 10 01 PM




  The Unpredictable Social and Economic Cost of
  the Coronavirus (Covid-19) Outbreak
  Posted by Patricio V. Marquez on Thu, 02/27/2020 - 10 01 PM




  With the realization that a novel coronavirus pandemic (Covid-19) is likely, people across the
  globe are getting alarmed, and nancial markets are starting to tumble. Given inadequate
  expenditures on public health and insuf cient disease prevention effort, perhaps this is an
  opportune time for high level political authorities, ministers of nance, and other global
  actors to once and for all be convinced that predictable and sustainable budgetary
  allocations for disease prevention, early detection, surveillance, preparedness, and
  response capacity across a medical care continuum is not an optional expenditure, that be
  neglected due to political shortsightedness or per the whims of scal rectitude.  Rather,
  these allocations should be considered priority investments in country budgets to enhance
  societal resilience and preparedness to prevent and control the emergence and reemergence
  of highly infectious pathogens, such as Covid-19. 




www.pvmarquez.com/coronavirus                                                                                                             1/8
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  If we look at the consequences of recent infectious disease outbreaks, one learns about their
  destructive potential, both in terms of human toll and severe economic disruptions. In
  particular, in uenza, a zoonotic disease (animal to human transmission), poses an
  unpredictable threat of international importance because of its potential capacity to mutate
  in ways that allows sustained human-to-human transmission across national borders and
  continents.

  The impact of the 1918-1919 In uenza Pandemic, for example, was enormous (Garrett, TA,
  2007).  It killed 40 million people worldwide from the early spring of 1918 through the late
  spring of 1919.  Only the Black Death that spread throughout Europe from 1348-1351 killed
  more people (roughly 60 million) over a similar time period.  Data for the United States shows
  that since males aged 18 to 40 were the hardest hit by the in uenza, it had serious economic
  consequences for the families that had lost their primary breadwinner.  Although the 1918-
  1919 in uenza pandemic in the United States was short-lived, an assessment by the US
  Federal Reserve Bank of St. Louis documented that many businesses, especially those in the
  service and entertainment industries, suffered double-digit losses in revenue. Other
  businesses that specialized in health care products, however, experienced an increase in
  revenues (Garrett, TA, 2008).

  More recently, the SARS outbreak in 2003 killed an estimated 10 percent of more than 8,000
  individuals infected (National Institute of Medicine, 2004). Estimates done suggest that the
  cost in 2003 of SARS for the world economy as a whole was close to US$40 billion. The SARS
  shock disproportionately affected Hong Kong due to its economic dependence on services
  (e.g., travel, tourism), and signi cant short-term losses also accrued in China as a result of a
  sharp decrease in foreign investment.

  What caused the economic loss? According to Jong-Wha Lee and Warwick J. McKibbin (2004),
  researchers who studied the economic impact of the SARS epidemic, the impact was due not
  to the consequence of the disease itself for the affected people, but to the impact of the
  disease on the behavior of many people within these economies. They also observed that
  the impact depended on the disease associated adjustment of expectations re ected in
  integrated real and nancial markets.  So, given the spread of the disease through droplet
  transmission, people tried to minimize face-to-face interactions. The result was a drop in
  demand in service sectors such as tourism, mass transportation, retail sales, hotels and
  restaurants. Business costs also increased due to workplace absenteeism, disruption of
  production processes and shifts to more costly procedures.




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  In low- and middle-income countries, infectious disease outbreaks have the potential to erase
  development gains, aggravating poverty and inequality.  World Bank Group estimates
  showed that the Ebola epidemic in West Africa in 2014-2015 severely weakened the
  economies of the affected countries (World Bank, 2015).  The three affected countries were
  growing briskly in the rst half of 2014, but full-year 2014 growth dropped to an estimated 0.5
  percent in Guinea, although a growth rate of 4.5 percent was expected before the crisis. In
  Liberia it fell to an estimated 2.2 percent from 5.9 percent expected before the crisis and, in
  Sierra Leone, it fell to 4.0 percent from 11.3 percent expected before the crisis. While these
  rates already imply shrinking economies in the second half of 2014, the estimates showed that
  second-round effects and investor aversion led to a 2015 growth of -0.2 percent in Guinea,
  3.0 percent in Liberia, and -2.0 percent in Sierra Leone. The estimates imply foregone
  income of about US$1.6 billion across the three countries in 2015 alone. This is more than
  12 percent of their combined GDP and has translated into weaker revenues, while
  government spending needs grew, with a severe negative impact on public nances that
  may derail country investments needed to attain the Sustainable Development Goals (SDG)
  by 2030.  Besides the nancial cost posed by these disease outbreaks, human capital
  development stand to be affected due to the loss of lives, particularly of health workers who
  were infected and died in the line of duty.

  While the world is nowadays concerned about the Covid-19 spread, with an increasing
  number of countries reporting new cases and deaths (as of today, 48 countries, 82,700
  infected people per of cial counts, and at least 2,809 people have died, all but 65 in mainland
  China), it is important to understand how this public health crisis is starting to impact
  economic activity globally.  As assessed in a Financial Times (FT) article (Greene, M, 2020),
  one transmission mechanism from China’s coronavirus is the interruptions to global supply
  chains which may cause problems for growth and international markets.  While the Chinese
  government has adopted measures to mitigate the impact on rms and households in the
  country, the resumption of activity may be hindered by bottlenecks caused by depleted
  inventories, delays in reopening factories, return of workers to places of work, reactivation of
  transport, and the reopening of ports.  Given that Chinese rms are integrated into
  “complex, global supply chains” and western rms depend on Chinese inputs for their
  production lines, the disruptions in China may cause rms in other countries to look for new
  suppliers (not an easy task), halt production as it already happened with Korean rms
  Hyundai and Kia, or simply go out of business.  On the latter point, it is important to observe,
  as highlighted in the FT article, that Hubei, the epicenter of the Covid-19 outbreak in China,
  is a “cog” in global supply chain in cars, health care, electronics, aerospace and defense, and
  construction materials.




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  In the nancial markets, fear of a potential hard hit to economic growth and markets if the
  virus becomes a full-blown global pandemic, is behind the stock market plunge in global
  markets as investors continued to dump stocks and seek safer investments.  In the United
  States, for example, the S&P 500 index plunged to its worst loss in almost nine years and
  investors worldwide grew increasingly fearful that the coronavirus outbreak could cause a
  recession as it squeezes corporate pro ts (New York Times, 2020). European stocks were also
  trading about 2.5 percent lower after the Nikkei in Japan closed down 2.1 percent. Oil prices
  have also fallen, while the price of gold rose, signaling continued nervousness among global
  investors.

  The New York Times (Phillips, M, 2020) is also reporting that the outbreak has taken a toll
  on multinational companies.  For instance, Anheuser-Busch InBev is forecasting a steep drop
  in quarterly pro t, which led to sharp drop in the value of its shares, while Marriott, the
  American hotel company, reported that the virus would weigh on its fee revenue this year.
  Shares of Microsoft, the most valuable company in the United States, fell 7 percent after the
  company announced that sales in the current quarter would be lower because of the
  outbreak’s effect on its supply chain. Companies such as the French cosmetics giant L’Oréal,
  and Nestlé, the Swiss-based food company, have announced that they are suspending all
  international business for their staff until the end of March. The outbreak could crush
  consumer demand as well, as people limit travel or stay home even without a government
  order to do so, aggravating economic performance.

  What to Do?

  A question to pose is what can countries do to contain and mitigate the health, social, and
  economic damage of the COVID-19 pandemic?

  Dr. Tom Frieden (2020), the former director of the US CDC, has outlined some immediate
  and medium-term actions to deal with the initiation and acceleration phases of the
  pandemic.  A summary of these actions is as follows:

        Find out more about how Covid-19 spreads, how deadly it is, and what we can do to
        reduce its harms. This information is critical as it would guide decisions about the
        interventions to implement.  
        Reduce the number of people who get infected.  The spread of the virus can be minimized
        by quickly isolating those who are ill, cleaning potentially contaminated surfaces often,
        and changing common routines. And the promotion and adoption of well-known hygienic
        habits such as washing hands, covering coughs, and, if a person is sick, staying home or
        wearing a mask. If it turns out that many of those infected become severely ill, drastic
        social distancing measures such as closing or curtailing hours of schools, limiting public
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        gatherings, and reducing social contact may be warranted. We also need to keep in mind,
        as advised by Dr. Anthony S. Fauci, director of the US National Institute of Allergy and
        Infectious Diseases, that travel restrictions become ‘irrelevant’ in a potential pandemic
        because “you can’t keep out the entire world” (Higgins-Dunn, 2020).
        Protect health care workers. As witnessed during the West Africa Ebola epidemic of 2014-
        2015, a large number of health workers and patients got infections in health care facilities.
        To prevent this occurrence, fast and drastic improvements in triage, treatment, cleaning,
        and overall infection prevention are required, including ensuring that enough medical
        masks are available for health care workers.
        Improve medical care and prevention of Covid-19. Since a vaccine is not yet available,
        preparation for a worst-case scenario will require training, equipment, and detailed
        operational plans for a surge in the number of patients who seek care and for the subset of
        those who need to be mechanically ventilated. 
        Protect health services. During the 2014-2016 Ebola epidemic in West Africa, more people
        died because of disruptions in day-to-day health care than died from Ebola. Telemedicine
        needs to become much more accessible, and people with chronic conditions should
        receive three months of medications whenever possible, in case there are supply
        disruptions. Routine vaccinations and other preventive services need to be preserved.
        Support social needs. Patients and their families will need support, especially those who
        are isolated and less familiar with virtual social support or delivery services.
        Protect economic stability. Continuing to plan, teach, learn, and work will reduce
        disruption. Businesses need to be ready to maximize telecommuting, increase cross-
        training, and operate with as many as 40 percent of their staff ill or quarantined. Mission-
        critical enterprises need practical plans to continue to operate.

  The Medium-Term Task

  Assuming that the world learns from this new disease outbreak, investment and recurrent-
  cost funding for veterinary and public health structures and functions in accordance with
  one-health principles, coupled with timely access to essential medical care for all when
  needed, are an inescapable budgetary priority for all countries to reduce vulnerability and
  build resilience to deal effectively with zoonotic diseases that account for 70 percent of
  emerging infectious diseases. Indeed, a collaborative, international, cross-sectoral,
  multidisciplinary one-health is required to address threats and reduce risks of detrimental
  infectious diseases at the animal-human-ecosystem interfaces.

  Let’s be clear:  globalization is not going to wither away, as it has been part of human history
  for millennia.  Rather, we are and will continue to live in an increasingly interconnected
  world.  While there are multiple bene ts from globalization, there are also public health risks

www.pvmarquez.com/coronavirus                                                                                                             5/8
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  that are associated with demographic and economic pressures on ecosystems that facilitate
  the transmission of new pathogens from animals to humans.  

   Moving forward, as a colleague from the World Bank Group mentioned to me today, we need
   to work hard to ensure that public health investment becomes ingrained in the DNA of
   country budgets and in the support programs of bilateral and multilateral organizations, as
   well as of private donors.  Neglecting to invest in public health will lead to new uncontrolled
   infectious disease outbreaks, preventable deaths, and signi cant economic losses.  

   To this end, echoing a suggestion that I recently made, it would be critical that institutions
   such as the World Bank Group and the International Monetary Fund spearhead efforts to
   include robust, well-structured and -funded veterinary and public health platforms, including
   disease surveillance and preparedness and essential medical care for all, as a critical
   indicator in country credit and investment risk assessments ratings, which are used to
   determine nancing terms and conditions of of cially supported export credits, as well as
   for commercial loans and direct investment decisions by nancial and corporate sectors
   (Marquez, PV 2020)  This type of institutional “nudge” at the international level is needed to
   prevent governments, along with other global stakeholders, from forgetting the lessons of
   recent disease outbreaks, with their associated high human toll and signi cant economic
   losses.

   Although the task at hand is dif cult and will require sustained effort over the medium- and
   longer terms, particularly in low- and lower-middle-income countries, it can be
   accomplished if we start acting now.

   As the saying goes, a crisis poses challenges but also offers opportunities to learn and
   evolve.  All of us in the global health community have an obligation not only to learn from the
   current coronavirus outbreak and what has worked before but to avoid, paraphrasing the
   Harvard philosopher George Santayana, being condemned to face unprepared similar crises
   in the future.

   Source of images:


   First Image:  Financial Times (FT Weekend), February 22/23 2020


   Second Image: Coronavirus Map: Tracking the Spread of the Outbreak, New York Times; data
   from The Center for Systems Science and Engineering at Johns Hopkins University; National
   Health Commission of the People's Republic of China; local governments. Data as of 9 30 p.m.
   E.T., Feb. 27, 2020.  

www.pvmarquez.com/coronavirus                                                                                                             6/8
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  Sources
  Frieden, T. 2020. “Former CDC director: A coronavirus pandemic is inevitable. W…
  (https://edition.cnn.com/2020/02/25/health/coronavirus-pandemic-frieden/index.html)
  Garrett, TA. 2007. “Economic Effects of the 1918 In uenza Pandemic. Implicatio…
  (https://www.stlouisfed.org/~/media/ les/pdfs/community-development/research-
  reports/pandemic_ u_report.pdf?la=en)
  Garrett, TA. 2008. “Pandemic Economics: The 1918 In uenza and Its Modern-Day I…
  (https:// les.stlouisfed.org/ les/htdocs/publications/review/08/03/Garrett.pdf)
  Greene, M. 2020. “Investors risk underestimating the impact of coronavirus.” F…
  (https://www.ft.com/content/44c9391c-5489-11ea-a1ef-da1721a0541e)
  Higgins-Dunn, N. 2020. “Travel restrictions ‘irrelevant’ if coronavirus becomes…
  (https://www.cnbc.com/2020/02/26/fauci-travel-restrictions-irrelevant-if-coronavirus-
  becomes-a-pandemic.html)
  Institute of Medicine. 2004. “Learning from SARS: Preparing for the Next Diseas…
  (https://www.nap.edu/catalog/10915/learning-from-sars-preparing-for-the-next-disease-
  outbreak-workshop)
  Marquez, PV. 2015. “Regional Disease Surveillance in a Globalized World.” World…
  (https://blogs.worldbank.org/health/regional-disease-surveillance-globalized-world)
  Marquez, PV. 2020 “Public Health Investments and Economic Gains: Learning from …
  (http://www.pvmarquez.com/disease_control)
  Phillips, M, 2020. “Coronavirus Fears Drive Stocks Down for 6th Day and Into C…
  (https://www.nytimes.com/2020/02/27/business/stock-market-coronavirus.html)
  Philipson, TJ. 2007. “Economic Epidemiology and Infectious Diseases.” NBER work…
  (https://books.google.com/books/about/Economic_Epidemiology_and_Infectious_Dis.html?
  id=iMUxAAAAMAAJ)
  Jong-Wha Lee, J-W and McKibbin, WJ. “Estimating the Global Economic Cost of SA…
  (https://www.nap.edu/catalog/10915/learning-from-sars-preparing-for-the-next-disease-
  outbreak-workshop)
  World Bank Group. 2015. “The economic impact of Ebola on sub-Saharan Africa: up…
  (http://documents.worldbank.org/curated/en/2015/01/23831803/economic-impact-ebola-
  sub-saharan-africa-updated-estimates-2015)




www.pvmarquez.com/coronavirus                                                                                                             7/8
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www.pvmarquez.com/coronavirus                                                                                                             8/8
1/12/2021         Public Health Investments and Economic Gains: Learning from Latin America and Caribbean History in the Time of Coronavirus | Patricio V. Marquez




  Public Health Investments and Economic Gains: Learning
  from Latin America and Caribbean History in the Time of
  Coronavirus
  Submitted by Patricio V. Marquez on Mon, 02/10/2020 - 05 41 PM




  Public Health Investments and Economic Gains: Learning
  from Latin America and Caribbean History in the Time of
  Coronavirus
  Posted by Patricio V. Marquez on Mon, 02/10/2020 - 05 41 PM




  With the advent of 2019-nCoV in China, the world has woken up once again to the inexorable reality that
  globalization, both the movement of people and goods and services across countries and from continent to
  continent, enables the spread of viruses and disease.  

  While the coronavirus appears to be more infectious than SARS but less lethal, it is already creating global
  havoc.  As the number of cases increases in China, and new cases are detected and con rmed in different countries,
  airlines have cancelled ights to and from China, the global economy is taking a hit, and fear among the population
  is rising.  The World Health Organization (WHO) with support of social media companies is stepping up its ght
  against “disinformation” and “fearmongering.”   Countries are also starting to issue calls that the virus is a “serious”
  health threat. 

  All this seems like the rerun of an old movie.  I remember vividly the days when working at the World Bank Group
  (I retired in August 2019 after 32 years of service globally), I was part of quickly assembled core task teams that were
  mandated to prepare in a matter of days, program and budgetary proposals that eventually became the US$1.3
  billion Global Avian In uenza Preparedness and Control Framework Program in 2006 and the US$390 million Ebola
  Emergency Response Program for West Africa in 2014.  In those days as today with coronavirus, panic and
  uncertainty in different forms were common currency.



www.pvmarquez.com/disease_control                                                                                                                               1/5
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  The question that we need to ask as these health events are not something new, is what have countries learned to
  be ready to deal with these threats?  Unfortunately, in many instances, it seems that once the sense of fear has
  diminished and the outbreak controlled, it is back to the common practice of undervaluing the importance of having
  in place strong “intelligence systems” in the form of disease surveillance systems, public health labs, and trained
  personnel, both in the veterinary and public health sectors operating in a coordinated manner.  It is clear that all
  countries need to have in place robust early detection and con rmation of cases, as well as preparedness platforms,
  including medical care systems, along a continuum of action, to deal on time and effectively with disease outbreaks. 
  Perhaps the most common “fatality” post-disease outbreaks is the lack of predictable and sustained funding for
  disease surveillance and emergency preparedness in national budgets that are protected from budgetary cuts that
  follow short-term “ scal rectitude” arguments or changing investment priorities that are assumed to have a higher-
  rate of return.

  Some Historical Antecedents

  If we look back in history, there are plenty of examples that illustrate that this should not be the case. History shows
  that travelers have spread contagious diseases for centuries. At the same time, the threat of disease has been a
  driver for supporting the continuous development of global public health practices and institutions, building
  upon accumulated and new scienti c knowledge and technological know-how.  The history of public health in
  Latin America and the Caribbean, for example, is replete with efforts in sanitation, hygiene, and disease control,
  especially directed at old scourges such as yellow fever and malaria.

  Since colonial times, outbreaks of disease were common in the countries of Latin America and the Caribbean,
  largely as a result of maritime trade and export of agricultural products and minerals that helped integrate them
  into the world economy, as well as the development of indigenous commercial interests. In 1515, a smallpox epidemic
  in Hispaniola—now the Dominican Republic and Haiti—spread to neighboring islands and to the mainland, leaving a
  toll of thousands of victims.  This episode was to be registered as the rst epidemic in the colonial period.  In the
  sixteenth and following centuries, epidemics of different kinds made devastating sweeps across the Americas.

  As the spread of disease largely re ected the maritime basis for trade among the colonies, and between the colonies
  and the metropolitan powers, such as Spain and Portugal, the principles of isolation and con nement followed in
  Europe to control disease outbreaks, were also applied in Latin America and the Caribbean.  In practice, beginning in
  Hispaniola in 1519, in accordance with the 1423 Venetian quarantine control system, measures to cope with
  epidemics centered on the detention of ships and the isolation of their crews and passengers outside the harbors
  until suf cient time had elapsed without the outbreak of “pestilences.”

  The latter years of the 19th Century and the early 20th Century saw various attempts by the Latin American and
  Caribbean countries and the United States to adopt uniform quarantine regulations at different international
  conferences, under the aegis of the newly established Pan American Sanitary Bureau in 1902, that preceded the
  establishment of WHO. These sought to remove barriers to steam navigation, and to codify new preventive
  measures into specific health legislation and programs based on the great microbiological discoveries of Pasteur,
  Koch, and Klebs that had revolutionized public health practice in Europe.

  From 1880 to 1930, national health departments, the forerunners of the present-day ministries of health, were
  created within the ministries of the interior in most Latin America countries. The initial mission of these
  departments was to combat the infectious diseases that hampered maritime trade in major port cities and
  diminished labor productivity in the countries' export-oriented economies, resting on the acceptance and
  application of the germ theory in disease causation that was supported by leading Latin American scientists such as
  the Brazilians Oswaldo Cruz and Carlos Chagas, the Cuban Carlos J. Finlay, as well as Walter Reed and others in the
  United States. As a result of these efforts, great inroads were made in the conquest of many of the diseases that had
www.pvmarquez.com/disease_control                                                                                                                               2/5
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  warranted quarantine, particularly yellow fever, commonly known as “Yellow Jack”. This represented the principal
  scourge of international trade throughout the colonial period, up to the beginning of the 20th Century. As a result of
  these efforts, yellow fever disappeared from its well-established foci, Havana, Panama, and Guayaquil.

  The completion of the Panama Canal in 1914 was only possible because of the success of major public health
  efforts against yellow fever and malaria, diseases that took a heavy toll in terms of lives lost among construction
  workers. In turn, the activities undertaken to help build the canal added further impetus to the development of
  sanitation programs in the countries of the region by supporting research on the etiology and transmission of
  yellow fever and malaria which led to the design of more effective control measures.

  In subsequent periods, the activities of the national health departments expanded with the support of the
  International Health Commission of the Rockefeller Foundation to undertake land sanitation programs centered
  on the control of hookworm infection and malaria, with the aim of improving the productivity of workers in
  exporting regions, such as those growing bananas and coffee.  The support of the Rockefeller Foundation was also
  important for the establishment in 1918 of the School of Public Health, University of São Paulo, following the
  example of the Johns Hopkins School of Hygiene and Public Health in Baltimore that was founded in 1916 also with a
  grant from the Foundation.  Additionally, the Foundation provided fellowships for the training of Latin American
  public health cadres (for example, epidemiologists, biostatisticians) to staff the departments, manage public health
  programs, and conduct public health research.

  During the 1930s and 1940s, changing economic and socio-political conditions led to the elevation of the health
  departments to the ministry level and the concurrent expansion of their activities to include the provision of
  personal health services for the unemployed and indigent populations. Similarly, the development of medical care
  programs under social insurance schemes was directly linked to the process of industrialization. In satisfying the
  demands of organized labor forces, these programs served as an important mechanism of social stabilization.  In the
  last three decades of the 20th Century and in the early 21st Century, the most important public health achievements
  in the Latin American and the Caribbean region have continued to be in the areas of infectious disease control. 
  Mortality rates have declined in virtually every country of the Americas, mainly at the expense of important declines
  in infectious diseases.

  Take-Away Message

  As we have seen throughout history, infectious diseases have recurrent patterns of outbreak and control or silent
  occurrence due to ecologic variables that are often difficult to manage, mainly because of social, political, and
  economic limitations on the application of known, effective measures for controlling their spread and treating
  infected people.  The recent outbreaks of infectious disease in the world clearly signal the need, as we saw from
  the historical examples in Latin America and the Caribbean, of building and maintaining strong institutions and
  systems to prevent the spread of infectious diseases and protect public health and the social and economic well-
  being of countries in an ever more interconnected world.  And this risk stands to be more menacing in the face of
  inaction and misplaced social and economic priorities when one adds the risks posed by rapid urbanization and the
  conglomeration of people living in large mega-cities with limited access to basic services, climate change that is
  driving the emergence of new pathogens such as the coronavirus and the reemergence of known pathogens such as
  Ebola, social con ict and wars that not only breed social dislocation and the displacement of large numbers of
  people, but also that hinder public health action, and massive disruption of global supply chains in interconnected
  economies.

  Indeed, commitment to public health objectives and program needs to be firmly entrenched in the development
  programs of governments and supported with the necessary budgetary allocations in a sustainable way.
   Financing essential public health functions is a government responsibility as it a basic public good.  In most of the
www.pvmarquez.com/disease_control                                                                                                                               3/5
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  world, however, misplaced priorities translate into very low budgetary allocations for essential public health
  functions, sometimes amounting to less than 1% of the total public expenditure on health. 

  While donor contributions help, particularly in low-income countries, governments can mobilize additional tax
  revenue as a share of GDP to fund and sustain public health and essential medical care services via better tax
  administration (including value-added taxes), tackling tax avoidance and evasion (e.g., taxing nancial capital ows),
  broadening the tax base by removing cost-ineffective tax expenditures (e.g., fuel subsidies), and increasing excise
  taxes on unhealthy products (including on tobacco, alcohol, and sugar-sweetened drinks).  This is needed, as clearly
  articulated in a recent article in Foreign Affairs by Nobel Laurate in Economics, Joseph E. Stiglitz and two of his
  colleagues, because

  “The state requires something simple to perform its multiple roles: revenue. It takes money to build roads and ports, to
  provide education for the young and health care for the sick, to nance the basic research that is the wellspring of all
  progress, and to staff the bureaucracies that keep societies and economies in motion. No successful market can survive
  without the underpinnings of a strong, functioning state.”

  So, it would be critical that institutions such as the World Bank Group and the International Monetary Fund
  spearhead efforts to include robust, well structured and funded public health platforms, including disease
  surveillance and preparedness, as a critical indicator in country credit and investment risk assessments ratings,
  which are used to determine nancing terms and conditions of of cially supported export credits, as well as for
  commercial loans and direct investment decisions by nancial and corporate sectors.  This type of institutional
  “nudge” at the international level is needed to prevent governments, along with other global stakeholders, from
  forgetting the lessons of recent disease outbreaks, with their associated high human toll and signi cant economic
  losses.

   

  The PHOTOGRAPH taken in 1918 at the US Army Hospital Number 30 in Royat, France, is from the Prints and
  Photographs Collection, History of Medicine Division, National Library of Medicine.  It was included in Fee E et al
  article (2001).  The pictures shows servicemen watching a movie during the In uenza Pandemic spread worldwide
  through 1918–1919. The article notes that “while a civilian debate raged over the compulsory wearing of masks as a
  means of slowing the transmission of in uenza, military authorities through the chain of command were more readily
  able to impose this requirement on the troops.” (Fee, Brown, Lazarus, Theerman, 2001). 

  The second photo is from https://www.dominicavibes.dm/wp-content/uploads/2016/07/pp-zika-mosquitos-
  getty.jpg 

   

   
  Sources
  Fee E, Brown TM, Lazarus J, and Theerman P. 2001. “The In uenza Pandemic of 1…
  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1446912/)
  Garcia JC. 1981. “La Medicina Estatal en America Latin, 1880-1930.” Revista Lat…
  (https://www.researchgate.net/publication/257074716_Social_thinking_in_health_in_Latin_America_revisiting_Ju
  Marquez PV, Joly DA. 1986. “Historical Overview of the Ministries of Public Hea… (https://doi.org/10.2307/3342464)
  Stiglitz JE, Tucker TN, and Zucman G. “The Starving State Why Capitalism’s Salv…
  (https://www.foreignaffairs.com/articles/united-states/2019-12-10/starving-state)

www.pvmarquez.com/disease_control                                                                                                                               4/5
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www.pvmarquez.com/disease_control                                                                                                                               5/5
1/12/2021                   Galapagos’ Charles Darwin Foundation: An International Good Practice that Needs to be Supported | Patricio V. Marquez




   Galapagos’ Charles Darwin Foundation:
   An International Good Practice that
   Needs to be Supported
   Submitted by Patricio V. Marquez on Fri, 02/07/2020 - 07 46 PM




   Galapagos’ Charles Darwin
   Foundation: An International Good
   Practice that Needs to be Supported
   Posted by Patricio V. Marquez on Fri, 02/07/2020 - 07 46 PM




   A couple of weeks ago, I had the honor of being invited by the Charles
   Darwin Foundation (CDF) to the screening of a new documentary directed
   by Evert van den Bos, Galapagos, Hope for the Future. It was held in New



www.pvmarquez.com/Galapagos_CDF                                                                                                                     1/10
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   York City as part of a meeting of the Foundation’s Board of Directors, which
   offered me the opportunity to meet some of the members and learn more
   about its work.

   In watching the documentary, I was greatly struck once again by the sheer
   beauty of these desolate islands and their unique animals and plants.  The
   documentary also presents with great clarity how, on a daily basis, teams of
   the Foundation and its Research Station, working alongside teams of the
   Galapagos National Park Service, conduct vital scienti c research and
   complementary action to ensure the conservation of the environment and
   biodiversity in the Galapagos Archipelago.

   The Archipelago, located in the Paci c Ocean off the coast of Ecuador, is a
   UNESCO World Natural Heritage Site.  Figuratively speaking, the Galapagos
   were “put on the map” and became a magnet of international curiosity and
   scienti c interest, with the publication in 1858 of Charles Darwin’s
   groundbreaking work of evolutionary biology, On the Origin of the Species. 
   Indeed, Darwin’s visit to some of the islands in the Archipelago during his
   expedition on the HMS Beagle in 1835 helped him collect evidence of
   evolution in the diversity of the Galapagos species that led to his
   observation that species descending from a common ancestor evolve over
   many generations through a process of natural selection (the process
   whereby organisms better adapted to their environment tend to survive and
   produce more offspring).

   In 1959, the Government of Ecuador designated all parts of the islands that
   were not inhabited by humans as a National Park (96% of the total
   archipelago’s surface area). The same year, the Charles Darwin Foundation
   was created, and in 1964, the Charles Darwin Research Station opened to
   conduct scienti c studies aimed at protecting indigenous plant and animal
   life. In 1968, the Galapagos National Park Service, a governmental
   institution, was established to protect the Archipelago. 
www.pvmarquez.com/Galapagos_CDF                                                                                                                     2/10
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   Institutions, such as foundations, can play a major role in a society.  Over the
   past 60 years, the CDF, operating with limited resources, has become a
   beacon of international good practice, offering valuable lessons for the rest
   of the world.  The vision statement of the CDF clearly illustrates how this
   type of role can be operationalized for the common good: “to contribute to
   a sustainable Galapagos by providing breakthrough research which informs
   conservation actions and inspires humanity to conserve this extraordinary
   Archipelago and our planet as a whole.”

   As shown in the documentary and described in the CDF’s most recent
   Annual Report, the range and value of the work conducted and supported by
   the Foundation are outstanding.  With a small team of staff and volunteers
   (about 217 people), the Foundation oversees and supports work by scholars
   and thesis students, both Ecuadorean and from other countries; visiting
   scientists developing their own projects with a research permit issued by
   the Galapagos National Park; and collaborating scientists who carry out
   projects linked to CDF projects. 

   The research includes marine projects as varied as the study of the status
   of the Galapagos penguin, ightless cormorant, and albatross populations;
   research on marine invasive species for the prevention, detection, and
   management of the Galapagos Marine Reserve (GMR); exploring and
   surveying seamounts and other deep water environments between depths
   of 40 to 3200 meters in the GMR ; and studies to reduce the threat of vessel
   impact for the green turtle in the Islands.   

   Terrestrial ecosystem research projects include research on ecological
   restoration and sustainable agriculture; analysis of satellite images and
   drone image processing to map the expansion of invasive plant species;
   restoration of scalesia forests, which have a very high biodiversity of
   associated plants, birds, and invertebrates, compared to other ecosystems in
   the Galapagos; and assessment of the health status of giant tortoise across a
www.pvmarquez.com/Galapagos_CDF                                                                                                                     3/10
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   human-modi ed environment. The latter study is looking in depth at the
   impact on the giant tortoise population of the cohabitation between
   tortoises, domestic animals, and humans in the islands that are inhabited by
   humans in terms of the spread of diseases and antimicrobial resistance that
   can pose a risk for the conservation of this unique species. 

   The CDF’s work also includes critical communication, outreach, and
   extension work, such as the Sharks Ambassadors education initiative
   program for high school-aged students, that focuses on shark conservation. 
   In terms of knowledge management, the CDF is custodian of four Natural
   History Collections—Herbarium (CDS), Terrestrial Invertebrates (ICCDRS);
   Marine Invertebrates (MCCDRS); and Vertebrates (VCCDRS)—which
   constitute the largest collections of endemic, native, and exotic species of
   the Galapagos in the world.  The library of the CDF is the main bibliographic
   repository of the Scienti c Station and also manages the archival materials. 
   Additionally, resources from the CDF fund conservation activities, such as
   the mangrove nch project, aimed to conserve this species and prevent its
   disappearance (there are currently only around 100 individuals left in the
   world). 

   The operation and work of the CDF relies 100 percent on private support
   from individuals, institutions, and corporations.  Therefore, for all of us
   interested in preserving the unique ecosystem of the Galapagos Archipelago
   as our legacy to future generations, a priority challenge is nancial resource
   mobilization to ensure predictable and sustainable funding for the CDF.  

   How can this be done in the short- and medium-terms? 

   An expansion and diversi cation of the CDF’s funding sources is perhaps
   required, involving both earmarked Ecuadorian Government contributions
   and private donations, for the implementation of a results-oriented
   medium-term strategy and action plan for the CDF.

www.pvmarquez.com/Galapagos_CDF                                                                                                                     4/10
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   First, in Ecuador, as in other countries, there is the potential to mobilize
   more in taxes as a share of GDP via better tax administration (including
   value-added taxes), tackling tax avoidance and evasion, broadening the tax
   base by removing cost-ineffective tax expenditures, and increasing excise
   taxes on unhealthy products (including on tobacco, alcohol, and sugar-
   sweetened drinks), and where feasible, some of which can ow to expand
     scal space for conservation work under the CDF and the Galapagos
   National Park. 

   Second, the national effort could be complemented with the establishment
   of dedicated trust funds with grant resources mobilized from ecological
   conservation and climate action-oriented governments in high-income
   countries.  The allocation of trust fund resources could be linked to the
   achievement of pre-de ned activities and results, such as the development
   of a monitoring program to assess the threat posed by marine plastic debris
   as potential transport for introducing non-native species that could become
   invasive and harmful to the ecosystem in the Islands.

   Third, with the support of the Government of Ecuador, grant resources for
   global public goods available under existing mechanisms in multilateral
    nance institutions such as the World Bank Group and the Inter-American
   Development Bank, could be explored and invite technical proposals from
   the CDF for consideration by these organizations.

   Fourth, diversi cation of private funding will be crucial.  Different
   foundations and philanthropies could be tapped to support the CDF as
   some of them are already committed to support the achievement of the
   Sustainable Development Goals (SDGs) of the United Nations by 2030, and
   the work of the CDF is focused on supporting the achievement of several
   SDGs’ economic, environmental, and social targets.  Entities such as the
   Bloomberg Philanthropies, The Bill and Melinda Gates Foundation, The
   Nippon Foundation, The Rockefeller Foundation, and The Carlos Slim

www.pvmarquez.com/Galapagos_CDF                                                                                                                     5/10
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   Foundation, are only a small sample of possible additional sources for
   diversifying CDF funding.  Donations from wealthy individuals, both in
   Ecuador and at the international level, and the general public could help to
   mobilize nancial support as well.

   Fifth, in pursuing active resource mobilization options, raising the pro le of
   the CDF and educating different stakeholders about the results and impact
   of its conservation work will be required.  Events organized by institutions
   such as the Salzburg Global Seminar and the World Economic Forum, as well
   as the Annual Meetings of the World Bank Group/International Monetary
   Fund, could serve as potential venues for information, communication, and
   education efforts geared to mobilize commitments and support from
   different international stakeholders.

   Naturally, any increase in funding levels would need to be accompanied by
   strong administrative and nancial arrangements at the CDF, complemented
   by robust monitoring, evaluation, and reporting mechanisms on resource
   use, activities undertaken, results, and impact achieved.

   Looking forward

   The preservation of World Natural Heritages sites, such as the Galapagos
   Archipelago, depends on the active and dedicated mobilization of support
   from a broad group of committed stakeholders, both in Ecuador and across
   the world.  If done ef ciently and effectively, this effort would help to ensure
   that the bene ts of this global public good will not be limited to the current
   generations but will also be for the enjoyment of future generations as our
   lasting legacy to them.  In doing so, we will be contributing to preserve the
   unique “natural history” of these islands, where, as observed by Charles
   Darwin in The Voyage of the Beagle:



www.pvmarquez.com/Galapagos_CDF                                                                                                                     6/10
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   “Most of the organic productions are aboriginal creations, found nowhere else;
   there is even a difference between the inhabitants of the different islands; yet
   all show a marked relationship with those of America, though separated from
   the continent by an open space of ocean, between 500 and 600 miles in width. 
   The archipelago is a little world within itself, or rather a satellite attached to
   America, whence it has derived a few stray colonists, and has received the
   general character of its indigenous productions.  Considering the small size of
   the islands, we feel the more astonished at the number of their aboriginal
   beings, and at their con ned range.  Seeing every height crowned with its
   crater, and the boundaries of most of the lava-streams still distinct, we are
   led to believe that within a period geologically recent the unbroken ocean was
   here spread out.  Hence, both in space and time, we seem to be brought
   somewhat near to the great fact—the mystery of mysteries—the rst
   appearances of new beings on this earth.”

   Contact information:

   Charles Darwin Foundation for the Galapagos Islands

   Puerto Ayora, Santa Cruz, Galapagos, Ecuador

   T: +593 (5) 2526 146

   E: cdrs@fcdarwin.org.ec (mailto:cdrs@fcdarwin.org.ec)

   W: www.darwinfoundation.org (http://www.darwinfoundation.org)

   PP Box 17-1-3891 Quito, Ecuador

    

   To make a donation:
www.pvmarquez.com/Galapagos_CDF                                                                                                                     7/10
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www.pvmarquez.com/Galapagos_CDF                                                                                                                     8/10
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www.pvmarquez.com/Galapagos_CDF                                                                                                                     9/10
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   Common Myths Against Tobacco Taxation:
   Not Borne Out by Global Evidence
   Submitted by Patricio V. Marquez on Sun, 02/02/2020 - 02 39 PM




   Common Myths Against Tobacco Taxation:
   Not Borne Out by Global Evidence
   Posted by Patricio V. Marquez on Sun, 02/02/2020 - 02 39 PM




   The newly-released Smoking Cessation: A Report of the Surgeon General of the United
   States (U.S. Department of Health and Human Services, 2020) reaf rms, on the basis of
   accumulated scienti c evidence over the past half century, that tobacco use leads to
   many adverse health effects, including negative reproductive health outcomes,

www.pvmarquez.com/tobacco_taxes                                                                                                   1/13
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   cardiovascular diseases, chronic obstructive pulmonary disease, and the risk of twelve
   cancers, including cancers of the lung; larynx; oral cavity and pharynx; esophagus;
   pancreas; bladder; stomach; colon and rectum; liver; cervix; kidney; and acute myeloid
   leukemia. The report is also clear in indicating that smoking cessation can be increased
   by raising the price of cigarettes.

   It is frequent, however, to come across common claims put forward by interest groups
   that oppose the enactment of tobacco tax policies.  These claims are often accepted
   uncritically by policy makers in countries at different income levels, without due
   consideration of available evidence. The question that we need to ask, then, is how do
   these claims stand vis-à-vis accumulated global evidence?  Are these claims part and
   parcel of the “economics of deception and manipulation” that drive aggressive
   industry-sponsored campaigns in the pursuit of pro ts and market share expansion? 
   Have the claims become just myths not borne out by accumulated country evidence?

   The results of recent research done by World Bank Group teams across the world,
   along with additional data and information, are presented below to shed light on these
   questions. 

   Myth 1 Raising tobacco taxes undermines the tax base and lowers tobacco tax
   revenue.

   Evidence:  A report from the International Monetary Fund (Petit and Nagy, 2016) is
   clear in indicating that “in many countries, raising tobacco taxes can offer a “win–win”:
   higher revenue and positive health outcomes.”  Higher tobacco taxes help boost
   cigarette prices, which are highly effective in reducing demand, which reduce use and
   the health risks associated with smoking. The positive impacts of higher tobacco taxes
   and prices go beyond direct health gains and indirect bene ts such as reduced health
   care expenditures and higher productivity. Increasing tobacco taxes can also enlarge a
   country’s tax base to augment domestic resource mobilization to fund priority
   investments and programs, including the expansion of universal health coverage. 

   The experience of the Philippines since the adoption of the Sin Tax Law of 2012 is one
   of the most compelling examples of ambitious national tobacco tax reform, including
   reduction in the number of tax tiers, indexation of tax rates to in ation, and substantial
   tax increases.  As shown in Figure 1, excise tax revenue on tobacco and alcohol products
   has more than doubled since 2012, reaching US$5.2 billion in additional revenues during
www.pvmarquez.com/tobacco_taxes                                                                                                   2/13
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   the rst 4 years of the Sin Tax Law implementation (about 1 percent of GDP). Tobacco
   accounts for about 80 percent of these additional tax revenues, which largely are
   earmarked under the budget to subsidize health insurance for low-income populations
   (Kaiser, Bredenkamp and Iglesias, 2016).




   The experience of Ukraine is also noteworthy (Smits et al 2017). The total tax burden
   (including excise taxes, value-added tax [VAT], and other duties on tobacco as a
   percentage of retail price) increased from 62 percent in 2015 to 77 percent in 2019.  As a
   result, national tobacco excise revenue increased from 22 billion UAH in 2015 (1.12% of
   GDP) to 40 billion UAH in 2018 (1.34% of GDP) (see Figure 2). 




   Moldova has also been able to collect additional tax revenue since 2017 from hiking
   tobacco taxes (Marquez et al, 2018).  Cigarette excise tax revenue in the country
   increased from MDL 1.73 billion (US$ 87 million) in 2016 to MDL 2.05 billion (US$ 110.6
   million) in 2017, or about 1.16 percent of Moldova’s GDP. The tobacco tax increases
   adopted by Moldova’s Parliament for 2018-2020 are projected to further increase excise
   tax revenue, hitting 3.31 billion MDL (US$194 million) or 1.45 percent of GDP in 2020. 

www.pvmarquez.com/tobacco_taxes                                                                                                   3/13
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   Colombia is another example (James et al, 2017). As part of a broad scal reform
   package approved by Colombia’s Congress on December 23, 2016, the speci c excise
   tax on a pack of 20 cigarettes was increased from COP 700 (US$ 0.25) in 2016 to COP
   1,400 (US$ 0.50) in 2017, and COP 2,100 (US$ 0.75) in 2018, with annual adjustments of
   Consumer Price Index (CPI) + 4 points in subsequent years. The ad valorem excise tax
   component was maintained at 10 percent of the total sale price of a 20-cigarette pack,
   and the general VAT rate was raised from 16 percent to 19 percent. As a result, the total
   tax burden (as percentage of retail price of a pack of 20 cigarettes) increased from 50
   percent in 2016 to 68 percent in 2018. The average price of a pack of 20 cigarettes
   increased by 42.5 percent over 2017-2018. The expected scal and health impacts of this
   measure are noteworthy. It is estimated that COP 1 trillion (about US$ 347 million) in
   additional revenue will be generated through 2022.

   The experience of Australia, United States, and the United Kingdom (UK) provide
   additional evidence (Fuchs, Marquez, Dutta, Gonzalez Icaza, 2019). The annual increases
   in tobacco excise taxes in the past decade have led Australia to have one of the highest
   prices of cigarettes in the world--a 20-pack of Marlboro costs approximately US$19,
   while the same pack costs only US$12 in the UK, US$7 in the United States, and US$3.88
   in South Africa. The high tobacco tax level has also contributed massive yearly tax
   revenue to the Government.  In the United States, the federal cigarette tax for
   cigarettes was increased signi cantly in 2009 from US$0.39 per pack to approximately
   US$1.01 per pack.  The tax increase was designed to help pay for the cost of children's
   health insurance under the State Children's Health Insurance Program (SCHIP). 
   Revenues more than doubled from US$7.6 billion in 2008 to US$17.1 billion in 2010, once
   the law fully took effect.  Although revenues have declined from the high level reached
   in 2010, they are still projected to represent in 2024 double the amount collected prior
   to the 2009 tax hike. In the UK, as a result of high taxes and prices, smoking rates have
   continued to decline over the past decade, and tobacco taxes contributed an estimated
   £10 billion in tax revenue to the UK Government over 2016-2017.   

   Assessment done by the World Bank Group in Russia show that that life expectancy in
   the country for men increased to 65.4 years in 2016, up from 58 years in 2003, and
   among women, to 76.2 years in 2016, up from 72 years in 2003 (Marquez and Gonima,
   2018). A big contributor to this change has been the effective measures adopted to
   control the consumption of tobacco and alcohol over this period, including the
   enactment of a law on tobacco control in 2013 and regular increases in tobacco excise
   taxes since 2010. Because of tax and price increases, along with other tobacco control
www.pvmarquez.com/tobacco_taxes                                                                                                   4/13
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   interventions, tobacco sales fell by almost 30 percent over this decade.  Not
   surprisingly, the number of smokers also decreased, by 21 percent between 2009 and
   2016, while higher tobacco taxes increased tax revenue for the country (Figure 3). 




   Similar experiences have been observed in other countries as varied as Botswana,
   China, European Union-Member States, Republic of Korea, South Africa, Turkey, and
   Uruguay (Marquez and Moreno-Dodson, 2017; Zheng, Hu, Marquez, Wang, Xiaoxia,
   2017; Bouw, 2017; Eun Choi and Marquez, 2018; Cetinkaya and Marquez, 2017; Marquez,
   2017).

   Myth 2   Increased price of tobacco products due to higher taxes is regressive
   because the poor are affected the most.

   Evidence:  Country-speci c research conducted by the World Bank Group, as well as
   the work done in the United States, show that the poor tend to smoke more and are
   more price responsive on average than richer individuals, so they get a far greater share
   of health bene ts from higher tobacco taxes than they pay.

   By discouraging consumption, taxes on tobacco products reduce the adverse health
   effects of tobacco, as well as the large associated medical and human capital costs to
   households and societies. Medical treatment of the numerous chronic diseases caused
   or exacerbated by tobacco drives up annual health care costs in public health care
   systems and households.   Smoking reduces household earning potential and labor

www.pvmarquez.com/tobacco_taxes                                                                                                   5/13
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   productivity, negatively affecting human capital accumulation and development. Hence,
   reducing tobacco use translates to lower smoking-related medical expenses, increases
   in life expectancy at birth, and reductions in disability. 




   A World Bank Group assessment done for Armenia (Postolovska et al, 2017) shows that
   increased excise taxes on tobacco would bring large health and nancial bene ts to
   Armenian households and be pro-poor: about 88,000 premature deaths, US$ 63 million
   of out-of-pocked medical expenditures, 22,000 poverty cases, and 33,000 cases of
   catastrophic health expenditures would be averted. Government savings on tobacco-
   related treatment costs would amount to US$26 million. Half of the premature deaths
   and 27 percent of poverty cases averted would be concentrated among the bottom 40
   percent of the population.

   The net total distributional impact of tobacco taxation estimated in World Bank
   assessments done in in Bosnia and Herzegovina, Chile, Moldova, Russia, South Africa,
   and Ukraine (Fuchs et al 2019), is shown in Figure 4.  Lower medical expenditures and
   additional working years help offset the negative direct income effect of an increase
   in tobacco prices. The total income effect associated with a 25 percent price increase is
   positive in the case of several income groups, especially at the lower end of the income
   distribution. However, most households in Bangladesh and Indonesia, and between 30
   and 50 percent of the population in Bosnia and Herzegovina, Chile, and South Africa,
   continue to be negatively affected. In the particular case of Indonesia, the distribution
   continues to be U-shaped. The net effect becomes positive and more progressive with
   higher price increases, as reduce affordability of cigarettes allows the health and
www.pvmarquez.com/tobacco_taxes                                                                                                   6/13
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   economic bene ts of the taxes on tobacco to kick in. In a 100 percent price increase
   scenario, only the 40 percent richest households in Chile, and the top 60 percent in
   Bangladesh—where medical expenses have lowest incidence—are negatively affected.
   The results are generally progressive in all eight countries.  




   A most recent assessment done for Vietnam (Fuchs et al, 2019), con rms that above
     ndings, as under moderate and to high price increase scenarios, the distribution of
   the net bene ts is highly progressive. Poor households capture relatively large income
   gains that increase with the magnitude of the price increase. Increasing the excise tax,
   for example, by D 10,000 (US$0.43 cents) could bring income gains of over 1.5 percent
   to the poorest 30 percent of the population in Vietnam. The effect among the top four
   income deciles would be closer to zero under all scenarios.

   In Tonga (Osornprasop 2019), the excise tax resulted in a price increase across all the
   taxed products, making cigarettes less affordable and affecting smokers’ behaviors. Tax
   on cigarettes has a greater effect on “less well-off” smokers, as a larger number of less
   well-off smokers reduced consumption of manufactured cigarettes. This is consistent
   with the other country ndings on the equity impacts of price policies, as low-income
   households respond to price changes more readily than higher income households.
   Price, rather than other factors, was the main reason among those who decided to
   change behaviors and reduce consumption.

   Assessing the situation in the United States, Furman (2017), concludes that the criticism
   against tobacco taxes is backward. The health bene ts of tobacco taxes far exceed the
   increase in tax liability, and they accrue disproportionately to lower-income
   households. Moreover, as Furman observes, it is important to also evaluate what the


www.pvmarquez.com/tobacco_taxes                                                                                                   7/13
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   additional revenue raised by the tobacco tax may be used for. The most recent
   increases in the United States, enacted in 1997 and 2009, were used to create and
   expand a very progressive children’s health insurance program.

   Myth 3 Higher taxes lead to increased smuggling and use of counterfeit tobacco

   Evidence: A recent global report by the World Bank Group focusing on over 30
   countries across the income and development spectrum (Dutta et al, 2019), shows that,
   contrary to tobacco industry arguments, tobacco taxes and prices have only a limited
   impact on the illicit market share at the country level.  The evidence presented in the
   report indicates that the illicit cigarette market is relatively larger in countries with
   low taxes and prices, while relatively smaller in countries with higher cigarette taxes
   and prices. Non-price factors such as governance status, weak regulatory framework,
   and the availability of informal distribution networks appear to be far more important
   factors. Countries reporting signi cant progress in the control of illicit tobacco trade
   adopted some key policy and institutional measures which contributed to their success.




   A good example is Ireland, where a high rate of tobacco excise taxes, and the
   consequent high price of tobacco products, makes the country attractive to those
   involved in the illicit tobacco trade. However, Ireland’s comprehensive and effective
   system of customs and tax enforcement, alongside strong regulatory control of the
   tobacco market, has contained the illicit ow of tobacco products onto the Irish
   market.  Indeed, Ireland’s most recent results indicate that the general trend for illicit
   cigarettes between 2007-2017 has been downward (13 presently). Notably, this has
   occurred during a period where price of cigarettes has risen and smoking prevalence
   has declined (by about 10 percentage points).  This suggest that, while the illicit trade



www.pvmarquez.com/tobacco_taxes                                                                                                   8/13
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   has not been eliminated, the extensive program of enforcement has contained it. 
   Analysis indicates that the main driver of illicit ows is not relative levels of
   price/taxation, but the effectiveness of customs and tax enforcement.

   A key lesson from the report’s country case studies is that strengthening the legal
   framework and tax administration and enforcement is complementary to tobacco tax
   policy reform as these measures reinforce one another.  As outlined in the World Bank
   Group report, experience shows that illicit tobacco trade can be controlled by legal
   means (e.g., use of prominent tax stamps, serial numbers, special package markings,
   health warning labels in local languages, adoption of uniform tax rates nationwide that
   facilitate successful collection at the points of manufacture and import), and by
   increased law enforcement (e.g., improving corporate auditing, better trace and
   tracking systems, and good governance).        

   Myth 4   Tobacco tax hikes lead to signi cant job losses

   Evidence: Policymakers considering tobacco tax hikes are often concerned about
   negative impacts on employment. World Bank Group research provides fresh evidence
   from eld studies and economic simulations focusing on Indonesia (Araujo et al 2018),
   one of the world’s largest tobacco producers. The results provide clearer understanding
   of the relationship between tobacco taxation and employment.




   Tobacco manufacturing represents only a small share of Indonesia’s economy-wide
   employment (0.60 percent) and a relatively low percentage of jobs in the
   manufacturing sector (5.3 percent). This compares to the food (27.43 percent),
   garment (11.43 percent), and textile (7.90 percent) sectors. The productivity of tobacco
   manufacturing workers is also quite low relative to the productivity of workers in other

www.pvmarquez.com/tobacco_taxes                                                                                                   9/13
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   comparable sectors. Indonesia’s tobacco manufacturing is geographically concentrated
   in East and Central Java (76 percent) and West Nusa Tenggara (18 percent). Only a few
   districts are substantially dependent on tobacco sector employment.

   Most tobacco farmers and manufacturing workers rely only partially on tobacco
   income. Income from kretek rolling represents 43 percent of household income among
   kretek households on average. About three-quarters of tobacco-farming households
   derived less than 50 percent of their income from tobacco cultivation, and over half of
   clove farmers generate less than 20 percent of their household income from cloves.

   Tobacco cultivation is not pro table for most farmers, and producing tobacco has
   high opportunity costs. This nding was mostly consistent across regions, type of
   tobacco grown, and whether the farmer was on contract to grow tobacco. Despite poor
   returns typically, farmers reported being drawn to the assured market, the better
   prospects for credit, and the potential to earn cash.

   Economic simulations suggest that raising cigarette taxes by an average of 12 percent
   that increases cigarette prices by an average 5 percent and simplifying Indonesia’s
   cigarette tax structure to six tiers will reduce cigarette demand by 1.89 percent,
   increase government revenue by 6.41 percent, and reduce gross employment in the
   tobacco manufacturing sector by 0.43 percent. This represents a reduction of less
   than 3,000 tobacco manufacturing jobs, most of them in the handmade kretek industry
   (2,245 fewer jobs). Importantly, these estimates do not consider the creation of jobs in
   other sectors due to the shift in consumers’ spending away from tobacco (the net
   effect).

   The estimated total household income loss from reduced employment in the handmade
   kretek industry amounts to a small fraction of 1 percent (0.16 percent) of the revenue
   gain that Indonesia will obtain by increasing cigarette taxes.

   To sum up, higher taxes, yielding higher retail prices, will cut tobacco consumption and
   reduce economic losses due to health care costs and compromised productivity, with
   low-income groups bene ting more as discussed above. Aggressive tobacco tax hikes
   will generate additional revenue that can more than compensate for the income loss
   following a reduction in employment in the kretek industry.

   Take-Away Message
www.pvmarquez.com/tobacco_taxes                                                                                                   10/13
1/12/2021                         Common Myths Against Tobacco Taxation: Not Borne Out by Global Evidence | Patricio V. Marquez

   The common claims used by interest groups to oppose tobacco tax increases, price
   hikes, and reductions in demand and use, are not supported nor borne out by
   accumulated country evidence.  Improved data availability and further research are
   required for updating and expanding the global evidence base to confront these claims
   as they have become widely-held “myths” often accepted uncritically by government
   of cials and stakeholders, as well as the general public.

   So, as stated in an article in The Economist (2017), the take-away message for policy
   makers and other stakeholders around the world, should be unambiguously clear:  "As
   the success in rich countries shows, there is no mystery about how to get people to
   stop smoking: a combination of taxes and public-health education does the job. This
   makes the abysmal record in poor countries a grave failure of public policy. The good
   news is that, following recent research, it is one that has just become easier to put
   right." 

   By adopting the United Nations Sustainable Development Goals (SDGs), countries
   across the world have committed to achieving a 30 percent reduction in death rates
   from noncommunicable diseases like cancer, stroke, and heart disease by 2030.
   Reducing tobacco use is critical for countries to reach this goal. To swiftly cut smoking
   rates, bold increases in tobacco excise tax rates are by far the most powerful tool. 

   High smoking prevalence condemns large numbers of people to avoidable sickness
   and death and weakens the country’s economic development. As observed by Jha and
   Peto (2014), attainment of the SDG target requires decreases not only in high-income
   countries but also in populous low- and middle-income countries “to prevent several
   tens of millions of tobacco- attributable deaths during the next few decades, and about
   200 million tobacco-attributable deaths during the century as a whole, mostly among
   people who are already alive, both by helping smokers to quit and by helping
   adolescents not to start.”

    
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www.pvmarquez.com/tobacco_taxes                                                                                                   11/13
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www.pvmarquez.com/tobacco_taxes                                                                                                   12/13
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www.pvmarquez.com/tobacco_taxes                                                                                                   13/13
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez




   High Prices for Essential Drugs: A Risk
   for Public Health, Catastrophic Health
   Spending, High-Debt Levels, and
   Impoverishment
   Submitted by Patricio V. Marquez on Tue, 01/28/2020 - 06 11 PM




   High Prices for Essential Drugs: A Risk
   for Public Health, Catastrophic Health
   Spending, High-Debt Levels, and
   Impoverishment
   Posted by Patricio V. Marquez on Tue, 01/28/2020 - 06 11 PM




pvmarquez.com/drug_prices                                                                                                                                          1/7
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez

   As all of us who have been sick or diagnosed with a chronic condition that
   requires adherence to a daily drug regime know, timely access to required
   medicines not only helps us get better or manage a health condition over
   the long term, but saves us from hospitalization if the disease is not
   controlled, helps us avoid being absent from work, improves our
   productivity, and enhances our quality of life. 

   So, from an ethical, societal, and public health point of view, it should not
   be accepted that the sick or those living with a chronic condition are put at
   risk of ill health, premature mortality and disability, catastrophic health
   spending, debt and impoverishment because they cannot afford essential
   medicines when needed, or are forced by high drug prices to ration their
   medication, aggravating their health condition and even putting them at risk
   of death.

   Although this dire reality is common in many countries of the world, the
   current political debate in the United States is illustrative of this global
   public health challenge as high drug prices are a top concern for families
   across the country, who face common threats often found under private
   health insurance arrangements: pre-existing clauses that do not cover a
   medical condition that started before a person's health insurance bene ts
   went into effect, as well as high deductibles, co-payments, and lifetime
   limitations in services and drug coverage. 

   The high cost of insulin, a lifesaving medication needed to manage Type-1
   diabetes, which affects about 5 percent of people with diabetes in the
   United States, is a good example of the ironies, inequities, and negative
   social impact of the lack of or limited access to essential drugs in the
   country. Indeed, it is not only ironic but I would say it is morally wrong that
   drug companies have been pro ting from selling insulin at high prices, in
   spite of the fact that Frederick Banting and John Macleod, who were


pvmarquez.com/drug_prices                                                                                                                                          2/7
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez

   awarded the 1923 Nobel Prize in Medicine for its discovery, sold the patent
   to the University of Toronto for $1 each because they felt that insulin
   belonged to the world and not for their enrichment.    

   As described by Michael Fralick and Aaron S. Kesselheim, in a recent article
   in the New England Journal of Medicine (NEJM), almost 100 years after its
   discovery, insulin is inaccessible to thousands of Americans because of its
   high cost. The information presented in the article shows that the price of
   insulin in the United States has risen substantially over the past two
   decades: “today, the price of 100 units of short-acting insulin for adults
   without insurance is about $18. The usual dose for regular insulin is 0.5 to 1.0
   units per kilogram per day (usually given before meals). Thus, for a person
   with type 1 diabetes who weighs 70 kg and is taking a dose of 1 unit per
   kilogram per day, 100 units will last less than 2 days. Most adults taking
   short-acting insulin also require either intermediate- or long-acting insulin,
   the latter of which is also quite costly” (see below table from the NEJM
   article).   




pvmarquez.com/drug_prices                                                                                                                                          3/7
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   The difference in drug prices between the United States and the rest of
   the world, is mindboggling.   In some cases, as with the fast-acting insulin
   Novolog, it is 74% cheaper when ordered from a pharmacy in Canada.  In
   should not surprise us, then, that while the United States represents only
   15% of the global insulin market, it generates almost half of the
   pharmaceutical industry’s insulin revenue.

   What can be done to deal with the rising cost of insulin and other
   prescription drugs in the United States and elsewhere?  How can essential
   drugs become more accessible and affordable?  

   While the mandatory provision of an essential outpatient drug bene t
   package for priority, high-burden diseases, such as Type 1 diabetes, under
   publicly-funded arrangements or health insurance plans is a critical
   measure to guarantee their timely access and affordability, additional
   measures as those now being debated in the United States are needed,
   including supply side measures such as price negotiation, changes in
   patent laws, and the manufacture of generics. 

   An essential drug bene t program, that eliminates or caps-out out-of-
   pocket drug spending for everyone,  could be funded through an improved
   allocation of overall public expenditures, including a shift toward long-
   term social needs such as health and away from less productive categories
   of public expenditures (for example, untargeted subsidies and transfers,
   general administration expenditures and unproductive public investments).
   Other funding options include, as already done in some countries,
   increasing taxes on cigarettes, alcohol, and sugar sweetened drinks, since
   current tax rates are evidently far below what is feasible in terms of revenue
   potential and the generation of health bene ts. 



pvmarquez.com/drug_prices                                                                                                                                          4/7
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez

   If we focus on insulin as a tracer of the problem, then the need for supply
   side measures becomes clearer.  As explained in Fralick and Kesselheim’s
   article, the rising cost of insulin in the United States can be attributed
   primarily to two phenomena: rst, the current law allows pharmaceutical
   manufacturers to price their products at whatever level they believe the
   market will bear and to raise prices over time without limit (this practice
   is the opposite of what England does, where the government sets a
   maximum price it will pay for a drug when directly negotiating with the
   pharmaceutical industry); and second, direct competition in the insulin
   market is lacking (approximately 90% of insulin sold in the United States is
   manufactured by one of three companies: Eli Lilly, Novo Nordisk, and
   Sano ).  

   The plan proposed by Michael Bloomberg, the former Mayor of New York
   and Global Philanthropist, to lower the prices for essential medications for
   everyone in the United States, offers a good road map that merits
   consideration. It calls for the adoption of legal measures and requirements
   that authorize governments and insurance companies to negotiate drug
   prices with the pharmaceutical industry in order to lower prices for
   everyone; it promotes the selection of most cost-effective drugs, including
   generics; it allows for the importation of safe drugs from other countries
   with good quality standards and where prices are lower; and it changes
   patents and intellectual property laws to foster competition by bringing
   generic drugs to the market faster (in the United States, brand-name drugs
   account for 72% of total drug spending despite representing only 10% of all
   prescriptions) to reduce drug costs.

   While timely access to medications such as insulin is critical  to manage
   Type-1 diabetes,  the promotion of health literacy (the capacity of
   individuals to obtain, communicate, process, and understand basic health
   information and services to make appropriate health decisions), is equally


pvmarquez.com/drug_prices                                                                                                                                          5/7
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez

   vital for the development of a disciplined daily nutritional regime, rich in
   proteins and vegetables, with reduced or no carbohydrates from
   processed foods, and physical activity, to manage this disease. 

   In pursuing universal health coverage, therefore, we need to remember that
   besides putting in place arrangements that ensure access to medical care
   and offer nancial protection to the population, investment in health
   literacy can empower people to be in the “driver’s seat” of health
   promotion and disease prevention, including the prevention of
   complications from existing chronic health conditions such as Type-1
   diabetes, to lead healthy, productive and happy lives.

     
   Sources
   Belluz, J. “The absurdly high cost of insulin, explained. Why Americans ration
   … (https:/  /www.vox.com/2019/4/3/18293950/why-is-insulin-so-
   expensive)
   Bloomberg, M. 2020. Drug Prices Plan.
   (https://www.mikebloomberg.com/2020/policies/drug-prices)
   Cooperman, T. “20 Drugs That Cost a Lot Less Outside the U.S.” HUFFPOST,
   Decemb… (https:/   /www.huffpost.com/entry/20-drugs-that-cost-a-lot-
   less-outside-the-us_b_5a217e73e4b0545e64bf9277)
   Fralick, M. and Kesselheim, AS. 2019. “The U.S. Insulin Crisis — Rationing a
   Li… (https:/ /www.nejm.org/doi/full/10.1056/NEJMp1909402)
   Image by Steve Buissinne from Pixabay
   (https://pixabay.com/photos/diabetes-blood-sugar-diabetic-528678/)
   Picture from freestocks.org (https:/ /unsplash.com/photos/nss2eRzQwgw)




pvmarquez.com/drug_prices                                                                                                                                          6/7
1/12/2021         High Prices for Essential Drugs: A Risk for Public Health, Catastrophic Health Spending, High-Debt Levels, and Impoverishment | Patricio V. Marquez




                                    
                                               (https://twitter.com/pvmarquez1956)




pvmarquez.com/drug_prices                                                                                                                                          7/7
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez




   Mental Health and Healthy Futures: A
   Priority Theme at WEF Davos 2020
   Submitted by Patricio V. Marquez on Wed, 01/22/2020 - 08 55 PM




   Mental Health and Healthy Futures: A
   Priority Theme at WEF Davos 2020
   Posted by Patricio V. Marquez on Wed, 01/22/2020 - 08 55 PM




   This week I have enjoyed participating in several livestreamed sessions of
   the 50th annual meeting of the World Economic Forum (WEF) under the
   theme “Stakeholders for a Cohesive and Sustainable World.”  One of the 7
   diverse topic areas being addressed during the Meeting is “Healthy
   Futures”, which I found to be not only highly relevant to the overall theme
pvmarquez.com/mental_health_davos                                                                                                 1/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   of the 2020 meeting, but highly evocative of Thomas Mann’s masterpiece
   “The Magic Mountain” which takes place before World War I in a
   tuberculosis sanatorium in Davos, the Swiss Alps town, where the WEF
   meeting is held yearly.

   I say this because a healthy population, both physically and mentally, should
   be seen as a key goal of a country’s development, as it is an essential
   building block for productive, inclusive, resilient, and happy societies. But,
   as in Mann’s novel, this social outcome requires “community” action, with
   active stakeholder participation, to deal with ill health and its multiple
   determinants and manifestations.

   I was quite pleased to watch Bollywood actor Deepika Padukone receive the
   WEF’s Crystal Award 2020 for her work in raising mental health awareness
   in India.  On receiving the award and later in a one-on-one session with
   Tedros Adhanom Ghebreyesus, the WHO Director General, she reinforced
   the need to shine a collective light on the still widespread silence, stigma,
   and discrimination that surrounds mental and substance use disorders
   globally.  She also conveyed hope and offered an example for other political,
   private sector, and cultural leaders to follow and engage in this issue: 
   "Depression is a common yet serious illness. It is important to understand
   that anxiety and depression are like any other illness and treatable. It was
   experience with this illness that encouraged me to set up Live Love Laugh,"
   she said while talking about the Foundation she has set up for this cause.

   The session “Protecting Mental Health in Youth” offered diverse
   perspectives on the challenges and options to scale up approaches to
   dealing with mental illnesses among children, adolescents, and young adults
   aged 14-25 years.  The special focus on this group is warranted because
   nearly 75% of mental health conditions begin before age 25, and suicide is a
   leading cause of death among youth, particularly among young women aged
   19-24 years in some countries, with research showing that early intervention

pvmarquez.com/mental_health_davos                                                                                                 2/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   is the best means of prevention.  Also, as argued by Patrick McGorry, a
   noted psychiatrist from Australia known for his development of the early
   intervention services for emerging mental disorders in young people, the
   experience in his country shows that an initial focus on mental health in
   youth helps bring the issue to the wider political arena since it can galvanize
   the attention of parents and families, who are concerned about the
   wellbeing of their children; organized community and interest groups;
   voters; and governments.  People living with mental health problems have a
   major role to play in speaking out, sharing their stories, and articulating
   their rights and demands, in the same manner as the movement of HIV-
   positive people did a couple of decades ago to demand access to life-saving
   drugs.

   The activation of a wider “conversation”, anchored in empathetic listening,
   is critical to overcome a range of social barriers, from the taboo of mental
   illnesses, the stigmatization of individuals who are affected by these
   disorders, the fear of discrimination among their families, to widespread
   beliefs that these conditions are not “real” health problems, or  are problems
   brought on by one’s own choices or “social deviant” behavior in the case of
   substance use disorders.    Indeed, as illustrated from the lived experience of
    Amornthep Sachamuneewongse, a WEF Global Shaper Bangkok  who
   participated in the panel, in many countries mentally ill individuals “live in
   places where people really do not understand what mental illness is, where
   there is no one to talk about it, or where one cannot express much, and
   (ultimately) attempts suicide” to overcome loneliness, stress, grief,
   depression, and anxiety. 

   Because the brain is extremely sensitive to environmental factors,
   particularly in the rst two decades of life, and because most mental health
   problems begin before young adulthood, the need to act early to prevent
   their onset was stressed by panelists, who argue for ensuring nurturing and
   safe environments for children and adolescents to thrive in schools, at

pvmarquez.com/mental_health_davos                                                                                                 3/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   home, and in communities.  Henrietta H. Fore, the Executive Director of
   UNICEF, eloquently noted that as con ict exposes populations to violence
   and high levels of stress, bottom-up, multisectoral approaches are required
   in humanitarian and development programs to address the needs of
   displaced population groups and refugees.  Indeed,  investment in
   education, social protection, and employment training would ameliorate
   social exclusion and build social resilience by serving the unique needs of
   vulnerable groups, such as children and young people who have been
   exposed to rape and other forms of violence, who have served as child
   soldiers, or who have witnessed the killing of close family members.  As she
   argued, affected children and youth need to feel safe, have someone who
   they can trust and talk to, and have access to the positive socialization
   that schools and other social support programs can provide to help “bring
   them back.” 

   Panelists also highlighted that private rms and enterprises have a vested
   interest in having mentally healthy workers, not only for “bottom line
   considerations”, but more importantly to increase productivity and
   competitiveness —a “top line” consideration. As mental illnesses account
   for a large share of absenteeism and presenteeism (a situation in which an
   employee is present for duty but is not fully capable of performing
   workplace tasks due to an illness or other condition) in the workplace,
   companies reduce economic losses and increase productivity and
   competitiveness by promoting the physical and mental wellbeing of
   employees, and in some cases their families.

   Although global healthcare spending has increased dramatically over the
   past decade, greatly helping to expand access to health services, a
   signi cant supply-side barrier across the world is the lack of mental health
   parity in the provision and nancing of health services.  To deal with this
   situation, as voiced by different panelists, mental health needs should be
   viewed in the same vein as physical health needs and be recognized as a

pvmarquez.com/mental_health_davos                                                                                                 4/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   basic human right.  Moving from advocacy to implementation, this would
   require a wider acceptance of the idea that mental health disorders are
   conditions of the brain that should not be treated differently than other
   chronic health conditions, such as heart disease or cancer. Nor, in fact, are
   they truly separable: If untreated, mental disorders can negatively affect
   management of such co-occurring diseases as tuberculosis and HIV,
   diabetes, hypertension, cardiovascular disease, and cancer. 

   As I have argued before, the realization of universal health coverage
   commitments by countries should include strategies and plans for the
   medium term to integrate mental health care into health services delivery
   platforms that focus on the whole patient rather than an aggregation of
   diseases.  This, in turn, requires a de nition of what mental health
   conditions to prioritize, as they range from autism and intellectual
   disability in childhood, to anxiety and depression, bipolar disorders,
   schizophrenia, to alcohol and substance use disorders in adulthood, and to
   dementia in old age; how to select a menu of evidence-based, cost-
   effective treatments to be offered for sets of conditions by service
   providers at different levels of care (as is commonly done for physical  health
   conditions); and how these services will be funded and reimbursed without
   perpetuating discrimination. Key barriers to overcome include lack of
   trained personnel for the provision of psychosocial support; limited
   availability of generic drugs in public facilities of peri-urban and rural areas;
   and under health insurance arrangements, pre-existing clauses that do not
   cover a medical condition that started before a person's health insurance
   bene ts went into effect, as well as high deductibles, copayments, and
   lifetime limitations in coverage, that increase the risk of catastrophic health
   expenditures and impoverishment among vulnerable population groups.

   As Jeremy Farrar, the Director of Wellcome Trust, observed, while it is
   common for WEF participants to elaborate on problems and propose
   solutions, what is needed for moving the “Healthy Futures” agenda,

pvmarquez.com/mental_health_davos                                                                                                 5/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   particularly multisectoral and multidisciplinary action to address mental and
   substance use disorders among youth, is to track commitments and make
   public and private stakeholders accountable for their realization.  Only if
   the talk is translated into a walk for action and measurable impact will we be
   able to ensure the availability of required investments for supporting scaled
   up interventions globally.  If this is done, as Fatima Azzahra El Azzouzi, the
   moderator of the session, noted, we can aspire to achieve an “emotional
   and mentally cohesive and sustainable future”.   

    
   Sources
   World Economic Forum Annual Meeting, 21—24 January 2020. Explore the
   World Eco… (https:/  /www.weforum.org/events/world-economic-forum-
   annual-meeting-2020/themes)
   World Economic Forum Annual Meeting, 21—24 January 2020. Session “The
   26th Annu… (https:/  /www.weforum.org/events/world-economic-forum-
   annual-meeting-2020/sessions/the-26th-annual-crystal-award-ceremony)
   World Economic Forum Annual Meeting, 21—24 January 2020. Session “An
   Insight, A… (https://www.weforum.org/events/world-economic-forum-
   annual-meeting-2020/sessions/an-insight-an-idea-with-deepika-
   padukone)
   World Economic Forum Annual Meeting, 21—24 January 2020. Session
   “Protecting Me… (https:/ /www.weforum.org/events/world-economic-
   forum-annual-meeting-2020/sessions/protecting-mental-health-in-youth)
   Marquez, PV, Hewlett, E. “Lessons from OECD countries: mental health is
   critica… (https://blogs.worldbank.org/health/lessons-oecd-countries-
   mental-health-critical-human-capital-development)
   Marquez, PV, Dutta, S. “On World Mental Health Day: A call to invest in
   interve… (https://blogs.worldbank.org/health/world-mental-health-day-
   call-invest-interventions-young-people)
   Marquez, PV. “Mental Health in Prisons: How to Overcome the Punishment
   Paradigm… (https:/  /blogs.worldbank.org/health/mental-health-prisons-
   how-overcome-punishment-paradigm)

pvmarquez.com/mental_health_davos                                                                                                 6/9
1/12/2021                           Mental Health and Healthy Futures: A Priority Theme at WEF Davos 2020 | Patricio V. Marquez

   Marquez, PV, Dutta, S. “Maternal Depression and Stunted Children: An
   Avoidable … (https://blogs.worldbank.org/health/maternal-depression-
   and-stunted-children-avoidable-reality)
   Marquez, PV. “The case for physical and mental wellness programs in the
   workpl… (https://blogs.worldbank.org/health/case-physical-and-mental-
   wellness-programs-workplace)
   Marquez, PV. 2017. “Mental health among displaced people and refugees:
   making t…
   (http://documents.worldbank.org/curated/en/916131486730755271/Mental-
   health-among-displaced-people-and-refugees-making-the-case-for-
   action-at-the-World-Bank-Group)
   Marquez, PV, Walker, M. “Mental health services in situations of con ict,
   frag… (https://blogs.worldbank.org/health/mental-health-services-
   situations-con ict-fragility-and-violence-what-do)
   Marquez, PV, Saxena, S. “Mental Health Parity in the Global Health and
   Developm… (https:/  /blogs.worldbank.org/health/mental-health-parity-
   global-health-and-development-agenda)
   Marquez, PV. Invisible wounds: Mental health among displaced people and
   refugee… (https://blogs.worldbank.org/voices/invisible-wounds-mental-
   health-among-displaced-people-and-refugees)




pvmarquez.com/mental_health_davos                                                                                                 7/9
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pvmarquez.com/mental_health_davos                                                                                                 8/9
1/12/2021                     How to Accelerate Universal Health Coverage in Latin America and the Caribbean? | Patricio V. Marquez




   How to Accelerate Universal Health
   Coverage in Latin America and the
   Caribbean?
   Submitted by Patricio V. Marquez on Thu, 01/16/2020 - 08 21 PM




   How to Accelerate Universal Health
   Coverage in Latin America and the
   Caribbean?
   Posted by Patricio V. Marquez on Thu, 01/16/2020 - 08 21 PM




   In Memory of Miguel A. Marquez, 1934-2014




pvmarquez.com/health_reform                                                                                                           1/9
1/12/2021                     How to Accelerate Universal Health Coverage in Latin America and the Caribbean? | Patricio V. Marquez

   Over the past four decades, major policy reforms were introduced in several
   Latin American and Caribbean countries to strengthen their health
   systems. While countries such as Brazil, Costa Rica, and Cuba managed to
   unify their health systems, and Chile, Colombia, and Mexico introduced
   organizational changes to expand health service coverage to the poorest
   populations as a right for all citizens, the institutional organization in most
   countries of the region at the beginning of the 2020 decade continues to be
   characterized by the coexistence of parallel subsystems that respond to the
   needs of different social groups in an often uncoordinated and fragmented
   manner.  In spite of the regional heterogeneity, this segmented model of
   heath care organization in most countries of the region segregates different
   population groups according to employment and socioeconomic status into
   three broad institutional arrangements for accessing health services: the
   ministry of health, the social security institute (s), and the private sector. 

   Why does this matter?  In 2014, PAHO/WHO Member States approved the
   Strategy for Universal Access to Health and Universal Health Coverage
   (UHC). The strategy emphasizes the need to strengthen health systems to
   achieve universal access and coverage, namely by reducing health inequities;
   expanding access to comprehensive, quality care; and improving the health
   and well-being of the population. The progressive realization of the UHC
   strategy in the region, therefore, requires a major health system
   transformation to deal with the fragmentation of nancing and service
   delivery and the differential access produced by population segregation. 

   In advancing the health reform process in Latin America and the Caribbean in
   the new 2020 decade, several factors merit consideration.  I will elaborate on
   some of them given their importance for increasing the political feasibility of
   reforms as well as for ensuring their nancial and institutional sustainability.

   Factors to Consider



pvmarquez.com/health_reform                                                                                                           2/9
1/12/2021                     How to Accelerate Universal Health Coverage in Latin America and the Caribbean? | Patricio V. Marquez

   The history of health care reform in the region and elsewhere shows that
   technically sound proposals backed by data and evidence are a vital but not
   suf cient condition to effect this transformation.  As public policy is an
   inherently political process, a clear understanding and careful but active
   modulation of the interrelationships among individuals, organized interest
   groups, and governments in a given context and period of time are of
   critical importance to in uence the design and enactment of policies, laws,
   and regulations that shape a health system.  This implies that reform
   proposals in the health sector rst and foremost need to clearly articulate
   how they will contribute to the achievement of broader social goals in a
   country, or more broadly stated, to construct societies that are more
   inclusive, where health care is a social good available to all on equal terms,
   rather than a private consumption good like other services such as food and
   housing, that is only fully afforded to the rich. The uni cation of vision and
   social goals as the frame of reference for health reform proposals is key to
   align the interests of different actors and mobilize their support for their
   adoption and sustainable implementation over time. 

   Indeed, as Professor Uwe E. Reinhardt, the distinguished late Princeton
   University health economist observed, having a clear understanding of “what
   kind of a society a country wants to have”, will ultimately guide policy and
   institutional decisions concerning the most appropriate and contextually
   relevant organizational forms, health care nancing arrangements, and
   service delivery mechanisms that could be adopted to attain the intermediate
   goals of a health system (improved access, quality, ef ciency, and fairness),
   which would in turn contribute to achievement of the ultimate goals of a
   health system (improved health status, nancial protection, and patient
   satisfaction with health care received).  

   The codi cation into laws of health as a right of citizenry is a vital step that
   is required to transform health systems as it helps to translate speci c policy
   proposals into legal mandates, institutionalizing a framework that ensures the

pvmarquez.com/health_reform                                                                                                           3/9
1/12/2021                     How to Accelerate Universal Health Coverage in Latin America and the Caribbean? | Patricio V. Marquez

   directionality and continuity of the reform process across political cycles and
   helps withstand recurring bouts of political opposition and changed social
   and economic interests in a country. 

   Recent examples in  the Americas offer good lessons on the interplay of
   policy formulation and advocacy and the sobering reality of the political
   processes needed for their approval and enactment that have reshaped
   health care organization and nancing, service delivery modalities, and
   expanded population coverage:

   Colombia, with the adoption of Law 100 in the mid-1990s, that introduced a
   universal health insurance program, which was amended in 2008 per the
   decision of the Constitutional Court that directed the Government to unify its
   contributory and subsidized insurance schemes; the 2003 approval by the
   Mexican Congress of revisions to the General Health Law that established the
   System of Social Protection in Health, with Seguro Popular expanding health
   insurance coverage to about half of the country’s population; and the Patient
   Protection and Affordable Care Act adopted in the United States in 2010.  In
   previous decades, health as a human right and citizens’ entitlement were
   codi ed in the Constitutions of countries such as Cuba, after the 1959
   revolution; Costa Rica in the 1960s; Brazil in the Constitution adopted in 1988;
   in Peru in 2002, with the introduction of the Comprehensive Health Insurance
   for poor and uninsured populations; and in Chile, with the adoption in 2005 of
   the Health Guarantees Law that introduced enforceable rights to health
   services for a set of diseases. 

   Dealing with inequitable nancing, particularly needed to realize the promise
   of timely access to medical care when needed and to reduce out-of-pocket
   expenditures that create risks for catastrophic and   impoverishing spending
   among the poor and underserved populations, is of upmost importance.
   Recent estimates show that out-of-pocket expenditures stood at 33 percent
   in 2014 and 28 percent in 2016 of total health spending on average in several
   countries; this level is far higher than the OECD countries average of 18
pvmarquez.com/health_reform                                                                                                           4/9
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   percent. This gures not only convey the stress households face in accessing
   health care, but acquires added relevance when one considers that among the
   world’s regions, Latin America and the Caribbean has one of the highest levels
   of social and health inequity, especially in terms of inequality in income
   distribution. Although income inequality has decreased over the past 15 years,
   in 2017, the Gini index (the most common measure of inequality; a higher Gini
   index indicates greater inequality, with high income individuals receiving
   much larger percentages of the total income of the population) stood at  0.51,
   the highest in the world.  If, as envisioned, the targets for UHC and the
   health- and poverty-related Sustainable Development Goals (SDGs) are to be
   achieved by 2030, a sustained effort of domestic resource mobilization and
   increase in the relative allocation for health in national budgets is required.

   Given the middle-income status of most countries in Latin America and the
   Caribbean, this effort, as outlined in a recent World Bank Group report for the
   G20, would mean in practice that as part of scal consolidation initiatives,
   governments would need to increase overall government revenue as a share
   of GDP, and where feasible, some of which can ow to expand scal space
   for health. To this end, there is an arsenal of measures to consider:
   improvements in tax administration; expansion of tax bases by increasing the
   range and level of taxes and charges; removal, although political dif cult, of
   ineffective subsidies (e.g., on fossil fuel) that disproportionately bene t the
   non-poor; raising taxes on tobacco products and other health-damaging
   products, such as alcohol and sugary drinks, which not only help to reduce
   health risks but also are more politically acceptable to the general
   population than other taxes in spite of likely opposition from powerful
   interest groups; and reduction of the reliance on wage-based deductions or
   voluntary forms of insurance to bolster prepaid and pooled funding.

   Leveraging health-related investments in other sectors—including, for
   example, in transport to reduce road traf c injuries and fatalities that impose
   a heavy burden on costly trauma care, in safe water and basic sanitation to

pvmarquez.com/health_reform                                                                                                           5/9
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   reduce the risk of gastrointestinal diseases and chronic malnutrition—would
    improve population health, reducing need, demand and utilization of health
   services.

   While additional funds for health would help, an equally important task is
   to improve the ef ciency of resource use in the region.  For example, a
   recent report suggested that 20 percent of all health expenditures in OECD
   countries was wasted and did not contribute to the desired health outcomes;
   in some Latin American and Caribbean countries, this gure may be higher.
   As suggested in the World Bank Group report, improvements in performance-
   informed planning and budgeting, enhanced budget execution, and stronger
   systems of public nancial management in the health system would help. 

   Also, better allocation of existing resources is needed in order to prioritize
   the delivery of cost-effective primary and community health services with
   appropriate referral systems, away from hospital-centric models of care, and
   strengthen public health functions, particularly disease surveillance, public
   health labs for case con rmation, and epidemiological intelligence capacity,
   to anticipate and control societal-wide health risks associated with the
   reemergence of infectious diseases and the emergence of new pathogens that
   cross borders and threatening loss of life, economic disruption, and costs to
   health systems.

   In the face of rapid demographic and health changes in Latin America and
   the Caribbean, particularly the aging of the population and the increase in
   the relative importance of chronic non-communicable diseases and
   injuries, as well as mental and substance use disorders, another priority
   area that merits attention for reforming health systems in the region is the
   need to support a fundamental rethinking of how to best keep people
   healthy and out of  hospitals. 




pvmarquez.com/health_reform                                                                                                           6/9
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   For starters, there has to be a widespread realization among policymakers,
   employers, health insurers, service providers, and the population at large, that
   the lion’s share of health care expenditures goes for treating diseases and
   injuries that could be “prevented”. 

   The realization of health promotion and disease and injury prevention would
   require supporting population-wide efforts to tackle social, environmental
   and behavioral determinants of ill health, premature mortality, and disability,
   such as scal and regulatory policies  to curb tobacco use, second hand
   smoke, alcohol and substance abuse, obesity, Type-2 diabetes, road traf c
   injuries, and in some countries, gun violence.  Insurance arrangements and
   health care organization and payment innovations could also be used to
   advance this public health agenda.  For example, insurance companies, by
   charging lower premiums for those who quit smoking, lose weight, and pass
   screening tests for artery-clogging cholesterol, high blood pressure, and high
   sugar levels, provide an incentive for individuals and families to assume
   responsibility for their health.  

   Moving forward

   Throughout the world there is an ongoing search for new and innovative ways
   to address health system shortcomings to better respond to present and
   future health challenges. Latin American and the Caribbean countries are not
   an exception.  Reforming long-entrenched health care organization and
    nancing arrangements is not an easy task that can be completed in the
   short-term. 

   Moving from policy intention toward the achievement of UHC as a broad
   development and social goal will require political commitment at the
   highest political level and the buy-in and active involvement of individuals,
   organized interest groups, and governments over the medium- and long-
   terms.  Well informed and inclusive political strategies and sound technical
   proposals would help pave the way for implementing needed health system
pvmarquez.com/health_reform                                                                                                           7/9
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   changes over the medium- and long-terms to eliminate social strati cation in
   accessing and funding health services, build more inclusive and resilient
   societies, and support the development of healthy populations in the region.
   Opposition from interest groups and backpeddling by governments, however,
   should be expected as an ever-present risk that will need to be monitored and
   confronted during this process.
   Sources
   Atun, R. et al. 2015. “Health-system reform and universal health coverage in
   La… (https:/ /doi.org/10.1016/S0140-6736(14)61646-9)
   Londoño, JL and Frenk, J. 1997. “Structured pluralism: towards an innovative
   m…
   (https://www.sciencedirect.com/science/article/abs/pii/S0168851097000109)
   Marquez, PV. 2016. “Time to put “health” into universal health coverage”.
   World… (http:/   /blogs.worldbank.org/health/time-put-health-universal-
   health-coverage)
   World Bank Group. 2019. “High-Performance Health Financing for Universal
   Health… (https:/  /openknowledge.worldbank.org/handle/10986/31930)




pvmarquez.com/health_reform                                                                                                           8/9
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                              
                                     (https://twitter.com/pvmarquez1956)




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  Is the Growing Attachment to Smartphones and Digital
  Media Bad for Our Health? An initial exploration
  Submitted by Patricio V. Marquez on Sun, 12/08/2019 - 09 36 AM




  Is the Growing Attachment to Smartphones and Digital
  Media Bad for Our Health? An initial exploration
  Posted by Patricio V. Marquez on Sun, 12/08/2019 - 09 36 AM




  This note served as background to a presentation delivered per the invitation of the Ecuador Mission to the United Nations at
  the Meeting on Social Media and Mental Health, organized by the Group of Friends on Mental Health and Well-Being, that is co-
  led by the Permanent Missions of the Kingdom of Bahrain, Belgium, Canada and Ecuador to the United Nations.  New York City,
  December 12, 2019


   

  Technological innovation is fueling momentous change in our daily lives. Indeed, as Professor Klaus Schwab, the
  chairman of the World Economic Forum (WEF) describes, the physical, digital and biological trends underpinning
  what he calls 'the fourth industrial revolution', are unleashing changes “unlike anything humankind has
  experienced before" (WEF 2015).  At the center of it all is the Internet, anchoring digital media.

  The WEF de nes “digital media” as “products and services that come from the media, entertainment and
  information industry and its subsectors. It includes digital platforms (e.g., websites and applications), digitized
  content (e.g., text, audio, video and images), and services (e.g., information, entertainment, and communication) that
  can be accessed and consumed through different digital devices” (WEF 2016).  Laptops and desktops are still the
  most widely used devices, but mobile devices, such as smartphones, are fast catching up in popularity and use.

  The easy-to-carry and handle, multi-functional smartphone, is a common feature of modern life globally. Billions of
  people are now connected to these mobile devices, with unprecedented processing power, storage capacity, and
  access to knowledge. In emerging countries, mobile technology is allowing consumers to leapfrog from “no digital
  use” straight to “mobile use” (WEF 2015).




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  There is a growing concern that our attachment to them and “what is in them” not only captures our full attention
  and a good share of our time, but is creating virtual barriers that hinder direct social interaction.  There are also
  concerns about their potential negative impact on the mental and physical health of people. 

  To learn about this topic, as it would not surprise anybody, I began searching the web for recent literature using the
  Google app in my smartphone while waiting at the dentist’s of ce, before turning to a laptop at home to review and
  write.  A summary of my initial exploration follows.

  Growing popularity and use

  Hundreds of millions of people are using smartphones, downloading apps, and browsing web sites. Smartphone
  subscriptions are growing at the rate of 17-19% per year and now total about 2.1 billion users, while consumer mobile
  internet traf c is accelerating at more than 60% every year (WEF 2015).  Smartphone ownership among young
  people aged 9 to 16 is also growing; for example, almost half of young people in Europe have a smartphone,
  according to a 2014 survey of 7 countries (Mascheroni and Ólafsson 2014).

  In the US, 48% of 11-year-olds reported owning a mobile phone, and among 14-year-olds, it was 85% (unpublished
  data; see go.nature.com/2eeffku, cited by Odgers 2018).

  Smartphones have become essential to the life of people.  It is not surprising to learn, then, that an estimated 87% of
  US millennials say their smartphone never leaves their side (Ziv, S). Similarly, a survey by Qualtrics and Accel
  Partners found that 79% of US millennials put their phones right by them when they sleep, 53% wake up at least
  once every night to check them, and that nearly 60% check them before they use the bathroom in the morning.
  Data reveals that 89% of mobile phone owners use them in social gatherings, to read texts or emails, take photo or
  video; or to place a call (Ziv, S).

  Social media, which have grown in popularity, are web platforms that allow individuals to create a pro le and
  connect to other people to share information, ideas, interests, and other forms of expression on the site regardless
  of location and time. The different types of social media platforms include: Social networking (Facebook, LinkedIn,
  Google+); Microblogging (Twitter, Tumblr); Photo sharing (Instagram, Snapchat, Pinterest); and Video sharing
  (YouTube, Facebook Live, Periscope, Vimeo).

  About 3.2 billion people or 40% of the world’s population are estimated to use social media.  Worldwide, as shown
  in the graph below, Facebook tops the list with 2.23 billion active users as of mid-2018, or almost a third of the
  world’s population, followed by YouTube and Instagram.  




  Source: Graph downloaded at https://www.dreamgrow.com/top-15-most-popular-social-networking-sites/
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  Adult social media users spend on average 2 to 3 hours every day sharing, liking, tweeting, and updating. Use
  prevalence among teenagers is growing rapidly. For example, survey data indicate that on average, US teens aged
  13–18 engage with digital media (from watching television or online videos to reading online and using social media)
  for more than 6.5 hours each day; mobile devices account for almost half this time (Rideout 2015).

  What are the negative aspects of these trends?

  We should not be surprised, then, that as individuals want to be connected more or less 24/7, the question that
  many people are asking is, how is all this impacting us, our children, and our social lives?

  The graph below depicts the negative psychological effects of social media:




  Source: Graph from Kelly, Zilanawala, Booker and Sacker. 2019. “Social Media Use and Adolescent Mental Health:
  Findings from the UK Millennium Cohort Study.” The Lancet. 

  The ndings of a 2016 assessment by the WEF expands on these negative effects: 

      Excessive digital media use can negatively in uence the development of cognitive (thinking, imagining,
      reasoning, and remembering abilities) and behavioral (reactions or actions that we take in response to stimuli
      present in our environment) skills and even mental and physical health of people.
      Hyper connectivity has the potential to change patterns of social interaction, as face-to-face interaction, that is
      essential to the give-and-take functioning of families, communities, and workplaces, may be substituted by
      online interaction.
      Levels of empathy (“understanding another’s situation or feelings and experiencing a sense of their emotional
      state”) are declining, perhaps as a result of the decrease in face-to-face communication.
      Digital media consumption may facilitate bullying, harassment, social defamation, and hate speech because
      potential costs of such behavior are reduced and the ease of engaging in behaviors that harm either others or
      ourselves is increased (Mascheroni and Cuman 2014).  Data from a global YouGov survey sponsored by Vodafone
      shows that of more than 4,700 teenagers surveyed worldwide, 50% felt that cyberbullying was worse than face-
      to-face bullying;  about one- fth reported having been cyberbullied; of those, 41% stated cyberbullying made
      them feel depressed, and 18% said it had made them consider suicide (Vodafone/YouGov 2015).

  Mental health risks




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  Research indicates that excessive digital media consumption and the way digital media are being used pose a
  number of risks to user health and well-being, particularly increased vulnerability to addiction, and harm mental
  and physical health. 

  The ndings in the 2016 assessment by the WEF identify three potential major mental health risks:

      Overload: Increased stress because of the volume and variety of social media contact,
      Invasion: Intrusion of media connections into personal life, and,
      Uncertainty: Continuous and unpredictable change in social media applications and requirements.

  As I can attest from my own experience, uninterrupted access to digital media content tends to intrude in a user’s
  work and personal lives, making one oblivious to the difference between business and personal activity and between
  time on and time off.

  Other potential risks identi ed in in the 2016 WEF assessment, include:

      Envy-related stress related to constant updates on friends’ latest professional successes, fantastic vacations,
      and personal triumphs.
      Decline in civility, facilitated by electronically mediated interactions that are more anonymous and often more
      bluntly negative than face-to-face encounters.
      Addictive behavior, as shown by evidence that some video gamers experience symptoms similar to those felt by
      people with substance abuse or gambling addiction and may be experiencing similar changes in brain chemistry
      related to the release of dopamine, an important chemical messenger in the brain that it is involved in reward,
      motivation, memory, attention, and even regulating body movements. When dopamine is released in large
      amounts, it creates feelings of pleasure and reward, which motivates you to repeat a speci c behavior.  
      Association with depression. Distinct patterns of social media use help explain the association of digital media
      with depression and anxiety symptoms. Those clustered as “Wired” and “Connected” in the research showed
      increased odds of elevated depression and anxiety symptoms (Shensa, Sidani, Dew, Escobar-Viera, Primack 2018).
      Similarly, a large longitudinal study of Americans aged 14-24 years found that heavy use of the internet and video
      games is associated with an increase in depression. Findings from the UK Millennium Cohort Study show that the
      magnitude of association between social media use and depressive symptoms was larger for girls than for boys.
      Poor sleep, online harassment, poor body image, and low self-esteem appear to be important pathways via which
      social media use is associated with depressive symptoms in young people (Kelly, Zilanawala, Booker, Sacker 2019).
      Impact on cognition. Social media use has been shown to reduce attention span and lower recall rates for
      information people believe they can access easily online.
      Reduced downtime. Increased social media use reduces periods of inactivity, which are critical to allow the brain
      to synthesize information, make connections between ideas, and develop a sense of self.

  Physical health risks

  Two major physical health risks from high digital media use can be highlighted: 

      Increased sedentary behavior.  Time spent on digital technology displaces time that could be spent on physical
      activity. Lack of physical activity has been identi ed as the fourth leading risk factor for global mortality (6% of
      deaths globally). Moreover, physical inactivity is estimated to be the main cause for approximately 21–25% of
      breast and colon cancers, 27% of diabetes cases, and approximately 30% of the ischemic heart disease burden.
      Childhood obesity, which is one of the most serious public health challenges of the 21st Century, is steadily
      affecting many low- and middle-income countries, particularly in urban settings. Globally, in 2016, the number of
      overweight children under the age of ve was estimated to be over 41 million. Overweight and obese children are
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      likely to stay obese into adulthood and more likely to develop noncommunicable diseases like diabetes and
      cardiovascular diseases at a younger age (accessed WHO data).
      Physical injury.  The use of handheld smartphones is now a major cause of road traf c injuries and fatalities in
      the world, particularly among young drivers. Studies in the United States show that dialing and texting when
      driving pose a substantial increase in the risk of being involved in a crash or near crash (cited in Marquez et al
      2009).  

  When driving light vehicles and cars:

      Placing a call on a cell phone made the risk of a crash or near-crash event 2.8 times higher than non-distracted
      driving.
      Talking on or listening on a cell phone made the risk of crash or near-crash event 1.3 times higher than non-
      distracted driving.
      Reaching for an object such as an electronic device made the risk of a crash or near-crash event 1.4 times higher
      than non-distracted driving.

  When driving heavy vehicles and trucks:

      Placing a call on a cell phone made the risk of a crash or near-crash event 5.9 times higher than non-distracted
      driving.
      Talking or listening on a cell phone made no difference to the risk of a crash or near-crash event compared to
      non-distracted driving.
      Use of or reaching for an electronic device made the risk of a crash or near-crash event 6.7 times higher than
      non-distracted driving.
      Text messaging made the risk of a crash or near-crash event 23.2 times higher than non-distracted driving (large
      trucks made up close to 10% of all vehicles involved in fatal crashes in the US).

  Impact on children’s well-being

  Studies in the 2016 WEF highlighted the following potential negative impact on children:

      Excessive new media use can lead to attention problems, school dif culties, sleep disorders (particularly for
      children aged three to ve years when exposed to violent content), and eating disorders and obesity.
      Digital media use is harmful to children if interaction with parents and others is replaced by interaction with
      digital media. Research has shown that brain development depends on social interaction with others during a
      critical period in early life and that lack of social interaction creates irreversible social and cognitive impairments
      throughout life.
      Healthy neurological development requires the engagement of all sensory systems, but heavy digital media
      consumption favors the visual and auditory systems over the vestibular (sense of balance), proprioceptive
      (sense of self-movement and body position), tactile (sense of touch), and attachment systems, creating possibly
      permanent imbalances.
      Delayed language development. Research has shown that very young children (aged 9-18 months) do not learn
      language by watching educational videos without active interaction with another person.
      Uncontrolled time spent on digital media often displaces time spent on academics, lowering academic
      achievement.
      Digital media make it easier to disseminate inaccurate as well as accurate information, and much that is online
      is potentially harmful to younger audiences.  For example, a recent New York Times article documents how
      through video games and online chats sexual predators are making virtual connections with children right in
      their victims’ homes.  The criminals strike up a conversation and gradually build trust, often posing as children,

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      con ding in their victims with false stories of hardship or self-loathing, with the goal of duping children into
      sharing sexually explicit photos and videos of themselves — which they use as blackmail for more imagery, much
      of it increasingly graphic and violent (Bowles N, Keller MH 2019).

  Impact on Adolescents

  Data show an increase in mental health problems among adolescents (Odgers 2018). Worldwide, it is estimated that
  10–20% of adolescents experience mental health issues (Marquez, Dutta 2018).

  Recent  data suggest that adolescents do perceive social media as a threat to mental wellbeing because: (1) social
  media is  believed to cause mood and anxiety disorders for some adolescents, (2) social media is viewed as a platform
  for cyberbullying,  and (3) the use of social media itself was often framed as a kind of 'addiction' (O’Reilly, Dogra,
  Whiteman, Hughes, Eruyar, Reilly 2018).

  Research based on a large, nationally representative dataset in the US found that more US adolescents and young
  adults in the late 2010s, as compared to the mid-2000s, are experiencing serious psychological distress, major
  depression, and suicidal thoughts and more attempted suicide and took their own lives. These trends are weak or
  nonexistent among adults 26 years old and over.  These trends suggest a generational shift in mood disorders and
  suicide-related outcomes rather than an overall increase across all ages; researchers posited that they may be
  associated with lack of sleep and the rise of social media in teens (Twenge, Cooper, Joiner, Duffy, Binau 2019).

  How can we leverage these tools and platforms to address mental and physical health risks?

  We should be clear that access to and use of digital media, while posing risks, is also bene cial to both individuals
  and society.   

  Digital tools and platforms are enabling unprecedented levels of communication, social interaction, and community
  building across boundaries of time, place, and social context (Seabrook, Kern, Rickard 2016).  In particular, as
  indicated by 61% of respondents to the Implications of Digital Media Survey (WEF 2016), digital media is considered
  helpful to maintaining existing relationships with friends, and 45% believe it is helpful in forming new ones. Also,
  social media facilitates the rapid sharing of accumulated knowledge and experiences within countries and globally. 

  In the health sector, digital tools and platforms are now becoming an asset for individuals and healthcare
  practitioners, to help improve access to care and reach vulnerable populations, particularly in low-income settings
  where healthcare delivery systems are limited.  A good example is the initiative by Mobile Technology for
  Community Health (MoTeCH) and the Grameen Foundation in Ghana, piloted in the Upper East Region and now
  being replicated in the Central, Greater Accra and Volta Regions, which  allowed women with limited literacy skills
  to be informed in the local language about the “do’s and don’ts” in pregnancy and childbirth (Marquez 2013). Women
  also receive reminders on clinical appointments, due dates, and required medication and immunization through
  their mobile phone. This technology also enables women, their partners and families, to recognize the signs of life-
  threating complications during pregnancy and empowers them to seek immediate care. Other applications allow
  community midwives and nurses to provide rapid response and care and to follow up with health service defaulters
  in the community.

  Mobile devices like smartphones are also giving the public, doctors, and researchers new ways to access help,
  monitor progress, and increase understanding of mental wellbeing (information from the National Institute of
  Mental Health website).  For example, text messages can help contact a crisis center; apps might use the device’s
  built-in sensors to collect information on a user’s typical behavior patterns, including detecting a change in
  behavior, and provide a signal that help is needed before a crisis occurs. Some stand-alone apps could help improve
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  memory or thinking skills, and others help the user connect to a peer counselor or to a healthcare professional. This
  support can be very simple but effective.  A meta-analysis found, for example, that brief interventions, such as
  computer-assisted cognitive behavioral therapy delivered through mobile devices, improved people’s psychological
  well-being and reduced reported symptoms of depression and anxiety (Versluis, Verkuil, Spinhoven, van der Ploeg,
  Brosschot 2016).

  In addition, digital media can facilitate education and life-long learning to build the skills of the future,
  contributing to human capital development in countries.

   
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  Shensa A, Sidani JE, Dew MA, Escobar-Viera CG, Primack BA. 2018. “Social Media …
  (https://www.ingentaconnect.com/contentone/png/ajhb/2018/00000042/00000002/art00011)
  Shukla A. 2019. “The Effect of Social Media on Mental Health and Well-Being.” C…
  (https://cognitiontoday.com/2019/08/effect-of-social-media-on-mental-health-well-being/)
  Spelman M. Co-Head, Future of the Internet Initiative, Member of the Executive …
  (https://www.weforum.org/agenda/2015/12/what-does-the-future-hold-for-the-internet/)
  Twenge JM, Cooper AB, Joiner TE, Duffy ME, Binau SG. 2019. “Age, Period, and Co…
  (https://www.apa.org/pubs/journals/releases/abn-abn0000410.pdf)
  Versluis A, Verkuil B, Spinhoven P, van der Ploeg MM, Brosschot JFJ. 2016. Smar…
  (https://www.nature.com/articles/d41586-018-02109-8)

www.pvmarquez.com/digital media_impacts                                                                                                                    7/8
1/12/2021                    Is the Growing Attachment to Smartphones and Digital Media Bad for Our Health? An initial exploration | Patricio V. Marquez

  Vodafone/YouGov. 2015. “Global Survey on Cyberbullying.” (https:/  /markets.ft.com/data/announce/full?
  dockey=1323-12509304-1Q8SVKBQINRPVIK2IJ53QU6KG4)
  WEF. 2015. “The Fourth Industrial Revolution: what it means, how to respond.”
  (https://www.weforum.org/agenda/2016/01/the-fourth-industrial-revolution-what-it-means-and-how-to-
  respond/)
  WEF. 2016. “Digital Media and Society Implications in a Hyperconnected Era. Sec…
  (http://www3.weforum.org/docs/WEFUSA_DigitalMediaAndSociety_Report2016.pdf)
  WHO site. “Global Strategy on Diet, Physical Activity and Health.”
  (https://www.who.int/dietphysicalactivity/childhood/en/.)
  Ziv S. “7 Scary Cell Phone Facts That'll Make You Question Your Addiction.” (https://www.themuse.com/advice/cell-
  phone-addiction-stats-scary)




                                                  
                                                         (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/digital media_impacts                                                                                                                    8/8
1/12/2021                                   Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | Patricio V. Marquez




  Plastic Pollution: A "Clear and Present Danger" to the
  Galapagos Islands
  Submitted by Patricio V. Marquez on Wed, 11/27/2019 - 08 14 AM




  Plastic Pollution: A "Clear and Present Danger" to the
  Galapagos Islands
  Posted by Patricio V. Marquez on Wed, 11/27/2019 - 08 14 AM




  People of my generation remember well the 1967 coming of age lm, “The Graduate.”  In the opening scene, a
  confused, wide-eyed young man, just returning home after nishing his university studies, is offered advice about
  his future by a middle-aged friend of his parents in a much-quoted exchange:

  MR. MCGUIRE: I want to say one word to you. Just one word.


  BENJAMIN: Yes, sir.


  MR. MCGUIRE: Are you listening?


  BENJAMIN: Yes, I am.


  MR. MGGUIRE: Plastics.




www.pvmarquez.com/plastic_pollution_galapagos                                                                                                1/6
1/12/2021                                   Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | Patricio V. Marquez

  As preadolescent in those years, I was precociously intrigued by the plot of the movie and captivated by the
  wonderful soundtrack of Simon and Garfunkel, but completely oblivious to its 1960s counterculture message.  Years
  later, I found out that the reference to “plastics” in the lm was considered as analogous with the perceived
  “unnatural”, “arti cial”, and “lifeless” materialism of the times. 

  Plastics have also been broadly appreciated economically for being low-cost, lightweight, strong, durable, resistant
  to corrosion, and nonconductors of electricity. It has been estimated that global plastics production rose
  exponentially since the 1950s, from 15 million tons in 1964 to over 311 million tons in 2014, or twenty-fold in 50 years.

  Moving the clock forward to the end of the second decade of the XXI Century, mass consumption, so greatly
  facilitated by plastics, is now widely understood and accepted as a direct threat to future life in our planet.  While
  the great versatility and usefulness of plastics is economically appealing, their broad use and fate can also harm.
  Indeed, the manufacture, wide use, and waste of all things plastic, particularly their prominence in marine debris, is
  comparable to climate change in terms of impact, breadth and complexity.

  On a recent visit to the Galapagos Islands, I was struck to learn that despite being located 600 miles westward of the
  South American continent and the dedicated work of Galapagos National Park’s rangers and volunteers to conduct
  coastal clean ups regularly, plastic waste being carried by strong oceanic currents is putting its fragile ecosystem at
  risk.  Indeed, information from different international organizations such as the National Geographic Society shows
  that a plethora of plastic bottles, oil containers, plastic takeaway containers, plastic cutlery, glass bottles, metal
  tanks, shing nets and traps, and plastic- ber rope are washing onshore into pristine lava elds, sandy beaches, and
  mangrove elds. As observed by the Galapagos Conservation Trust, the increase of visitors to the Islands in recent
  years, as well as the increase in the permanent residents, also implies that the amount of waste created is growing,
  adding to plastic pollution. 

  It should be clear to all of us, therefore, that in spite of their “splendid isolation”, man-made waste and pollution are
  becoming a major risk that threatens the Galapagos Islands’ unique fauna and ora, both inland and in the Galapagos
  Marine Reserve. In particular, the native wildlife of Galapagos, that includes animal species not found anywhere else
  in the world, are highly vulnerable to the introduction of plastic pollution as it may cause adverse changes to natural
  habitats and injury and death when animals get entangled in heaps of debris.  Iconic creatures such as the giant land
  tortoise and marine turtles are particularly affected when debris in the ocean is mistaken for food and ingested,
  causing internal abrasions and gut blockages. The human population is also at health risk as the unintended
  ingestion of plastic substances disrupts endocrine functions*, which can cause cancerous tumors, birth defects, and
  other developmental disorders.

  We also have to understand that this environmental risk to the preservation of the Galapagos Islands is part of a
  growing interconnected problem across continental South America and the rest of the world.  Indeed, World Bank
  Group assessments have documented the magnitude of this challenge globally. In 2010 alone, 4-12 million tons of
  plastic were estimated to wash ashore globally.  Of the estimated 275 million tons of plastic waste generated in 2010,
  over 60 percent is thought to have originated from plastic packaging, which is primarily designed for single use. 

  Effective action to minimize this risk will require robust advocacy grounded in scienti c evidence to mobilize high-
  level political support to counter “commercial determinants” of environmental and public health risks and active
  engagement of government entities, private enterprises, and the population as a whole; medium-and long term
  policies and regulatory mechanisms such as the sustainability certi cation standards; raising consumer and farmer
  awareness of and ability to address the challenges of plastics use, as well as nudging the immense market power of
  consumers to shape and in uence farming practices; and predictable and suf cient funding levels to support
  sustained action over the medium-and long term.

www.pvmarquez.com/plastic_pollution_galapagos                                                                                                2/6
1/12/2021                                   Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | Patricio V. Marquez

  As noted by the World Bank, much is known about the major avenues for mitigating plastics pollution-- from
  improving how plastics are managed once they enter the waste stream or even further upstream during their useful
  life, to reducing how much is produced, used, or enters the waste stream.  Promising approaches to deal with this
  problem include:

       Recycling to reduce the production of new plastic and how much enters the waste stream. Plastics have been
       recycled for decades, and recycling is now accepted as a good practice globally. 
       Waste-to-energy: This involves turning plastics into fuel or directly into energy (through gasi cation using
       pyrolysis and incineration, respectively). As with recycling, however, its effectiveness can be limited by collection
       challenges upstream.
       Materials innovation/biodegradable plastics: Certain plastics can be made biodegradable, thus lessening the
       likelihood that they will persist for a very long term in their plastic state, as they have the potential to be
       composted or to photodegrade (or to otherwise degrade).
       Improved collection and waste management:  Expanding collection, improving waste transport systems to
       reduce illegal dumping, and closing or upgrading dumping sites located near waterways can prevent leakage of
       plastics into the environment.  When plastic waste is not collected, it is more than twice as likely to leak into the
       ocean. 

  Similarly, as the global experience with “public health taxes” levied on cigarettes, alcohol, and sugary drinks shows,
  imposition of or hiking the level of taxes to raise the price of single-use plastic bags to carry groceries or other
  items, needs to be adopted as a win-win policy measure to discourage the use of thin,  disposable plastic
  shopping bags to help the environment and reduce plastic trash, while helping mobilize additional domestic
  resources to fund environmental protection in national budgets.  This measure is of upmost importance in periods
  of economic austerity as currently facing the Ecuadorian Government and should be included and supported as part
  of scal consolidation efforts.    

  To help address this issue globally, innovative nancing mechanisms are being tapped.  For example, the World
  Bank launched in April 2019 a Sustainable Development Bond targeting institutional and individual investors to
  draw attention to the challenge of plastic waste pollution in oceans.  This bond, which raised US$10 million, would
  contribute to fund projects to support the sustainable use of ocean and marine resources, including through better
  waste management, in developing countries.

  The growing economic, environmental, human health, and aesthetic risk posed to the Galapagos Islands by marine
  plastic debris from continental Ecuador and neighboring countries can be contained and minimized by collective
  action.  If this is not done, plastic waste stands to cause irreparable damage to the Galapagos Islands in an ominous
  way similar to Charles Darwin’s observation in The Voyage of the Beagle with regard to the “havoc” that may be
  caused by the “introduction of any new beast of pray…before the instincts of the indigenous inhabitants have become
  adapted to the stranger’s craft or power”. 

   

  Note*: The endocrine system is the collection of glands that produce hormones that regulate metabolism, growth
  and development, tissue function, sexual function, reproduction, sleep, and mood, among other things. This system
  affects almost every organ and cell in the body, according to the Merck Manual.

    

   
  Sources

www.pvmarquez.com/plastic_pollution_galapagos                                                                                                3/6
1/12/2021                                   Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | Patricio V. Marquez

  Plastics Scene from “The Graduate” (1967). (https:/  /www.bing.com/videos/search?
  q=plastic%20in%20the%20Graduate&qpvt=plastic%20in%20the%20Graduate&view=detail&mid=B10C80827D443C5C7
  “What is the meaning behind the quote "plastics" from "The Graduate?" Comment b…
  (https://www.quora.com/What-is-the-meaning-behind-the-quote-plastics-from-The-Graduate)
  National Geographic. “Impact of plastic garbage reaches the Galapagos Islands” …
  (https://blog.nationalgeographic.org/2018/04/22/impact-of-plastic-garbage-reaches-the-galapagos-islands/)
  Galapagos Conservation Trust. As Tourism Increases in Galapagos so do Threats s…
  (https://galapagosconservation.org.uk/about-galapagos/conservation/pollution/)
  World Bank Group. Agricultural Pollution: Plastics.
  (http://documents.worldbank.org/curated/en/122161521208357388/pdf/124346-repl-WB-Knowledge-Plastic.pdf)
  Acharya, A. “World Oceans Day & plastic pollution: Is the planet overdosing on …
  (https://blogs.worldbank.org/eastasiapaci c/world-oceans-day-plastic-pollution-planet-overdosing-miracle-
  product)
  World Bank Group. Tackling Increasing Plastic Waste. (http:/  /datatopics.worldbank.org/what-a-
  waste/tackling_increasing_plastic_waste.html)
  World Bank Launched Bonds to Highlight the Challenge of Plastic Waste in Oceans…
  (https://www.worldbank.org/en/news/press-release/2019/04/03/world-bank-launches-bonds-to-highlight-the-
  challenge-of-plastic-waste-in-oceans)
  Darwin, C. “The Voyage of the Beagle. A Journal of researches into the natural …
  (https://www.amazon.com/Voyage-National-Geographic-Adventure-Classics-ebook/dp/B000MAH7J0)
  Kickbusch, I., Allen, L., and Franz, C. 2016. “The commercial determinants of h…
  (https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(16)30217-0/fulltext)
  Marquez, PV. 2019. “Retracing Darwin’s Footsteps in the Galapagos”. (http://pvmarquez.com/node/5)




www.pvmarquez.com/plastic_pollution_galapagos                                                                                                4/6
1/12/2021                                   Plastic Pollution: A "Clear and Present Danger" to the Galapagos Islands | Patricio V. Marquez




www.pvmarquez.com/plastic_pollution_galapagos                                                                                                5/6
1/12/2021                                       Retracing Darwin’s Footsteps in the Galapagos | Patricio V. Marquez




  Retracing Darwin’s Footsteps in the Galapagos
  Submitted by Patricio V. Marquez on Sun, 11/24/2019 - 12 37 PM




  Retracing Darwin’s Footsteps in the Galapagos
  Posted by Patricio V. Marquez on Sun, 11/24/2019 - 12 37 PM




  In the latter part of February 1535, a caravel carrying Fray Tomas de Berlanga, bishop of Panama, enroute to Peru,
  drifted off course in the Paci c Ocean amid the equatorial doldrums, disappearing wind, and strong currents to an
  unknown and strange land. In his report to Charles V, King of Spain, who had mandated him to journey to settle
  disputes in his new empire, he described the nature of the shore in vivid detail:

  “There were some small stones that we stepped on as we landed, and they were diamond-like stones, and others amber
  colored; but on the whole island I do not think that there is a place where one might sow a bushel of corn, because most
  of it is full of very big stones, so much so that it seems as though at some time God had showered stones; and the earth
  that there is, is like slag, worthless, because it does not have the virtue to create a little grass, but only some thistles, the
  leaf of which I said we picked.”


  Three centuries later, Charles Darwin, sailing in the H.M.S. Beagle, arrived in the Galapagos Islands, an archipelago
  located six hundred miles westward of the coast of Ecuador, as part of his ve-year voyage to South America and
  the South Paci c.  Upon landing on Chatham Island (now San Cristobal), Darwin noted in similar terms that:

  “Nothing could be less inviting that the rst appearance. A broken eld of black basaltic lava, thrown into the most
  rugged waves, and crossed by great ssures, is covered by stunted, sun-burnt brushwood, which shows little signs of
  life.”

www.pvmarquez.com/node/5                                                                                                              1/4
1/12/2021                                    Retracing Darwin’s Footsteps in the Galapagos | Patricio V. Marquez

  As I found out on a recent visit to eight islands in the Galapagos aboard the Lindblad Expeditions/National
  Geographic’s Endeavor II (https:/  /www.expeditions.com/why-us/our- eet/national-geographic-endeavour-
  ii/overview/) vessel, the observations made by de Berlanga and Darwin have in large measure withstood the passage
  of centuries. Indeed, one is not only captivated by a sense of distance and isolation from mainland Ecuador, but is
  confronted by a strange mixture of volcanic terrain pummeled by strong ocean currents, tick mists that make the
  islands disappear and then reappear at sunrise, lea ess shrubs, large cacti, and strange animals, that are not afraid
  of humans.

  While one nds scarce remains of visits by pirates, buccaneers, and whalers from the late 1500s through the early
  1800s, and later of repeated, but failed, colonization attempts by penal colonies and settlers, the archipelago
  continues to be, as observed by Darwin during his visit in 1835, “a little world within itself, or rather a satellite
  attached to America, whence it has derived a few stray colonists, and has received the general character of its
  indigenous productions.”

  The geological formations in the islands combine rocky stretches of shoreline, pristine beaches with sand of various
  colors (rust red as in Rábida, created from lava with high iron oxide; ash black in Togus Cove; and beautiful white in
  Cerro Brujo or Wizard Hill), and active volcanos such as the Salcedo Volcano in Isabela Island and Fernandina Island,
  at about 1 million years old, the youngest  and most volcanic of the archipelago as well as long-extinguished ones
  such as Ecuador Volcano, bisected by the Equator line on Isabela Island, that has collapsed and slumped away into
  the Paci c Ocean.  There are also verdant highland regions as in Santiago Island and patches of red Sesuvium, a
  plant that adds color to the uninhabited areas of San Cristobal.  Beautiful isolated rock outcroppings such as the
  León Dormido (“Sleeping Lion”), facing San Cristobal Island, offer a dreamlike view at sunset. And “in vivo” geological
  forces, such as the marine reef off the coast of Urbina Bay that was uplifted by as much as 15 feet, are a testament to
  unrelentless volcanic forces, oceanic currents, and trade winds that shape the islands.

  The unique fauna of the Galapagos Islands, which transports us to another era in time, stimulated “the origin” of
  Darwin’s ideas about evolution.  Indeed, an observation recorded in The Voyage of the Beagle, a journal that
  underpinned his seminal work On the Origin of the Species, changed the scienti c understanding of the natural
  world by putting forward his theory of “descent with modi cation” by noting:

  “Considering the small size of the islands, we feel the more astonished at the number of their aboriginal beings, and at
  their con ned range. Seeing every height crowned with its crater, and the boundaries of most of the lava-streams still
  distinct, we are led to believe that within a period geologically recent the unbroken ocean was here spread out. Hence,
  both in space and time, we seem to be brought somewhat near to that great fact--the mystery of mysteries--the rst
  appearance of new beings on this earth.”

  The richness of the species that inhabit the Galapagos Islands, “peculiar to the group” and some “found nowhere
  else”, include the blue- and red-footed boobies, frigate birds, and several species of nches in different islands.
  Other species, like the American amingo and land iguanas, have a more restricted distribution, and some species
  are restricted to just one island, such as the waved albatross, that nests exclusively on Isla Española, and the
   ightless cormorant, found only on Isabela and Fernandina Islands. The “saddle-shaped” giant tortoises, iconic
  species of the archipelago, with an average life expectancy of close to 200 years, move between the highlands and
  dry zones, depending on the island and season.

  The wildlife at sea include cold-water penguins, green sea turtles, marine iguanas, sea lions, fur seals, and Sally
  Lightfoot crabs, along with many species of sea and shore birds. There is also a rich and diverse underwater world,
  nurtured by diverse ocean currents that converge on these remote shores, including tropical-reef sh, whales and
  dolphins, and a variety of shark species, including white-tip, Galapagos, and hammerhead sharks.

www.pvmarquez.com/node/5                                                                                                     2/4
1/12/2021                                   Retracing Darwin’s Footsteps in the Galapagos | Patricio V. Marquez

  About 30,000 people live in four of the 13 large islands in the archipelago, making a living from tourism, shing, and
  farming.  While Puerto Baquerizo Moreno, on San Cristobal Island, is the capital of the Ecuadorian Province of
  Galapagos, over half of all Galapagueños live in the city of Puerto Ayora on Santa Cruz Island, which is the center of
  tourism and conservation.

  As an Ecuadorian living abroad for most of my adult life, I felt great pride for the work done by my compatriots in
  preserving this UNESCO World Natural Heritage Site. After of cially taking possession of the Galapagos Islands in
  1830, the Ecuadorian Government converted in 1959 all parts of the islands that were not inhabited by humans as a
  National Park (96% of the total archipelago surface area). The same year, the Charles Darwin Foundation
  (https://www.darwinfoundation.org/en/) was established with the objective of conserving the unique Galapagos
  ecosystems, and the Charles Darwin Research Station (https:/     /www.darwinfoundation.org/en/about/cdrs) was
  inaugurated in 1964 to conduct scienti c studies aimed at protecting indigenous plant and animal life. In 1968, the
  Galapagos National Park Service, a governmental institution, was created to protect the archipelago. 

  I also felt great pride observing that the high-quality service standards aboard the Lindblad Expeditions/National
  Geographic Endeavour II vessel, depends for its operation on a top-quality Ecuadorian crew and a superb team of
  knowledgeable and diplomatic technical guides and staff, many of them Galapagueños, to offer to visitors an
  environmental, historical, cultural, and culinary exploration at its best.

  Herman Melville, the author of Moby Dick, observed in 1854 about the Galapagos Islands that “the special curse, as
  one may call of the Encantadas*, that which exalts them in desolation...is that to them change never comes-neither the
  change of seasons or of sorrows”.  Echoing those words, I concluded my visit with a deep conviction that we all have
  an obligation to protect the Galapagos Islands as a legacy of humanity for the enjoyment of future generations.  This
  realization acquires more relevance in periods of scal austerity as the one currently facing the Government of
  Ecuador, when “siren calls”, both domestic and international, try to use cyclical downturns as an opportunity to
  advance short-term, self-serving economic interests, without due consideration to the long-term impact on the
  environment. 

  I also feel that globally we have an obligation to help mobilize additional nancial resources, to complement regular
  budgetary allocations by the Ecuadorian Government, to support with adequate funding levels the critical
  conservation work of the Galapagos National Park Service and the Charles Darwin Foundation. 

  For my part, I began to do so before departing, with a contribution to the Lindblad Expeditions-National Geographic
  (LEX-NG) Fund (https:/ /www.expeditions.com/why-us/global-stewardship/Galapagos/), that supports in the
  National Geographic’s Early Career Grant program and partner institutions such as the Galapagos National Park and
  the Charles Darwin Research Station.  We should all join the good ght of protecting the unique Galapagos
  ecosystems, as I am planning to continue to do so.  Indeed, I feel that we need to do so as the Galapagos Islands are
  a global public good.

  Note*: Early Spanish sailors called the islands “Las Encantadas,” meaning “the enchanted,” a reference to the fact
  that the islands would seem to disappear and then reappear due to mists and ocean currents.
  Sources
  Darwin, C. “The Voyage of the Beagle. A Journal of researches into the natural …
  (https://www.amazon.com/Voyage-National-Geographic-Adventure-Classics-ebook/dp/B000MAH7J0/)
  Darwin, C. “On the Origin of Species (with an Introduction by Charles W. Eliot)… (https://www.amazon.com/Origin-
  Species-Introduction-Charles-Eliot/dp/1420953125/ref=asc_df_1420953125/?tag=bingshoppinga-
  20&linkCode=df0&hvadid=&hvpos=&hvnetw=o&hvrand=&hvpone=&hvptwo=&hvqmt=e&hvdev=c&hvdvcmdl=&hvlocint=
  4584207577261323&psc=1/)


www.pvmarquez.com/node/5                                                                                                   3/4
1/12/2021                              Retracing Darwin’s Footsteps in the Galapagos | Patricio V. Marquez

  Stewart, P.D. “Galapagos The Islands that Changed the World (with a Foreword by…
  (https://www.amazon.com/Galápagos-Islands-That-Changed-World/dp/0300122306/ref=asc_df_0300122306/?
  tag=bingshoppinga-
  20&linkCode=df0&hvadid=&hvpos=&hvnetw=o&hvrand=&hvpone=&hvptwo=&hvqmt=e&hvdev=c&hvdvcmdl=&hvlocint=
  4584207580741912&psc=1/)
  Lindblad Expeditions/National Geographic. “Expedition Guide. Galapagos Aboard N…
  (https://www.expeditions.com/)
  Perez, W. and Weisberg, M. “Galapagos Life in Motion.” (2018) (https:/ /www.amazon.com/Galápagos-Life-Motion-
  Walter-Perez/dp/069117413X/ref=asc_df_069117413X/?tag=bingshoppinga-
  20&linkCode=df0&hvadid=&hvpos=&hvnetw=o&hvrand=&hvpone=&hvptwo=&hvqmt=e&hvdev=c&hvdvcmdl=&hvlocint=
  4583795261458359&psc=1/)
  Lindblad Expeditions-National Geographic (LEX-NG) Fund
  (https://www.expeditions.com/globalassets/pdf/lex_ng_fund_2018_2019_rpt.pdf/)
  Charles Darwin Foundation (https:/ /www.darwinfoundation.org/en/donate)
  For information on how to create a lasting legacy in Galapagos (https:/ /www.darwinfoundation.org/en/get-
  involved/give/fundraise-for-us)
  Melville, H. "The Encantadas, or Enchanted Isles" (2017; First published in Put…
  (https://www.amazon.com/Encantadas-Enchanted-Isles-Melville-Illustrated/dp/1521134855/ref=sr_1_1?
  keywords=melville%20herman%20enchanted&qid=1574695354&sr=8-1)




                                   
                                       (https://twitter.com/pvmarquez1956)




www.pvmarquez.com/node/5                                                                                     4/4
1/12/2021                           An Ode to Halloween, Birthdays and Aging | Patricio V. Marquez




   An Ode to Halloween, Birthdays and
   Aging
   Submitted by Patricio V. Marquez on Wed, 10/30/2019 - 10 39 AM




   An Ode to Halloween, Birthdays and
   Aging
   Posted by Patricio V. Marquez on Wed, 10/30/2019 - 10 39 AM




www.pvmarquez.com/halloween_aging                                                                    1/5
1/12/2021                           An Ode to Halloween, Birthdays and Aging | Patricio V. Marquez

   With the arrival of Halloween, a celebration observed in several countries on
   October 31st, I am celebrating my birthday and moving well into my early
   sixties. Birthdays are usually the time of the year when I tend to pause and
   look back to all that happened in the prior months while looking ahead with
   new ideas, commitments, and resolutions.  In a true sense, this is my real
   “new year” rather than at the beginning of the year in January.

   This Halloween is special.  For the rst time, in more than 30 years, I am not
   working or actively searching for a job. After retiring a couple months ago, I
   have been immersed in nding a new modus operandi for this next chapter
   in my life. 

   While the mirror clearly re ects the marks of time on my face--particularly
   a whiter beard--I feel that nothing has really changed. I continue to take
   long walks daily and enjoy riding my bike on some days, feeling physically t
   although a little overweight. Intellectually, I am still as passionate as before
   about exploring the complex social, economic, environmental, and political
   web that interacts with the genetic and biological make-up of people to
   impact and determine physical and mental health, mortality and survival,
   disability, and general well-being. Devoting more time to reading
   accumulated and new literature, magazines, newspapers, and Twitter;
   watching Copa Libertadores and Champions League soccer matches, boxing
   and ultimate ghting events, and over the past few days, the baseball World
   Series; an occasional movie or two; and a couple of trips with my wife that
   renewed our bond and expanded our minds, are helping me to tame feelings
   of anxiety that tend to appear un-invited, questioning whether I should be
   “working or searching for work”. I am starting to enjoy as well the good
   feeling of sharing accumulated knowledge and experience as a guest
   speaker at graduate classes in three universities covering various global
   public health topics.  Also, I guess my family is happy getting “a la carte”



www.pvmarquez.com/halloween_aging                                                                    2/5
1/12/2021                           An Ode to Halloween, Birthdays and Aging | Patricio V. Marquez

   services from a dedicated private UBER driver, grocery shopper, purchaser
   of all kind of tickets, handyman, and grill master, who has also learned to
   prepare good black beans, Cuban-style.

   Life continues, not linearly, but with a certain direction in spite of
   occasional steps backward or the inevitable U-turns. I wonder, however,
   whether my situation is unique, given my good health, mental curiosity,
   family support, and pension income?

   Recently, I read an article by Camilla Cavendish at the Financial Times, that
   argued that there is mounting evidence that retirement can be bad,
   especially if you enjoy your job, which I did immensely, along with its
   comradery and sense of meaning.  Also, it is argued that work has many
   bene ts and an important social function.  Since we are on average living
   longer lives, the question that we need to pose is why should not we push
   retirement well into the late sixties or early seventies then?

   Although global experiences show that working longer is feasible, the
   answer to this question has multiple caveats. A key condition for staying at
   work an extra decade or even more, as well argued in Cavendish’s article, is
   not just increased average life expectancy, but more importantly, healthy life
   expectancy.  This is a key observation as not everybody will bene t from
   working longer given the sometimes wide and growing gaps in healthy life
   expectancy between different income groups and in different regions within
   countries.  Also, the decision to stay at work or “unretire” will depend on the
   accumulated skill set of individual workers, effective life-long learning
   opportunities to retrain and reskill older workers, existing health insurance
   and pension bene ts, as well as public support systems to care for elderly
   family members.  Workplace facilitating environment and attitudes towards
   older workers, including stigma and discrimination, are also important
   considerations.


www.pvmarquez.com/halloween_aging                                                                    3/5
1/12/2021                           An Ode to Halloween, Birthdays and Aging | Patricio V. Marquez

   From a social perspective, we have to be mindful as well that the world
   population is growing older. In some countries, the age structure of the
   population is changing rapidly by falling birth rates, which is further
   impacted by youth migration in some of them.  This means that skills
   shortages are nowadays a real challenge that will not be met solely by robots
   or arti cial intelligence tools that take over many cognitive tasks.  Rather,
   older workers will not be easily be replaced. They are and will continue to be
   needed given their accumulated formal and tacit knowledge, institutional
   memory, skills set and wisdom, including interpersonal skills, that often cut
   across disciplines, work streams, and interconnected but distinct country
   social and cultural contexts. 

   So, on this Halloween, besides wishing myself a happy birthday, I should feel
   happy and less anxious realizing that I although “retired” I am part of a
   distinct population group that possesses valuable human capital that should
   be put to use with good impact, either as a volunteer or in formal
   employment, to help advance social and economic initiatives that bene t all,
   particularly in the intergenerational transmission of knowledge,
   experiences, and skills to younger generations.  To realize this potential,
   however, we “oldies” need to be mindful and disciplined in devoting time
   and effort to engaging in health promotion and disease prevention, as well
   as on life-long learning.  Yes, we can or as I would say in Spanish, si se puede,
   as we need to be t to purpose for that metaphorically “extra inning or
   round” in life.

    

    
   Sources
   Cavendish, C. “The case for staying at work an extra decade—or event more”.
   FTW… (https:/ /www.ft.com/content/f4cd91aa-c4d8-11e9-ae6e-
   a26d1d0455f4)

www.pvmarquez.com/halloween_aging                                                                    4/5
1/12/2021                                   An Ode to Halloween, Birthdays and Aging | Patricio V. Marquez

   Murray, J. “Work has many bene ts and an important social function” FT
   Letter… (https://www.ft.com/content/4610cb60-bf5a-11e9-b350-
   db00d509634e)
   Marquez, P. 2016. “Income inequality and differential mortality: An ominous
   com… (http:/ /blogs.worldbank.org/voices/income-inequality-and-
   differential-mortality-ominous-combination)
   Cavedish, C. 2019. “Extra Time: Ten Lessons for An Aging World”.
   (https://www.harpercollins.com/9780008362829/extra-time-10-lessons-
   for-an-aging-world/)




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www.pvmarquez.com/halloween_aging                                                                            5/5
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez




   Social Disparities Among Indigenous
   Peoples in the Americas: A Legacy to
   Overcome
   Submitted by Patricio V. Marquez on Sun, 10/27/2019 - 08 19 PM




   Social Disparities Among Indigenous
   Peoples in the Americas: A Legacy to
   Overcome
   Posted by Patricio V. Marquez on Sun, 10/27/2019 - 08 19 PM




   The recent social unrest in Ecuador brought to world attention the often ignored
   and marginalized indigenous peoples that led the opposition to economic reform
   proposals advanced by the Government.  While the unrest ended after some of the
   proposals were rescinded following a public dialogue between the Government
   and the leaders of the indigenous movement, deep-seated grievances remain that
   need to be addressed to improve the social conditions of indigenous peoples.  


www.pvmarquez.com/legacy_to_overcome                                                                                                         1/6
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez

   The situation of indigenous peoples in Ecuador, however, is not different from that
   in other Latin American countries, as well as in Canada and the United States, each
   with considerable indigenous populations. 

   Overall, there are between 45 and 50 million indigenous peoples living in Central
   and South America and the Caribbean, representing approximately 13 percent of
   the total population. In the United States, approximately 5.2 million persons self-
   identify as American Indian or Alaskan Native, and in Canada 1.4 million people
   self-identify as indigenous. As shown in the graph below, Mexico, Bolivia, Peru, and
   Guatemala have the largest populations in both absolute and proportional terms,
   accounting for more than 34 million indigenous people. The indigenous peoples
   represent more than 400 groups, with 560 diverse languages, cultures, and
   knowledge systems. 

   World Bank research has shown that despite the social progress achieved in the
   past couple of decades in Latin America, indigenous peoples did not bene t to the
   same extent as the rest of the population. Poverty af icts 43 percent of the
   indigenous population—more than twice the proportion of non-indigenous—while
   24 percent of all indigenous people live in extreme poverty, 2.7 times more than the
   proportion of non-indigenous people.  

   This situation is also apparent in in Canada, where over 60 percent of children
   living on First Nations reserves live in poverty, compared with 41 percent of all
   indigenous children and 18 percent of all children. In the United States, it is
   estimated that the median income of Native American households is nearly
   $30,000 less than the median income of white households. 

   Furthermore, being born to indigenous parents substantially increases the
   probability of being raised in a poor household, contributing to a poverty trap that
   hampers the full development of indigenous children.  In Ecuador, the probability
   of a household being poor increases by 13 percent if the household head belongs to
   an indigenous group, regardless of his or her level of education, gender, urban or
   rural location, and number of dependents. In Bolivia and Mexico, the probability is
   11 percent and 9 percent higher, respectively. 


www.pvmarquez.com/legacy_to_overcome                                                                                                         2/6
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez

   Contrary to common assumption, nearly half of Latin America’s indigenous
   population now lives in urban areas, but often are exposed to new dimensions of
   exclusion. About 36 percent of all indigenous urban dwellers live in insecure,
   unsanitary, and polluted environments, which contribute to increased health risks.
   For example, in Mexico, indigenous urban dwellers have less than half the access to
   electricity and piped water than other city dwellers have, one- fth the access to
   sanitation, and live nearly three times more often in houses with dirt oors.  

   World Bank data also show that while improved educational outcomes among
   indigenous people have been one of the most important advances in the last
   decade in Latin America, additional efforts are needed to increase education
   quality, make it culturally appropriate and bilingual, and to reduce a wide gap in
   education between indigenous men and women.

   In cities, indigenous people work mostly in low-skill/low-paying jobs. In countries
   with large urban indigenous populations, such as Peru, Ecuador, Bolivia, and
   Mexico, the percentage of indigenous persons occupying high-skill and stable jobs
   is two to three times smaller than the percentage of non-indigenous people.
   Indigenous workers, who often are engaged in informal occupations, are less likely
   to receive retirement and health insurance bene ts. Household data show that,
   regardless of educational background, gender, age, number of dependents, and
   place of residence, an indigenous person likely earns 12 percent less than a non-
   indigenous person in urban Mexico and about 14 percent less in rural areas. In
   Bolivia, an indigenous person likely earns 9 percent less in urban settings and 13
   percent less in rural areas. In Peru and Guatemala, indigenous persons earn about
   6 percent less than non-indigenous populations.  And Bolivian indigenous women
   earn about 60 percent less than non-indigenous women for the same type of jobs.

   Another common problem in the Americas is glaring health disparities that re ect
   not only high poverty levels but wide health care access gaps between indigenous
   peoples and the rest of the population. PAHO/WHO data show that infant
   mortality in consistently higher among indigenous children than among non-
   indigenous children in 11 countries in Latin America for which data were available. 
   In Panama and Peru, for example, infant mortality among indigenous children was
   three times higher than in non-indigenous children. The data also show greater
www.pvmarquez.com/legacy_to_overcome                                                                                                         3/6
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez

   maternal mortality among indigenous women and that under-5 mortality rates are
   far higher for children of indigenous background than for those of other ethnic
   groups. In a national survey study throughout Brazil, indigenous women were
   found to have a higher prevalence of obesity, anemia, and hypertension.  In
   Canada, infant mortality was 4.6 times higher in Inuit-inhabited areas than that
   reported in non-indigenous-inhabited areas. In the United States, under-5
   mortality for Native Americans at 8 deaths per 1,000 births, is second highest after
   African Americans at 11 deaths per 1,000 live births. From 2012–2015, compared
   with white women, the incidence of severe maternal morbidity was 148% higher
   for American Indian/Alaska Native women in the United States.  

   High rates of chronic undernutrition among indigenous children further
   undermine their human capital development.  In Latin America and the Caribbean,
   prevalence rates of stunting in children are higher in indigenous than in non-
   indigenous peoples. For example, in Guatemala, where levels of stunting are high
   compared with other countries, 58 percent of indigenous children are stunted,
   compared with 34 percent of non-indigenous children. 

   Higher prevalence of health risk factors, chronic diseases, and mental and
   substance use disorders are also found among indigenous people. In the United
   States, CDC reports evidence that colorectal cancer screening prevalence is
   lowest, binge drinking is highest, motor vehicle crash rate is highest, and drug-
   induced death rates are highest in American Indian/Alaskan Natives compared to
   other ethnicities. Additionally, in the United States, smoking prevalence is highest
   among indigenous youth compared to non-indigenous peers. In Canada, the
   suicide rate for First Nations males aged 15–24 is four times higher than that of
   non-indigenous young people.  First Nations populations are particularly at risk for
   substance abuse, contracting tuberculosis and/or HIV, and developing diabetes.
   Indigenous women in Canada are ve to seven times more likely than other women
   to die as the result of violence. 

   These data provide compelling evidence that poverty among indigenous people in
   the Americas is about more than income. Indeed, unsafe and unsanitary living
   conditions and wide health and education disparities are all measures of
   multidimensional poverty that require broad, sustained, multisectoral efforts to
www.pvmarquez.com/legacy_to_overcome                                                                                                         4/6
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez

   overcome.  To be effective, however, these efforts must be rooted in consultation
   with and active participation of indigenous people, while respecting their cultures
   and identities. As the recent experience in Ecuador shows, the voices of indigenous
   peoples are now an integral part of the political process. They demand to be heard
   and must be part of the planning and implementation of economic and social
   policies and programs to ensure acceptance and sustainability.

    
   Sources
   World Bank Group. “Indigenous Latin America in the Twenty-First Century”.
   (https://www.worldbank.org/en/region/lac/brief/indigenous-latin-america-in-
   the-twenty- rst-century-brief-report-page)
   United Nations. “State of the World’s Indigenous Peoples”.
   (https://www.un.org/development/desa/indigenouspeoples/wp-
   content/uploads/sites/19/2018/03/The-State-of-The-Worlds-Indigenous-
   Peoples-WEB.pdf)
   PAHO/WHO. “Just Societies: Health Equity and Digni ed Lives. Report of the
   Com… (https:/   /www.paho.org/hq/index.php?
   option=com_content&view=article&id=1245%3Apaho-
   publications&Itemid=1497&lang=en)
   PAHO/WHO. “Core Indicators 2019 Health Trends in the Americas”.
   (https://www.paho.org/hq/index.php?
   option=com_content&view=article&id=15499%3Acore-indicators-2019-health-
   trends-in-the-americas&Itemid=1894&lang=en)
   NIH. “MATERNAL MORBIDITY AND MORTALITY What Do We Know? How Are We
   Addressing I…
   (https://orwh.od.nih.gov/sites/orwh/ les/docs/ORWH_MMM_Booklet_508C.pdf)
   Babyar, J. “In search of Pan-American indigenous health and harmony”.
   (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381669/)
   Picture in blog by David Diaz Arcos/Bloomberg
   (https://www.bloomberg.com/news/articles/2019-10-12/ecuador-s-scorned-
   indigenous-rise-up-as-moreno-s-biggest-threat)




www.pvmarquez.com/legacy_to_overcome                                                                                                         5/6
1/12/2021                          Social Disparities Among Indigenous Peoples in the Americas: A Legacy to Overcome | Patricio V. Marquez




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www.pvmarquez.com/legacy_to_overcome                                                                                                         6/6